The Belief That Cuts Dementia Risk In Half
The simple belief about old age that halves your dementia risk. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - October 13, 2023 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Dementia Source Type: blogs
Armchair diagnosis
I used to think it was a slowly progressive form of frontotemporal dementia, rather than Alzheimer ' s disease, but now I ' m starting to suspect that the frontotemporal dementia and severe personality disorder are indeed complicated by Alzheimer ' s,and that the rate of progression is increasing. I don ' t have anything to add to that personally, the guy has clearly lost his marbles. Not that he ever had a full bag.What is disturbing is that the cultists applaud and cheer uproariously for his incoherent ranting, and even completely incomprehensible, unintelligible passages accompanied by bizarre gestures and sounds....
Source: Stayin' Alive - October 13, 2023 Category: American Health Source Type: blogs
T Cell Exhaustion and the Role of Infections in Alzheimer's Disease
In this study we examined immune system alterations early in the progression to Alzheimer's disease (AD). We observed multiple changes across the peripheral innate and adaptive immune systems associated with amyloid and cognitive status within our aging cohort. In the innate immune system, we observed increased plasmacytoid and myeloid dendritic cells in amyloid positive participants, but these changes were particularly pronounced in those with mild cognitive impairment. We also observed a decrease in total natural killer cells with amyloid positivity. When the adaptive immune system was examined, we observed increases in ...
Source: Fight Aging! - October 10, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Arguing for Mitochondrial DNA Damage to Spread Between Neurons in Parkinson's Disease
The most noticeable symptoms of Parkinson's disease occur because of the loss of a small but vital population of dopamine-generating neurons in the brain. The condition is associated with the spread of misfolded, aggregated α-synuclein throughout brain tissue. α-synuclein is one of the few molecules in the body capable of misfolding in ways that encourage other molecules o α-synuclein to also misfold in the same way. It can thus spread from cell to cell, perhaps carried in extracellular vesicles. It is thought that misfolding of α-synuclein often first occurs in the intestines, and only then spreads to the brain throug...
Source: Fight Aging! - October 9, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, October 9th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - October 8, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
4 Key Antioxidant Deficiencies In Brains With Alzheimer ’ s (M)
The antioxidants are found in abundance in certain types of plants. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - October 6, 2023 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Dementia subscribers-only Source Type: blogs
A Bidirectional Relationship Between Hearing Loss and Cognitive Decline?
In today's open access review paper, researchers lay out summarize hypotheses and evidence for there to be a bidirectional relationship between age-related hearing loss and loss of cognitive function. Their summary is informative, but in their view the present literature is too sparse to be conclusive, and further studies are needed to provide a greater breadth of human data.
There is good reason to think that hearing loss contributes directly to a more rapid pace of cognitive decline. The brain is very much a "use it or lose it" organ, and lacking use in later life, it declines more rapidly. Evidence from study pop...
Source: Fight Aging! - October 5, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, October 2nd 2023
In conclusion, we identified several candidate genes that may confer cancer resistance in cetaceans, providing a new avenue for further research into the mechanisms of lifespan extension.
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A Relationship Between the Gut Microbiome and Bone Density
https://www.fightaging.org/archives/2023/09/a-relationship-between-the-gut-microbiome-and-bone-density/
Changes in the gut microbiome take place with advancing age, an increase in populations that provoke chronic inflammation, a reduction in the populations producing beneficial metabolites. Even only considering rising levels of in...
Source: Fight Aging! - October 1, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
WHO Report: Tackling Hypertension Could Avert 76M Deaths Globally
Conclusion
Hypertension, often referred to as the “silent killer,” isn’t just a mere health term; it’s a pressing global challenge with vast implications.
As the World Health Organization’s report underscores, controlling high blood pressure is more than a matter of personal health. It’s about potentially averting millions of deaths worldwide by 2050.
It’s heartening to see countries like Canada and South Korea lead the charge with effective treatment programs, offering hope and a pathway for others to follow.
Yet, the contrasting statistics on sodium intake and the p...
Source: The EMT Spot - September 26, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: News Source Type: blogs
Four reasons to question “new generation” monoclonal antibody Alzheimer’s drugs such as aducanumab (Aduhelm), lecanemab (Leqembi), donanemab
New Alzheimer’s Drugs Don’t Deserve the Hype (Being Patient):
A prominent childhood memory is of my grandparents living with and then dying from dementia. As is universal with dementia, there was a double blow: watching my grandparents lose their identity and seeing the suffering of those closest to them.
… Enter three drugs, tentatively FDA-approved aducanumab (Aduhelm); fully FDA-approved lecanemab (Leqembi); and donanemab … currently in clinical trials and soon to be considered for FDA approval) that remove amyloid, the protein thought to cause Alzheimer’s disease… But how useful are these drugs going t...
Source: SharpBrains - September 25, 2023 Category: Neuroscience Authors: SharpBrains Tags: Brain/ Mental Health aducanumab Aduhelm Alzheimer's drugs brain bleeding brain swelling dementia donanemab hype lecanemab Leqembi monoclonal antibody Alzheimer's drugs MRI-scans Source Type: blogs
Blarcamesine Slows Progression of Alzheimer's Disease in a Human Trial
Is maladaptive loss of autophagy a meaningful contributing factor in Alzheimer's disease? The results of a recent clinical trial suggest so. Autophagy is the name given to a collection of cellular maintenance processes responsible for recycling unwanted proteins, molecular waste, and damaged cell components. Improving autophagy should in turn improve cell function. The drug development program noted here has reached the stage of later human trials to assess efficacy, and is focused on correcting one specific mechanism that appears to negatively affect autophagy in the Alzheimer's brain, and that in turn helps to clear out ...
Source: Fight Aging! - September 25, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, September 25th 2023
In conclusion, this individual patient data meta-analysis of longitudinal cohort studies found that antihypertensive use was associated with decreased dementia risk compared with individuals with untreated hypertension through all ages in late life. Individuals with treated hypertension had no increased risk of dementia compared with healthy controls.
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Results from Human Clinical Trials Do Not Support Metformin as a Longevity Drug
https://www.fightaging.org/archives/2023/09/results-from-human-clinical-trials-do-not-support-metformin-as-a-longevity-drug/
The SENS Research Fou...
Source: Fight Aging! - September 24, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Familiar Pill That Reduces Dementia Risk By 13%
Treating this condition in mid- or later life can halt dementia. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - September 23, 2023 Category: Psychiatry & Psychology Authors: Mina Dean Tags: Blood Pressure Dementia Source Type: blogs
Medical Control of Hypertension Largely Removes Increased Risk of Dementia
In conclusion, this individual patient data meta-analysis of longitudinal cohort studies found that antihypertensive use was associated with decreased dementia risk compared with individuals with untreated hypertension through all ages in late life. Individuals with treated hypertension had no increased risk of dementia compared with healthy controls. (Source: Fight Aging!)
Source: Fight Aging! - September 20, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Different Invasive Bacterial Species are Found in Alzheimer's Brains versus Normal Brains
Research into the effects of the human microbiome on health and aging has progressed quite rapidly in recent years. It now costs little to sequence a sample to determine the which bacterial species are present and in what proportions. With age, the intestinal barrier, blood vessels, and blood-brain barrier begin to leak, allowing greater passage of microbes into the body. Additionally, the immune system declines in function, reducing the ability to clear these microbes from tissues.
In the case of patients with Alzheimer's disease, researchers are finding that the gut microbiome exhibits characteristic differences w...
Source: Fight Aging! - September 20, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
