Rejuvenate Bio to Launch a Gene Therapy Trial for Heart Failure in Dogs
One of the many possible paths towards developing a new medical technology is to first focus on veterinary use. It is considerably less costly in time and resources to develop a therapy for dogs, say, than it is to develop a therapy for humans. Later, given robust success in veterinary medicine, the therapy can be brought into the sphere of human medicine. This is the approach taken by Rejuvenate Bio for their class of regenerative gene therapies. As noted here, the company is moving forward to trials in companion animals, starting later this year.
Back in 2015, the Church lab at Harvard began testing a variety of...
Source: Fight Aging! - May 15, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Acute chest pain in a patient with cardiomyopathy and a paced rhythm.
A 70-something with h/o cardiomyopathy, ICD, LVH was awoken with sharp chest pain, 8/10, non-radiating. It worsened through the morning and she was eventually brought to the hospital.An ECG was recorded:What do you think?Here is one from 3 years prior:There is a paced rhythm in all 12 leads. The new ECG has new ST Elevation that meets the Smith modified Sgarbossa criteria in leads I, aVL, and V2. (ST elevation at the J-point is at least 25% of the depth of the preceding S-wave). Meeting the criteria in just one lead is very specific for OMI in paced rhythm.She was given aspirin, ticagrelor, and...
Source: Dr. Smith's ECG Blog - May 12, 2019 Category: Cardiology Authors: Steve Smith Source Type: blogs
Fight Aging! Newsletter, April 29th 2019
In this study, we report the age-associated differences between fetal MSC (fMSC) populations and MSCs isolated from elderly donors with respect to their transcriptomes. We successfully reprogrammed fMSCs (55 days post conception) and adult MSC (aMSC; 60-74 years) to iPSCs and, subsequently, generated the corresponding iMSCs. In addition, iMSCs were also derived from ESCs. The iMSCs were similar although not identical to primary MSCs. We unraveled a putative rejuvenation and aging gene expression signature. We show that iMSCs irrespective of donor age and cell type re-acquired a similar secretome to that of their parent...
Source: Fight Aging! - April 28, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
MicroRNAs Assist in Heart Regeneration
Many researchers are exploring the therapeutic utility of microRNAs involved in fundamental cellular processes such as replication. These molecules act to regulate the processes of gene expression, determining how much of specific proteins are produced from their genetic blueprints, and when. Protein amounts are the switches and dials of cellular operation, and delivering microRNAs into cells is one possible way to steer cells into useful behavior - through the sheer complexity of the cell makes identifying the right tools to use quite difficult, and any given microRNA may produce quite sweeping changes, only few of which ...
Source: Fight Aging! - April 26, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Ultrasound Case 091
Dr James Rippey Ultrasound Case 091
A 56 year old woman presents with chest pain and shortness of breath. Her ECG demonstrates widespread precordial ischaemic change. (Source: Life in the Fast Lane)
Source: Life in the Fast Lane - April 21, 2019 Category: Emergency Medicine Authors: Dr James Rippey Tags: Cardiology TOP 100 Ultrasound apical ballooning Cardiac ultrasound echocardiography fractional shortening octopus trap Tako-Tsubo Takotsubo Takotsubo cardiomyopathy TCM Source Type: blogs
What is Detoxing From Alcohol Like, and How We Can Help Make It Comfortable
Detoxing from Alcohol
Detoxing from alcohol can look very different to many different people. The way you may feel when you detox from alcohol depends on the severity of your addiction and how long you have been addicted to alcohol for. If someone has had a few too many drinks at a celebration, chances are, they might feel hungover the next morning. They might experience nausea or a headache, but are able to feel back to normal later that day or the following day.
However, for someone suffering from an alcohol addiction, the experience is much different. The body of someone suffering from alcohol addiction is chemically wi...
Source: Cliffside Malibu - April 17, 2019 Category: Addiction Authors: Jaclyn Uloth Tags: Addiction Addiction Recovery Alcohol Alcohol Rehab Information Alcoholism Detox Resources for Alcohol and Drugs/Opiates Drinking Substance Abuse alcohol abuse alcohol dependence alcohol dependency alcohol detox alcohol treatment Source Type: blogs
Tachycardia, fever to 105, and ischemic ST Elevation -- a Bridge too Far
Discussion of Figure-1: As per Dr. Smith — ECG #1 showed marked sinus tachycardia at ~140/minute — with diffuse ST segment elevation.I often find it difficult to determine the precise amount of ST elevation when the heart rate is very fast. For clarity — I ’ve added short horizontal RED lines in Figure-1 to show what I took as the “baseline” for assessing the amount of J-point ST elevation for the 2 ECGs in this figure.It may be especially difficult when there is marked tachycardia to identify the J-point that defines the number of millimeters of ST elevation. T...
Source: Dr. Smith's ECG Blog - April 14, 2019 Category: Cardiology Authors: Steve Smith Source Type: blogs
An elderly woman transferred to you for chest pain, shortness of breath, and positive troponin - does she need the cath lab now?
Written by Alex Bracey, with edits by Smith and MeyersA female in her 70s presented to the ED at sign out while working in our acute zone (medium acuity). I picked up the chart and the triage note indicated that the patient was transferred from another hospital, with " EKG changes " and elevated troponin, for cardiology evaluation of NSTEMI. Symptoms were ongoing.Interest now piqued, I looked at the EKG and saw the following:What do you think? Baseline for comparison below.This is nearly pathognomonic! Of what?Baseline on file from outside hospital:This is her first ECG at our hospital:Meyers ECG interpretation: ...
Source: Dr. Smith's ECG Blog - April 4, 2019 Category: Cardiology Authors: Pendell Source Type: blogs
Fight Aging! Newsletter, April 1st 2019
In conclusion, long-term aerobic exercise appears to attenuate the decline in endothelial vascular function, a benefit which is maintained during chronological aging. However, currently there is not enough evidence to suggest that exercise interventions improve vascular function in previously sedentary healthy older adults.
Hijacking the Proteasome to Dispose of Unwanted Molecules in Age-Related Disease
https://www.fightaging.org/archives/2019/03/hijacking-the-proteasome-to-dispose-of-unwanted-molecules-in-age-related-disease/
Cells are equipped with a protein disposal system in the form of the proteas...
Source: Fight Aging! - March 31, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Investigations and management of dilated cardiomyopathy
Investigations in dilated cardiomyopathy
Chest X-ray PA view will assess the cardiac size in dilated cardiomyopathy and show evidence of pulmonary congestion. Sick persons may present with features of frank pulmonary edema in the form of hilar haze or bat wing pattern of pulmonary edema. Significant left ventricular dysfunction can exist without much of cardiomegaly on chest X-ray as well.
ECG may show sinus tachycardia, left atrial overload and sometimes left ventricular hypertrophy. A wide QRS complex with left bundle branch block pattern may indicate potential benefit from cardiac resynchronization therapy (CRT). ECG ...
Source: Cardiophile MD - March 30, 2019 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: General Cardiology Source Type: blogs
Heart failure with false negative BNP – Cardiology MCQ
Heart failure with false negative BNP – Cardiology MCQ
In which of the following conditions with heart failure can false negative BNP (B-type natriuretic peptide) values occur?
Myocardial infarction
Dilated cardiomyopathy
Mitral stenosis
Mitral regurgitation
Post your answer as a comment below (Source: Cardiophile MD)
Source: Cardiophile MD - March 29, 2019 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs
Phase II Clinical Trial Results for the Eidos Therapeutics Approach to Transthyretin Amyloidosis
This study represents the first clinical experience with AG10 in the target patient population of transthyretin amyloidosis cardiomyopathy (ATTR-CM). Administration of AG10 was well tolerated and was not associated with safety signals of potential clinical concern. In the present study AG10 treatment increased serum TTR levels from baseline and brought those levels to within the normal range in all subjects, both mutant and wild-type. This included subjects whose baseline levels were markedly below the normal range. The 28-day treatment duration of the present study limits any assessment of clinical benefit.
The ser...
Source: Fight Aging! - March 27, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
On Adult Cardiac Stem Cells and their Aging
Does the adult mammalian heart contain a population of stem cells capable of tissue repair? If so, they are not very active; the heart is one of the least regenerative of organs, alongside the brain and the rest of the central nervous system. Opinions and study results differ on whether or not cardiac stem cells exist in any meaningful sense in the adult heart. If they do, there is the possibility of coercing them into greater efforts in tissue maintenance. This is possibly a faster path to regeneration of a damaged or aging heart than any of the other options. However, this would also require that these stem cells not onl...
Source: Fight Aging! - March 27, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Chronic tachycardia induced cardiomyopathy
(Source: Notes from Dr. RW)
Source: Notes from Dr. RW - March 19, 2019 Category: Internal Medicine Tags: cardiovascular Source Type: blogs
IVCD, Saddleback STE in III, with reciprocal STD in aVL: Is it pseudoOMI or OMI? Echo with Speckle Tracking gives the answer.
A 77 y.o. woman with a history of hypertension and congestive heart failure presented for acute onset chest pain and shortness of breath. She stated that she woke up in the morning with a central chest pressure with associated shortness of breath. She had been feeling well the day before.She had no h/o CAD but had a history of " unspecified cardiomyopathy "No old EKGs or angiogram were available.This ECG was texted to me with no information:What do you think?There is ST elevation in inferior leads, with reciprocal ST depression in aVL, so one must strongly suspect acute inferior MI.However, 3 features made me think that it...
Source: Dr. Smith's ECG Blog - March 17, 2019 Category: Cardiology Authors: Steve Smith Source Type: blogs
