Design, synthesis and biological evaluation of novel podophyllotoxin derivatives as tubulin-targeting anticancer agents

CONCLUSIONS: This research lays the groundwork for advancing cancer treatment through developing and using PPT derivatives. The encouraging results associated with E5 call for extended research and clinical validation, leading to novel and more effective cancer therapies.PMID:38393642 | DOI:10.1080/13880209.2024.2318350

Source: Pharmaceutical Biology - February 23, 2024 Category: Drugs & Pharmacology Authors: Yujin Guo Beibei Chen Jinxiu Guo Pei Jiang Jianhua Wang Wenxue Sun Source Type: research