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Fight Aging! Newsletter, February 4th 2019
In this study, we examined the benefits of early-onset, lifelong AET on predictors of health, inflammation, and cancer incidence in a naturally aging mouse model. Lifelong, voluntary wheel-running (O-AET; 26-month-old) prevented age-related declines in aerobic fitness and motor coordination vs. age-matched, sedentary controls (O-SED). AET also provided partial protection against sarcopenia, dynapenia, testicular atrophy, and overall organ pathology, hence augmenting the 'physiologic reserve' of lifelong runners. Systemic inflammation, as evidenced by a chronic elevation in 17 of 18 pro- and anti-inflammatory cytokin...
Source: Fight Aging! - February 3, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Advanced Medical Solutions Group plc: Acquisition of Sealantis
Winsford, UK, 31 January 2019: Advanced Medical Solutions Group plc (AIM: AMS), the surgical and advanced wound care specialist company, today announces it has acquired Sealantis Limited ( “Sealantis”), a developer of an alginate-based tissue adhesive technology platform, for $US 25m (approximately £19m) in cash with royalties due until December 2027 on sales of any of its products that are currently in development.Overview of SealantisSealantis is an Israeli-based medical device company with a patent-protected alga-mimetic sealants technology platform with a wide range of potential surgical indications under developm...
Source: Medical Hemostat - February 1, 2019 Category: Medical Devices Authors: hemostatguy at gmail.com (hemostat guy) Source Type: blogs

Silicon Photonics Device to Screen for Arterial Stiffness: Interview with Roel Baets and Patrick Segers, Imec and Ghent University
Imec, a research and innovation hub for nanoelectronics and digital technologies based in Belgium, in collaboration with numerous partners, has developed a new medical device to screen for arterial stiffness, a risk-factor for cardiovascular disease. Routine screening of arterial stiffness in a doctor’s office is currently impossible, meaning that this risk-factor is underused in the fight against cardiovascular disease. The new device is based on silicon photonics and could enable minimally skilled medical staff to easily and non-invasively assess patients for arterial stiffness at the point of care. The silicon photoni...
Source: Medgadget - January 31, 2019 Category: Medical Devices Authors: Conn Hastings Tags: Cardiology Diagnostics Exclusive Medicine Vascular Surgery Source Type: blogs

Silicon Photonics Device for Arterial Stiffness: Interview with Roel Baets and Patrick Segers, Imec and Ghent University
Imec, a research and innovation hub for nanoelectronics and digital technologies based in Belgium, in collaboration with numerous partners, has developed a new medical device to screen for arterial stiffness, a risk-factor for cardiovascular disease. Routine screening of arterial stiffness in a doctor’s office is currently impossible, meaning that this risk-factor is underused in the fight against cardiovascular disease. The new device is based on silicon photonics and could enable minimally skilled medical staff to easily and non-invasively assess patients for arterial stiffness at the point of care. The silicon photoni...
Source: Medgadget - January 31, 2019 Category: Medical Devices Authors: Conn Hastings Tags: Cardiology Diagnostics Exclusive Medicine Vascular Surgery Source Type: blogs

The Goal of Symbiotic Microbes in Tissues, Generating Additional Oxygen as Required
We live in an era of biotechnology, of tremendous year by year increases in the capacity to engineer the fundamental mechanisms of life and disease. The research community and funding institutions should aim high, aim at the new and the amazing, rather than slouching forward in the service of crafting yet more marginal, incremental improvements to existing forms of therapy. Sadly, mediocrity rules when it comes to all too much of the research community. Vision is lacking, and far too few people are willing to tread the roads yet untraveled. Why is it necessary to spend so much time and effort to convince people to f...
Source: Fight Aging! - January 31, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

MediPines Gas Exchange Monitor Cleared by FDA for Comprehensive Lung Function Analysis
MediPines, a company based in California’s Orange County, obtained FDA clearance for its MediPines Gas Exchange Monitor. The device is used to measure and monitor a variety of respiratory parameters and indices of patients presenting with lung conditions. It can help to quickly triage patients and make decision making easier by providing parameters such as PIO2, PETCO2, and Oxygen Deficit. Even the pulse rate and oxygen saturation of blood (SpO2) can be obtained by the patient simply breathing into a mouthpiece. A comprehensive test takes only a few minutes and it is non-invasive and can be performed at the point ...
Source: Medgadget - January 31, 2019 Category: Medical Devices Authors: Editors Tags: Medicine Thoracic Surgery Source Type: blogs

Handheld Photonic Device Measures Arterial Stiffness
A collaboration between nine different European research organizations, including the medical device giant Medtronic, has developed a prototype device for quick and easy measurement of arterial stiffness. This is an important development, as arterial stiffness is a biomarker for high blood pressure, but there are no reliable ways of measuring it without a cardiologist bearing special equipment. The silicon photonic chips to perform laser doppler vibrometry on a patient’s skin to deduce metrics for arterial stiffness and to diagnose cardiovascular diseases The new device looks like a blow dryer, but it emits low powered l...
Source: Medgadget - January 29, 2019 Category: Medical Devices Authors: Editors Tags: Cardiology Diagnostics Medicine Vascular Surgery Source Type: blogs

ECG in Ebstein ’ s anomaly of tricuspid valve
ECG in Ebstein’s anomaly of tricuspid valve ECG in Ebstein’s anomaly of tricuspid valve ECG in Ebstein’s anomaly of tricuspid valve showing right axis deviation of QRS, notched R waves in II, III, aVF and V1 suggesting fragmented QRS. Peaked P waves indicate a right atrial abnormality, though the typical voltage criteria for right atrial enlargement (more than 0.25 mV) is not satisfied. Fragmented QRS occurs in Ebstein’s anomaly due to abnormal conduction in the atrialised right ventricle [1]. A portion of the right ventricle is atrialised because of distal displacement of the septal and posterior ...
Source: Cardiophile MD - January 26, 2019 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: ECG / Electrophysiology ECG Library fragmented QRS Source Type: blogs

Fatty liver disease: What it is and what to do about it
Non-alcoholic fatty liver disease (NAFLD), a condition of extra fat buildup in the liver, is on the rise — it now affects roughly 20% to 40% of the US population. It usually doesn’t cause any symptoms, and is often first detected by accident when an imaging study (such as an abdominal ultrasound, CT scan, or MRI) is requested for another reason. A fatty liver may also be identified on an imaging test as a part of investigating abnormal liver blood tests. NAFLD is intimately related to conditions like diabetes and obesity. It’s also linked to an increased risk of cardiovascular disease. Understanding NAFLD and its cau...
Source: Harvard Health Blog - January 10, 2019 Category: Consumer Health News Authors: Wynne Armand, MD Tags: Digestive Disorders Health Source Type: blogs

Considering Mesenchymal Stem Cell Therapy for Atherosclerosis
Mesenchymal stem cell (MSC) therapies as presently practiced, even given considerable differences in what exactly is meant by "mesenchymal stem cell", fairly reliably reduce the chronic inflammation of aging for an extended period of time. They are much less reliable at inducing regeneration of tissues, and where that does occur it probably results from dampened inflammation. One of the many detrimental consequences of the always-on inflammatory signaling that arises with age is a disruption of regenerative capacity. Given the ability of MSC transplantation to suppress inflammation, it is possible that this could be at lea...
Source: Fight Aging! - January 3, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Last Month in Oncology with Dr. Bishal Gyawali: November 2018
By BISHAL GYAWALI MD Keynote speech There was a very sobering piece in NEJM by the FDA last month in which the authors try to explore what went wrong with the Keynote-183, Keynote-185 and checkmate 602 trials testing PD-1 inhibitors combinations with pomalidomide or lenalidomide and dexamethasone in multiple myeloma. Interim analysis of Keynote 183 and 185 revealed detrimental effects on overall survival (OS) with hazard ratios of 1.61 and 2.06, not explained by differences in toxicities alone. The checkmate 602 trial was also halted in light of these findings and also showed higher mortality in the nivolumab combina...
Source: The Health Care Blog - December 17, 2018 Category: Consumer Health News Authors: matthew holt Tags: Pharmaceuticals Physicians Bishal Gyawali Cancer drugs cancer immunotherapy Clinical Trials FDA Oncology PD-1 inhibitors Source Type: blogs

Fight Aging! Newsletter, December 17th 2018
In this study, we found that TNF-α resulted in an impairment of autophagic flux in microglia. Concomitantly, an increase of M1 marker expression and reduction of M2 marker expression were observed in TNF-α challenged microglia. Upregulation of autophagy via serum deprivation or pharmacologic activators (rapamycin and resveratrol) promoted microglia polarization toward M2 phenotype, as evidenced by suppressed M1 and elevated M2 gene expression, while inhibition of autophagy with 3-MA or Atg5 siRNA consistently aggravated the M1 polarization induced by TNF-α. Moreover, Atg5 knockdown alone was sufficient to trigger...
Source: Fight Aging! - December 16, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

BMC ‘Research in progress’ photo competition 2018: winning images
The objective of this collage is therefore to recognize diversity, as an essential aspect of our existence. “Look into my eyes”Lidianne Salvatierra, Federal University of Tocantins (UFT), Brazil Frontal face of a jumping spider (Salticidae). Jumping spiders have well developed eyes and can actually form images. The post BMC ‘Research in progress’ photo competition 2018: winning images appeared first on Research in progress blog. (Source: BioMed Central Blog)
Source: BioMed Central Blog - December 14, 2018 Category: General Medicine Authors: Davy Falkner Tags: Open Access Publishing Research in progress photo competition Source Type: blogs

Versius Robotic Surgical System Coming to U.S.
CMR Surgical, a UK firm, is making a big push at introducing its Versius robotic surgical system in the U.S. by partnering with the Nicholson Center in Florida and launching the first U.S.-based training program for the Versius. In preparation of the program, and to get the kinks worked out in the training, 27 surgical teams including more than 100 clinicians worked during nine weeks of FDA validation studies of the robot. The Versius robotic system can be moved from room to room, expanding the potential for robotic surgery in many hospitals. Each of the robotic arms is mounted on a separate wheeled cart, so the whole sys...
Source: Medgadget - December 13, 2018 Category: Medical Devices Authors: Editors Tags: Ob/Gyn Surgery Thoracic Surgery Urology Source Type: blogs