Radiation doses received by major organs at risk in children and young adolescents treated for cancer with external beam radiation therapy: a large-scale study from 12 European countries.
Childhood cancer survivors are at high risk of long-term iatrogenic events, in particular those treated with radiotherapy. The prediction of risk of such events is mainly based on the knowledge of the radiation dose received to healthy organs and tissues during treatment of childhood cancer diagnosed decades ago. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 3, 2024 Category: Radiology Authors: Ibrahima Diallo, Rodrigue S. Allodji, Cristina Veres, St éphanie Bolle, Damien Llanas, Safaa Ezzouhri, Wael Zrafi, Ghazi Debiche, Vincent Souchard, Romain Fauchery, Nadia Haddy, Neige Journy, Charlotte Demoor-Goldschmidt, David L. Winter, Lars Hjorth, Th Tags: Clinical Investigation Source Type: research
New | phs002790.v6.p1 | Childhood Cancer Data Initiative (CCDI): Molecular Characterization Initiative
Childhood Cancer Data Initiative (CCDI): Molecular Characterization Initiative (study page |release notes) (Source: dbGaP, the database of Genotypes and Phenotypes)
Source: dbGaP, the database of Genotypes and Phenotypes - April 2, 2024 Category: Genetics & Stem Cells Tags: StudyRelease Source Type: research
Effects of hypertension and use of antihypertensive drugs in pregnancy on the risks of childhood cancers in Taiwan
ConclusionsIn this cohort study, children whose mothers had chronic and gestational hypertension had an increased risk of developing childhood cancer. (Source: Cancer Causes and Control)
Source: Cancer Causes and Control - April 1, 2024 Category: Cancer & Oncology Source Type: research
3. Does mesna (mercapto-ethanesulphonate sodium) protect ovarian reserve after cyclophosphamide exposure?
Chemotherapy-induced ovarian failure is one of the severe challenges that female cancer survivors face in the reproductive age. Oocyte and ovarian tissue cryopreservation are fertility preservation methods with growing evidence yet remain an expensive option for many. Alternative fertility-preserving agents should be tailored according to the underlying mechanism of cytotoxic treatment the survivor is exposed to. Cyclophosphamide is one of the most common cytotoxic agents, with a wide spectrum of indications from childhood cancers to autoimmune diseases. (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - April 1, 2024 Category: OBGYN Authors: Hayriye Baghaki, Cihan Kaya, Erdem Soztutar, Nilay Aksoy, Levent Yasar, Murat Ekin Source Type: research
Factors Associated with In-patient and Outpatient Rehabilitation Services among Childhood Cancer Survivors
Despite evidence indicating benefits of early intervention with occupational therapy (OT) and physical therapy (PT) for improving functional outcomes, (Source: Archives of Physical Medicine and Rehabilitation)
Source: Archives of Physical Medicine and Rehabilitation - April 1, 2024 Category: Rehabilitation Authors: Maria Swartz, Shiming Zhang, Keri Schadler, Clark Andersen, Donna Kelly, Alakh Rajan, Eduardo Gonzalez Villarreal, Amy Heaton, Karen Moody Tags: Oral Presentation 2420332 Source Type: research
Excess healthcare expenditure in adults treated for solid cancer in childhood: a cohort study in France
ConclusionsOf the variables that influence excess healthcare expenditure, a lever for action is the type of treatment administered. Future research should focus on addressing the long-term cost-effectiveness of new approaches, especially those related to radiotherapy. (Source: The European Journal of Health Economics)
Source: The European Journal of Health Economics - April 1, 2024 Category: Health Management Source Type: research
Modeling childhood cancer in Drosophila melanogaster
We describe how this cancer paradigm allows assessing two critical aspects of tumorigenesis during juvenile stages: (1) viability (do animals with particular cancer mutations survive into adulthood?), and (2) tumor burden (what percentage of animals bearing the cancer mutations actually develop cancer and what is the extent of the tumor?). We highlight the potential of Drosophila as a molecular therapeutic tool for drug screening and drug repurposing of medicines already approved to treat other diseases in children, thereby accelerating the potential translation of results into humans. This preclinical animal model sustain...
Source: Cancer Control - March 31, 2024 Category: Cancer & Oncology Authors: Isabel Adrados Luc ía García-López Mario Aguilar-Aragon Eva Maranillo Mar ía Domínguez Source Type: research
Associations of seven measures of biological age acceleration with frailty and all-cause mortality among adult survivors of childhood cancer in the St. Jude Lifetime Cohort
Nat Cancer. 2024 Mar 29. doi: 10.1038/s43018-024-00745-w. Online ahead of print.ABSTRACTSurvivors of childhood cancer may experience accelerated biological aging, resulting in premature frailty and death. We used seven measures of biological age in the St. Jude Lifetime (SJLIFE) Cohort to compare biological age acceleration between the SJLIFE Cohort and the third United States National Health and Nutrition Examination Survey controls, explore trajectories of biological age according to cancer treatment and type, and test associations of biological age acceleration with frailty and death (mean follow-up of 26.5 years) among...
Source: Cancer Control - March 30, 2024 Category: Cancer & Oncology Authors: Jennifer L Guida Geehong Hyun Daniel W Belsky Gregory T Armstrong Matthew J Ehrhardt Melissa M Hudson Paige A Green Leslie L Robison Brennan P Streck Emily S Tonorezos Yutaka Yasui Carmen L Wilson Zhaoming Wang Kirsten K Ness Source Type: research
