Clomiphene citrate administered in peri-conception phase causes fetal loss and developmental impairment in mice
Endocrinology. 2024 Apr 12:bqae047. doi: 10.1210/endocr/bqae047. Online ahead of print.ABSTRACTClomiphene citrate is a common treatment for ovulation induction in subfertile women, but its use is associated with elevated risk of adverse perinatal outcomes and birth defects. To investigate the biological plausibility of a causal relationship, this study investigated in mice the consequences for fetal development and pregnancy outcome of peri-conception clomiphene citrate administration at doses approximating human exposures. A dose-dependent adverse effect of clomiphene citrate given twice in the 36 h after mating was seen,...
Source: Endocrinology - April 12, 2024 Category: Endocrinology Authors: Peck Y Chin Tom E C Kieffer Jelmer R Prins Darryl L Russell Michael J Davies Sarah A Robertson Source Type: research
Clomiphene citrate administered in peri-conception phase causes fetal loss and developmental impairment in mice
Endocrinology. 2024 Apr 12:bqae047. doi: 10.1210/endocr/bqae047. Online ahead of print.ABSTRACTClomiphene citrate is a common treatment for ovulation induction in subfertile women, but its use is associated with elevated risk of adverse perinatal outcomes and birth defects. To investigate the biological plausibility of a causal relationship, this study investigated in mice the consequences for fetal development and pregnancy outcome of peri-conception clomiphene citrate administration at doses approximating human exposures. A dose-dependent adverse effect of clomiphene citrate given twice in the 36 h after mating was seen,...
Source: Endocrinology - April 12, 2024 Category: Endocrinology Authors: Peck Y Chin Tom E C Kieffer Jelmer R Prins Darryl L Russell Michael J Davies Sarah A Robertson Source Type: research
Clomiphene citrate administered in peri-conception phase causes fetal loss and developmental impairment in mice
Endocrinology. 2024 Apr 12:bqae047. doi: 10.1210/endocr/bqae047. Online ahead of print.ABSTRACTClomiphene citrate is a common treatment for ovulation induction in subfertile women, but its use is associated with elevated risk of adverse perinatal outcomes and birth defects. To investigate the biological plausibility of a causal relationship, this study investigated in mice the consequences for fetal development and pregnancy outcome of peri-conception clomiphene citrate administration at doses approximating human exposures. A dose-dependent adverse effect of clomiphene citrate given twice in the 36 h after mating was seen,...
Source: Endocrinology - April 12, 2024 Category: Endocrinology Authors: Peck Y Chin Tom E C Kieffer Jelmer R Prins Darryl L Russell Michael J Davies Sarah A Robertson Source Type: research
Long-term use of clomiphene in male macroprolactinomas with persistent hypogonadism
ConclusionCC should be seen as a safe treatment option for men with macroprolactinoma and persistent hypogonadism. (Source: Endocrine)
Source: Endocrine - April 5, 2024 Category: Endocrinology Source Type: research
Genes, Vol. 15, Pages 393: Theoretical Studies of DNA Microarray Present Potential Molecular and Cellular Interconnectivity of Signaling Pathways in Immune System Dysregulation
This study was geared towards utilizing transcriptomics approaches for the assessment of microarray data, which is different from the use of traditional genomic analyses. Such a research design for investigating correlations among autoimmune diseases may be the first of its kind. (Source: Genes)
Source: Genes - March 22, 2024 Category: Genetics & Stem Cells Authors: Jon Patrick T. Garcia Lemmuel L. Tayo Tags: Article Source Type: research
Superfetation and heterotopic pregnancy: Case report of two rare phenomena coexisting and implications in the era of assisted reproductive technologies
We report a case where both coexisted, challenges in diagnosis and management and association with the widespread use of assisted reproductive technologies (ARTs). A 32-year-old woman, who previously underwent ovulation induction therapy, presented with abdominal pain at 8 weeks pregnancy according to her last menstrual period. The patient had high quantitative serum beta-human chorionic gonadotropin (b-hCG) (30,883 mIU/mL). She was vitally stable and not anemic. Transvaginal ultrasound (TVUS) revealed two pregnancies at different gestational ages: an intrauterine pregnancy at 5 weeks and 3 days, and a right intact ...
Source: Clinical Case Reports - March 19, 2024 Category: General Medicine Authors: Merhan Badran,
Mazed Labib,
Omar Abouali,
Prakriti Pokhrel Tags: CASE REPORT Source Type: research
Risk of borderline ovarian tumors after fertility treatment - Results from a Danish cohort of infertile women
CONCLUSIONS: No marked associations between use of fertility drugs and borderline ovarian tumors were observed. However, the cohort's relatively young age at end of follow-up emphasizes the importance of extending the follow-up period for women who have used fertility drugs.PMID:38382167 | DOI:10.1016/j.ygyno.2024.02.013 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - February 21, 2024 Category: Cancer & Oncology Authors: Anna Kj ær Kristensen Clarissa Lima Brown Frandsen Bugge N øhr Jakob Hansen Viuff Marie Hargreave Kirsten Frederiksen Susanne K Kj ær Allan Jensen Source Type: research
Risk of borderline ovarian tumors after fertility treatment - Results from a Danish cohort of infertile women
CONCLUSIONS: No marked associations between use of fertility drugs and borderline ovarian tumors were observed. However, the cohort's relatively young age at end of follow-up emphasizes the importance of extending the follow-up period for women who have used fertility drugs.PMID:38382167 | DOI:10.1016/j.ygyno.2024.02.013 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - February 21, 2024 Category: Cancer & Oncology Authors: Anna Kj ær Kristensen Clarissa Lima Brown Frandsen Bugge N øhr Jakob Hansen Viuff Marie Hargreave Kirsten Frederiksen Susanne K Kj ær Allan Jensen Source Type: research
Risk of borderline ovarian tumors after fertility treatment - Results from a Danish cohort of infertile women
CONCLUSIONS: No marked associations between use of fertility drugs and borderline ovarian tumors were observed. However, the cohort's relatively young age at end of follow-up emphasizes the importance of extending the follow-up period for women who have used fertility drugs.PMID:38382167 | DOI:10.1016/j.ygyno.2024.02.013 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - February 21, 2024 Category: Cancer & Oncology Authors: Anna Kj ær Kristensen Clarissa Lima Brown Frandsen Bugge N øhr Jakob Hansen Viuff Marie Hargreave Kirsten Frederiksen Susanne K Kj ær Allan Jensen Source Type: research
Risk of borderline ovarian tumors after fertility treatment - Results from a Danish cohort of infertile women
CONCLUSIONS: No marked associations between use of fertility drugs and borderline ovarian tumors were observed. However, the cohort's relatively young age at end of follow-up emphasizes the importance of extending the follow-up period for women who have used fertility drugs.PMID:38382167 | DOI:10.1016/j.ygyno.2024.02.013 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - February 21, 2024 Category: Cancer & Oncology Authors: Anna Kj ær Kristensen Clarissa Lima Brown Frandsen Bugge N øhr Jakob Hansen Viuff Marie Hargreave Kirsten Frederiksen Susanne K Kj ær Allan Jensen Source Type: research
Statement of retraction: Clomiphene citrate or aromatase inhibitors combined with gonadotropins for superovulation in women undergoing intrauterine insemination: a prospective randomised trial
J Obstet Gynaecol. 2024 Dec;44(1):2309104. doi: 10.1080/01443615.2024.2309104. Epub 2024 Feb 8.NO ABSTRACTPMID:38328929 | DOI:10.1080/01443615.2024.2309104 (Source: Journal of Obstetrics and Gynaecology)
Source: Journal of Obstetrics and Gynaecology - February 8, 2024 Category: OBGYN Source Type: research
Effect of Pentaclethra macrophyla Benth. Leaf on expression of P53, IRS, HsD17 β2, FTO, and CYP11a genes in letrozole-induced polycystic ovarian syndrome rats
AbstractHyperandrogenism and menstruation difficulties are the hallmarks of polycystic ovarian syndrome (PCOS), a disorder affecting women in their reproductive years. The purpose of this study is to determine ifPentaclethra macrophylla leaf extract is beneficial in treating letrozole-induced PCOS rats. To ascertain the antioxidant characteristics of the plant extract, in vitro tests including the hydroxyl radical scavenging assay, FRAP, DPPH radical scavenging assay, and iron chelating assay were performed. A toxicology study was also conducted. Following PCOS induction, the standard and plant extract groups received trea...
Source: Comparative Clinical Pathology - February 5, 2024 Category: Pathology Source Type: research
Clinical and neonatal outcomes of complete zona pellucida removal by laser-assisted hatching after single vitrified-warmed blastocyst transfer
This study compared 160 SVBT with ZP that were completely removed using laser-assisted (laser beams of 10–15, a wavelength of 1.48 μm, and duration of 1.8–2 .2 ms) to 160 cases of intact SVBT. Fisher’s exact test, chi-squared test, and logistic regression are used for statistical analysis. The women’s age, cause of infertility, BMI, transferred embryo day, insemination methods, and blastocyst grade were not significantly different between two group s. The implantation rate (66.2% vs. 51.2%,P < 0.01), the clinical pregnancy rate (CPR, 52.5% vs. 39.3%,P = 0.01), and the live birth rate (LBR, 43.7% vs. ...
Source: Lasers in Medical Science - January 29, 2024 Category: Laser Surgery Source Type: research
Fibroids and unexplained infertility treatment with epigallocatechin gallate: a natural compound in green tea (FRIEND) - protocol for a randomised placebo-controlled US multicentre clinical trial of EGCG to improve fertility in women with uterine fibroids
This study addresses the pressing need for non-hormonal, non-surgical treatment options for women with fibroids desiring pregnancy. Previous preclinical and clinical studies have shown that epigallocatechin gallate (EGCG) effectively reduces uterine fibroid size. We hypothesise that EGCG from green tea extract will shrink fibroids, enhance endometrial quality and increase pregnancy likelihood. To investigate this hypothesis, we initiated a National Institute of Child Health and Human Development Confirm-funded trial to assess EGCG’s efficacy in treating women with fibroids and unexplained infertility.
Methods and an...
Source: BMJ Open - January 12, 2024 Category: General Medicine Authors: Al-Hendy, A., Segars, J. H., Taylor, H. S., Gonzalez, F., Siblini, H., Zamah, M., Alkelani, H., Singh, B., Flores, V. A., Christman, G. M., Johnson, J. J., Huang, H., Zhang, H. Tags: Open access, Obstetrics & Gynaecology Obstetrics and gynaecology Source Type: research
