3. Does mesna (mercapto-ethanesulphonate sodium) protect ovarian reserve after cyclophosphamide exposure?

Chemotherapy-induced ovarian failure is one of the severe challenges that female cancer survivors face in the reproductive age. Oocyte and ovarian tissue cryopreservation are fertility preservation methods with growing evidence yet remain an expensive option for many. Alternative fertility-preserving agents should be tailored according to the underlying mechanism of cytotoxic treatment the survivor is exposed to. Cyclophosphamide is one of the most common cytotoxic agents, with a wide spectrum of indications from childhood cancers to autoimmune diseases.
Source: Journal of Pediatric and Adolescent Gynecology - Category: OBGYN Authors: Source Type: research