Pharmacological evaluation of the anxiolytic-like effects of an aqueous extract of the Raphanus sativus L. sprouts in mice
Biomed Pharmacother. 2023 Mar 27;162:114579. doi: 10.1016/j.biopha.2023.114579. Online ahead of print.ABSTRACTRaphanus sativus L. (Brassicaceae), commonly known as radish, is consumed worldwide as a vegetable. However, its benefits on mental health are unknown. The aim of this study was to evaluate its anxiolytic-like effects and safety using different experimental models. An aqueous extract of R. sativus sprouts (AERSS) was pharmacologically evaluated by intraperitoneal route (i.p.) at 10, 30, and 100 mg/kg and orally (p.o.) at 500 mg/kg on behavior by using open-field and plus-maze tests. In addition, its acute toxicity ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 29, 2023 Category: Drugs & Pharmacology Authors: Laura Yunuen Hern ández-Sánchez Mar ía Eva González-Trujano Diego A Moreno Heike Vibrans Israel Castillo-Ju árez Alejandro Dorazco-Gonz ález Marcos Soto-Hern ández Source Type: research
Pharmacological evaluation of the anxiolytic-like effects of an aqueous extract of the Raphanus sativus L. sprouts in mice
Biomed Pharmacother. 2023 Mar 27;162:114579. doi: 10.1016/j.biopha.2023.114579. Online ahead of print.ABSTRACTRaphanus sativus L. (Brassicaceae), commonly known as radish, is consumed worldwide as a vegetable. However, its benefits on mental health are unknown. The aim of this study was to evaluate its anxiolytic-like effects and safety using different experimental models. An aqueous extract of R. sativus sprouts (AERSS) was pharmacologically evaluated by intraperitoneal route (i.p.) at 10, 30, and 100 mg/kg and orally (p.o.) at 500 mg/kg on behavior by using open-field and plus-maze tests. In addition, its acute toxicity ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 29, 2023 Category: Drugs & Pharmacology Authors: Laura Yunuen Hern ández-Sánchez Mar ía Eva González-Trujano Diego A Moreno Heike Vibrans Israel Castillo-Ju árez Alejandro Dorazco-Gonz ález Marcos Soto-Hern ández Source Type: research
Green synthesis of silver nanoparticles based on the Raphanus sativus leaf aqueous extract and their toxicological/microbiological activities
Environ Sci Pollut Res Int. 2023 Mar 24. doi: 10.1007/s11356-023-26499-z. Online ahead of print.ABSTRACTSilver nanoparticles (AgNPs) have several uses. Many scientists are working on producing AgNPs from plant extracts for use as biomedicines against drug-resistant bacteria and malignant cell lines. In the current study, plant-based AgNPs were synthesized using Raphanus sativus L. (RS) leaf aqua extract. Different concentrations of AgNO3 were used to optimize the synthesis process of RS-AgNPs from the aqueous leaf extract. Energy-dispersive X-ray analysis (EDX), transmission electron microscopy (TEM), scanning electron mic...
Source: Cell Research - March 25, 2023 Category: Cytology Authors: Abdulkerim Hatipo ğlu Ay şe Baran Cumali Keskin Mehmet F ırat Baran Aziz Eftekhari Sabina Omarova Dawid Janas Rovshan Khalilov Mehmet Tevfik Adican Sevgi İrtegün Kandemir Source Type: research
Green synthesis of silver nanoparticles based on the Raphanus sativus leaf aqueous extract and their toxicological/microbiological activities
Environ Sci Pollut Res Int. 2023 Mar 24. doi: 10.1007/s11356-023-26499-z. Online ahead of print.ABSTRACTSilver nanoparticles (AgNPs) have several uses. Many scientists are working on producing AgNPs from plant extracts for use as biomedicines against drug-resistant bacteria and malignant cell lines. In the current study, plant-based AgNPs were synthesized using Raphanus sativus L. (RS) leaf aqua extract. Different concentrations of AgNO3 were used to optimize the synthesis process of RS-AgNPs from the aqueous leaf extract. Energy-dispersive X-ray analysis (EDX), transmission electron microscopy (TEM), scanning electron mic...
Source: Environmental Science and Pollution Research International - March 25, 2023 Category: Environmental Health Authors: Abdulkerim Hatipo ğlu Ay şe Baran Cumali Keskin Mehmet F ırat Baran Aziz Eftekhari Sabina Omarova Dawid Janas Rovshan Khalilov Mehmet Tevfik Adican Sevgi İrtegün Kandemir Source Type: research
Green synthesis of silver nanoparticles based on the Raphanus sativus leaf aqueous extract and their toxicological/microbiological activities
Environ Sci Pollut Res Int. 2023 Mar 24. doi: 10.1007/s11356-023-26499-z. Online ahead of print.ABSTRACTSilver nanoparticles (AgNPs) have several uses. Many scientists are working on producing AgNPs from plant extracts for use as biomedicines against drug-resistant bacteria and malignant cell lines. In the current study, plant-based AgNPs were synthesized using Raphanus sativus L. (RS) leaf aqua extract. Different concentrations of AgNO3 were used to optimize the synthesis process of RS-AgNPs from the aqueous leaf extract. Energy-dispersive X-ray analysis (EDX), transmission electron microscopy (TEM), scanning electron mic...
Source: Cell Research - March 25, 2023 Category: Cytology Authors: Abdulkerim Hatipo ğlu Ay şe Baran Cumali Keskin Mehmet F ırat Baran Aziz Eftekhari Sabina Omarova Dawid Janas Rovshan Khalilov Mehmet Tevfik Adican Sevgi İrtegün Kandemir Source Type: research
Cancers, Vol. 15, Pages 1906: Thai Rat-Tailed Radish Prevents Hepatocarcinogenesis in Rats by Blocking Mutagenicity, Inducing Hepatic Phase II Enzyme, and Decreasing Hepatic Pro-Inflammatory Cytokine Gene Expression
In conclusion, the RS extract consisting of phenolics and isothiocyanates exerted significant chemopreventive activity against DEN-induced liver carcinogenesis. (Source: Cancers)
Source: Cancers - March 22, 2023 Category: Cancer & Oncology Authors: Piman Pocasap Natthida Weerapreeyakul Rawiwan Wongpoomchai Tags: Article Source Type: research
Molecules, Vol. 28, Pages 2874: Bioactive Compounds, Antioxidant Activities, and HPLC Analysis of Nine Edible Sprouts in Cambodia
Natthida Weerapreeyakul
The non-nutritional health benefits of sprouts are unconfirmed. Thus, nine sprout methanolic extracts were tested for phytoconstituents and antioxidant activity. The TPC, TCC, TFC, TAC, and TALC were measured. ABTS and DPPH radical scavenging and ferric-reducing antioxidant power assays were used to assess the antioxidant activity. HPLC detected gallic acid, vanillin, syringic acid, chlorogenic acid, caffeic acid, and rutin in the extracts. The sprout extracts contained six compounds, with caffeic acid being the most abundant. Gallic acid, syringic acid, chlorogenic acid, caffeic acid, vanilli...
Source: Molecules - March 22, 2023 Category: Chemistry Authors: Visessakseth So Philip Poul Sokunvary Oeung Pich Srey Kimchhay Mao Huykhim Ung Poliny Eng Mengkhim Heim Marnick Srun Chantha Chheng Sin Chea Tarapong Srisongkram Natthida Weerapreeyakul Tags: Article Source Type: research
Decompression Mechanism of Radish Seed in Prehypertension Rats through Integration of Transcriptomics and Metabolomics Methods
In this study, we analyzed the effects of RS in a rat model of prehypertension and assessed the mechanistic basis by integrating transcriptomics and metabolomics. RS administration significantly reduced blood pressure in prehypertensive male Wistar rats, negatively regulated endothelin-1, increased nitric oxide levels, and reduced the exfoliation of endothelium cells. In vitro vascular ring experiments further confirmed the effects of RS on vascular endothelial cells. Furthermore, we identified 65 differentially expressed genes (DEGs; P adj < 0.05 and fold change (FC) > 2) and 52 metabolites (VIP > 1, P < 0.05 ...
Source: Evidence-based Complementary and Alternative Medicine - February 10, 2023 Category: Complementary Medicine Authors: Qiang Jia Yuchen Qi Hanbo Li Hai Ding Dongmei Qi Yunlun Li Source Type: research
Identification of haemanthamine as a phytotoxic alkaloid in < em > Narcissus pseudonarcissus L. < /em > (Daffodil) emerging buds
Nat Prod Res. 2023 Feb 6:1-7. doi: 10.1080/14786419.2023.2174536. Online ahead of print.ABSTRACTEmerging buds of Narcissus pseudonarcissus were found to accumulate the alkaloid haemanthamine (1) at high concentrations, exceeding that of narciclasine (2), the most abundant constituent in bulbs of the plant. A phytoactivity screening assay demonstrated the novel phytotoxicity of haemanthamine against Raphanus sativus (radish), Lactuca sativus (lettuce), Triticum aestivum (red wheat), Solanum lycopersicum (tomato), Cucumis sativus (cucumber), Ipomoea (Morning glory), and Lens culinaris (lentil). Haemanthamine (1) phytotoxicit...
Source: Natural Product Research - February 6, 2023 Category: Biochemistry Authors: Christine J Kempthorne Suresh Borra Manoj Kumar Chanti Babu Dokuburra David K Liscombe James McNulty Source Type: research
Physiological and biochemical markers of gamma irradiated white radish ( < em > Raphanus sativus < /em > )
CONCLUSION: It can be concluded the gamma irradiation was a useful method for increasing the growth and biochemical content of white radish plants.PMID:36731458 | DOI:10.1080/09553002.2023.2176561 (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - February 2, 2023 Category: Radiology Authors: Amina Aly Noha Eliwa Ahmed Taha Zeyad Borik Source Type: research
Biotransformation of bisphenol A in vivo and in vitro by laccase-producing Trametes hirsuta La-7: Kinetics, products, and mechanisms
Environ Pollut. 2023 Jan 25;321:121155. doi: 10.1016/j.envpol.2023.121155. Online ahead of print.ABSTRACTBisphenol A (BPA) is a ubiquitous endocrine disruptor that poses adverse human health risks. Herein, biotransformation kinetics, products, and mechanisms of BPA undergoing a laccase-producing Trametes hirsuta La-7 metabolism were for the first time reported. Strain La-7 could completely biotransform ≤0.5 mmol·L-1 BPA within 6 d in vivo. Notably, its extracellular crude laccase solution (ECLS) and intracellular homogenized mycelium (HM) only required 6 h to convert 85.71% and 84.24% of 0.5 mmol·L-1 BPA in vitro, resp...
Source: Environmental Pollution - January 28, 2023 Category: Environmental Health Authors: Jie Liu Kai Sun Rui Zhu Xun Wang Michael Gatheru Waigi Shunyao Li Source Type: research
Biotransformation of bisphenol A in vivo and in vitro by laccase-producing Trametes hirsuta La-7: Kinetics, products, and mechanisms
Environ Pollut. 2023 Jan 25:121155. doi: 10.1016/j.envpol.2023.121155. Online ahead of print.ABSTRACTBisphenol A (BPA) is a ubiquitous endocrine disruptor that poses adverse human health risks. Herein, biotransformation kinetics, products, and mechanisms of BPA undergoing a laccase-producing Trametes hirsuta La-7 metabolism were for the first time reported. Strain La-7 could completely biotransform ≤0.5 mmol·L-1 BPA within 6 d in vivo. Notably, its extracellular crude laccase solution (ECLS) and intracellular homogenized mycelium (HM) only required 6 h to convert 85.71% and 84.24% of 0.5 mmol·L-1 BPA in vitro, respecti...
Source: Environmental Pollution - January 28, 2023 Category: Environmental Health Authors: Jie Liu Kai Sun Rui Zhu Xun Wang Michael Gatheru Waigi Shunyao Li Source Type: research
Isothiocyanate-Rich Extracts from Cauliflower ( < em > Brassica oleracea < /em > Var. Botrytis) and Radish ( < em > Raphanus sativus < /em > ) Inhibited Metabolic Activity and Induced ROS in Selected Human HCT116 and HT-29 Colorectal Cancer Cells
Int J Environ Res Public Health. 2022 Nov 13;19(22):14919. doi: 10.3390/ijerph192214919.ABSTRACTCruciferous vegetables such as cauliflower and radish contain isothiocyanates exhibiting chemoprotective effects in vitro and in vivo. This research aimed to assess the impact of cauliflower (CIE) and radish (RIE) isothiocyanate extracts on the metabolic activity, intracellular reactive oxygen species (ROS), and LDH production of selected human colorectal adenocarcinoma cells (HCT116 and HT-29 for early and late colon cancer development, respectively). Non-cancerous colon cells (CCD-33Co) were used as a cytotoxicity control. The...
Source: Cell Research - November 26, 2022 Category: Cytology Authors: Mardey Liceth Cuellar-Nu ñez Ivan Luzardo-Ocampo Sarah Lee-Mart ínez Michelle Larrauri-Rodr íguez Guadalupe Zald ívar-Lelo de Larrea Rosa Martha P érez-Serrano Nicol ás Camacho-Calderón Source Type: research
