Recombinant Klotho Treatment Improves Cognitive Function in Old Rhesus Macaques
Klotho is one of the few genuinely longevity-associated genes, in that greater than normal expression increases life span in mice, while lower than normal expression shortens life span in mice. In humans, greater levels of circulating soluble klotho correlate with greater longevity. Klotho is thought to operate in the kidneys, in some way that is protective against the mechanisms of age-related decline, but there is a great deal of evidence for greater circulating klotho to improve cognitive function. At the same time, it seems unclear as to whether klotho is actually doing anything in the brain; it may be that the benefit...
Source: Fight Aging! - July 12, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Resistance Exercise Slows the Onset of Pathology in a Mouse Model of Alzheimer's Disease
With the caveat that mouse models of Alzheimer's disease are quite artificial, as aged wild-type mice do not suffer from any condition resembling Alzheimer's, and the models are thus built upon assumptions about which processes are important to the progression of the condition, researchers here show that resistance exercise slows the pathology and loss of cognitive function in one such model. Resistance exercise is well demonstrated to improve metabolism, immune function, and reduce mortality in both older animals and humans. It would not be too surprising to find that sedentary individuals are performing more poorly in th...
Source: Fight Aging! - July 11, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
How To Make Your Brain 20 Years Younger
This can benefit adults of any age. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - July 10, 2023 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Dementia Source Type: blogs
Fight Aging! Newsletter, July 10th 2023
In conclusion, the examination of the GBA can aid in understanding the etiology and development of NDs, which may benefit the improvement of clinical treatments for these disorders and ND interventions. This review indicates existing knowledge about the involvement of microbiota present in the gut in NDs and potential treatment options.
The Aging of the Enteric Nervous System
https://www.fightaging.org/archives/2023/07/the-aging-of-the-enteric-nervous-system/
The enteric nervous system is the nervous system of the intestines, and likely an important part of the relationship between the gut microbiome ...
Source: Fight Aging! - July 9, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Rationing Health Care
Lately we ' ve touched upon the absurd cost of medical services in the U.S. -- we spend twice as much as the next biggest spender and three or four times as much as others -- and we ' re less healthy for it. There are a few reasons for this, but here I ' m going to touch the third rail.In the United States, in contrast to other nations, if the FDA approves a treatment, insurance has to pay for it. The FDA does not consider cost, but only whether there is evident of clinical benefit that outweighs risks or (non-financial) harms. The definition of benefit and harm, and how to value them, is of course far from obvious, but we...
Source: Stayin' Alive - July 7, 2023 Category: American Health Source Type: blogs
Memory Loss: This Supplement Slows Brain Shrinkage By 50%
The supplement halves the rate of brain shrinkage. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - July 7, 2023 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Dementia Source Type: blogs
The Vitamin Deficiency That ’ s Putting Your Mental Health At Risk
The deficiency is linked to depression and poorer brain function, lower verbal fluency and even dementia. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - July 5, 2023 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Depression Source Type: blogs
Progress Towards Rejuvenation as a Matter of Investment versus a Matter of Time
It is not hard to argue that there is too little investment in progress towards the treatment of aging as a medical condition. Collectively, the underlying mechanisms of degenerative aging are the cause of two-thirds of human mortality, and likely a somewhat greater fraction of loss of function, suffering, and pain. The cost of that mortality is vast, no matter how one likes to model the value of a human life, or a year spent alive in good health. This is much the same argument that can be made for greater investment in medical research in general. Medical research funding as a whole is a very, very tiny fraction of the co...
Source: Fight Aging! - July 4, 2023 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
The Business Reality of Healthcare AI
BY KIM BELLARD
I was at the barbershop the other day and overheard one barber talking with his senior citizen customer about when – not if – robot AIs would become barbers. I kid you not.
Now, I don’t usually expect to heard conversations about technology at the barber, but it illustrates that I think we are at the point with AI that we were with the Internet in the late ‘90’s/early ‘00s: people’s lives were just starting to change because of it, new companies were jumping in with ideas about how to use it, and existing companies knew they were going to have to figure out ways to incorporate it if they ...
Source: The Health Care Blog - July 4, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Tech Healthcare AI healthcare delivery Kim Bellard Source Type: blogs
Cognitive Impairment Correlates with an Altered Gut Microbiome
This study aims to investigate the gut microbial composition associated with MCI, cognitive functions, and structural brain differences. A nested case-control study was conducted in a community-based prospective cohort where detailed cognitive functions and structural brain images were collected. Thirty-one individuals with MCI were matched to sixty-five cognitively normal controls by age strata, gender, and urban/rural area. Fecal samples were examined using 16S ribosomal RNA (rRNA) sequencing. Compositional differences between the two groups were identified and correlated with the cognitive functions and volumes/thicknes...
Source: Fight Aging! - July 3, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, July 3rd 2023
In this study, cultured adipose-derived stem cells (ASCs) were derived from subcutaneous white adipose tissue isolated from mice fed a normal diet. We performed senescence-associated-β-galactosidase (SA-β-gal) staining, real-time PCR, and Western blot to evaluate the levels related to cellular senescence markers.
The mRNA expression levels of senescence markers were significantly increased in the later passages of ASCs. We show that light activation reduced the expression of senescent genes, and SA-β-Gal in all cells at passages. Moreover, the light-activated ASCs-derived exosomes decrease the expression of senes...
Source: Fight Aging! - July 2, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
These Fruits And Veg Reduce Cognitive Decline Risk The Most
The fruits and vegetables that provide the highest protection against cognitive decline. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - June 30, 2023 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Dementia Source Type: blogs
The Vitamin Deficiency In The Brain Linked To Dementia
The study looked directly at levels of this vitamin in the brain, about which little is known. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - June 29, 2023 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Dementia Source Type: blogs
Senescent Astrocytes in the Aging of the Brain
Cellular senescence in the supporting cells of the brain is increasingly implicated in the onset and progression of neurodegenerative conditions. Senescent cells accumulate with age, as the immune system becomes less competent and falters in their timely removal. These errant cells secrete pro-inflammatory factors that are disruptive of tissue structure and function, contributing to the neuroinflammation that is characteristic of age-related cognitive decline and dementia. We can hope that senolytic treatments capable of passing the blood-brain barrier will help to prevent and treat many forms of neurodegenerative disease ...
Source: Fight Aging! - June 29, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Frailty Correlates with Cognitive Decline
The objective of this work is to determine if frailty is associated with cognitive decline among older adults from different countries. We analyzed the baseline the Study on Global Ageing and Adult Health (SAGE), that includes six countries (Ghana, South Africa, Mexico, China, Russia, and India). A cross-sectional analysis was used to assess how frailty was related with the Clinical Frailty Scale (CFS) decision tree, while cognitive decline was evaluated using standardized scores of tests used in SAGE.
A total of 30,674 participants aged 50 years or older were included. To the best of our knowledge this is the fir...
Source: Fight Aging! - June 28, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
