Whole genome sequencing of uropathogenic E. coli from Ireland reveals diverse resistance mechanisms and strong correlation with phenotypic (EUCAST) susceptibility testing
In this study, we analysed 57 UPEC isolates from different UTI patients following EUCAST guidelines. A selection of 17 representative strains underwent WGS, phylotyping, MLST, and comparative analysis to connect laboratory susceptibility data with predictive genomics based on key resistance genes and chromosomal mutations in antimicrobial targets. Trimethoprim resistance consistently correlated with dfr genes, with six different alleles detected among the isolates. These dfr genes often coexisted with class 1 integrons, with the most common gene cassette combining dfr and aadA. Furthermore, 52.9% of isolates harboured the ...
Source: Infection, Genetics and Evolution - May 1, 2024 Category: Genetics & Stem Cells Authors: Shane Whelan Francesca Bottacini Colin Buttimer Karen Finn Brigid Lucey Source Type: research
From Wastewater to Clean Water: Recent Advances on the Removal of Metronidazole, Ciprofloxacin, and Sulfamethoxazole Antibiotics from Water through Adsorption and Advanced Oxidation Processes (AOPs)
Environ Res. 2024 Apr 27:119029. doi: 10.1016/j.envres.2024.119029. Online ahead of print.ABSTRACTAntibiotics released into water sources pose significant risks to both human health and the environment. This comprehensive review meticulously examines the ecotoxicological impacts of three prevalent antibiotics-ciprofloxacin, metronidazole, and sulfamethoxazole-on the ecosystems. Within this framework, our primary focus revolves around the key remediation technologies: adsorption and advanced oxidation processes (AOPs). In this context, an array of adsorbents is explored, spanning diverse classes such as biomass-derived bios...
Source: Environmental Research - April 30, 2024 Category: Environmental Health Authors: Amirreza Erfani Gahrouei Sajjad Vakili Ali Zandifar Sina Pourebrahimi Source Type: research
From Wastewater to Clean Water: Recent Advances on the Removal of Metronidazole, Ciprofloxacin, and Sulfamethoxazole Antibiotics from Water through Adsorption and Advanced Oxidation Processes (AOPs)
Environ Res. 2024 Apr 27:119029. doi: 10.1016/j.envres.2024.119029. Online ahead of print.ABSTRACTAntibiotics released into water sources pose significant risks to both human health and the environment. This comprehensive review meticulously examines the ecotoxicological impacts of three prevalent antibiotics-ciprofloxacin, metronidazole, and sulfamethoxazole-on the ecosystems. Within this framework, our primary focus revolves around the key remediation technologies: adsorption and advanced oxidation processes (AOPs). In this context, an array of adsorbents is explored, spanning diverse classes such as biomass-derived bios...
Source: Environmental Research - April 30, 2024 Category: Environmental Health Authors: Amirreza Erfani Gahrouei Sajjad Vakili Ali Zandifar Sina Pourebrahimi Source Type: research
Doxycycline, levofloxacin, and moxifloxacin are superior to ciprofloxacin in treating anthrax meningitis in rabbits and NHP
Antimicrob Agents Chemother. 2024 Apr 30:e0161023. doi: 10.1128/aac.01610-23. Online ahead of print.ABSTRACTEfficient treatment of anthrax-related meningitis in patients poses a significant therapeutic challenge. Previously, we demonstrated in our anthrax meningitis rabbit model that ciprofloxacin treatment is ineffective with most of the treated animals succumbing to the infection. Herein we tested the efficacy of doxycycline in our rabbit model and found it highly effective. Since all of our findings are based on a rabbit model, we test the efficacy of ciprofloxacin or doxycycline in a specific central nervous system (CN...
Source: Antimicrobial Agents and Chemotherapy - April 30, 2024 Category: Microbiology Authors: Amir Ben-Shmuel Itai Glinert Assa Sittner Elad Bar-David Josef Schlomovitz Haim Levy Shay Weiss Source Type: research
Ciprofloxacin salts of benzene mono/di-carboxylate: Crystal structures and the improvement of solubility
CrystEngComm, 2024, Accepted Manuscript DOI: 10.1039/D4CE00213J, PaperYujun Zhu, Ruoxi Liu, Leyao Wang, Chen Chen, Yupei Zhao, Wei Guo, Zhi-Hui Zhang To improve the solubility, a series of novel pharmaceutical salts prepared by ciprofloxacin as the active pharmaceutical ingredient (API) and phthalic acid and its isomers or substituted benzene carboxylic acids... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - CrystEngComm latest articles)
Source: RSC - CrystEngComm latest articles - April 30, 2024 Category: Chemistry Authors: Yujun Zhu Source Type: research
The Cytotoxic Effect of Ciprofloxacin Laetrile Combination on Esophageal Cancer Cell Line
CONCLUSION: The study found that the combination of ciprofloxacin and laetrile had a greater inhibitory effect on the growth of esophageal cancer cells compared to ciprofloxacin or laetrile alone. This suggests a synergistic effect between the components of the mixture, which can be attributed to a complementary mechanism between the ingredients in the combination.PMID:38680005 | DOI:10.31557/APJCP.2024.25.4.1433 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Azal Hamoody Jumaa Ahmed Hazem Abdulkareem Youssef Shakuri Yasin Source Type: research
Extra-intestinal salmonellosis in a tertiary care centre in South India
CONCLUSION: The diagnosis of extra-intestinal salmonellosis requires a high degree of clinical suspicion and should be included in the differential diagnosis in patients with deep-seated abscesses.PMID:38682064 | PMC:PMC11055438 | DOI:10.18502/ijm.v16i1.14885 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - April 29, 2024 Category: Microbiology Authors: Vithiya Ganesan Shyamala Ravikoti Raja Sundaramurthy Monica Raghavan Rajendran Tiruvanamalai Source Type: research
The Cytotoxic Effect of Ciprofloxacin Laetrile Combination on Esophageal Cancer Cell Line
CONCLUSION: The study found that the combination of ciprofloxacin and laetrile had a greater inhibitory effect on the growth of esophageal cancer cells compared to ciprofloxacin or laetrile alone. This suggests a synergistic effect between the components of the mixture, which can be attributed to a complementary mechanism between the ingredients in the combination.PMID:38680005 | DOI:10.31557/APJCP.2024.25.4.1433 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Azal Hamoody Jumaa Ahmed Hazem Abdulkareem Youssef Shakuri Yasin Source Type: research
Extra-intestinal salmonellosis in a tertiary care centre in South India
CONCLUSION: The diagnosis of extra-intestinal salmonellosis requires a high degree of clinical suspicion and should be included in the differential diagnosis in patients with deep-seated abscesses.PMID:38682064 | PMC:PMC11055438 | DOI:10.18502/ijm.v16i1.14885 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - April 29, 2024 Category: Microbiology Authors: Vithiya Ganesan Shyamala Ravikoti Raja Sundaramurthy Monica Raghavan Rajendran Tiruvanamalai Source Type: research
The Cytotoxic Effect of Ciprofloxacin Laetrile Combination on Esophageal Cancer Cell Line
CONCLUSION: The study found that the combination of ciprofloxacin and laetrile had a greater inhibitory effect on the growth of esophageal cancer cells compared to ciprofloxacin or laetrile alone. This suggests a synergistic effect between the components of the mixture, which can be attributed to a complementary mechanism between the ingredients in the combination.PMID:38680005 | DOI:10.31557/APJCP.2024.25.4.1433 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Azal Hamoody Jumaa Ahmed Hazem Abdulkareem Youssef Shakuri Yasin Source Type: research
Extra-intestinal salmonellosis in a tertiary care centre in South India
CONCLUSION: The diagnosis of extra-intestinal salmonellosis requires a high degree of clinical suspicion and should be included in the differential diagnosis in patients with deep-seated abscesses.PMID:38682064 | PMC:PMC11055438 | DOI:10.18502/ijm.v16i1.14885 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - April 29, 2024 Category: Microbiology Authors: Vithiya Ganesan Shyamala Ravikoti Raja Sundaramurthy Monica Raghavan Rajendran Tiruvanamalai Source Type: research
