Association Between Benign Ovarian Tumors and Ovarian Cancer Risk: A Meta-Analysis of Ten Epidemiological Studies
CONCLUSIONS: Benign ovarian tumors were associated with an increased risk of ovarian cancer. Due to the high heterogeneity among the studies and the risks of bias, more studies are warranted to confirm these findings.PMID:35646702 | PMC:PMC9133501 | DOI:10.3389/fonc.2022.895618 (Source: Cancer Control)
Source: Cancer Control - June 1, 2022 Category: Cancer & Oncology Authors: Jiao Guo Haoshen Feng Xi Gu Source Type: research
The cytokeratin 17 expression in primary ovarian tumors has diagnostic but not prognostic significance
AbstractWe assessed the value of cytokeratin 17 (CK17) expression for the differential diagnosis between primary ovarian mucinous tumors and metastases from the gastrointestinal tract (GIT) and the significance of CK17 expression in a broad spectrum of primary ovarian tumors with respect to their prognosis. The sample set consisted of 554 primary ovarian tumors and 255 GIT tumors. In the primary ovarian tumors, a higher CK17 expression (in > 10% of tumors cells) was present only in 0–11.4% of all tumors (including mucinous tumors, micropapillary serous borderline tumors, clear cell, endometrioid, and high-grade ...
Source: Virchows Archiv - May 13, 2022 Category: Pathology Source Type: research
Peripheral lymphocyte populations in ovarian cancer patients and correlations with clinicopathological features
CONCLUSIONS: Ovarian cancer patients have altered circulating lymphocyte profile (elevated Treg cell, depressed CD3+CD8+ T and CD8+CD28+ T cells). Low level of B cells might be related to disease aggressiveness, and it recovered after the removal of tumor, which merits further study.PMID:35410290 | DOI:10.1186/s13048-022-00977-3 (Source: Cell Research)
Source: Cell Research - April 12, 2022 Category: Cytology Authors: Shuang Ye Wei Chen Yuwei Zheng Yutuan Wu Libing Xiang Teng Li Bo Ping Xiaoming Zhang Huijuan Yang Source Type: research
Cancers, Vol. 14, Pages 1557: Long Non-Coding RNA-Based Functional Prediction Reveals Novel Targets in Notch-Upregulated Ovarian Cancer
In this study, we performed in silico analyses using The Cancer Genome Atlas data to discover novel Notch-related lncRNAs and validated our transcriptome data via NOTCH1/3 silencing in serous ovarian cancer cells. The expression of novel Notch-related lncRNAs was down-regulated by a Notch inhibitor and was upregulated in high-grade serous ovarian cancers, compared to benign or borderline ovarian tumors. Functionally, Notch-related lncRNAs were tightly linked to Notch-related changes in diverse gene expressions. Notably, genes related to DNA repair and spermatogenesis showed specific correlations with Notch-related lncRNAs....
Source: Cancers - March 18, 2022 Category: Cancer & Oncology Authors: Seonhyang Jeong Sunmi Park Young Suk Jo Moon Jung Choi Gibbeum Lee Seul Gi Lee Min Chul Choi Hyun Park Won Duk Joo Sang Geun Jung Jandee Lee Tags: Article Source Type: research
