Commentary on More Drastic Scenarios of Partial Brain and Full Body Replacement
Is outright replacement of tissues a viable option for the treatment of aging? There are factions within the longevity-interested community who think that the paths to either (a) engineering replacement brain tissue for parts of the brain not involved in memory, or (b) transplantation of an old head onto a young body or brain into a young body, are short enough to be worth pursuing, where "short enough" means a few decades of work given sufficient funding. To my mind, major surgery of the sort implied by replacement of large sections of tissue or entire organs is something to be avoided in later life, given the risks and c...
Source: Fight Aging! - January 10, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, December 5th 2022
In conclusion, the PAAIs examined (i.e. mTOR loss of function, Ghrhr loss of function, intermittent fasting-based version of dietary restriction) often influenced age-sensitive traits in a direct way and not by slowing age-dependent change. Previous studies often failed to include young animals subjected to PAAI to account for age-independent PAAI effects. However, any study not accounting for such age-independent intervention effects will be prone to overestimate the extent to which an intervention delays the effects of aging on the phenotypes studied. This can result in a considerable bias of our view on how modifiable a...
Source: Fight Aging! - December 4, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

What is the most common cause of acquired heart disease in children in developed countries?
Kawasaki disease is the most common cause of acquired heart disease in children in developed countries. In developing countries it will be rheumatic heart disease. Timely treatment of Kawasaki disease with intravenous immunoglobulin can reduce the incidence of coronary aneurysms from 25% to around 4%. Children with coronary aneurysms due to Kawasaki disease needs lifelong cardiology follow up. The prognosis depends on the initial and current level of coronary involvement. Some children may develop coronary obstruction and thrombosis leading to myocardial infarction. Revascularization procedures may be needed in some of th...
Source: Cardiophile MD - November 17, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs

The Ultimate EMT Guide to Vital Signs (Part 1): Pulse
There are few things that EMT’s should claim as their domain. There are certain skills that the EMT provider should simple dominate. Vital signs are one such skill. No medical provider anywhere should be able to hold a candle to the EMT when vitals signs are the name of the game. Vital signs are, to the EMT, what sharp shooting is to the sniper; what the fast ball is to the closing pitcher; what swordsmanship is to Zorro. It’s the EMT bread-and-butter skill. And yet…so many EMTs fumble through vital signs like it’s amateur hour. No more. Over the next few weeks we’re going to break down vital signs here at The...
Source: The EMT Spot - November 15, 2022 Category: Emergency Medicine Authors: Steve Whitehead Tags: EMT Source Type: blogs

Electrospun Construct Mimics Elasticity of Blood Vessels
Researchers at the University of Sydney in Australia have developed an electrospun blood vessel replacement. The material contains tropoelastin, a natural precursor for elastin, a key component of blood vessel walls. Elastin is present in concentric circles in natural blood vessels and provides the elastic properties which allow them to distend slightly and then reform their original shape in response to changes in blood flow and blood pressure. This latest construct allows similar layers of elastin to form when implanted into the body, and over time the grafted vessel appears to develop into something approaching a functi...
Source: Medgadget - November 7, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Cardiac Surgery Materials Pediatrics Thoracic Surgery Vascular Surgery electrospinning Sydney_Uni Source Type: blogs

Fight Aging! Newsletter, November 7th 2022
In conclusion, the national prevalence of dementia and MCI in 2016 found in this cross-sectional study was similar to that of other US-based studies. Clearing Microglia Reverses Age-Related Disruption of Sleeping Patterns in Mice https://www.fightaging.org/archives/2022/11/clearing-microglia-reverses-age-related-disruption-of-sleeping-patterns-in-mice/ Microglia are innate immune cells of the central nervous system. They are analogous to macrophages in the rest of the body, but undertake additional duties relating to the function of neurons and in brain tissue. Microglia become overly active and inflamm...
Source: Fight Aging! - November 6, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

FDA-Approved At-Home Spirometer: Interview with Charvi Shetty, Co-Founder and CEO at Aluna
The COVID-19 pandemic has put lung health firmly in our minds. For those with chronic lung diseases, such as asthma and COPD, an important way to keep track of lung health is to use a spirometer to measure how well air can move in and out of the lungs during forced breathing. However, patients would typically attend with a lung specialist to perform this test. This is inconvenient and precludes regular monitoring to keep a close eye on lung health and spot any upcoming disease exacerbation. This is the motivation behind this latest technology, an at-home digital spirometer, created by a medical startup called Aluna. The...
Source: Medgadget - October 17, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Cardiac Surgery Cardiology Diagnostics Exclusive Medicine Pediatrics Rehab Thoracic Surgery Source Type: blogs

Taking your brain vitals: Stories from a techno-optimist inventing the future of human performance
We examined how experts currently measured brain health—like the neurologist who met my dad, gave him some tests, and made a determination. No matter how gifted the neurologist may be, there was no way for him to know whether my dad’s cognition had declined, improved, or stayed the same over the past months or even years. Yet I’d expected that doctor to have all the answers. We proposed a new approach. Rather than boil the ocean trying to characterize every aspect of cognition, we said, “Let’s track brain health as if it’s a vital sign.” To do this, we needed a tracking tool that was as easy to use as, say, a...
Source: SharpBrains - October 11, 2022 Category: Neuroscience Authors: Dr. Cori Lathan Tags: Brain/ Mental Health Technology & Innovation AnthroTronix brain health cognition cognitive changes Cognitive-tests concussions Dana dementia-diagnosis detect cognitive changes mild-cognitive-impairment neurologist neuropsychologi Source Type: blogs

A man in his 30s with cardiac arrest and STE on the post-ROSC ECG
Conclusions: outpatients with witnessed cardiac arrest and primary PEA carry a high probability of Massive Pulmonary Embolism________________Case Continued:" Initial ROSC EKG showed what appeared to be in atrial fibrillation with inferior ST elevations, depressions in aVL, concerning for STEMI. "He had multiple cardiac arrests with ROSC regained each time. " Endotracheal tube re-intubation was confirmed multiple times, bilateral breath sounds, yet O2 saturation remained in the 50s and 60s. I was able to visualize the ETT on initial intubation pass through the cords however given his continued hypoxemia, I felt it...
Source: Dr. Smith's ECG Blog - October 10, 2022 Category: Cardiology Authors: Pendell Source Type: blogs

Fight Aging! Newsletter, October 10th 2022
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - October 9, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

TLC Todd-versations: Todd Linsky in Conversation with Dr. Alan Greene
Todd Linsky, a food and organic industry veteran, hosts the podcast Todd-versations. He interviews guests from around the globe — influencers, leaders, and innovators in their respective fields. In this episode, Todd and Dr. Greene discuss the pediatric roots of longevity, the importance of nutrition in health, Dr. Greene’s reasons for creating DrGreene.com, his next projects, and a whole host of side topics. Transcript of Todd-versation Podcast with Todd Linsky and Dr. Greene 0:00 this conversation is brought to you in part by Calavo Growers the family of fresh! 0:19 hey there everybody good ...
Source: Conversations with Dr Greene - October 6, 2022 Category: Child Development Authors: Alan Greene MD Tags: Dr. Greene's Blog Source Type: blogs

PROTECTED TAVR – Cerebral embolic protection?
PROTECTED TAVR – Cerebral embolic protection? Higher rates of stroke have been considered as a limitation of transcatheter aortic valve replacement (TAVR) in comparison with surgical aortic valve replacement (SAVR) [1,2]. Stroke following TAVR has been shown to increase the 30 day mortality from 3.7% to 16.7% according to a retrospective report from Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapies Registry. The registry had 101 430 patients who were treated with femoral and non-femoral TAVR at 521 US hospitals between 2011 and 2017 [3]. A previous study had used cerebral embol...
Source: Cardiophile MD - October 5, 2022 Category: Cardiology Authors: Johnson Francis Tags: Angiography and Interventions General Cardiology Structural Heart Disease Interventions Source Type: blogs

Transcatheter edge-to-edge repair (TEER) of the tricuspid valve
After transcatheter edge-to-edge repair (TEER) for mitral valve, TEER for tricuspid valve is catching up. Data from the United States of America has been published in May 2022. They queried the Nationwide Readmissions Database and identified 918 hospitalizations for TEER of tricuspid valve from 2016 to 2019. There was a rise from 13 cases in the first quarter of 2016 to 122 cases in the last quarter of 2019. Concomitant TEER of mitral valve was performed in 42.1% of the admissions. Overall in-hospital mortality was 2.1% and surgical tricuspid valve replacement was needed in 1.1% of admissions; none of them died during the...
Source: Cardiophile MD - October 1, 2022 Category: Cardiology Authors: Johnson Francis Tags: Angiography and Interventions Structural Heart Disease Interventions Source Type: blogs

Transcatheter Edge-to-Edge Repair (TEER) of Mitral Valve
Transcatheter Edge-to-Edge Repair (TEER) of the mitral valve is done for treatment of mitral regurgitation [1]. Anterior and posterior leaflets of mitral valve are approximated using a clipping device and is similar to the corresponding surgical procedure known as Alfieri stitch [2]. Earlier porcine study had used left thoracotomy for placing the flexible delivery catheter with a clip in the left atrium. The clip grasped and approximated the mid portion of the anterior and posterior mitral leaflets with echocardiographic and fluoroscopic guidance. Clip was detached from the system and the catheter withdrawn after confirma...
Source: Cardiophile MD - September 27, 2022 Category: Cardiology Authors: Johnson Francis Tags: Angiography and Interventions Structural Heart Disease Interventions Source Type: blogs

Weekly Overseas Health IT Links –17th September, 2022.
This study adds to the evidence showing that expanded access to these services could have a longer-term positive impact if continued.”Roughly 1 in 8 beneficiaries in the pandemic group received OUD-related telehealth services compared with 1 in 800 in the prepandemic group, the research revealed. Access to telehealth services was associated with better treatment retention and lower risk of medically treated overdose in the pandemic group compared to those not receiving telehealth services.-----https://healthimaging.com/topics/management/education-training/ai-deterring-students-pursuing-radiologyConcerns about the future ...
Source: Australian Health Information Technology - September 17, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs