It’s in the Urine
​"I just put a young woman in her mid-30s back in room 9," the triage nurse said. I made a mental note that that was the GYN room. The nurse continued, "She feels bad, fatigued, and just not right in her stomach." The obvious question flew from my mouth. "Is she pregnant?"​"I have the urine, but the quality controls are being run now, so it will be a few minutes."I glanced at the EMR before heading back to the room: normal vitals, no fever, no medications, a couple of kids, no surgeries, last period three weeks before. Not much there to go on, but I could see her while waitin...
Source: Lions and Tigers and Bears - February 28, 2018 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs

Dr. Google: The top 10 health searches in 2017
Follow me on Twitter @RobShmerling Ever wonder what other people are wondering about? I know I do. So, here are the top 10 health searches in Google for 2017. And just so you don’t have to look each one up, I’ve provided a brief answer. You’re welcome. 1.  What causes hiccups? I was surprised this one made it to the top 10 list of health searches. Maybe this search is common because hiccups are as mysterious as they are universal. I’ve written about hiccups before, but let’s just say the cause in any individual person is rarely known or knowable. Then again, the reason hiccups stop is also unknown. Some triggers...
Source: Harvard Health Blog - February 21, 2018 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Health Source Type: blogs

Precision Medicine and the Reinvention of Human Disease (Book Index)
In January, 2018, Academic Press published my bookPrecision Medicine and the Reinvention of Human Disease. This book has an excellent " look inside " at itsGoogle book site, which includes the Table of Contents. In addition, I thought it might be helpful to see the topics listed in the Book ' s index. Note that page numbers followed by f indicate figures, t indicate tables, and ge indicate glossary terms.AAbandonware, 270, 310geAb initio, 34, 48ge, 108geABL (abelson leukemia) gene, 28, 58ge, 95 –97Absidia corymbifera, 218Acanthameoba, 213Acanthosis nigricans, 144geAchondroplasia, 74, 143ge, 354geAcne, 54ge, 198, 220geAcq...
Source: Specified Life - January 23, 2018 Category: Information Technology Tags: index jules berman jules j berman precision medicine Source Type: blogs

Tolvaptan: Vasopressin Antagonist
Tolvaptan is vasopressin antagonist which acts on the V2 receptors in the renal tubules. Activation of V2 receptors increases water permeability in the renal collecting duct resulting in passive reabsorption of water. V2 receptor antagonism causes aquaresis or free water clearance. Syndrome of inappropriate anti-diuretic hormone secretion (SIADH), heart failure and cirrhosis can be associated with increased secretion of arginine vasopressin (AVP). This leads to water retention or inadequate water excretion and hyponatremia (dilutional hyponatremia). The drug binds to V2 receptors and induces excretion of electrolyte-fre...
Source: Cardiophile MD - January 11, 2018 Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: General Cardiology Source Type: blogs

The moment I became a passionate doctor
I was nearing the end of my pediatrics rotation as a third-year medical student when the senior resident asked me to admit a patient to the general pediatrics floor. The only information I had as I headed down to the intensive care unit was that she was a ten-year-old girl who had survived an extensive resuscitation at home. By this point in my education, I was certain that I wanted to be a pediatrician. I had recently finished my internal medicine rotation. Fresh in my mind were hospitalized patients who were suffering from their past choices, like drug addiction and alcoholic cirrhosis. I had cared for a man who, as soon...
Source: Kevin, M.D. - Medical Weblog - December 10, 2017 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/jo-ann-gates" rel="tag" > Jo Ann Gates, MD < /a > Tags: Physician Critical Care Pediatrics Source Type: blogs

The Dangers of Carb Loading
Carb loading is viewed as an essential practice by people who engage in vigorous exercise. But it is a practice that can lead, over time, to disastrous health consequences, including heart disease, dysbiosis, and fatty liver. And it is also entirely unnecessary, a dietary mistake created by a misinterpretation of scientific studies conducted 70 -80 years ago. About Undoctored: We are entering a new age in which the individual has astounding power over health–but don’t count on the doctor or healthcare system to tell you this. We draw from the health information of the world, collaborate, share experiences, coll...
Source: Wheat Belly Blog - December 1, 2017 Category: Cardiology Authors: Dr. Davis Tags: Undoctored Wheat Belly Lifestyle gluten gluten-free grain-free grains Inflammation low-carb Source Type: blogs

We need to accept our failure as doctors
Why do we want to become doctors? What was our main motivation that we have written in our motivation letters and repeated in our interviews? Regardless of the specific incident or the general motivation, it can be all summarized in one sentence: We are here to save lives. After all, this is what the physicians do, isn’t it? Preventing deaths is actually hinted to by the original Hippocratic Oath, written between the third and fifth century B.C. through the following: “Neither will I administer a poison to anybody when asked to do so … Similarly, I will not give to a woman a pessary to cause abortion.” According to...
Source: Kevin, M.D. - Medical Weblog - November 16, 2017 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/samer-bou-karroum" rel="tag" > Samer Bou Karroum < /a > Tags: Physician Hospital-Based Medicine Palliative Care Primary Care Source Type: blogs

Instinct is Learned
Mr. Reynolds is a vivid 83 year old who lived alone at home. He walks everyday int he morning first thing before he has a small cup of coffee. His kids bought him an ipad and he uses it to browse the Washington Post, the Wall Street Journal, and the Pittsburgh Post Gazette while eating breakfast. Every morning it’s the same breakfast…toast with honey and a small cup of yogurt. Then he’s ready to start the day, just when the rest of his neighbors are waking up. Today however, he ate hist toast and his stomach grumbled, louder than usual.  He thought to himself that he’d better get to the bathroom qu...
Source: Mr. Hassle's Long Underpants - November 10, 2017 Category: Emergency Medicine Authors: Doc Shazam Tags: Clinical Source Type: blogs

Instinct is Learned
Mr. Reynolds is a vivid 83 year old who lived alone at home. He walks everyday int he morning first thing before he has a small cup of coffee. His kids bought him an ipad and he uses it to browse the Washington Post, the Wall Street Journal, and the Pittsburgh Post Gazette while eating breakfast. Every morning it’s the same breakfast…toast with honey and a small cup of yogurt. Then he’s ready to start the day, just when the rest of his neighbors are waking up. Today however, he ate hist toast and his stomach grumbled, louder than usual.  He thought to himself that he’d better get to the bathroom qu...
Source: Mr. Hassle's Long Underpants - November 10, 2017 Category: Emergency Medicine Authors: Doc Shazam Tags: Clinical Source Type: blogs

Instinct is Learned
Mr. Reynolds is a vivid 83 year old who lived alone at home. He walks everyday int he morning first thing before he has a small cup of coffee. His kids bought him an ipad and he uses it to browse the Washington Post, the Wall Street Journal, and the Pittsburgh Post Gazette while eating breakfast. Every morning it’s the same breakfast…toast with honey and a small cup of yogurt. Then he’s ready to start the day, just when the rest of his neighbors are waking up. Today however, he ate hist toast and his stomach grumbled, louder than usual.  He thought to himself that he’d better get to the bathroom qu...
Source: Mr. Hassle's Long Underpants - November 10, 2017 Category: Emergency Medicine Authors: Doc Shazam Tags: Clinical Source Type: blogs

Endothelial Cell Therapy for Damaged Livers
Cell therapies have shown some ability to reduce fibrosis, the generation of scar-like structures in place of functional tissue that appears with aging and a variety of forms of organ failure. Fibrosis is one of the consequences of growing numbers of senescent cells and the chronic inflammation they cause. The normal intricate coordination of cell populations in regeneration and tissue maintenance runs awry. Cell therapies may help by pushing the balance of cell signaling back towards a more youthful, normal pattern, and reducing inflammation, at least for a time. This doesn't appear to be as be as potentially beneficial a...
Source: Fight Aging! - November 1, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Traveling The Valley Of The Shadow Of Death In 2017
My mother has a letter from her mother written in 1942, telling of the death from pneumonia of a middle-aged neighbor with whom my grandmother had spoken at the post office just a week earlier. For most of human history, that sudden turn to death has been the common experience. Few managed to live into old age; and even for elders, the dying was usually fairly abrupt. There was little risk of living long with dementia, Parkinson’s disease, heart failure, cirrhosis, serious injuries, childbirth complications, or other fatal illnesses. Diabetes was fatal within a few months in 1900. Now, most of us will instead experience ...
Source: Health Affairs Blog - October 18, 2017 Category: Health Management Authors: Joanne Lynn Tags: End of Life & Serious Illness elder care health care reform long-term care reform MediCaring Communities Program of All-Inclusive Care of the Elderly Source Type: blogs

Fight Aging! Newsletter, October 16th 2017
In this study, we have shown that the lipid chaperones FABP4/FABP5 are critical intermediate factors in the deterioration of metabolic systems during aging. Consistent with their roles in chronic inflammation and insulin resistance in young prediabetic mice, we found that FABPs promote the deterioration of glucose homeostasis; metabolic tissue pathologies, particularly in white and brown adipose tissue and liver; and local and systemic inflammation associated with aging. A systematic approach, including lipidomics and pathway-focused transcript analysis, revealed that calorie restriction (CR) and Fabp4/5 deficiency result ...
Source: Fight Aging! - October 15, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs