Cellular Senesence, a Key Target in the Treatment of Aging
Scores of animal studies provide compelling evidence for cellular senescence to contribute meaningfully to many age-related conditions, and yet more such studies demonstrate rapid and sizable rejuvenation via targeted removal of senescent cells in old animals using varieties of senolytic therapy. Senescent cells are created constantly in the body, the result of cells reaching the Hayflick limit on replication, tissue injury, or encountering cellular damage or toxicity. When an individual is young, these newly senescent cells are near all removed by a combination of programmed cell death and the actions of the immune system...
Source: Fight Aging! - August 10, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
An asymptomatic man in his 50s with heart rate in the 160s - what is the diagnosis? How will you manage this?
Written by Pendell MeyersA man in his late 50s with history of CAD with CABG, COPD, smoking, cirrhosis, and other comorbidities presented for an outpatient scheduled stress test which had been ordered for some exertional shortness of breath, palpitations, and presyncopal episodes over the past few months. When he presented to the office for the stress test, his screening vitals before any test or intervention were remarkable only for a heart rate of 160 bpm. He denied any symptoms whatsoever.A 12-lead ECG was performed in the office:What do you think?The ECG shows a wide complex regular monomorphic tachycardia. I mea...
Source: Dr. Smith's ECG Blog - April 2, 2022 Category: Cardiology Authors: Pendell Source Type: blogs
Weekly Overseas Health IT Links – 26th March, 2022.
Here are a few I came across last week.Note: Each link is followed by a title and few paragraphs. For the full article click on the link above title of the article. Note also that full access to some links may require site registration or subscription payment.-----https://mhealthintelligence.com/news/55-of-telehealth-providers-frustrated-with-overblown-patient-expectations55% of Telehealth Providers Frustrated With Overblown Patient ExpectationsProviders also cited their ability to provide quality care and technical difficulties as among their top frustrations with telehealth, a new survey shows.ByAnuja VaidyaMarch 18, 202...
Source: Australian Health Information Technology - March 26, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
Treatment of infective endocarditis
Discussion of whole list of options of antimicrobials for different varieties of endocarditis is quite a large topic. This discussion is only a broad outline of the antimicrobial treatment of infective endocarditis, meant mainly for exam purpose rather than actual clinical treatment. References to more detailed guidelines have been provided for those who wish to learn more.
Inoculum Effect
High microbial density as in vegetations cause less antimicrobial activity of some antimicrobial agents. This is known as inoculum effect and has been documented with β-lactams and glycopeptides but not linezolid, in the treatment of St...
Source: Cardiophile MD - July 16, 2021 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs
Fight Aging! Newsletter, July 5th 2021
In conclusion, the findings suggest that DNAm GrimAge is a strong predictor of mortality independent of genetic influences.
Heart Failure Correlates with Increased Cancer Risk
https://www.fightaging.org/archives/2021/07/heart-failure-correlates-with-increased-cancer-risk/
Age-related disease results from the underlying cell and tissue damage that causes aging. Different people accumulate that damage at modestly different rates, the result of lifestyle choices and exposure to infectious disease. Thus the presence of a sufficient burden of damage to produce one age-related disease will be accompanied by a...
Source: Fight Aging! - July 4, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Are Senescent Cells an Important Cause of Non-Alcoholic Fatty Liver Disease Pathology?
Raised levels of senescent cells are found in the liver of patients and animal models exhibiting non-alcoholic fatty liver disease (NAFLD), which progresses to the more serious nonalcoholic steatohepatitis (NASH). These conditions are a consequence of obesity, which is also correlated with a higher burden of senescent cells throughout the body, and particularly in fat deposits. Senescent cells secrete signals that provoke chronic inflammation and disrupt tissue structure and function. They are an important contributing cause of aging and age-related disease. In this sense, we might think of many of the consequences of obes...
Source: Fight Aging! - June 29, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Benefits of Taking a Break from Alcohol
Alcohol abuse and alcoholism are serious issues across the nation. In fact, there are over 95,000 alcohol-related deaths each and every year. Despite how problematic alcohol can be, it is still the most used substance across the country – many don’t realize the risks and health-related problems associated with alcohol.
Before we look at how taking even a short break can help you in the long-term let’s first look at the major risks associated with excessive alcohol use and binge drinking.
Major Risks of Alcohol Use
When it comes to alcohol abuse, there are many issues that can occur – from long-term physica...
Source: PickTheBrain | Motivation and Self Improvement - May 5, 2021 Category: Consumer Health News Authors: Joe Gilmore Tags: depression featured happiness health and fitness productivity tips self-improvement addiction alcohol self improvement Source Type: blogs
A story of esophageal variceal rupture
An excerpt from 50 Years in the OR: True Stories of Life, Loss, and Laughter While Giving Anesthesia. Chronic long-term alcoholism causes many health problems, not the least of which is cirrhosis of the liver. In advanced cases of cirrhosis, the liver becomes full of scar tissue and its many functions are then impaired, causing […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 7, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/ron-whitchurch" rel="tag" > Ron Whitchurch, CRNA < /a > < /span > Tags: Conditions Emergency Medicine Gastroenterology Source Type: blogs
Fight Aging! Newsletter, November 30th 2020
We examined specific aspects of metabolism in male PolG+/mut mice at 6 and 12 months of age under three dietary conditions: normal chow (NC) feeding, high-fat feeding (HFD), and 24-hr starvation. We performed mitochondrial proteomics and assessed dynamics and quality control signaling in muscle and liver to determine whether mitochondria respond to mtDNA point mutations by altering morphology and turnover. In the current study, we observed that the accumulation of mtDNA point mutations failed to disrupt metabolic homeostasis and insulin action in male mice, but with aging, metabolic health was likely preserved by counterme...
Source: Fight Aging! - November 29, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Look at the Damage Done by Senescent T Cells in the Aged Immune System
Cells become senescent and cease replication in response to damage, a toxic environment, or reaching the Hayflick limit. Such cells near all self-destruct or are destroyed by the immune system. In later life, however, they begin to linger and accumulate. This is an issue, as the secretions of senescent cells are quite harmful when sustained over the long term, producing chronic inflammation and disruption of tissue structure and function. The cells of the immune system are no less subject to the burden of cellular senescence than is the case for any other cell type, in fact arguably more so given that infection results in ...
Source: Fight Aging! - November 26, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
I am an emergency and critical care physician. I had COVID-19 infection twice and I ’m tired.
I am a critical care and emergency medicine physician, I have had COVID-19 infection twice, and I ’m tired. My first infection was early on in the pandemic. I had to place a Blakemore tube in a young man who was going to die from his massive bleeding from cirrhosis. I didn’t know then that the […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - November 22, 2020 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/kara-ward" rel="tag" > Kara Ward, MD < /a > < /span > Tags: Physician Critical Care Emergency Medicine Hospital-Based Medicine Source Type: blogs
Fight Aging! Newsletter, November 23rd 2020
In conclusion, the study indicates that HBOT may induce significant senolytic effects that include significantly increasing telomere length and clearance of senescent cells in the aging populations.
Data on the Prevalence of Liver Fibrosis in Middle Age
https://www.fightaging.org/archives/2020/11/data-on-the-prevalence-of-liver-fibrosis-in-middle-age/
Fibrosis is a consequence of age-related disarray in tissue maintenance processes, leading to the deposition of scar-like collagen that disrupts tissue structure and function. It is an ultimately fatal issue for which there are only poor treatment options ...
Source: Fight Aging! - November 22, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Data on the Prevalence of Liver Fibrosis in Middle Age
Fibrosis is a consequence of age-related disarray in tissue maintenance processes, leading to the deposition of scar-like collagen that disrupts tissue structure and function. It is an ultimately fatal issue for which there are only poor treatment options at present. Hopefully that will change with further exploration of the relationship between accumulation of senescent cells in aged tissues and the development of fibrosis. In mice, the use of senolytic therapies to selectively destroy senescent cells has reversed fibrosis in a number of different organs.
A substantial minority of participants from the Framingham...
Source: Fight Aging! - November 16, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Hepatitis C
is a recently discovered disease. Harvey J. Alter identified the variant form of Hepatitis during the 70s, which then became known as a ‘non-A, non-B Hepatitis (NANBH)’. In the 1980s, Michael Houghton and his team isolated the genome of the new virus, and it was named ‘Hepatitis C’. Finally, in 1997 Charles M. Rice proved that the virus is a disease agent, capable of acting alone to cause Hepatitis.
This year’s Nobel Prize in Medicine has been jointly awarded to Harvey J. Alter, Michael Houghton, and Charles M. Rice for the discovery of the virus. Their contributions (illustrated below) have led to improved unde...
Source: GIDEON blog - November 10, 2020 Category: Databases & Libraries Authors: Kristina Symes Tags: Epidemiology News Source Type: blogs
Fight Aging! Newsletter, October 26th 2020
In conclusion, all NAFLD histological stages were associated with significantly increased overall mortality, and this risk increased progressively with worsening NAFLD histology. Most of this excess mortality was from extrahepatic cancer and cirrhosis, while in contrast, the contributions of cardiovascular disease and HCC were modest.
BMP6 as a Target for Pro-Angiogenic Therapies
https://www.fightaging.org/archives/2020/10/bmp6-as-a-target-for-pro-angiogenic-therapies/
Today's research materials are focused on the fine details of angiogenesis, the formation of new blood vessels, and point to BMP6 as a p...
Source: Fight Aging! - October 25, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
