Trans-Ancestral Genetic Risk Factors for Treatment-Related Type 2 Diabetes Mellitus in Survivors of Childhood Cancer
CONCLUSION: Our findings suggest therapy-related genetic risks contribute to the increased T2D burden among non-Hispanic Black childhood cancer survivors. Additional study of how therapy-related genetic susceptibility contributes to this disparity is needed.PMID:38652878 | DOI:10.1200/JCO.23.02281 (Source: Cancer Control)
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: Cindy Im Achal Neupane Jessica L Baedke Brian Lenny Angela Delaney Stephanie B Dixon Eric J Chow Sogol Mostoufi-Moab Tianzhong Yang Melissa A Richard M Monica Gramatges Philip J Lupo Noha Sharafeldin Smita Bhatia Gregory T Armstrong Melissa M Hudson Kirst Source Type: research
Exercise and QUality diet After Leukemia (EQUAL): A randomized weight loss trial among adult survivors of childhood leukemia in the Childhood Cancer Survivor Study
CONCLUSIONS: A remote weight-loss intervention that was successful among adults with CV conditions did not result in significant weight loss among adult survivors of childhood ALL.IMPACT: Future interventions in this population must be tailored to the unique needs of survivors to encourage engagement and adherence.PMID:38652494 | DOI:10.1158/1055-9965.EPI-23-1601 (Source: Cancer Control)
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: Danielle Novetsky Friedman Joanne F Chou Jeanne M Clark Chaya S Moskowitz Jennifer S Ford Gregory T Armstrong Nidha Z Mubdi Aaron McDonald Paul C Nathan Charles A Sklar Lakshmi V Ramanathan Leslie L Robison Kevin C Oeffinger Emily S Tonorezos Source Type: research
Flow cytometric minimal residual disease measurement accounting for cytogenetics in children with non ‐high‐risk acute lymphoblastic leukemia treated according to the ALL‐MB 2008 protocol
ConclusionOur data show that combining clinical risk factors with MFC-MRD measurement is the most useful tool for risk group stratification of children with BCP-ALL in the reduced-intensity protocols. However, this algorithm can be supplemented with cytogenetic data for part of the ImR group. (Source: Cancer Medicine)
Source: Cancer Medicine - April 23, 2024 Category: Cancer & Oncology Authors: Alexander Popov,
Guenter Henze,
Grigory Tsaur,
Oleg Budanov,
Julia Roumiantseva,
Mikhail Belevtsev,
Tatiana Verzhbitskaya,
Liudmila Movchan,
Svetlana Lagoyko,
Liudmila Zharikova,
Yulia Olshanskaya,
Tatiana Riger,
Alena Valochnik,
Natalia Miak Tags: RESEARCH ARTICLE Source Type: research
Incidence and prevalence of musculoskeletal health conditions in survivors of childhood and adolescent cancers: A report from the Swiss childhood cancer survivor study
ConclusionMSHCs are prevalent in survivors, the risk is increasing in younger survivor cohorts, and MSHCs usually occur in multimorbid survivors. Strengthening of rehabilitation services and appropriate referrals are needed to mitigate the effects of the cancer and cancer treatment. (Source: Cancer Medicine)
Source: Cancer Medicine - April 23, 2024 Category: Cancer & Oncology Authors: Salome Christen,
Katharina Roser,
Luzius Mader,
Maria Otth,
Katrin Scheinemann,
Grit Sommer,
Claudia Kuehni,
Gisela Michel Tags: RESEARCH ARTICLE Source Type: research
Reasons why the idea that radiation exposures induce cancer needs to be revisited
CONCLUSION: In mouse experiments, radiation exposures did not lead to the induction of a large increase in the proportion of tumor deaths when life-long observations were made. Human epidemiologic data are also in line with the earlier onset hypothesis of radiation action. It should be cautioned, however, that the earlier onset model applies only to malignancies whose mortality increases rapidly with the increase of age and does not apply to diseases of short latency such as childhood leukemia and thyroid cancers.PMID:38647670 | DOI:10.1080/09553002.2024.2338516 (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - April 22, 2024 Category: Radiology Authors: Nori Nakamura Source Type: research
METTL14 promotes neuroblastoma formation by inhibiting YWHAH via an m6A-YTHDF1-dependent mechanism
Cell Death Discov. 2024 Apr 22;10(1):186. doi: 10.1038/s41420-024-01959-8.ABSTRACTNeuroblastoma (NB) is a common childhood tumor with a high incidence worldwide. The regulatory role of RNA N6-methyladenosine (m6A) in gene expression has attracted significant attention, and the impact of methyltransferase-like 14 (METTL14) on tumor progression has been extensively studied in various types of cancer. However, the specific influence of METTL14 on NB remains unexplored. Using data from the Target database, our study revealed significant upregulation of METTL14 expression in high-risk NB patients, with strong correlation with p...
Source: Cancer Control - April 22, 2024 Category: Cancer & Oncology Authors: Jianwei Wang Hongli Yin Gen Li Di Wu Yunyun Xu Yanling Chen Xiaodong Wang Yujiao Xing Ting Zhang Danhong Fei Pengcheng Yang Fang Fang Yanfang Tao Xiaolu Li Juanjuan Yu Yang Yang Zhiheng Li Lei Shi Zimu Zhang Jian Pan Source Type: research
Oncolytic virotherapy stimulates anti ‑tumor immune response and demonstrates activity in advanced sarcoma: Report of two cases
Oncol Lett. 2024 Apr 3;27(6):244. doi: 10.3892/ol.2024.14377. eCollection 2024 Jun.ABSTRACTSarcoma is derived from mesenchymal neoplasms and has numerous subtypes, accounting for 1% of all adult malignancies and 15% of childhood malignancies. The prognosis of metastatic or recurrent sarcoma remains poor. The current study presents two cases of sarcoma enrolled in a phase I dose escalation trial for solid tumor, who had previously failed all standard therapies. These patients were treated with VG161, an immune-stimulating herpes simplex virus type 1 oncolytic virus with payloads of IL-12, IL-15 and IL-15 receptor α unit, a...
Source: Oncology Letters - April 19, 2024 Category: Cancer & Oncology Authors: Yeting Qiu Aijun Qin Ronghua Zhao Jun Ding William Wei-Guo Jia Manu Singh Yanal Murad Qian Tan Ganessan Kichenadasse Source Type: research
Oncolytic virotherapy stimulates anti ‑tumor immune response and demonstrates activity in advanced sarcoma: Report of two cases
Oncol Lett. 2024 Apr 3;27(6):244. doi: 10.3892/ol.2024.14377. eCollection 2024 Jun.ABSTRACTSarcoma is derived from mesenchymal neoplasms and has numerous subtypes, accounting for 1% of all adult malignancies and 15% of childhood malignancies. The prognosis of metastatic or recurrent sarcoma remains poor. The current study presents two cases of sarcoma enrolled in a phase I dose escalation trial for solid tumor, who had previously failed all standard therapies. These patients were treated with VG161, an immune-stimulating herpes simplex virus type 1 oncolytic virus with payloads of IL-12, IL-15 and IL-15 receptor α unit, a...
Source: Herpes - April 19, 2024 Category: Infectious Diseases Authors: Yeting Qiu Aijun Qin Ronghua Zhao Jun Ding William Wei-Guo Jia Manu Singh Yanal Murad Qian Tan Ganessan Kichenadasse Source Type: research
Decision-Making Factors in Advanced or Incurable Childhood Cancer Diagnosis in Low- and Middle- Income Countries
1. Using a structured approach, participants will self-report the ability to understand the static and dynamic factors that influence treatment decision-making at diagnosis for children presenting with advanced cancer in LMICs.2. Participants will reflect on the need to revise and develop treatment guidelines that are adaptable to resource-constrained settings and consider challenges faced by physicians caring for children presenting with advanced cancer at diagnosis, considering also the need to explore decision-making approaches of other key decision-partners. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Alaina Rule, Marta Salek Source Type: research
Oncologists Endorse Divergent ‘Best Practices’ for Disclosing Prognosis in Advanced Pediatric Cancer (RP124)
1. Describe (and self-reflect on) how clinicians may make assumptions about what prognostic information patients/families want to hear and how they want to hear it, as well as how clinicians may lack comfort in eliciting these preferences directly from patients/families.2. Recognize a deficit in s takeholder-driven guidance to encourage and support clinicians in provision of person-centered, timely prognostic communication in advanced childhood cancer and other pediatric serious illnesses. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Erica C. Kaye, Harmony Farner, Shoshana Mehler, Nidhi Mali, Kelly Bien, Justin N. Baker, Jennifer Mack Source Type: research
Factors Modifying Decision-Making at Diagnosis of Advanced Childhood Cancer in Low- and Middle-Income Countries (RP223)
1. Participants will be able to describe challenges physicians practicing in low-and middle-income countries face, when making treatment decisions for children presenting with advanced cancer, as well as the factors that modify treatment recommendations.2. Participants will be able to suggest inte rventions or future studies that will help support physicians and other decision-makers in low-and middle-income countries when determining treatment plans for children presenting with advanced cancer. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Marta Salek, Alaina Rule, Jamie Zeal, Shoshana Mehler, Joanne Canedo, Essy Maradiege Chirinos, Mae Concepcion J. Concepcion J. Dolendo, Diego Figueredo, Sanjeeva Gunasekera, Roman Kizyma, Hoa Thi Kim Nguyen, Irene Nzamu, Muhammad Rafie Raza, Khilola Rusta Source Type: research
Doing Instead, Flexing to Accommodate, and Guarding the Future: Quality of Life During Childhood Cancer Treatment (RP201)
1. After engaging with the research presentation, participants will apply and further refine the concepts of "doing instead," "flexing to accommodate," and "imagined future person," in research with children with cancer and other seriously ill children receiving disease-modifying treatments that may threaten social isolation and changes to other identity-forming/affirming activities.2. During and after engaging with the research presentation, participants will critically consider strengths and weaknesses of the employed research methods (data generation via semi-structured interviews, theore tical sampling, and use of...
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Alexandra Merz, Katharine E. Brock, Sarah E. Stevens, Anna C. Revette, Joanne Wolfe, Angela M. Feraco Source Type: research
The PERCEIVE Study: Pediatric Oncology Nurses ’ Perspectives on Roles as Psychosocial Interventionists
1. Learners will identify potential opportunities related to their clinician roles that may facilitate psychosocial resources for families facing childhood cancer.2. Learners will demonstrate increased knowledge related to systemic obstacles in the provision of psychosocial care for African American families with children diagnosed with cancer. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Ijeoma Julie Eche-Ugwu, Teri B. Aronowitz, Elizabeth G. Broden, Alexandra Merz, Joanne Wolfe, Angela M. Feraco Source Type: research
Early detection of gastrointestinal polyps and neoplasia following radiation for childhood-onset cancer
A massive and rapidly increasing burden of care exists for all physicians caring for the 80–90% of childhood cancer survivors. All paediatricians and general practitioners (GPs) seeing these adolescents must attain a sound knowledge of the risks, current and future, faced by these young people. Provision of improved care and appropriate surveillance during adolescence, with information for adult services at time of transition, will also empower patients and their families to advocate for and act upon the essential requirements for long-term surveillance. Not all these risks are yet commonly recognised. Exposure to ab...
Source: Archives of Disease in Childhood - April 18, 2024 Category: Pediatrics Authors: Atlas, G., Zacharin, M. R. Tags: PostScript Source Type: research
Associations between mitochondrial copy number, exercise capacity, physiologic cost of walking, and cardiac strain in young adult survivors of childhood cancer
ConclusionsIncreased mtDNA-CN is associated with decreased odds of abnormal cardiac function in childhood cancer survivors.Implications for Cancer SurvivorsThese findings demonstrate a potential role for mtDNA-CN as a biomarker of early cardiac dysfunction in this population. (Source: Journal of Cancer Survivorship)
Source: Journal of Cancer Survivorship - April 18, 2024 Category: Cancer & Oncology Source Type: research
