MKSAP: 67-year-old woman who takes diclofenac
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians. A 67-year-old woman is evaluated during a routine examination. She has a history of hip and knee pain related to degenerative joint disease. The joint pain is now well controlled with diclofenac, which was started 3 months ago. A previous trial of high-dose acetaminophen was not effective. She does not have any gastrointestinal symptoms, and she takes the diclofenac with food most of the time. Her medical history is otherwise notable for type 2 diabetes mellitus, hyperlipidemia, and hypertension. Her parents bot...
Source: Kevin, M.D. - Medical Weblog - August 5, 2017 Category: General Medicine Authors: < a href="http://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions GI Medications Orthopedics Source Type: blogs

Psychology Around the Net: July 15, 2017
Discussion: Because some of you might not have seen this on social media (and, obviously, other news outlets), I don’t want to give any spoiler alerts on this “larger discussion,” but I promise you might just walk away from it with the urge to talk with your own boss about company policies. Or, if you’re the boss, it might make you take a closer look at your employees’ mental health needs. These Are the 7 Things That Drive People to Get Things Done, According to Psychology: Clinical psychologist Mary C. Lamia takes a look at the different motivations that move people to chase not just success,...
Source: World of Psychology - July 15, 2017 Category: Psychiatry & Psychology Authors: Alicia Sparks Tags: Bipolar Creativity Depression Disorders Health-related Industrial and Workplace Men's Issues Policy and Advocacy Psychology Around the Net Research Schizophrenia Sleep Stress Substance Abuse Success & Achievement Women's Issu Source Type: blogs

Centenarians Suffer from Significantly Lower Rates of Chronic Age-Related Disease than Younger Cohorts
Aging is an accumulation of molecular damage and its consequences. The greater the level of damage, the greater the dysfunction in organs and the immune system, then the closer the individual comes to the arbitrary dividing line at which that dysfunction becomes a formal, named age-related disease. Further, the more damage, the higher the mortality rate. Given this view of aging, it should be no great surprise to find that the longest lived people have a history of comparatively little age-related disease: the only ways to become extremely old are to either (a) have accumulated damage at a slower rate that everyone else, m...
Source: Fight Aging! - June 28, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

MKSAP: 56-year-old woman with type 2 diabetes mellitus
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians. A 56-year-old woman presents to the office to discuss management of her type 2 diabetes mellitus. She is unhappy with her recent HbA1c value. She adheres to the maximum dose metformin monotherapy, which she has been taking for 1 year. Additionally, she has been working toward weight reduction without success; however, weight loss remains a top priority for this patient. Medical history is significant for hypertension, dyslipidemia, and recurrent vulvovaginal candidiasis. Family history includes type 2 diabetes i...
Source: Kevin, M.D. - Medical Weblog - June 17, 2017 Category: General Medicine Authors: < a href="http://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions Diabetes Source Type: blogs

Fight Aging! Newsletter, June 5th 2017
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - June 4, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The Degree to which Vascular Stiffness and Hypertension are Secondary Aging
Today's research results provide data to indicate the degree to which vascular stiffening and hypertension across today's population are the consequences of avoidable lifestyle choices and environmental factors rather than consequences of unavoidable processes of damage. The study suggests that cardiovascular aging can be influenced considerably until a comparatively late age, and in this it may be one of the most malleable of the many distinct aspects of aging. All of aging is some mix of primary and secondary contributions, varying widely between organs and circumstances. One can think of primary aging as the list of cel...
Source: Fight Aging! - May 30, 2017 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Health Insurance Benefits Should Be Equitable, Not Necessarily Equal
As policy makers grapple with potentially undoing or modifying the largest expansion of health insurance in a generation, the cost and generosity of benefits hold center stage. Traditional underpinnings of insurance plans—premiums, deductibles, copayments, and coinsurance—frequently create barriers to the optimal use of these plans by consumers. They also can exacerbate inequities in health care, by inhibiting the use of services known to benefit health. Novel approaches to insurance plan design to produce a more equitable and efficient distribution of health care expenditures are warranted. Following the princ...
Source: Health Affairs Blog - May 22, 2017 Category: Health Management Authors: Betsy Q. Cliff, Michael Rozier and A. Mark Fendrick Tags: Costs and Spending Featured Health Equity Insurance and Coverage health insurance benefits insurance plan design value-based insurance design Source Type: blogs

Funtabulously Frivolous Friday Five 190
LITFL: Life in the Fast Lane Medical Blog LITFL: Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog Just when you thought your brain could unwind on a Friday, you realise that it would rather be challenged with some good old fashioned medical trivia FFFF…introducing Funtabulously Frivolous Friday Five 190. This week we focus on #middleclassinjuries. Question 1 Finally you get the weekend off you’ve been waiting for, ready to dive into your brunch with the standard artisan bread. What sourdough injury should you be wary of? + Reveal the Funtabulous Answer expand(docu...
Source: Life in the Fast Lane - May 18, 2017 Category: Emergency Medicine Authors: Neil Long Tags: Frivolous Friday Five avocado hand kilner sprain Meryl Streep middle class injuries middle class injury middleclassinjuries necrotising fasciitis oyster shuck pestle and mortar Sourdough gum vibrio vulnificus Source Type: blogs

Funtabulously Frivolous Friday Five 190
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog Just when you thought your brain could unwind on a Friday, you realise that it would rather be challenged with some good old fashioned medical trivia FFFF…introducing Funtabulously Frivolous Friday Five 190. This week we focus on #middleclassinjuries. Question 1 Finally you get the weekend off you’ve been waiting for, ready to dive into your brunch with the standard artisan bread. What sourdough injury should you be wary of? + Reveal the Funtabulous Answer expan...
Source: Life in the Fast Lane - May 18, 2017 Category: Emergency Medicine Authors: Neil Long Tags: Frivolous Friday Five avocado hand kilner sprain Meryl Streep middle class injuries middle class injury middleclassinjuries necrotising fasciitis oyster shuck pestle and mortar Sourdough gum vibrio vulnificus Source Type: blogs

MKSAP: 57-year-old man is seen after results of a carotid ultrasound
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians. A 57-year-old man is seen for follow-up evaluation after results of a carotid ultrasound obtained to investigate a left neck bruit show a mixed density plaque at the origin of the left internal carotid artery. Stenosis is estimated to be 60% to 80%. He has had no focal neurologic symptoms or visual loss. The patient has coronary artery disease (CAD) with stable angina, hypertension, dyslipidemia, type 2 diabetes mellitus, and mild kidney failure. He has a 30-pack-year smoking history but stopped smoking 7 years ...
Source: Kevin, M.D. - Medical Weblog - May 6, 2017 Category: Journals (General) Authors: < a href="http://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions Heart Source Type: blogs

Simple Arterial Health Measures as a Basis for a Biomarker of Aging
In this study, we attempt the dissection of biochemical and clinical predictors of age, the development of a predictive model for biological age, and exploration of the deviation of these predictions from chronological age in a cohort of 303 individuals. We quantified 89 clinical and biochemical parameters, then selected the top five parameters with a highest Pearson's correlation with chronological age. Importantly, all five of these parameters reflect the functioning of the cardiovascular system. The outputs of the gender-specific linear regression models predicting chronological age were compared to actual age of the su...
Source: Fight Aging! - May 5, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Contego Medical ’s Vanguard IEP Cleared in Europe for Safer Balloon Angioplasties
Contego Medical of Raleigh, North Carolina won the European CE Mark to introduce its Vanguard IEP peripheral balloon angioplasty system. The product features the firm’s Integrated Embolic Protection (IEP) technology that captures embolic debris coming off occlusions being treated within the superficial femoral artery. The IEP looks a bit like a parachute that extends around the distal tip of the Vanguard, covering the arterial lumen, whatever its size, so that just about all the blood flows through its filtrating material. Large objects, greater than the 150-micron pores of the parachute, are captured during ball...
Source: Medgadget - May 2, 2017 Category: Medical Equipment Authors: Editors Tags: Radiology Vascular Surgery Source Type: blogs

The suicide rate is increasing. Why is that?
Those of us who work in pediatric intensive care have frequent encounters with the problem of suicide and attempted suicide. It has seemed to me for some years that the numbers are increasing, and this has been shown to be the case. After years of declining, the suicide rate in our country has been increasing, now at about 125 percent of the rate of several decades ago. This increase accelerated after 2006. Although all age groups showed an increase, the rate among women, particularly adolescent girls, took a notable jump. In 2012 suicide was the second leading cause of death in adolescents aged 12 to 19 years, accounting ...
Source: Kevin, M.D. - Medical Weblog - April 11, 2017 Category: Journals (General) Authors: < a href="http://www.kevinmd.com/blog/post-author/christopher-johnson" rel="tag" > Christopher Johnson, MD < /a > Tags: Conditions Psychiatry Source Type: blogs

OPDP Picks Up Steam on Enforcement Letters
After a fairly slow 2016, the United States Food and Drug Administration’s (FDA) Office of Prescription Drug Promotion (OPDP) issued a quick burst of letters in the span of nine days in December. This flurry of activity more than doubled the enforcement letters that had been issued up to that point in the year. Although there was an apparent increase in enforcement activity in December (perhaps related to the new Administration and the mark the old Administration wanted to leave on the industry), the type of activity and the nature of Draft Guidances issued in 2017 prior to the Trump Administration taking office indicat...
Source: Policy and Medicine - April 5, 2017 Category: American Health Authors: Thomas Sullivan - Policy & Medicine Writing Staff Source Type: blogs

MKSAP: 81-year-old man after a percutaneous coronary intervention
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians. An 81-year-old man is evaluated in the office 3 days following a percutaneous coronary intervention with placement of a bare metal stent in the left anterior descending artery for angina refractory to maximal medical therapy. He indicates that he feels well except for palpitations that were not present before the procedure. Medical history is significant for hypertension and type 2 diabetes mellitus. He has no risk factors for or history of significant bleeding. Medications are aspirin, clopidogrel, lisinopril, ...
Source: Kevin, M.D. - Medical Weblog - March 25, 2017 Category: Journals (General) Authors: < a href="http://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions Heart Source Type: blogs