Senescent T Cells as a Contributing Cause of Age-Related Autoimmunity
We reported that a unique PD-1+ MP CD4+ T cell population is increased with age, now termed senescence-associated (SA-) T cells. The SA-T cells show characteristic signs and features of cellular senescence and emerge as follicular T cells in spontaneous germinal centers (GCs) that occur in aged mice. Spontaneous development of GCs is a hallmark of systemic autoimmune diseases, and among a number of changes in immune function with age is an increasing risk for autoimmunity.
Link: https://www.ncbi.nlm.nih.gov/books/NBK500331/
Source: Fight Aging! - Category: Research Authors: Reason Tags: Daily News Source Type: blogs
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