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Prenatal Restraint Stress-Induced Maternal Exposure and Clomifene Citrate Administration Modulates Reproductive Programming in Female Wistar Rats
Conclusion:</b> Evidence indicated that stress alters reproductive potential in female rats and also, reduces the effectiveness of CC in inducing ovulation.PMID:36978274 | DOI:10.3923/pjbs.2022.1066.1076 (Source: Pakistan Journal of Biological Sciences: PJBS)
Source: Pakistan Journal of Biological Sciences: PJBS - March 29, 2023 Category: Biomedical Science Authors: Daubry Tarela Melish Elias Nwogueze Bartholomew Chukwuebuka Toloyai Pere-Ebi Yabrade Ehebha Santos Ehizokhale Ossai Nduka Richard Olowe Gideon Temitope Obasi David Chukwu Ebuwa Emmanuel Ikemefune Aloamaka Chukwuemeka Peter Source Type: research

Low-dose clomiphene citrate does not reduce implantation and live birth rates in otherwise unstimulated modified natural cycle IVF —retrospective cohort study
ConclusionLow-dose CC does not reduce pregnancy or live birth rate per transferred embryo. It can be used in infertility treatment without negatively affecting the endometrium and implantation. (Source: Archives of Gynecology and Obstetrics)
Source: Archives of Gynecology and Obstetrics - March 17, 2023 Category: OBGYN Source Type: research

The effects of first-line pharmacological treatments for reproductive outcomes in infertile women with PCOS: a systematic review and network meta-analysis
CONCLUSIONS: Most first-line pharmacological treatments were effective in improving clinical pregnancy. CC + MET + PIO should be recommended as the optimal therapeutic strategy to improve pregnancy outcomes. However, none of the above treatments had a beneficial effect on clinical pregnancy in obese PCOS.TRIAL REGISTRATION: CRD42020183541; 05 July 2020.PMID:36869381 | DOI:10.1186/s12958-023-01075-9 (Source: Reproductive Biology)
Source: Reproductive Biology - March 3, 2023 Category: Reproduction Medicine Authors: Ge Peng Zhe Yan Yuqi Liu Juan Li Jinfang Ma Nanwei Tong Yan Wang Source Type: research

Effect of anti-estrogen and anti-progesterone on spermatogenesis, testosterone production and expression of steroidogenic enzyme genes in adult male rats
Reprod Biol. 2023 Mar 1;23(2):100749. doi: 10.1016/j.repbio.2023.100749. Online ahead of print.ABSTRACTThe present study was planned to investigate the anti-spermatogenic and anti-steroidogenic effects of Clomiphene Citrate (CC) an anti-estrogen and Mifepristone (MT) an anti-progesterone in the testis of male rats. Following the oral administration of 1.0 mg and 5.0 mg/kg b.w/day of each for the duration of 30 and 60 days, quantitation of spermatogenesis, RIA for serum and intra-testicular testosterone levels, western blotting and RT-PCR for expression of StAR, 3β-HSD and P450arom enzymes in the testis was done. Clomiphen...
Source: Reproductive Biology - March 3, 2023 Category: Reproduction Medicine Authors: Rekha Meena Shilpa Bharti Source Type: research