Evaluation of serum CA125, HE4 and CA724 and the risk of ovarian malignancy algorithm score in the diagnosis of high-grade serous ovarian cancer
CONCLUSION: The new algorithm using CA125 and BRCA1/2 helped to distinguish between patients with HGSOC and patients with non-HGSOC.PMID:38663180 | DOI:10.1016/j.ejogrb.2024.04.022 (Source: Reproductive Biology)
Source: Reproductive Biology - April 25, 2024 Category: Reproduction Medicine Authors: Deyu Hu Jun Qian Fenghua Yin Bing Wei Jiayu Wang Huijuan Zhang Haiou Yang Source Type: research
I saw the “sea anemone” sign: Puffy face of borderline ovarian tumors
The sea anemone sign is a radiologic sign seen on magnetic resonance imaging (MRI) studies that indicates the morphological development of serous borderline ovarian tumors (SBOTs), as papillary projections originating from the wall of the cystic lesion. The presence of T2 hypointense fibrous stroma in the center of the papilla is a helpful tip in the diagnosis of SBOTs. Those projections might also be assumed to have a frond-like appearance which can be seen as branching papillary projections, especially on T2-weighted imaging. (Source: Clinical Imaging)
Source: Clinical Imaging - April 16, 2024 Category: Radiology Authors: Yesim Yekta Yuruk, Hilal Şahin Tags: Body Imaging Source Type: research
In Silico Approach to Molecular Profiling of the Transition from Ovarian Epithelial Cells to Low-Grade Serous Ovarian Tumors for Targeted Therapeutic Insights
Curr Issues Mol Biol. 2024 Feb 26;46(3):1777-1798. doi: 10.3390/cimb46030117.ABSTRACTThis paper aims to elucidate the differentially coexpressed genes, their potential mechanisms, and possible drug targets in low-grade invasive serous ovarian carcinoma (LGSC) in terms of the biologic continuity of normal, borderline, and malignant LGSC. We performed a bioinformatics analysis, integrating datasets generated using the GPL570 platform from different studies from the GEO database to identify changes in this transition, gene expression, drug targets, and their relationships with tumor microenvironmental characteristics. In the ...
Source: Mol Biol Cell - March 27, 2024 Category: Molecular Biology Authors: Asim Leblebici Ceren Sancar Bahar Tercan Zerrin Isik Mehmet Emin Arayici Ender Berat Ellidokuz Yasemin Basbinar Nuri Yildirim Source Type: research
Fertility potential and safety assessment of residual ovarian cortex in young women diagnosed with epithelial borderline and early-stage malignant ovarian tumors
CONCLUSIONS: Personalized counseling for fertility preservation is required in the event of BOTs and early-stage EOCs. Fertility-sparing surgery and adjuvant gamete preservation should be considered, balancing the oncological risks according to tumor stage and histotype and fertility potential, especially at a younger age.PMID:38492474 | DOI:10.1016/j.ygyno.2024.03.008 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - March 16, 2024 Category: Cancer & Oncology Authors: L Cacciottola A Camboni E Gatti E Marbaix M Vignali J Donnez M M Dolmans Source Type: research
Fertility potential and safety assessment of residual ovarian cortex in young women diagnosed with epithelial borderline and early-stage malignant ovarian tumors
CONCLUSIONS: Personalized counseling for fertility preservation is required in the event of BOTs and early-stage EOCs. Fertility-sparing surgery and adjuvant gamete preservation should be considered, balancing the oncological risks according to tumor stage and histotype and fertility potential, especially at a younger age.PMID:38492474 | DOI:10.1016/j.ygyno.2024.03.008 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - March 16, 2024 Category: Cancer & Oncology Authors: L Cacciottola A Camboni E Gatti E Marbaix M Vignali J Donnez M M Dolmans Source Type: research
Fertility potential and safety assessment of residual ovarian cortex in young women diagnosed with epithelial borderline and early-stage malignant ovarian tumors
CONCLUSIONS: Personalized counseling for fertility preservation is required in the event of BOTs and early-stage EOCs. Fertility-sparing surgery and adjuvant gamete preservation should be considered, balancing the oncological risks according to tumor stage and histotype and fertility potential, especially at a younger age.PMID:38492474 | DOI:10.1016/j.ygyno.2024.03.008 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - March 16, 2024 Category: Cancer & Oncology Authors: L Cacciottola A Camboni E Gatti E Marbaix M Vignali J Donnez M M Dolmans Source Type: research
Risk of borderline ovarian tumors after fertility treatment - Results from a Danish cohort of infertile women
CONCLUSIONS: No marked associations between use of fertility drugs and borderline ovarian tumors were observed. However, the cohort's relatively young age at end of follow-up emphasizes the importance of extending the follow-up period for women who have used fertility drugs.PMID:38382167 | DOI:10.1016/j.ygyno.2024.02.013 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - February 21, 2024 Category: Cancer & Oncology Authors: Anna Kj ær Kristensen Clarissa Lima Brown Frandsen Bugge N øhr Jakob Hansen Viuff Marie Hargreave Kirsten Frederiksen Susanne K Kj ær Allan Jensen Source Type: research
Risk of borderline ovarian tumors after fertility treatment - Results from a Danish cohort of infertile women
CONCLUSIONS: No marked associations between use of fertility drugs and borderline ovarian tumors were observed. However, the cohort's relatively young age at end of follow-up emphasizes the importance of extending the follow-up period for women who have used fertility drugs.PMID:38382167 | DOI:10.1016/j.ygyno.2024.02.013 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - February 21, 2024 Category: Cancer & Oncology Authors: Anna Kj ær Kristensen Clarissa Lima Brown Frandsen Bugge N øhr Jakob Hansen Viuff Marie Hargreave Kirsten Frederiksen Susanne K Kj ær Allan Jensen Source Type: research
Risk of borderline ovarian tumors after fertility treatment - Results from a Danish cohort of infertile women
CONCLUSIONS: No marked associations between use of fertility drugs and borderline ovarian tumors were observed. However, the cohort's relatively young age at end of follow-up emphasizes the importance of extending the follow-up period for women who have used fertility drugs.PMID:38382167 | DOI:10.1016/j.ygyno.2024.02.013 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - February 21, 2024 Category: Cancer & Oncology Authors: Anna Kj ær Kristensen Clarissa Lima Brown Frandsen Bugge N øhr Jakob Hansen Viuff Marie Hargreave Kirsten Frederiksen Susanne K Kj ær Allan Jensen Source Type: research
Risk of borderline ovarian tumors after fertility treatment - Results from a Danish cohort of infertile women
CONCLUSIONS: No marked associations between use of fertility drugs and borderline ovarian tumors were observed. However, the cohort's relatively young age at end of follow-up emphasizes the importance of extending the follow-up period for women who have used fertility drugs.PMID:38382167 | DOI:10.1016/j.ygyno.2024.02.013 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - February 21, 2024 Category: Cancer & Oncology Authors: Anna Kj ær Kristensen Clarissa Lima Brown Frandsen Bugge N øhr Jakob Hansen Viuff Marie Hargreave Kirsten Frederiksen Susanne K Kj ær Allan Jensen Source Type: research
The effect of androgens on the risk of endometriosis sub-phenotypes and ovarian neoplasms: A Mendelian Randomization study
J Steroid Biochem Mol Biol. 2024 Feb 16:106482. doi: 10.1016/j.jsbmb.2024.106482. Online ahead of print.ABSTRACTEndometriosis is a complex gynecological pathology with a broad spectrum of symptoms, affecting around 10% of reproductive-aged women. Ovarian cancer (OC) is a heterogeneous disease for which we lack effective diagnostic and therapeutic strategies. The etiology and pathogenesis of both diseases remain ambiguous. Androgens in endometriosis could have a distinct role beyond serving as estrogen sources, whereas in the case of serous OC could be important in the formation of precursor lesions which ultimately lead to...
Source: Mol Biol Cell - February 18, 2024 Category: Molecular Biology Authors: Marija Gjorgoska Tea Lanisnik Rizner Source Type: research
The effect of androgens on the risk of endometriosis sub-phenotypes and ovarian neoplasms: A Mendelian Randomization study
J Steroid Biochem Mol Biol. 2024 Feb 16:106482. doi: 10.1016/j.jsbmb.2024.106482. Online ahead of print.ABSTRACTEndometriosis is a complex gynecological pathology with a broad spectrum of symptoms, affecting around 10% of reproductive-aged women. Ovarian cancer (OC) is a heterogeneous disease for which we lack effective diagnostic and therapeutic strategies. The etiology and pathogenesis of both diseases remain ambiguous. Androgens in endometriosis could have a distinct role beyond serving as estrogen sources, whereas in the case of serous OC could be important in the formation of precursor lesions which ultimately lead to...
Source: Mol Biol Cell - February 18, 2024 Category: Molecular Biology Authors: Marija Gjorgoska Tea Lanisnik Rizner Source Type: research
Expression of selected epithelial –mesenchymal transition (EMT) transcription factors in serous borderline ovarian tumors and type I ovarian cancers
Introduction: Epithelial ovarian neoplasms are a heterogeneous group including tumor subsets with distinct clinicopathologic and molecularfeatures. The transformation of borderline ovarian tumors into an invasive neoplasm is associated with an array of molecular changes (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - February 1, 2024 Category: OBGYN Authors: P. Sad łecki Source Type: research
Somatic genomic and transcriptomic characterization of primary ovarian serous borderline tumors and low-grade serous carcinomas.
Low-grade serous carcinomas (LGSC) probably develop from serous borderline tumors (SBT), where the micropapillary type (mSBT) has the highest risk of progression. The sensitivity of LGSC to standard chemotherapy is limited, so alternative therapeutic approaches are needed, including targeted treatment. However, current knowledge about molecular landscape of LGSC and mSBT is limited.A sample set of 137 pathologically well-defined cases of 40 mSBT and 97 LGSC was analysed using capture DNA NGS (727 genes) and RNA-Seq (147 genes) to show the landscape of somatic mutations, gene fusions, and the expression pattern, as well as ...
Source: Journal of Molecular Diagnostics - January 24, 2024 Category: Pathology Authors: Ivana Stru žinská, Nikola Hájková, Jan Hojný, Eva Krkavcová, Romana Michálková, Quang Hiep Bui, Radoslav Matěj, Jan Laco, Jana Drozenová, Pavel Fabian, Petr Škapa, Zuzana Špůrková, David Cibula, Filip Frühauf, Tomáš Jirásek, Tomáš Zima Tags: Regular Article Source Type: research
Radiomics nomogram for preoperative differentiation of early-stage serous borderline ovarian tumors and serous malignant ovarian tumors
ConclusionsThe nomogram model can be employed as an individualized preoperative non-invasive tool for differentiating early-stage SBOTs from SMOTs. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - January 15, 2024 Category: Cancer & Oncology Source Type: research
