Incidence of blood culture-related sepsis in neonates and antibiotics sensitivity of implicated organisms in a secondary healthcare facility in Ghana
CONCLUSION: Late-onset sepsis is a common sepsis category, and the implicated microorganisms are resistant to commonly prescribed antibiotics.FUNDING: This work was funded by Upper East Regional Hospital, Bolgatanga.PMID:38504752 | PMC:PMC10846657 | DOI:10.4314/gmj.v57i2.8 (Source: Ghana Medical Journal)
Source: Ghana Medical Journal - March 20, 2024 Category: African Health Authors: Francis K Wuni Margaret W Kukeba Kwashie S N Dzotsi Abu Osman Patrick Atobrah Rasheed Ofosu-Poku Source Type: research

Analysis of carbapenem-resistant < em > Acinetobacter baumannii < /em > carbapenemase gene distribution and biofilm formation
CONCLUSION: The clinical strains have a high resistance rate to carbapenems, and the CRAB with blaOXA-51 and blaOXA-23 genes has a high resistance to antibiotics and a strong biofilm.PMID:38505565 | PMC:PMC10944714 (Source: International Journal of Molecular Epidemiology and Genetics)
Source: International Journal of Molecular Epidemiology and Genetics - March 20, 2024 Category: Genetics & Stem Cells Authors: Lin Wang Qi-Wei Chen Yan-Chun Qin Xue-Li Yi Hong Zeng Source Type: research

Antibacterial, Fatigue-Resistant, and Self-Healing Dressing from Natural-Based Composite Hydrogels for Infected Wound Healing
Biomacromolecules. 2024 Mar 19. doi: 10.1021/acs.biomac.3c01385. Online ahead of print.ABSTRACTThe treatment of infected wounds faces substantial challenges due to the high incidence and serious infection-related complications. Natural-based hydrogel dressings with favorable antibacterial properties and strong applicability are urgently needed. Herein, we developed a composite hydrogel by constructing multiple networks and loading ciprofloxacin for infected wound healing. The hydrogel was synthesized via a Schiff base reaction between carboxymethyl chitosan and oxidized sodium alginate, followed by the polymerization of th...
Source: Biomacromolecules - March 19, 2024 Category: Biochemistry Authors: Ming Yan Shi-Yu Hu Zhi-Guo Wang Rui Hong Xu Peng Maja Kuzmanovi ć Min Yang Rui Dai Yanqiong Wang Juxiang Gou Ka Li Jia-Zhuang Xu Zhong-Ming Li Source Type: research

Antibacterial, Fatigue-Resistant, and Self-Healing Dressing from Natural-Based Composite Hydrogels for Infected Wound Healing
Biomacromolecules. 2024 Mar 19. doi: 10.1021/acs.biomac.3c01385. Online ahead of print.ABSTRACTThe treatment of infected wounds faces substantial challenges due to the high incidence and serious infection-related complications. Natural-based hydrogel dressings with favorable antibacterial properties and strong applicability are urgently needed. Herein, we developed a composite hydrogel by constructing multiple networks and loading ciprofloxacin for infected wound healing. The hydrogel was synthesized via a Schiff base reaction between carboxymethyl chitosan and oxidized sodium alginate, followed by the polymerization of th...
Source: Biomacromolecules - March 19, 2024 Category: Biochemistry Authors: Ming Yan Shi-Yu Hu Zhi-Guo Wang Rui Hong Xu Peng Maja Kuzmanovi ć Min Yang Rui Dai Yanqiong Wang Juxiang Gou Ka Li Jia-Zhuang Xu Zhong-Ming Li Source Type: research

Combination MEG3 lncRNA and Ciprofloxacin dramatically decreases cell migration and viability as well as induces apoptosis in GC cells in vitro
In conclusion, combining MEG3 lncRNA with Ciprofloxacin may be an effective therapeutic approach for GC treatment by influencing the miR-14-BCl-2 axis, resulting in reduced cell viability, migration, and increased apoptosis. (Source: Biotechnology and Applied Biochemistry)
Source: Biotechnology and Applied Biochemistry - March 19, 2024 Category: Biochemistry Authors: Dena Najafi, Goli Siri, Maryam Sadri, Omid Yazdani, Romina Esbati, Parvin Karimi, Ali Keshavarz, Amirreza Mehmandar ‐Oskuie, Mehmet Ilktac Tags: ORIGINAL ARTICLE Source Type: research

Combination MEG3 lncRNA and Ciprofloxacin dramatically decreases cell migration and viability as well as induces apoptosis in GC cells in vitro
In conclusion, combining MEG3 lncRNA with Ciprofloxacin may be an effective therapeutic approach for GC treatment by influencing the miR-14-BCl-2 axis, resulting in reduced cell viability, migration, and increased apoptosis.PMID:38499448 | DOI:10.1002/bab.2578 (Source: Cancer Control)
Source: Cancer Control - March 18, 2024 Category: Cancer & Oncology Authors: Dena Najafi Goli Siri Maryam Sadri Omid Yazdani Romina Esbati Parvin Karimi Ali Keshavarz Amirreza Mehmandar-Oskuie Mehmet Ilktac Source Type: research

Mesenchymal stem cell-based adjunctive therapy for Pseudomonas aeruginosa-induced keratitis: A proof-of-concept in-vitro
CONCLUSION: MSC-CM holds promise as an adjunctive therapeutic approach for P. aeruginosa-induced corneal epithelial damage.PMID:38494102 | DOI:10.1016/j.exer.2024.109863 (Source: Experimental Eye Research)
Source: Experimental Eye Research - March 17, 2024 Category: Opthalmology Authors: Sreya Mitra Vasudeva Tati Prabhudatta Das Joveeta Joseph Bhupesh Bagga Sachin Shukla Source Type: research

Effect of ciprofloxacin on the one-stage partial nitrification and anammox biofilm system: A multivariate analysis focusing on size-fractionated organic components
Chemosphere. 2024 Mar 15:141731. doi: 10.1016/j.chemosphere.2024.141731. Online ahead of print.ABSTRACTThe impact of ciprofloxacin (CIP) in the partial nitrification and anammox biofilm system was investigated by multivariate analysis, focusing on size-fractionated organic components. The CIP dose of 10 μg/L did not inhibit the total nitrogen (TN) removal efficiency, even though the abundance of antibiotic resistant genes (ARGs) (i.e., qnrD, qnrB, qnrA, qnrS, and arcA) was elevated. However, a gradual higher CIP dosing up to 100 μg/L inhibited the TN removal efficiency, while the abundance of ARGs was still increased. Mo...
Source: Chemosphere - March 17, 2024 Category: Chemistry Authors: Keke Xiao Gudrun Abbt-Braun Robert Pleitner Harald Horn Source Type: research

Effect of ciprofloxacin on the one-stage partial nitrification and anammox biofilm system: A multivariate analysis focusing on size-fractionated organic components
Chemosphere. 2024 Mar 15:141731. doi: 10.1016/j.chemosphere.2024.141731. Online ahead of print.ABSTRACTThe impact of ciprofloxacin (CIP) in the partial nitrification and anammox biofilm system was investigated by multivariate analysis, focusing on size-fractionated organic components. The CIP dose of 10 μg/L did not inhibit the total nitrogen (TN) removal efficiency, even though the abundance of antibiotic resistant genes (ARGs) (i.e., qnrD, qnrB, qnrA, qnrS, and arcA) was elevated. However, a gradual higher CIP dosing up to 100 μg/L inhibited the TN removal efficiency, while the abundance of ARGs was still increased. Mo...
Source: Chemosphere - March 17, 2024 Category: Chemistry Authors: Keke Xiao Gudrun Abbt-Braun Robert Pleitner Harald Horn Source Type: research

Mesenchymal stem cell-based adjunctive therapy for Pseudomonas aeruginosa-induced keratitis: A proof-of-concept in-vitro
CONCLUSION: MSC-CM holds promise as an adjunctive therapeutic approach for P. aeruginosa-induced corneal epithelial damage.PMID:38494102 | DOI:10.1016/j.exer.2024.109863 (Source: Cell Research)
Source: Cell Research - March 17, 2024 Category: Cytology Authors: Sreya Mitra Vasudeva Tati Prabhudatta Das Joveeta Joseph Bhupesh Bagga Sachin Shukla Source Type: research

Mesenchymal stem cell-based adjunctive therapy for Pseudomonas aeruginosa-induced keratitis: A proof-of-concept in-vitro
CONCLUSION: MSC-CM holds promise as an adjunctive therapeutic approach for P. aeruginosa-induced corneal epithelial damage.PMID:38494102 | DOI:10.1016/j.exer.2024.109863 (Source: Experimental Eye Research)
Source: Experimental Eye Research - March 17, 2024 Category: Opthalmology Authors: Sreya Mitra Vasudeva Tati Prabhudatta Das Joveeta Joseph Bhupesh Bagga Sachin Shukla Source Type: research