Synthesis, characterization, and assessment of chitosan-nanomatrix enriched with antifungal formulation against biodeterioration of active ingredients of selected herbal raw materials
Int J Biol Macromol. 2023 Feb 13:123684. doi: 10.1016/j.ijbiomac.2023.123684. Online ahead of print.ABSTRACTAflatoxin B1 (AFB1), a potent natural group 1 carcinogen produced by Aspergillus flavus is considered an unavoidable toxic contaminant of herbal raw materials, which often deteriorates their active ingredients making them less effective and hazardous during their formulation in herbal drugs. The present investigation reports the antifungal (0.5 μl/ml) and AFB1 inhibitory (0.4 μl/ml) effects of the developed formulation CIM based on a mixture of essential oils (Carum carvi, and Illicium verum), and methyl anthranila...
Source: International Journal of Biological Macromolecules - February 15, 2023 Category: Biochemistry Authors: Vishal Gupta Prem Pratap Singh Bhanu Prakash Source Type: research
A novel brain penetrant c-Abl tyrosine kinase inhibitor: paving a path forward to success in disease modification in Parkinson ’s disease
Tanya Simuni, MD has served as a consultant for 4D Pharma, Acadia, AcureX, AskBio, Amneal, Blue Rock Therapeutics, Caraway Therapeutics, Critical Path for Parkinson's Consortium (CPP), Denali, Michael J Fox Foundation, Neuroderm, Sanofi, Sinopia, Sunovion, Roche, Takeda, UCB, Vanqua Bio and Voyager. Dr. Simuni served on the ad board for Acadia, AcureX, AskBio, Amneal, Denali, Sunovion, Roche. Dr. Simuni has served as a member of the scientific advisory board of 4D Pharma, Neuroderm, Sanofi and UCB. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - February 15, 2023 Category: Neurology Authors: Tanya Simuni, Kalpana Merchant Source Type: research
Effects of methyl jasmonate elicitation on the carvone and limonene contents, phenolic compounds and antioxidant activity in caraway ( < em > Carum carvi < /em > L.) callus cultures
This study investigated the elicitation effects of several methyl jasmonate (MeJ) concentrations (0, 25, 50, and 100 µM) on various biochemical traits of caraway (Carum carvi L.) callus cultures. The 25 μM MeJ concentration yielded the highest callus growth rate (0.57 mm day-1), total flavonols content (2.58 mg QE g-1 FW) and total carotenoids content (0.04 μg g-1 FW), whereas the highest relative fresh weight (75.72%), total phenolics content (76.90 mg GAE g-1 FW), total flavonoids content (58.49 mg QE g-1 FW) and phenylalanine ammonia lyase activity (3.40 nmol cinnamic acid mg-1 h-1 FW) were obtained with the 50 μM M...
Source: Natural Product Research - January 20, 2023 Category: Biochemistry Authors: Maryam Rahmati Pooran Golkar Mostafa Tarkesh Source Type: research
Effects of methyl jasmonate elicitation on the carvone and limonene contents, phenolic compounds and antioxidant activity in caraway ( < em > Carum carvi < /em > L.) callus cultures
This study investigated the elicitation effects of several methyl jasmonate (MeJ) concentrations (0, 25, 50, and 100 µM) on various biochemical traits of caraway (Carum carvi L.) callus cultures. The 25 μM MeJ concentration yielded the highest callus growth rate (0.57 mm day-1), total flavonols content (2.58 mg QE g-1 FW) and total carotenoids content (0.04 μg g-1 FW), whereas the highest relative fresh weight (75.72%), total phenolics content (76.90 mg GAE g-1 FW), total flavonoids content (58.49 mg QE g-1 FW) and phenylalanine ammonia lyase activity (3.40 nmol cinnamic acid mg-1 h-1 FW) were obtained with the 50 μM M...
Source: Natural Product Research - January 20, 2023 Category: Biochemistry Authors: Maryam Rahmati Pooran Golkar Mostafa Tarkesh Source Type: research
Effects of methyl jasmonate elicitation on the carvone and limonene contents, phenolic compounds and antioxidant activity in caraway ( < em > Carum carvi < /em > L.) callus cultures
This study investigated the elicitation effects of several methyl jasmonate (MeJ) concentrations (0, 25, 50, and 100 µM) on various biochemical traits of caraway (Carum carvi L.) callus cultures. The 25 μM MeJ concentration yielded the highest callus growth rate (0.57 mm day-1), total flavonols content (2.58 mg QE g-1 FW) and total carotenoids content (0.04 μg g-1 FW), whereas the highest relative fresh weight (75.72%), total phenolics content (76.90 mg GAE g-1 FW), total flavonoids content (58.49 mg QE g-1 FW) and phenylalanine ammonia lyase activity (3.40 nmol cinnamic acid mg-1 h-1 FW) were obtained with the 50 μM M...
Source: Natural Product Research - January 20, 2023 Category: Biochemistry Authors: Maryam Rahmati Pooran Golkar Mostafa Tarkesh Source Type: research
IJERPH, Vol. 20, Pages 33: Higher Risk for Sensitization to Commonly Consumed Herbs among Adults and Youngsters Suffering from Birch, Mugwort or Grass Pollinosis
Conclusion: The study demonstrates that youngsters suffering from pollinosis are at high risk of developing allergic reactions to herbs and highlights the importance of including native skin prick tests with herbs in the diagnostic work-up for suspected food allergy. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - December 20, 2022 Category: Environmental Health Authors: Waldemar Wagner Krzysztof Buczy łko Aneta Wagner Angelika Szwed-Kowalska Anna Stasiak Tags: Article Source Type: research
Menthacarin, a proprietary peppermint oil and caraway oil combination, improves multiple complaints in patients with functional gastrointestinal disorders – a systematic review and meta-analysis
Conclusions: Menthacarin was shown to be effective and safe for the treatment of FD and represents a promising option for symptoms of IBS. (Source: Digestive Diseases)
Source: Digestive Diseases - December 9, 2022 Category: Gastroenterology Source Type: research
Molecules, Vol. 27, Pages 8532: GC-MS Analysis and Microbiological Evaluation of Caraway Essential Oil as a Virulence Attenuating Agent against Pseudomonas aeruginosa
In conclusion, caraway essential oil is a promising virulence-attenuating agent that can be used against topical infections caused by P. aeruginosa. (Source: Molecules)
Source: Molecules - December 3, 2022 Category: Chemistry Authors: Mona Fekry Galal Yahya Ali Osman Mohammed W. Al-Rabia Islam Mostafa Hisham A. Abbas Tags: Article Source Type: research
Biomarkers for Chronic Pain: Significance and Summary of Recent Advances
Pain Res Manag. 2022 Nov 7;2022:1940906. doi: 10.1155/2022/1940906. eCollection 2022.ABSTRACTChronic pain can be difficult to predict and a challenge to treat. Biomarkers for chronic pain signal an opportunity for advancements in both management and prevention, and through their research and development offer new insights into the complex processes at play. This review considers the latest research in chronic pain biomarker development and considers how close we are to bringing these from bench to bedside. While some headway has been made that offers efficiencies in patient selection, it is unlikely that a single test will...
Source: Pain Research and Management - November 17, 2022 Category: Anesthesiology Authors: Sam Eldabe Ilona Obara Catherine Panwar David Caraway Source Type: research
Biomarkers for Chronic Pain: Significance and Summary of Recent Advances
Pain Res Manag. 2022 Nov 7;2022:1940906. doi: 10.1155/2022/1940906. eCollection 2022.ABSTRACTChronic pain can be difficult to predict and a challenge to treat. Biomarkers for chronic pain signal an opportunity for advancements in both management and prevention, and through their research and development offer new insights into the complex processes at play. This review considers the latest research in chronic pain biomarker development and considers how close we are to bringing these from bench to bedside. While some headway has been made that offers efficiencies in patient selection, it is unlikely that a single test will...
Source: Pain Research and Management - November 17, 2022 Category: Anesthesiology Authors: Sam Eldabe Ilona Obara Catherine Panwar David Caraway Source Type: research
Biomarkers for Chronic Pain: Significance and Summary of Recent Advances
Pain Res Manag. 2022 Nov 7;2022:1940906. doi: 10.1155/2022/1940906. eCollection 2022.ABSTRACTChronic pain can be difficult to predict and a challenge to treat. Biomarkers for chronic pain signal an opportunity for advancements in both management and prevention, and through their research and development offer new insights into the complex processes at play. This review considers the latest research in chronic pain biomarker development and considers how close we are to bringing these from bench to bedside. While some headway has been made that offers efficiencies in patient selection, it is unlikely that a single test will...
Source: Pain Research and Management - November 17, 2022 Category: Anesthesiology Authors: Sam Eldabe Ilona Obara Catherine Panwar David Caraway Source Type: research
Biomarkers for Chronic Pain: Significance and Summary of Recent Advances
Pain Res Manag. 2022 Nov 7;2022:1940906. doi: 10.1155/2022/1940906. eCollection 2022.ABSTRACTChronic pain can be difficult to predict and a challenge to treat. Biomarkers for chronic pain signal an opportunity for advancements in both management and prevention, and through their research and development offer new insights into the complex processes at play. This review considers the latest research in chronic pain biomarker development and considers how close we are to bringing these from bench to bedside. While some headway has been made that offers efficiencies in patient selection, it is unlikely that a single test will...
Source: Pain Research and Management - November 17, 2022 Category: Anesthesiology Authors: Sam Eldabe Ilona Obara Catherine Panwar David Caraway Source Type: research
Biomarkers for Chronic Pain: Significance and Summary of Recent Advances
Pain Res Manag. 2022 Nov 7;2022:1940906. doi: 10.1155/2022/1940906. eCollection 2022.ABSTRACTChronic pain can be difficult to predict and a challenge to treat. Biomarkers for chronic pain signal an opportunity for advancements in both management and prevention, and through their research and development offer new insights into the complex processes at play. This review considers the latest research in chronic pain biomarker development and considers how close we are to bringing these from bench to bedside. While some headway has been made that offers efficiencies in patient selection, it is unlikely that a single test will...
Source: Pain Research and Management - November 17, 2022 Category: Anesthesiology Authors: Sam Eldabe Ilona Obara Catherine Panwar David Caraway Source Type: research
Biomarkers for Chronic Pain: Significance and Summary of Recent Advances
Pain Res Manag. 2022 Nov 7;2022:1940906. doi: 10.1155/2022/1940906. eCollection 2022.ABSTRACTChronic pain can be difficult to predict and a challenge to treat. Biomarkers for chronic pain signal an opportunity for advancements in both management and prevention, and through their research and development offer new insights into the complex processes at play. This review considers the latest research in chronic pain biomarker development and considers how close we are to bringing these from bench to bedside. While some headway has been made that offers efficiencies in patient selection, it is unlikely that a single test will...
Source: Pain Research and Management - November 17, 2022 Category: Anesthesiology Authors: Sam Eldabe Ilona Obara Catherine Panwar David Caraway Source Type: research
Biomarkers for Chronic Pain: Significance and Summary of Recent Advances
Pain Res Manag. 2022 Nov 7;2022:1940906. doi: 10.1155/2022/1940906. eCollection 2022.ABSTRACTChronic pain can be difficult to predict and a challenge to treat. Biomarkers for chronic pain signal an opportunity for advancements in both management and prevention, and through their research and development offer new insights into the complex processes at play. This review considers the latest research in chronic pain biomarker development and considers how close we are to bringing these from bench to bedside. While some headway has been made that offers efficiencies in patient selection, it is unlikely that a single test will...
Source: Pain Research and Management - November 17, 2022 Category: Anesthesiology Authors: Sam Eldabe Ilona Obara Catherine Panwar David Caraway Source Type: research
