Fight Aging! Newsletter, January 22nd 2024
In this study, we found that DMC reduced the SASP level in senescent cells. Furthermore, senescent cells enter irreversible cell cycle arrest, which involves the activation of p53/p21 and Rb/p16. In this study we found that the expression levels of p21 and p16 were decreased after DMC treatment. The downregulation of p21 may be attributed to the decrease of p53. In this study, we found that the mRNA level of p53 was reduced after DMC treatment.
Ferroptosis is an iron-dependent cell death process, which is accompanied by iron accumulation. Our previous study reported an important role of FECH, an enzyme inserts ferro...
Source: Fight Aging! - January 21, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
How gender and race deepen the cancer care divide
In 2023, roughly 2 million people will have been diagnosed with some form of cancer, and while cancer can affect everyone, it does not affect everyone equally. Women – especially women of color and women with lower socioeconomic standing – often face significant hurdles when it comes to accessing the health care they need to
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How gender and race deepen the cancer care divide originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - January 20, 2024 Category: General Medicine Authors: Meera Ravindranathan, MD Tags: Physician Oncology/Hematology Source Type: blogs
Prostate cancer privacy vs. public right to know: Secretary of Defense Lloyd Austin ’ s dilemma
First, a disclaimer. I do not know Secretary of Defense Lloyd Austin, and I am not involved in his medical care. As an academic infectious disease physician, I am ignorant of the internecine hierarchy of the Defense Department. However, I listen to the news and thus am aware of his recent prostate cancer diagnosis and
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Prostate cancer privacy vs. public right to know: Secretary of Defense Lloyd Austin’s dilemma originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - January 18, 2024 Category: General Medicine Authors: Catherine Diamond, MD Tags: Conditions Urology Source Type: blogs
Health IT – 2024 Health IT Predictions
As we kick off 2024, we wanted to start the new year with a series of 2024 Health IT predictions. We asked the Healthcare IT Today community to submit their predictions and we received a wide ranging set of responses that we grouped into a number of themes. In fact, we got so many that we had to narrow them down to just the best and most interesting. Check out our community’s predictions below and be sure to add your own thoughts and/or places you disagree with these predictions in the comments and on social media.
All of this year’s 2024 health IT predictions (updated as they’re shared):
John and ...
Source: EMR and HIPAA - January 18, 2024 Category: Information Technology Authors: John Lynn Tags: Ambulatory C-Suite Leadership Health IT Company Healthcare IT Hospital - Health System LTPAC 2024 Health IT Predictions Aasim Saeed Amenities Health Andrew Harding Ankit Gupta Anthony Hare Ash Wellness Availity Bicycle Health Source Type: blogs
The Inflammasome as a Target for the Next Generation of Anti-Inflammatory Therapies
With advancing age, a wide range of mechanisms act to provoke the immune system into a state of constant inflammatory signaling and activation. Age-related mitochondrial dysfunction leads to mislocalized mitochondrial DNA fragments that trigger the cGAS-STING pathway to provoke inflammation. Senescent cells produce pro-inflammatory signaling, and their numbers increase with age. Visceral fat tissue produces signaling similar that resulting from infected cells. The increased presence of protein aggregates aggravates immune cells inside and outside of the brain. And so forth. Given all of this, actually fixing the issue of a...
Source: Fight Aging! - January 17, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Uses of AI in Healthcare – 2024 Health IT Predictions
As we kick off 2024, we wanted to start the new year with a series of 2024 Health IT predictions. We asked the Healthcare IT Today community to submit their predictions and we received a wide ranging set of responses that we grouped into a number of themes. In fact, we got so many that we had to narrow them down to just the best and most interesting. Check out our community’s predictions below and be sure to add your own thoughts and/or places you disagree with these predictions in the comments and on social media.
All of this year’s 2024 health IT predictions (updated as they’re shared):
John and ...
Source: EMR and HIPAA - January 17, 2024 Category: Information Technology Authors: John Lynn Tags: Administration AI/Machine Learning Ambulatory C-Suite Leadership Clinical Health IT Company Healthcare IT Hospital - Health System LTPAC 2024 Health IT Predictions 2bPrecise Alexander Nazem Anish Sebastian Arascia Arun Nagdev Source Type: blogs
Research Organism Superheroes: Fruit Flies
Credit: iStock.
Those pesky little bugs flying around the overripe bananas in your kitchen may hold the key to understanding something new about how our bodies work. That’s right, the fruit fly (Drosophila melanogaster) is a widely used research organism in genetics because of its superpower of reproducing quickly with similar genes to people.
Researchers have been studying fruit flies for over a century for many reasons. First, they’re easy to please—just keep them at room temperature and feed them corn meal, sugar, and yeast (or those bananas on your counter!). Second, they reproduce more quickly and have shor...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - January 17, 2024 Category: Research Authors: Chrissa Chverchko Tags: STEM Education Tools and Techniques Cool Creatures Research Organisms Source Type: blogs
The Flavonoid 4,4 ′-dimethoxychalcone is Senolytic
In this study, we found that DMC reduced the SASP level in senescent cells. Furthermore, senescent cells enter irreversible cell cycle arrest, which involves the activation of p53/p21 and Rb/p16. In this study we found that the expression levels of p21 and p16 were decreased after DMC treatment. The downregulation of p21 may be attributed to the decrease of p53. In this study, we found that the mRNA level of p53 was reduced after DMC treatment.
Ferroptosis is an iron-dependent cell death process, which is accompanied by iron accumulation. Our previous study reported an important role of FECH, an enzyme inserts ferro...
Source: Fight Aging! - January 16, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Why new cancer treatments cannot save us
In 2020, the ICPerMed (International Consortium for Personalized Medicine) published a ten-year vision for how personalized medicine, a new form of medicine, has the potential to rebuild an equitable and accessible health care system by 2030. Precision or personalized medicines are drugs developed with genomic sequencing technologies, targeting the critical genes in specific types of cancer
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Why new cancer treatments cannot save us originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - January 16, 2024 Category: General Medicine Authors: Yongjia Wang Tags: Meds Oncology/Hematology Source Type: blogs
Caregiving and Families
Alan S. Gutterman, Caregiving and Families (2023): Due to the onset of chronic conditions that occur as people age, as well as illnesses such as dementia and cancer, older people often need more assistance with the basic and essential activities... (Source: HealthLawProf Blog)
Source: HealthLawProf Blog - January 16, 2024 Category: Medical Law Authors: Katharine Van Tassel Source Type: blogs
Self-management skills we don ’ t often discuss
I’m back from my summer break (I’m in Aotearoa/New Zealand – we shut down over Christmas/New Year just like the US and UK do over July/August!), and I want to begin with a cracker of a topic: medication management!
Now I am not a prescriber. I don’t hold any ability to write prescriptions of any kind, not even exercise ;-). Yet most of the people I’ve seen in clinical practice have started their journey living with pain by being prescribed medications.
All medications have side effects, true effects (well… maybe), adverse effects, and the human factor: taking them in the way that o...
Source: HealthSkills Weblog - January 14, 2024 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Chronic pain Coping strategies Research Science in practice pain management self-management Therapeutic approaches Source Type: blogs
Bonus Features – January 14, 2024 – Epic Research shows telehealth results in more follow-up visits that in-office care, Elevance Health to offer smartphones to qualified Medicaid beneficiaries, plus 21 more stories
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job.
News and Studies
Follow-up rates for telehealth and in-office visits have remained consistent since 2020, according to analysis from Epic Research. That said, telehealth visits are more likely to result in follow-ups at the 7-, ...
Source: EMR and HIPAA - January 14, 2024 Category: Information Technology Authors: Brian Eastwood Tags: Ambulatory Health IT Company Healthcare IT Hospital - Health System LTPAC Abbott Alliance for Pediatric Device Innovation American Telemedicine Association Atropos Health Butterfly Network Caregility Cedar Gate Technologies Childre Source Type: blogs
How comprehensive data documentation holds the power to transform maternal mortality rates
The United States is a global medical care leader in many aspects, including the development of new pharmaceuticals, acute stroke care, and cancer screening. Yet, despite our advances and wealth, we lead peer nations in maternal mortality and morbidity. While the vast majority of the nearly four million women who give birth in America every year do
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How comprehensive data documentation holds the power to transform maternal mortality rates originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - January 14, 2024 Category: General Medicine Authors: Melissa Clarke, MD Tags: Conditions OB/GYN Source Type: blogs
Fight Aging! Newsletter, January 15th 2024
In conclusion, FMD cycles have high potential to be effective in increasing the toxicity of a range of therapies against ALL and other blood cancers and should be tested in randomized clinical trials, especially in combination with immunotherapy and low toxicity cancer therapies.
In summary, we present a new strategy for improving leukemia treatment by combining FMD with chemotherapy to promote the killing of ALL cells in part by an immune-dependent mechanism. Fasting/FMD has been shown to reduce chemotherapy-associated toxicity in pre-clinical and clinical studies and thus represents a safe and potentially effectiv...
Source: Fight Aging! - January 14, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Weekly Roundup – January 13, 2024
Welcome to our Healthcare IT Today Weekly Roundup. Each week, we’ll be providing a look back at the articles we posted and why they’re important to the healthcare IT community. We hope this gives you a chance to catch up on anything you may have missed during the week.
2024 Health IT Predictions: AI Regulations and Ethics. This week, we published several more posts in our series on 2024 Health IT Predictions. We received a lot of interesting thoughts on the ethics of AI, including validating AI models, a tighter regulatory environment for AI tools, and managing the fast pace of innovation. Read more…
2024 Health ...
Source: EMR and HIPAA - January 13, 2024 Category: Information Technology Authors: Brian Eastwood Tags: Healthcare IT Healthcare IT Today Weekly Roundup Source Type: blogs
