Cardiology MCQ – Treatment of transthyretin amyloid cardiomyopathy
Cardiology MCQ – Treatment of transthyretin amyloid cardiomyopathy
Recently developed pharmacotherapy which has been shown to halt and reverse the progression of transthyretin amyloid cardiomyopathy:
Trastuzumab
Tafamidis
Tranexamic acid
Tamoxifen
Click here for the correct answer (Source: Cardiophile MD)
Source: Cardiophile MD - December 13, 2019 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs
All About Blood Alcohol Levels
Blood alcohol levels, also known as blood alcohol content, is a way to measure an individual’s level of alcohol intoxication. It represents the percentage of alcohol that is concentrated in the bloodstream. Blood alcohol levels are used for legal purposes, such as measuring individuals for drunk driving incidents, and for medical purposes, such as testing patients who enter the hospital for alcohol-related health issues.
What Are The Different Blood Alcohol Levels?
There are many factors that influence a person’s blood alcohol levels. They can include body weight, gender, genetics, tolerance to alcohol, drinking patte...
Source: Cliffside Malibu - December 11, 2019 Category: Addiction Authors: Jaclyn Uloth Tags: Addiction Alcohol Alcoholism alcohol abuse alcohol dependence alcohol dependency alcohol detox alcohol treatment alcohol treatment center alcohol treatment facility alcohol use Alcoholics Anonymous Source Type: blogs
BioethicsTV (Dec 2-6, 2019): #TheResident
by Craig Klugman, Ph.D.
The start of the winter holidays means winter hiatus for many shows. This week only one show dealt with bioethical issues.
The Resident (Season 3: Episode 9): Maternal-fetal conflict; Politics, Business, and Torture; Problems with outpatient surgery in offices
In one storyline, a pregnant patient has trouble breathing during a standard ultrasound. She is diagnosed with an enlarged heart, cardiomyopathy brought on by her prior chemo. Okafor suggests delivering the baby early to protect her heart. This situation is a classic case of maternal-fetal conflict: What is good for the baby (being carried to...
Source: blog.bioethics.net - December 6, 2019 Category: Medical Ethics Authors: Craig Klugman Tags: BioethicsTV Featured Posts Professionalism Reproductive Ethics harm Source Type: blogs
Why ventricular tachycardia has wide QRS complex ?
Why VTs have wide QRS complex?
Brief answer: VT usually presents with wide QRS tachycardia because it originates in ventricular myocardium, travels muscle to muscle instead of the normal conduction system. However, VTs need not be wide always, if it captures the conduction system early and more proximally it can be as narrow as SVT.
Further reading: Only for cardiology fellows
Two empirical statements are made here. (The scientific chances of both being reasonably correct are fair)
80 % of wide QRS tachycardia by default is VT. That means 20 % of wide QRS is not VT. We all accept that.
80 % of narrow QRS tachycardia i...
Source: Dr.S.Venkatesan MD - December 4, 2019 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized Source Type: blogs
Maternal Mortality – Separating Signal from Noise
By AMEYA KULKARNI, MD
When Samuel Morse left his New Haven home to paint a portrait of the
Maquis du Lafayette in Washington DC, it was the last time he would see his
pregnant wife. Shortly after his arrival in Washington, his wife developed
complications during childbirth. A messenger took several days on horseback to
relay the message to Mr Morse. Because the trip back to New Haven took several
more, his wife had died by the time he arrived at their home. So moved was he by the tragedy of lost time
that he dedicated the majority of the rest of his life to make sure that this
would never happen to anyone again. H...
Source: The Health Care Blog - December 3, 2019 Category: Consumer Health News Authors: Christina Liu Tags: Health Policy Medical Practice Ameya Kulkarni Global Health Maternal mortality public health Source Type: blogs
A 50-something Australian with sudden severe epigastric and chest pain presented looking extremely ill.
A 50-something with sudden severe epigastric and chest pain presented looking extremely ill.Here is her ECG:What do you think?There is ST Elevation in V2-V6, worrisome for ischemia.Or is it?Notice the very large R-waves and the very prominent J-point notching, with small S-waves.This is typical ofBenign T-wave Inversion, which is commonly seen in black patients of African heritage.This case was sent from Australia and the patient was aboriginal. I have never heard of or seen benign T-wave inversion in Australian aboriginal blacks.The cath lab was activated and the patient was taken for angiogram, which was norma...
Source: Dr. Smith's ECG Blog - November 26, 2019 Category: Cardiology Authors: Steve Smith Source Type: blogs
Fight Aging! Newsletter, November 25th 2019
This study demonstrates for the first time that senescent cells secrete functional LTs, significantly contributing to the LTs pool known to cause or exacerbate idiopathic pulmonary fibrosis.
Against Senolytics
https://www.fightaging.org/archives/2019/11/against-senolytics/
There is no consensus in science that is so strong as to have no heretics. So here we have an interview with a naysayer on the matter of senolytic treatments, who argues that the loss of senescent cells in aged tissues will cause more harm to long-term health than the damage they will do by remaining. To be clear, I think this to be a...
Source: Fight Aging! - November 24, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Dogs as a Model of Human Aging
Dogs are an interesting species when it comes to the study of aging. Firstly they are much closer to human metabolism and cellular biochemistry than mice, and secondly selective breeding has generated lineages with a very wide range of sizes and life spans. Thirdly, they occupy a good compromise position in the range of life spans, study cost, and similarity to humans. Mice live short lives, so studies are rapid and comparatively cheap, but there are sizable, important differences between mouse and human biochemistry. Humans live so long that most studies of aging are simply out of the question. Even in non-human primates ...
Source: Fight Aging! - November 21, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, November 4th 2019
In this study, we hypothesized that moderately and chronically reducing ACh could attenuate the deleterious effects of aging on NMJs and skeletal muscles. To test this hypothesis, we analyzed NMJs and muscle fibers from heterozygous transgenic mice with reduced expression of the vesicular ACh transporter (VAChT), VKDHet mice, which present with approximately 30% less synaptic ACh compared to control mice.
Because ACh is constitutively decreased in VKDHet, we first analyzed developing NMJs and muscle fibers. We found no obvious morphological or molecular differences between NMJs and muscle fibers of VKDHet and contro...
Source: Fight Aging! - November 3, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A man in his 50s with witnessed arrest and ST elevation in aVR
Written by Meyers, edits by SmithA 50-ish year old man was working construction when he suddenly collapsed. Coworkers started CPR within 1 minute of collapse. EMS arrived within 10 minutes and continued CPR and ACLS, noting alternating asystole and sinus bradycardia during rhythm checks. He received various ACLS medications and arrived at the ED with a perfusing rhythm.Initial vitals included heart rate around 100 bpm and BP 174/96. Here is his initial ECG, very soon after ROSC:What do you think?Sinus tachycardia. There is incomplete RBBB (QRS duration less than 120 ms). There is diffuse STD, maximal in V4-V5 a...
Source: Dr. Smith's ECG Blog - November 2, 2019 Category: Cardiology Authors: Pendell Source Type: blogs
Is LV dilatation (with normal EF) Indicate LV dysfunction?
LV dysfunction is one of the most commonly used terminology by cardiac professionals.It can be systolic, diastolic or global, regional etc. But, before dysfunction sets in, the heart fights. The Left ventricle can behave in many different ways when confronted with stress. It increases the force of contraction, elevates it’s Intra cavitary filling pressure and still accomplishes its task of pumping adequately. Further, It can build fresh muscle (LVH). It can double up with more heartbeats. (All these factors are referred to as cardiac reserve mechanisms)
These reserve mechanisms can be activated in the short or long ...
Source: Dr.S.Venkatesan MD - November 2, 2019 Category: Cardiology Authors: dr s venkatesan Tags: cardaic physiology cardiac physiology LV dilatation is diastolic dysfunction cardiac reserve cardiology research papers cardiology thesis topics dilated left ventricle lv dilatation is lv dysfunction Source Type: blogs
NLRP3 Knockout Extends Maximum Life Span by 29% in Mice
Today's open access research is an interesting demonstration of the importance of chronic inflammation in aging. Researchers generate a mouse lineage in which the NLRP3 gene is deleted, and show that these mice live significantly longer, and in better health, as a result. The protein produced from the NLRP3 gene is important in the innate immune response; it is a component part of one of the inflammasomes, protein complexes with a central role in regulation of the inflammatory response. NLRP3 appears important in the inflammatory signaling generated by senescent cells as well.
Inflammation is a necessary part of wou...
Source: Fight Aging! - October 28, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
40-something male in a head-on Motor Vehicle Collision and Splenic Injury
A 40-something male presents to the stabilization room for evaluation following head on motor vehicle collision (MVC). Pt was reported restrained driver, hit at city speeds, with + airbag deployment.The MVC was unquestionably caused by the other car, not by this driver.The patient complained to EMS of chest pain and a prehospital EKG en route was concerning for STEMI.The patient was at all times hemodynamically stable, without evidence of any profuse bleeding.He had an ECG recorded on arrival to the ED:Anterior and Inferior STEMI with diffuse hyperacute T-waves. This ECG really can ' t be anything else.&nb...
Source: Dr. Smith's ECG Blog - October 26, 2019 Category: Cardiology Authors: Steve Smith Source Type: blogs
A 50-something woman with chest pain, BP 230/120, and LBBB with 7 mm ST Elevation
A 50-something woman with history of CHF of unknown etiology, and of HTN, presented for evaluation of chest pressure.Her BP was 223/125, Sp02 98% on RA. HR 106, RR 18. Here was her ED ECG:There is sinus rhythm with Left Bundle Branch Block (LBBB)There is a large amount of ST Elevation in V2 and V3 (more than 5 mm)Thus, this meets the unweighted Sgarbossa Criteria of 5 mm of discordant ST ElevationBut it does NOT meet the Smith Modified Sgarbossa Criteria, which depend on the ST/S ratio.This ratio is critical because LBBB with very large depolarization voltage (QRS) also has very large repolarization voltage (ST/T).Her...
Source: Dr. Smith's ECG Blog - September 24, 2019 Category: Cardiology Authors: Steve Smith Source Type: blogs
Ischemic cardiomyopathy: Why is it, still searching for a definition?
The term Ischemic cardiomyopathy(ICM) was originally coined by Dr. Burch from Tulane University, New Orleans, USA in 1970. For many decades there was skepticism regarding the existence of such entity. WHO classification over the years never included this term. ESC working group of 2008 (Elliott P, European Heart 29(2):270–276) decided not to include CAD as a cause for cardiomyopathy. Even the current MOGES system doesn’t invoke CAD as a cause for cardiomyopathy. But, I am sure, most of practicing cardiologists would agree, there is a need for such an entity.
Why there is much reluctance to diagnose Ische...
Source: Dr.S.Venkatesan MD - September 21, 2019 Category: Cardiology Authors: dr s venkatesan Tags: Criteria and Nomenclature ischemic cardiomyopathy Uncategorized defintion of ischemic cardiomyopathy MOGES classification what is ischemic cardiomyopathy who whf classification of cardiomyopathy Source Type: blogs
