Effect of Pentaclethra macrophyla Benth. Leaf on expression of P53, IRS, HsD17 β2, FTO, and CYP11a genes in letrozole-induced polycystic ovarian syndrome rats
AbstractHyperandrogenism and menstruation difficulties are the hallmarks of polycystic ovarian syndrome (PCOS), a disorder affecting women in their reproductive years. The purpose of this study is to determine ifPentaclethra macrophylla leaf extract is beneficial in treating letrozole-induced PCOS rats. To ascertain the antioxidant characteristics of the plant extract, in vitro tests including the hydroxyl radical scavenging assay, FRAP, DPPH radical scavenging assay, and iron chelating assay were performed. A toxicology study was also conducted. Following PCOS induction, the standard and plant extract groups received trea...
Source: Comparative Clinical Pathology - February 5, 2024 Category: Pathology Source Type: research
Clinical and neonatal outcomes of complete zona pellucida removal by laser-assisted hatching after single vitrified-warmed blastocyst transfer
This study compared 160 SVBT with ZP that were completely removed using laser-assisted (laser beams of 10–15, a wavelength of 1.48 μm, and duration of 1.8–2 .2 ms) to 160 cases of intact SVBT. Fisher’s exact test, chi-squared test, and logistic regression are used for statistical analysis. The women’s age, cause of infertility, BMI, transferred embryo day, insemination methods, and blastocyst grade were not significantly different between two group s. The implantation rate (66.2% vs. 51.2%,P < 0.01), the clinical pregnancy rate (CPR, 52.5% vs. 39.3%,P = 0.01), and the live birth rate (LBR, 43.7% vs. ...
Source: Lasers in Medical Science - January 29, 2024 Category: Laser Surgery Source Type: research
Fibroids and unexplained infertility treatment with epigallocatechin gallate: a natural compound in green tea (FRIEND) - protocol for a randomised placebo-controlled US multicentre clinical trial of EGCG to improve fertility in women with uterine fibroids
This study addresses the pressing need for non-hormonal, non-surgical treatment options for women with fibroids desiring pregnancy. Previous preclinical and clinical studies have shown that epigallocatechin gallate (EGCG) effectively reduces uterine fibroid size. We hypothesise that EGCG from green tea extract will shrink fibroids, enhance endometrial quality and increase pregnancy likelihood. To investigate this hypothesis, we initiated a National Institute of Child Health and Human Development Confirm-funded trial to assess EGCG’s efficacy in treating women with fibroids and unexplained infertility.
Methods and an...
Source: BMJ Open - January 12, 2024 Category: General Medicine Authors: Al-Hendy, A., Segars, J. H., Taylor, H. S., Gonzalez, F., Siblini, H., Zamah, M., Alkelani, H., Singh, B., Flores, V. A., Christman, G. M., Johnson, J. J., Huang, H., Zhang, H. Tags: Open access, Obstetrics & Gynaecology Obstetrics and gynaecology Source Type: research
Alternative treatment of polycystic ovary syndrome: pre-clinical and clinical basis for using plant-based drugs
The most common cause of infertility and metabolic problems among women of reproductive age is polycystic ovary syndrome (PCOS), a multifaceted disorder. It is an endocrine disorder that occurs in approximately one in seven women. Among these PCOS patients, two thirds will not ovulate on a regular basis and seek treatment for ovulation induction. The symptoms vary in their severity, namely ovulation disorders, excessive androgen levels, or polycystic ovarian morphology. All these symptoms require a therapeutic approach. Many drugs are used to eradicate PCOS symptoms, like metformin, clomiphene citrate, spironolactone, and ...
Source: Frontiers in Endocrinology - January 11, 2024 Category: Endocrinology Source Type: research
Protective Effects of Chia Seeds and Omega-3 Fatty Acid against Cyclophosphamide-Induced Oligospermia in Male Wistar Rats: Potential Risks of Adverse Drug Interaction with Chia Seeds
Conclusions: In our study, chia seeds as well as omega-3 fatty acid treatment were found to be protective against cyclophosphamide-induced reproductive toxicity in rats. However, the adverse effect of hemorrhage associated with drug interaction of chia seeds with cytotoxic chemotherapeutic drugs needs careful attention and further investigation.PMID:38161578 | PMC:PMC10751874 | DOI:10.59249/PAEJ4854 (Source: The Yale Journal of Biology and Medicine)
Source: The Yale Journal of Biology and Medicine - January 1, 2024 Category: Universities & Medical Training Authors: Prince B Vaghela Archana M Navale Chirangi B Patel Nishant H Patidar Prachi D Nahar Farmi Patel Zainab Pathan Barsha Kumari Source Type: research
