Cognitive Decline Is A Myth: The Real Reason Names Are Harder To Recall With Age
A steady decline? Experts question whether the human brain really slows down with age. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - March 19, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Dementia Source Type: blogs
Microplastics, Major Problem
By KIM BELLARD
It’s been almost four years since I first wrote about microplastics; long story short, they’re everywhere. In the ground, in the oceans (even at the very bottom), in the atmosphere. More to the point, they’re in the air you breathe and in the food you eat. They’re in you, and no one thinks that is a good thing. But we’re only starting to understand the harm they cause.
The Washington Post recently reported:
Scientists have found microplastics — or their tinier cousins, nanoplastics — embedded in the human placenta, in blood, in the heart and in the liver and bowels. In one re...
Source: The Health Care Blog - March 19, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Tech Kim Bellard Microplastics Source Type: blogs
Towards a Better Understanding of the Role of the Gut Microbiome in Alzheimer's Disease
This article summarizes research presented at the virtual symposium and workshop, "New Approaches for Understanding the Potential Role of Microbes in Alzheimer's Disease." The objective of these events was to review the evidence base and catalyze research to address knowledge gaps in the hypothesis that infections or microbes play some causative role in the development or progression of Alzheimer's disease. Alzheimer's disease is a complex disease; this symposium was rooted in an understanding that its pathogenesis could be triggered by both microbe-dependent and microbe-independent pathways and the two are not mutually ex...
Source: Fight Aging! - March 15, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
This Early Sign Of Dementia Doubles The Risk
Losing this sense is the strongest early sign of dementia. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - March 15, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Dementia Source Type: blogs
Is the Aging Hippocampus Particularly Vulnerable to Blood-Brain Barrier Dysfunction?
The hippocampus in the brain is vital to cognitive functions involving learning and memory. In today's open access paper, researchers review the evidence for the hippocampus to be particularly vulnerable to damaging mechanisms, including those involved in aging. It is tentatively suggested that physiological and biochemical differences in the hippocampus point to a greater fragility of the hippocampal blood-brain barrier as a common thread underlying pathological changes observed in aging and Alzheimer's disease. The blood-brain barrier is a specialized layer of cells that wrap blood vessels passing through the central ner...
Source: Fight Aging! - March 13, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The Personality Trait That Lowers Dementia Risk
The trait may encourage people to keep their mind active, which is a protective factor against dementia. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - March 12, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Dementia Personality Source Type: blogs
Fight Aging! Newsletter, March 11th 2024
In conclusion, this Mendelian randomization study found that Streptococcus was causally associated with Bioage acceleration. Further randomized controlled trials are needed to investigate its role in the aging process.
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Considering the Mechanisms of Vascular Calcification
https://www.fightaging.org/archives/2024/03/considering-the-mechanisms-of-vascular-calcification/
Harmful calcification of structures in the cardiovascular system proceeds alongside the development of the fatty lesions of atherosclerosis. Both disease processes are accelerated by chronic inflammation, but d...
Source: Fight Aging! - March 10, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Request for Startups in the Rejuvenation Biotechnology Space, 2024 Edition
Investors focused on funding biotechnology startups tend to exhibit herd behavior, much like investors everywhere these days. Funding is primarily deployed towards fads and popular trends, not necessarily towards what makes the most sense, even if sometimes the sensible manages to align with the popular. These days that means drug discovery platforms with a strong computational component and partial epigenetic reprogramming. But even in this environment, the path to true success is to work on important projects that few other people are touching. Be the champion for a potential solution to a tough, high-value, comparativel...
Source: Fight Aging! - March 8, 2024 Category: Research Authors: Reason Tags: Investment Source Type: blogs
The Common Drink That Reduces Alzheimer ’ s Risk
Alzheimer’s is the most common form of dementia. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - March 3, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Dementia Source Type: blogs
Fight Aging! Newsletter, March 4th 2024
In conclusion, HSV (but not CMV) infection may be indicative of doubled dementia risk.
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Increased Dietary Leucine Activates mTOR Signaling in Macrophages, Accelerating Atherosclerosis
https://www.fightaging.org/archives/2024/02/increased-dietary-leucine-activates-mtor-signaling-in-macrophages-accelerating-atherosclerosis/
Leucine is an essential amino acid, only obtained from the diet rather than synthesized by our cells. Leucine supplementation has been proposed as a way to slow the loss of muscle mass with age, as leucine processing becomes dysregulated with aging in a way...
Source: Fight Aging! - March 3, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
This Is The Effect Of Sugar On Your Brain ’ s Memory Centres (M)
The sweet enemy of memory lurking in your diet. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - March 2, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Dementia subscribers-only Source Type: blogs
NPTX2 Involved in Neurodegeneration Driven by TDP-43 Aggregation
Altered, misfolded forms of TDP-43 are thought to contribute to neurodegeneration in a number of age-related conditions, primarily amyotrophic lateral sclerosis and frontotemporal dementia. As is the case for other misfolded proteins associated with neurodegeneration, aberrant TDP-43 may accumulate in much of the older population to levels sufficient to meaningfully contribute to cognitive decline. That TDP-43 has this negative impact is a relatively recent discovery, and in comparison to amyloid-β, tau, and α-synuclein little is known of the mechanisms by which TDP-43 aggregation causes dysfunction and death in brain ce...
Source: Fight Aging! - February 29, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Particulate Air Pollution Correlates with Risk of Alzheimer's Disease
Researchers here use data on air pollution from a single US metropolitan area to show a correlation with Alzheimer's disease risk. Air pollution is shown to increase chronic inflammation via the interaction of particulates with lung tissue, and inflammation is an important component of the onset and progression of neurodegenerative conditions such as Alzheimer's disease. That said, the researchers were primarily interested in traffic as a source of particulate air pollution, and one might think that this introduces a correlation with wealth, given the usual distribution of cost of living versus proximity to major flows of ...
Source: Fight Aging! - February 29, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Mystery Of Cognitive Decline: Why Only Some People Age Gracefully (M)
From education to cognitive reserve, discover the key factors that slow down cognitive decline as we age. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - February 28, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Dementia subscribers-only Source Type: blogs
An Update on Progress Towards Treating Atherosclerosis at Cyclarity
Today I'll point out an interview with one of the Cyclarity Therapeutics founders, illustrative of the degree to which biotech companies are at the mercy of regulators once they arrive at the clinical stage of development. Cyclarity, formerly Underdog Pharmaceuticals, is a spin-out from the SENS Research Foundation, an organization that aims to clear roadblocks in the translational research needed for the production of rejuvenation therapies. The program that led to Cyclarity was focused on finding a way to clear 7-ketocholesterol from the body. 7-ketocholesterol is a form of oxidized cholesterol, created as a result of ox...
Source: Fight Aging! - February 27, 2024 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
