Design, synthesis and biological evaluation of novel podophyllotoxin derivatives as tubulin-targeting anticancer agents
CONCLUSIONS: This research lays the groundwork for advancing cancer treatment through developing and using PPT derivatives. The encouraging results associated with E5 call for extended research and clinical validation, leading to novel and more effective cancer therapies.PMID:38393642 | DOI:10.1080/13880209.2024.2318350 (Source: Cancer Control)
Source: Cancer Control - February 23, 2024 Category: Cancer & Oncology Authors: Yujin Guo Beibei Chen Jinxiu Guo Pei Jiang Jianhua Wang Wenxue Sun Source Type: research
Design, synthesis and biological evaluation of novel podophyllotoxin derivatives as tubulin-targeting anticancer agents
CONCLUSIONS: This research lays the groundwork for advancing cancer treatment through developing and using PPT derivatives. The encouraging results associated with E5 call for extended research and clinical validation, leading to novel and more effective cancer therapies.PMID:38393642 | DOI:10.1080/13880209.2024.2318350 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - February 23, 2024 Category: Drugs & Pharmacology Authors: Yujin Guo Beibei Chen Jinxiu Guo Pei Jiang Jianhua Wang Wenxue Sun Source Type: research
Serum endocan, asymmetric dimethylarginine and lipid profile in children with familial Mediterranean fever
CONCLUSION: Serum ADMA and lipid profile might be used as potential markers for endothelial dysfunction and increased cardiovascular risk in FMF patients.IMPACT: Theoretically, serum ADMA may affect lipid profiles and serum endocan represents an intriguing biomarker related to inflammation. Coexistence of dyslipidemia represents an additional risk factor that contributes to the onset of early atherosclerosis. A few studies investigated the role of changes in lipid profile and lipid ratios in accelerated atherosclerosis pathogenesis in FMF patients. The relationship between colchicine and lipid profile is contradictory. Alt...
Source: Atherosclerosis - February 23, 2024 Category: Cardiology Authors: Rania S El Zayat Fahima M Hassan Noran T Aboelkhair Walaa F Abdelhakeem Ahmed S Abo Hola Source Type: research
Serum endocan, asymmetric dimethylarginine and lipid profile in children with familial Mediterranean fever
CONCLUSION: Serum ADMA and lipid profile might be used as potential markers for endothelial dysfunction and increased cardiovascular risk in FMF patients.IMPACT: Theoretically, serum ADMA may affect lipid profiles and serum endocan represents an intriguing biomarker related to inflammation. Coexistence of dyslipidemia represents an additional risk factor that contributes to the onset of early atherosclerosis. A few studies investigated the role of changes in lipid profile and lipid ratios in accelerated atherosclerosis pathogenesis in FMF patients. The relationship between colchicine and lipid profile is contradictory. Alt...
Source: Pediatric Research - February 23, 2024 Category: Pediatrics Authors: Rania S El Zayat Fahima M Hassan Noran T Aboelkhair Walaa F Abdelhakeem Ahmed S Abo Hola Source Type: research
Design, synthesis and biological evaluation of novel podophyllotoxin derivatives as tubulin-targeting anticancer agents
CONCLUSIONS: This research lays the groundwork for advancing cancer treatment through developing and using PPT derivatives. The encouraging results associated with E5 call for extended research and clinical validation, leading to novel and more effective cancer therapies.PMID:38393642 | DOI:10.1080/13880209.2024.2318350 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - February 23, 2024 Category: Drugs & Pharmacology Authors: Yujin Guo Beibei Chen Jinxiu Guo Pei Jiang Jianhua Wang Wenxue Sun Source Type: research
Design, synthesis and biological evaluation of novel podophyllotoxin derivatives as tubulin-targeting anticancer agents
CONCLUSIONS: This research lays the groundwork for advancing cancer treatment through developing and using PPT derivatives. The encouraging results associated with E5 call for extended research and clinical validation, leading to novel and more effective cancer therapies.PMID:38393642 | PMC:PMC10896134 | DOI:10.1080/13880209.2024.2318350 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - February 23, 2024 Category: Drugs & Pharmacology Authors: Yujin Guo Beibei Chen Jinxiu Guo Pei Jiang Jianhua Wang Wenxue Sun Source Type: research
Cluster of Differentiation-44-Targeting Prussian Blue Nanoparticles Onloaded with Colchicine for Atherosclerotic Plaque Regression in a Mice Model
In this study, the cluster of differentiation-44 receptor was verified to be overexpressed in inflammatory macrophages within plaques both in vitro and in vivo. Subsequently, a Prussian blue-based nanomedical loading system with hyaluronic acid (HA) coating was constructed, and its effects were observed on the atherosclerosis regression. Colchicine and Cy5.5 were encapsulated within Prussian blue nanoparticles through self-assembly, followed by conjugation with hyaluronic acid to create col@PBNP@HA. The formulated col@PBNP@HA displayed a cubic shape and scattered distribution. Importantly, col@PBNP@HA demonstrated specific...
Source: Atherosclerosis - February 19, 2024 Category: Cardiology Authors: Yan Zhu Yan Fang Yujia Wang Dong Han Jing Liu Lei Tian Mengqi Xu Yabin Wang Feng Cao Source Type: research
Mesenteric artery smooth muscle cells from hypertensive rats have increased microtubule acetylation
Conclusions:</p> Acetylation of tubulin at Lys40 is elevated in mesenteric arteries from the SHR. Furthermore, this study shows that tubacin has an endothelial-dependent bimodal effect on isoprenaline-mediated vasorelaxation.PMID:38373073 | DOI:10.1042/BCJ20230420 (Source: The Biochemical Journal)
Source: The Biochemical Journal - February 19, 2024 Category: Biochemistry Authors: Anthony M Mozzicato Joakim A Bastrup Jose L Sanchez Alonso Jennifer van der Horst Julia Gorelik Per M årten Hägglund Thomas Jepps Source Type: research
Cluster of Differentiation-44-Targeting Prussian Blue Nanoparticles Onloaded with Colchicine for Atherosclerotic Plaque Regression in a Mice Model
In this study, the cluster of differentiation-44 receptor was verified to be overexpressed in inflammatory macrophages within plaques both in vitro and in vivo. Subsequently, a Prussian blue-based nanomedical loading system with hyaluronic acid (HA) coating was constructed, and its effects were observed on the atherosclerosis regression. Colchicine and Cy5.5 were encapsulated within Prussian blue nanoparticles through self-assembly, followed by conjugation with hyaluronic acid to create col@PBNP@HA. The formulated col@PBNP@HA displayed a cubic shape and scattered distribution. Importantly, col@PBNP@HA demonstrated specific...
Source: Atherosclerosis - February 19, 2024 Category: Cardiology Authors: Yan Zhu Yan Fang Yujia Wang Dong Han Jing Liu Lei Tian Mengqi Xu Yabin Wang Feng Cao Source Type: research
Mesenteric artery smooth muscle cells from hypertensive rats have increased microtubule acetylation
Conclusions:</p> Acetylation of tubulin at Lys40 is elevated in mesenteric arteries from the SHR. Furthermore, this study shows that tubacin has an endothelial-dependent bimodal effect on isoprenaline-mediated vasorelaxation.PMID:38373073 | DOI:10.1042/BCJ20230420 (Source: The Biochemical Journal)
Source: The Biochemical Journal - February 19, 2024 Category: Biochemistry Authors: Anthony M Mozzicato Joakim A Bastrup Jose L Sanchez Alonso Jennifer van der Horst Julia Gorelik Per M årten Hägglund Thomas Jepps Source Type: research
Molecules, Vol. 29, Pages 914: Novel Antineoplastic Inducers of Mitochondrial Apoptosis in Human Cancer Cells
l
I propose a new strategy to suppress human cancer completely with two entirely new drug compounds exploiting cancer&rsquo;s Warburg effect characterized by a defective mitochondrial aerobic respiration, substituted by cytosolic aerobic fermentation/glycolysis of D-(+)-glucose into L-(+)-lactic acid. The two essentially new drugs, compound 1 [P(op)T(est)162] and compound 3 (PT167), represent new highly symmetric, four-bladed propeller-shaped polyammonium cations. The in vitro antineoplastic highly efficacious drug compound 3 represents a covalent combination of compound 1 and compound 2 (PT166). The intermedia...
Source: Molecules - February 19, 2024 Category: Chemistry Authors: Andreas J. Kesel Tags: Article Source Type: research
Interventions to prevent postoperative atrial fibrillation in Dutch cardiothoracic centres: a survey study
CONCLUSION: Despite the use of various preventive strategies, the reported incidence of POAF was similar in Dutch cardiothoracic centres. This study highlights limited use of prophylactic amiodarone and colchicine, despite recommendations by numerous guidelines, and restricted implementation of surgical strategies to prevent POAF.PMID:38358408 | DOI:10.1007/s12471-023-01849-1 (Source: Netherlands Heart Journal)
Source: Netherlands Heart Journal - February 15, 2024 Category: Cardiology Authors: Angelique Emiola Jolanda Kluin Sulayman El Mathari Joris R de Groot Wim-Jan van Boven Cardiothoracic Surgery Data Registration Committee of the Netherlands Heart Registry Source Type: research
