Determination of drugs in exhumed liver and brain tissue after over 9 years of burial by LC ‐MS/MS Part 1: Cardiovascular drugs
AbstractThis paper presents analytical results of cardiovascular drugs which were determined in exhumed liver and brain tissue in a total of 115 cases. Exhumations were executed after 9.5 ‐16.5 years of burial. Analysis was performed by solid‐phase‐extraction and liquid chromatography‐electrospray‐mass spectrometry. Bisoprolol, verapamil and xipamide could be proven in all cases in which these were supposedly administered within a defined time frame. Amiodarone was detectab le in over 90%, amlodipine in over 80% and cafedrine, clonidine, phenprocoumon as well as torsemide in over 50% of relevant cases. By contras...
Source: Drug Testing and Analysis - October 4, 2020 Category: Drugs & Pharmacology Authors: Katarina Bolte, Marek Dziadosz, Naomi Kono, Benedikt Vennemann, Michael Klintschar, J örg Teske Tags: RESEARCH ARTICLE Source Type: research

Beta Blockers For HFrEF: Are Guidelines Being Followed?
Heart failure (HF) is a chronic health condition that affects over 5 million people annually and is the cause of over one million hospitalizations annually. Patients hospitalized for HF are at high risk for all-cause rehospitalization, with a 1-month readmission rate of 25%. The ACCF/AHA 2013 guidelines made a Class I recommendation for patients with stage B HF with reduced ejection fraction (EF), to utilize specific beta blockers (carvedilol, bisoprolol and metoprolol succinate) to decrease morbidity and mortality from disease, sudden cardiac death, hospitalization rates, and improve heart failure symptoms. (Source: Journ...
Source: Journal of Cardiac Failure - September 30, 2020 Category: Cardiology Authors: Christabel E. Nyange, Neha Gupta, Rebecca Mazurkiewicz, Akshai Bhandary Tags: 384 Source Type: research

An attempt at administering a transdermal formulation of bisoprolol in patients with acute cardiac symptoms
Bisono ® is the world's first transdermal formulation of a bisoprolol, which is approved for the treatment of hypertension in Japan. We aimed to investigate the usefulness of this formulation in patients who were admitted to our hospital with cardiac symptoms suggestive of acute coronary syndrome or an ac ute exacerbation of heart failure. (Source: The American Journal of Emergency Medicine)
Source: The American Journal of Emergency Medicine - September 29, 2020 Category: Emergency Medicine Authors: Ayumu Nozaki, Tomoko Kobayashi, Kazumasa Naruhashi, Hiroshi Okugawa, Nozomu Horiuchi, Hirokazu Nakanishi, Yuka Kobayashi, Shigeru Nakamura Source Type: research

Incremental prognostic value of a novel metabolite ‐based biomarker score in congestive heart failure patients
ConclusionsIn patients with CHF, incorporating a panel of three metabolite ‐based biomarkers into a risk score improved the prognostic utility of NT‐proBNP by predicting long‐term cardiovascular death more precisely. This novel approach holds promise to improve clinical risk assessment in CHF patients. (Source: ESC Heart Failure)
Source: ESC Heart Failure - August 27, 2020 Category: Cardiology Authors: Peter McGranaghan, Hans ‐Dirk Düngen, Anshul Saxena, Muni Rubens, Joseph Salami, Jasmin Radenkovic, Doris Bach, Svetlana Apostolovic, Goran Loncar, Marija Zdravkovic, Elvis Tahirovic, Jovan Veskovic, Stefan Störk, Emir Veledar, Burkert P Tags: Original Research Article Source Type: research

Treatment Updates in Postural Tachycardia Syndrome
AbstractPurpose of reviewPostural tachycardia syndrome is a common condition characterized by the presence of orthostatic intolerance in conjunction with excessive postural tachycardia. This review will focus on treatment updates in postural tachycardia syndrome and will include a discussion of rehabilitative, vasopressor, heart rate modulation, volume expansion, and immunomodulatory treatment strategies.Recent findingsA recent study added to existing literature the benefits of exercise retraining in postural tachycardia syndrome (POTS) patients who were able to successfully complete a 3-month exercise regimen. Another rec...
Source: Current Treatment Options in Neurology - August 24, 2020 Category: Neurology Source Type: research

Several Antihypertensive Medications Associated With Reduced Depression
Adults who take blood pressure medications are not at an increased risk of depression, according to areport published today inHypertension. In fact, nine of the 41 medications assessed in the study were associated with a decreased incidence of depression.The medications that were found to protect against depression were amlodipine, atenolol, bisoprolol, carvedilol, enalapril, propranolol, ramipril, verapamil, and verapamil combinations.Studies have shown that about 30% of people with hypertension or other cardiovascular problems have comorbid depression. Moreover, individuals with both disorders have worse mortality and a ...
Source: Psychiatr News - August 24, 2020 Category: Psychiatry Tags: antihypertensive beta blocker depression health registry high blood pressure hypertension Lars Vedel Kessing propranolol vermapamil Source Type: research

Drugs for Migraine
Date: October 5, 2020 Issue #:  1608Summary:  An oral nonopioid analgesic is often sufficient for acute treatment of mild to moderate migraine headache without severe nausea or vomiting. A triptan is the drug of choice for treatment of moderate to severe migraine headache pain in most patients without vascular disease. Early treatment of pain when it is still mild to moderate in intensity improves headache response and reduces the risk of recurrence. (Source: The Medical Letter)
Source: The Medical Letter - August 18, 2020 Category: Drugs & Pharmacology Authors: admin Tags: Acetaminophen acupuncture Aimovig Ajovy Almotriptan Amerge Amitriptyline Antidepressants Antiepileptics Aspirin Atenolol Aventyl Beta blockers Bisoprolol Botox Botulinum toxin Butalbital Cafergot Caffeine Cambia Can Source Type: research

The Impact of Beta Blockers on Survival in Heart Transplant Recipients: Insights from the Zabrze HTx Registry.
Conclusions: The use of BBs in our cohort of patients after HTx was not associated with survival benefits. PMID: 32774914 [PubMed] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - August 13, 2020 Category: Cardiology Authors: Kubiak GM, Kwieciński R, Ciarka A, Tukiendorf A, Przybyłowski P, Hrapkowicz T, Zembala MO Tags: Cardiol Res Pract Source Type: research

The effects of β1 and β1+2 adrenergic receptor blockade on the exercise-induced mobilization and ex vivo expansion of virus-specific T cells: implications for cellular therapy and the anti-viral immune effects of exercise.
This study determined if β2 adrenergic receptor (AR) signaling precipitated the VST response to acute exercise. Healthy participants (n = 12) completed 30 min of steady-state cycling exercise after ingesting a placebo, a β1 + 2 AR antagonist (nadolol) or a β1 AR antagonist (bisoprolol). Circulating VSTs to cytomegalovirus (CMV), Epstein-Barr virus (EBV), and adenovirus (AdV) antigens were enumerated before and after exercise, and peripheral blood mononuclear cells were cultured with viral peptides for 8 days to expand multi-VSTs. Compared with placebo, nadolol blunted th...
Source: Cell Stress and Chaperones - August 9, 2020 Category: Cytology Authors: Kunz HE, Agha NH, Hussain M, LaVoy EC, Smith KA, Mylabathula P, Diak D, Baker FL, O'Connor DP, Bond RA, Katsanis E, Bollard CM, Simpson RJ Tags: Cell Stress Chaperones Source Type: research

Resting heart rate in ambulatory heart failure with reduced ejection fraction treated with beta ‐blockers
ConclusionsIn our single ‐centre experience, the majority of patients with chronic HFrEF treated with beta‐blocker therapy did not achieve target doses over time, and a substantial proportion had inadequate control of resting HR. There was no relationship between achieved beta‐blocker target dose and resting HR contro l. (Source: ESC Heart Failure)
Source: ESC Heart Failure - August 4, 2020 Category: Cardiology Authors: Kenneth D. Varian, Xinge Ji, Justin L. Grodin, Frederik H. Verbrugge, Alex Milinovich, Michael W. Kattan, W.H. Wilson Tang Tags: Original Research Article Source Type: research

Association Between Dose and Plasma Concentration of Bisoprolol in Patients with Heart Failure (CVI ARO 6).
Authors: Arita T, Suzuki S, Kato Y, Kano H, Yajima J, Matsuno S, Otsuka T, Semba H, Uejima T, Oikawa Y, Nagashima K, Yagi N, Sagara K, Tanabe G, Yamashita T Abstract Although bisoprolol is used widely to treat patients with heart failure (HF), little information is available regarding the association between the dose of bisoprolol administered and the bisoprolol plasma concentration (Bis-PC) in real-world clinical practice.This was a single-center, observational study in 114 patients with HF receiving once-daily bisoprolol. After determination of trough Bis-PC, the relationship between the dose of bisoprolol and Bi...
Source: International Heart Journal - July 22, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Sequential nephron blockade with combined diuretics improves diastolic function in patients with resistant hypertension
AbstractAimsHypertension is a major contributor to cardiac diastolic dysfunction. Different therapeutics strategies have been proposed to control blood pressure (BP), but their independent impact on cardiac function remains undetermined. In patients with resistant hypertension, we compared the changes in cardiac parameters between two strategies based on sequential nephron blockade (NBD) with a combination of diuretics or sequential renin ‐angiotensin system blockade (RASB).Methods and resultsAfter a 4 ‐week period where all patients received Irbesartan 300 mg/day + hydrochlorothiazide 12.5 mg/day&n...
Source: ESC Heart Failure - June 28, 2020 Category: Cardiology Authors: David Fouassier, Anne Blanchard, Antoine Fayol, Guillaume Bobrie, Pierre Boutouyrie, Michel Azizi, Jean ‐Sébastien Hulot Tags: Original Research Article Source Type: research

Population pharmacokinetic analysis of bisoprolol in type 2 diabetic patients with hypertension
ConclusionRoutine assessment of renal function should be carried out before the initiation of treatment with bisoprolol in order to individualize the dose and to prevent possible accumulation and adverse drug reactions. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - June 24, 2020 Category: Drugs & Pharmacology Source Type: research

To Intensify or Not to Intensify? Consideration of Competing Risks in the Management of Locoregionally Advanced p16+ Oropharyngeal Cancer
A 65-year-old man with a history of preventricular contractions treated with bisoprolol, a glomerular filtration rate of 64 to 78  mL/min/1.73 m2, a body mass index of 26.5, no significant tobacco history, and Zubrod performance status of 0 presented to his general practitioner with a sore throat. He underwent an esophagoscopy to evaluate for esophagitis and was found to have a large mass in the tongue base, obliterating the epiglottis. A biopsy showed p16+ squamous cell carcinoma. Imaging, including diagnostic computed tomography, magnetic resonance imaging, and positron emission tomography/computed tomogra...
Source: International Journal of Radiation Oncology * Biology * Physics - June 24, 2020 Category: Radiology Authors: Aaron B. Simon, Loren K. Mell Tags: Gray Zone Source Type: research

Bisoprolol responses (PK/PD) in hypertensive patients: A Cytochrome P450 (CYP) 2D6 Targeted Polymorphism Study
Publication date: Available online 20 June 2020Source: Saudi Journal of Biological SciencesAuthor(s): Huda Mohammed Alkreathy, Khlood Mohammed Eid Alsayyid, Jumana Y. Alaama, Kamal Al Ghalayini, Shahid Karim, Ahmed Esmat, Zoheir A. Damanhouri (Source: Saudi Journal of Biological Sciences)
Source: Saudi Journal of Biological Sciences - June 22, 2020 Category: Biology Source Type: research

Randomized controlled trial of landiolol, a short-acting beta-1 adrenergic receptor blocker, illustrating changes in high-molecular weight adiponectin levels after elective percutaneous coronary intervention
AbstractAdiponectin (APN) has cardioprotective properties and bisoprolol has been reported to increase myocardial APN expression and reduce myocardial damage. Administration of landiolol, which has a higher cardio-selectivity and shorter half-life than bisoprolol, during the percutaneous coronary intervention (PCI) may increase serum APN and high-molecular weight (HMW)-APN, an active form of APN, in patients with stable angina pectoris (SAP). We recruited 70 patients with SAP and randomized them to intravenous landiolol during PCI (N = 35) or control group (N = 35). The primary endpoint was seru...
Source: Heart and Vessels - June 11, 2020 Category: Cardiology Source Type: research

β1-Blocker improves survival and ventricular remodelling in rats with lethal crush injury
ConclusionsOur findings demonstrated the presence of myocardial injury in the early stage of compression in rats with a crush injury. Pretreatment with a β1-blocker (bisoprolol) with fluid resuscitation significantly reduced mortality, decreased myocardial tissue damage, and improved ventricular remodelling in rats with a lethal crush injury. (Source: European Journal of Trauma and Emergency Surgery)
Source: European Journal of Trauma and Emergency Surgery - June 1, 2020 Category: Emergency Medicine Source Type: research

Safety and Tolerability of Neurohormonal Antagonism in Cardiac Amyloidosis.
CONCLUSIONS: ACEi/ARB and MRA can be safely used in CA, provided that no contraindications are present, treatment is started at a low dose and slowly up-titrated, and patients are monitored quite closely. Beta-blocker therapy is less tolerated in patients with AL amyloidosis and/or worse haemodynamic function. PMID: 32475765 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - May 27, 2020 Category: Internal Medicine Authors: Aimo A, Vergaro G, Castiglione V, Rapezzi C, Emdin M Tags: Eur J Intern Med Source Type: research

Enantiospecific behaviour of chiral drugs in soil.
Abstract The importance of stereochemistry on the behaviour and effects of chiral pharmaceutical and illicit drugs in amended agricultural soils has been over looked to date. Therefore, this study was aimed at investigating the enantiospecific behaviour of a chemically diverse range of chiral drugs including naproxen, ibuprofen, salbutamol, bisoprolol, metoprolol, propranolol, acebutolol, atenolol, chlorpheniramine, amphetamine, fluoxetine and citalopram in soil microcosms. Considerable changes of the enantiomeric composition of ibuprofen, naproxen, atenolol, acebutolol and amphetamine were observed within 56 ...
Source: Environmental Pollution - May 25, 2020 Category: Environmental Health Authors: Bertin S, Yates K, Petrie B Tags: Environ Pollut Source Type: research

Comparison of the Transdermal Bisoprolol Patch with Oral Bisoprolol Fumarate Administration as a Therapeutic Agent for Idiopathic Frequent Premature Ventricular Contractions.
Authors: Shinohara M, Wada R, Yao S, Yano K, Akitsu K, Koike H, Kinoshita T, Yuzawa H, Suzuki T, Fujino T, Ikeda T Abstract The transdermal bisoprolol patch (TB) was designed to maintain a sustained concentration of bisoprolol in plasma by a higher trough concentration than oral bisoporolol (OB). We compared the efficacy between TB and OB in patients with idiopathic premature ventricular contractions (PVCs) while considering their duration of action.A total of 78 patients with a PVC count of ≥ 3,000 beats/24 hours were divided into groups treated with TB 4 mg (n = 43) or OB 2.5 mg (n = 35). PVCs were divided int...
Source: International Heart Journal - May 20, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Resting heart rate control and prognosis in coronary artery disease patients with hypertension previously treated with bisoprolol: a sub-group analysis of the BISO-CAD study.
Abstract BACKGROUND: Resting heart rate (RHR) is considered as a strong predictor of total mortality and hospitalization due to heart failure in hypertension patients. Bisoprolol fumarate, a second-generation beta-adrenoreceptor blockers (β-blocker) is commonly prescribed drug to manage hypertension. The present study was to retrospectively evaluate changes in the average RHR and its association with cardiovascular outcomes in bisoprolol-treated coronary artery disease (CAD) patients from the CAD treated with bisoprolol (BISO-CAD) study who had comorbid hypertension. METHODS: We performed ad-hoc analysis...
Source: Chinese Medical Journal - May 19, 2020 Category: General Medicine Authors: Chen YD, Yang XC, Pham VN, Huang SA, Fu GS, Chen XP, Truong BQ, Yang Y, Liu SW, Ma TR, Kim DS, Kim TH Tags: Chin Med J (Engl) Source Type: research

Compelling indications should be listed for individual beta-blockers (due to diversity), not for the whole class.
Conclusions BBs differ within the class in so many ways that it is not only logical but also practical for real-life clinical practice that experts in the field make a list of the compelling indications for individual BBs. Time has come to incorporate our knowledge about BBs into a new approach of presenting these useful and very individual drugs. PMID: 32418526 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - May 17, 2020 Category: Drugs & Pharmacology Authors: Koracevic G, Micic S, Stojanovic M, Lovic D, Simic D, Colic M, Koracevic M, Stojkovic A, Paunovic M Tags: Curr Vasc Pharmacol Source Type: research

Assessment of adherence to diuretics and β-blockers by serum drug monitoring in comparison to urine analysis.
Conclusion: This study suggests that assessment of adherence can be performed more precisely on the basis of serum drug concentrations with individually calculated lower DRC than by using the TRR or qualitative urinalysis. PMID: 32400211 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - May 15, 2020 Category: Hematology Tags: Blood Press Source Type: research

Eptinezumab (Vyepti) for Migraine Prevention
Date: June 1, 2020 Issue #:  1599Summary:  The FDA has approved eptinezumab-jjmr (Vyepti– Lundbeck), a calcitonin gene-related peptide (CGRP) antagonist administered IV once every 3 months, for migraine prevention in adults. It is the fourth monoclonal antibody to be approved for this indication; erenumab (Aimovig), fremanezumab(Ajovy), and galcanezumab (Emgality), which are all given subcutaneously once monthly (fremanezumab can also be given once every 3 months), were approved earlier. (Source: The Medical Letter)
Source: The Medical Letter - April 29, 2020 Category: Drugs & Pharmacology Authors: admin Tags: Aimovig Ajovy Amitriptyline Atacand Atenolol Beta blockers Bisoprolol Botox Candesartan Corgard Cymbalta Depakote Duloxetine Effexor Emgality Epival eptinezumab erenumab fremanezumab galcanezumab Inderal Lopressor Source Type: research

Drugs for Hypertension
Date: May 18, 2020 Issue #:  1598Summary:  Drugs available for treatment of chronic hypertension and their dosages, adverse effects, and costs are listed in the tables. Treatment of hypertensive urgencies and emergencies is not discussed here. (Source: The Medical Letter)
Source: The Medical Letter - April 29, 2020 Category: Drugs & Pharmacology Authors: admin Tags: Accupril Accuretic ACE inhibitors Acebutolol Adalat Aldactone aliskiren Altace Amiloride Amlodipine ARBs Atacand Atenolol Avalide Avapro azilsartan benazapril Benicar Beta blockers Betaxolol Bisoprolol Bumetanide Source Type: research

Cold Flow Evaluation in Transdermal Drug Delivery Systems by Measuring the Width of the Oozed Adhesive.
The objective of this study was to develop a simpler and more practical quantitative evaluation method of cold flow (CF) in transdermal drug delivery systems (TDDSs). CF was forcibly induced by loading a weight on a punched-out sample (bisoprolol and tulobuterol tapes). When the extent of CF was analyzed using the area of oozed adhesive as following a previously reported method, the CF profiles were looked different between the samples 12 mm in diameter subjected to a 0.5-kg weight and samples 24 mm in diameter subjected to a 2.0-kg weight despite an equal load per unit area (4.42 g/mm2). The width of oozed ...
Source: AAPS PharmSciTech - April 21, 2020 Category: Drugs & Pharmacology Authors: Miyazaki T, Kanno H, Yamamoto E, Ando D, Izutsu KI, Goda Y Tags: AAPS PharmSciTech Source Type: research

Effect of Bisoprolol on the Level of Dabigatran
Conclusions: This study demonstrated the interaction between dabigatran and bisoprolol, which is modulated with dabigatran dosage and concomitant treatment with proton-pump inhibitor and digoxin. (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - March 1, 2020 Category: Drugs & Pharmacology Tags: Original Investigations Source Type: research

Chiral separation of beta-blockers by high-performance liquid chromatography and determination of bisoprolol enantiomers in surface waters.
E, Galić N Abstract Beta-blockers are chiral compounds with enantiomers that have different bioactivity, which means that while one is active, the other can be inactive or even harmful. Due to their high consumption and incomplete degradation in waste water, they may reach surface waters and affect aquatic organisms. To address this issue we developed a chromatographic method suitable for determining beta-blocker enantiomers in surface waters. It was tested on five beta-blockers (acebutolol, atenolol, bisoprolol, labetalol and metoprolol) and validated on bisoprolol enantiomers. Good enantioseparation of all anal...
Source: Arhiv za Higijenu Rada i Toksikologiju - February 29, 2020 Category: Occupational Health Authors: Pocrnić M, Ansorge M, Dovhunová M, Habinovec I, Tesařová E, Galić N Tags: Arh Hig Rada Toksikol Source Type: research

Double ‐chambered right ventricle complicated by hypertrophic obstructive cardiomyopathy diagnosed as Noonan syndrome
We present a case of double ‐chambered right ventricle (DCRV) complicated by hypertrophic obstructive cardiomyopathy (HOCM) inKRAS mutation ‐associated Noonan syndrome. The diagnosis was incidental and made during diagnostic testing for an intradural extramedullary tumour. Spinal compression, if not surgically treated, may cause paralysis of the extremities. We decided to pursue pharmacological therapy to control biventricular obstruc tions and reduce the perioperative complication rate. We initiated treatment with cibenzoline and bisoprolol; the doses were titrated according to the response. After 2 weeks, the peak pr...
Source: ESC Heart Failure - February 27, 2020 Category: Cardiology Authors: Masahiro Yamamoto, Seiji Takashio, Naoya Nakashima, Shinsuke Hanatani, Yuichiro Arima, Kenji Sakamoto, Eiichiro Yamamoto, Koichi Kaikita, Yoko Aoki, Kenichi Tsujita Tags: Case Report Source Type: research

Effects of Bisoprolol Transdermal Patches for Prevention of Perioperative Myocardial Injury in High-Risk Patients Undergoing Non-Cardiac Surgery  - Multicenter Randomized Controlled Study.
CONCLUSIONS: Bisoprolol patches do not influence the incidence of PMI and cardiovascular events in high-risk patients undergoing non-cardiac surgery, but perioperative use of these patches is safe. PMID: 32092717 [PubMed - as supplied by publisher] (Source: Circulation Journal)
Source: Circulation Journal - February 20, 2020 Category: Cardiology Authors: Toda H, Nakamura K, Shimizu K, Ejiri K, Iwano T, Miyoshi T, Nakagawa K, Yoshida M, Watanabe A, Nishii N, Hikasa Y, Hayashi M, Morita H, Morimatsu H, Ito H, MAMACARI Investigators Tags: Circ J Source Type: research

A validated LC–MS/MS method for the quantification of amlodipine, bisoprolol, enalapril and enalaprilat—Application to pharmacokinetic study in healthy volunteers
Publication date: June 2020Source: Microchemical Journal, Volume 155Author(s): Liliya Logoyda, Sergiy Kovalenk, Moustafa Gaafar, Ahmed M. Abdel-Megied, Fawzy A. ElbarbryAbstractIn this work, a highly sensitive and rapid liquid chromatography-tandem mass spectrometry (LC–MS/MS) method for the simultaneous determination of amlodipine (AML), bisoprolol (BIS) and enalapril maleate (ENA) in the presence of its metabolite enalaprilat (ENT) in real human plasma was developed and validated using felodipine, propranolol, ramipril, and captopril, as internal standards (IS), respectively. The prepared samples were chromatograph...
Source: Microchemical Journal - February 14, 2020 Category: Chemistry Source Type: research

Association between bisoprolol plasma concentration and worsening of heart failure: (CVI ARO 6).
CONCLUSIONS: Bis-PC was increased by age and renal dysfunction, and high Bis-PC was associated with worsening of HF in elderly and HFpEF patients. Care should be taken to avoid overdose. PMID: 32044255 [PubMed - as supplied by publisher] (Source: Drug Metabolism and Pharmacokinetics)
Source: Drug Metabolism and Pharmacokinetics - February 13, 2020 Category: Drugs & Pharmacology Tags: Drug Metab Pharmacokinet Source Type: research

Severe impaired blood pressure control caused by baroreflex failure as a late sequela of neck irradiation
A 64-year-old man, whose medical history was significant only for locally advanced squamocellular carcinoma of the right palatine tonsil treated with extended neck radiotherapy 9 years before, was evaluated for traumatic cerebral haemorrhage secondary to syncope after a postural change. The selective angiographic study of cerebral vessels was negative. No heart arrhythmias were recorded at ECG monitoring. The 24-h ABPM revealed sudden pressor and depressor episodes during day-time and a reverse dipper pattern during night-time. Noninvasive autonomic nervous system function testing showed supine hypertension and orthostatic...
Source: Journal of Hypertension - February 7, 2020 Category: Cardiology Tags: Case Report Source Type: research

Bisoprolol transdermal patch improves orthostatic hypotension in patients with chronic heart failure and hypertension.
Abstract β blockers (BBs) play an important role in heart failure (HF) treatment. However, orthostatic hypotension (OH) is sometimes caused by BBs. The bisoprolol transdermal patch works more slowly and is long acting compared with the bisoprolol fumarate tablet. The risk of OH may be reduced by using the bisoprolol transdermal patch. We evaluated 57 consecutive patients who were taking the bisoprolol fumarate tablet for chronic HF with hypertension from November 2016 to September 2017. We switched the patients to the bisoprolol transdermal patch. Because 12 of 57 subjects could not continue using the bisopro...
Source: Clinical and Experimental Hypertension - February 1, 2020 Category: Cardiology Authors: Kiuchi S, Hisatake S, Kabuki T, Oka T, Dobashi S, Fujii T, Sano T, Ikeda T Tags: Clin Exp Hypertens Source Type: research

Systemic β-Adrenergic Receptor Activation Augments the ex vivo Expansion and Anti-Tumor Activity of Vγ9Vδ2 T-Cells
TCR-gamma delta (γδ) T-cells are considered important players in the graft-vs.-tumor effect following allogeneic hematopoietic cell transplantation (alloHCT) and have emerged as candidates for adoptive transfer immunotherapy in the treatment of both solid and hematological tumors. Systemic β-adrenergic receptor (β-AR) activation has been shown to mobilize TCR-γδ T-cells to the blood, potentially serving as an adjuvant for alloHCT and TCR-γδ T-cell therapy. We investigated if systemic β-AR activation, using acute dynamic exercise as an experimental model, can increase the m...
Source: Frontiers in Immunology - January 23, 2020 Category: Allergy & Immunology Source Type: research

"In-House" Data on the Outside - A Mobile Health Approach.
"In-House" Data on the Outside - A Mobile Health Approach. Clin Pharmacol Ther. 2020 Jan 19;: Authors: Huang Q, Crumley T, Walters C, Cluckers L, Heirman I, Railkar R, Bhatia G, Cantor M, Benko C, Izmailova ES, Rottey S, Stoch SA Abstract Mobile health (mHealth) technologies have the potential to capture dense patient data on the background of real-life behavior. Merck & Co., Inc. (Kenilworth, NJ, USA), in collaboration with Koneksa Health, conducted a Phase I clinical trial to validate cardiovascular mHealth technologies for concordance with traditional approaches and to establish sensi...
Source: Clinical Pharmacology and Therapeutics - January 18, 2020 Category: Drugs & Pharmacology Authors: Huang Q, Crumley T, Walters C, Cluckers L, Heirman I, Railkar R, Bhatia G, Cantor M, Benko C, Izmailova ES, Rottey S, Stoch SA Tags: Clin Pharmacol Ther Source Type: research

Effects of Simvastatin on the Metabolism of Fatty Acids in Combined Secondary Prevention of Coronary Heart Disease: Dosage and Gender Differences between the Effects.
CONCLUSIONS: Considering the formation of saturated fatty acids, statin performed better in males. With Omega-3 polyunsaturated fatty acids involved, changes in lipoproteins, cholesterol and fatty acids (liver and myocardium) were similar to those caused by small doses of a statin drug. Effects from the combination of bisoprolol and acetylsalicylic acid were completely different from those caused by the use of statin. PMID: 31916523 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - January 10, 2020 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Neonatal effects of intrauterine metoprolol/bisoprolol exposure during the second and third trimester: a cohort study with two comparison groups
Conclusion: Long-term intrauterine exposure to metoprolol or bisoprolol may increase the risk of being born small-for-gestational-age. It is still a matter of debate to which extent maternal hypertension contributes to the lower birth weight. Serious neonatal symptoms are rare. Altogether, metoprolol and bisoprolol are well tolerated treatment options, but a case-by-case decision on close neonatal monitoring is recommended. (Source: Journal of Hypertension)
Source: Journal of Hypertension - January 10, 2020 Category: Cardiology Tags: ORIGINAL PAPERS: Treatment Source Type: research

(Source: Reactions Weekly)
Source: Reactions Weekly - December 31, 2019 Category: Drugs & Pharmacology Source Type: research

Bisoprolol transdermal patch for perioperative care of non-cardiac surgery in patients with hypertrophic obstructive cardiomyopathy
Non-cardiac surgery for hypertrophic obstructive cardiomyopathy (HOCM) is considered to require meticulous perioperative care. β-blockers are considered the first-line drugs for patients with HOCM, and they pl... (Source: BMC Cardiovascular Disorders)
Source: BMC Cardiovascular Disorders - December 30, 2019 Category: Cardiology Authors: Yoichi Imori, Hitoshi Takano, Hiroshi Mase, Junya Matsuda, Hideto Sangen, Yuki Izumi, Yukichi Tokita, Takeshi Yamamoto and Wataru Shimizu Tags: Research article Source Type: research

Assessment of the ecotoxicity of the pharmaceuticals bisoprolol, sotalol, and ranitidine using standard and behavioral endpoints.
row F Abstract The pharmaceuticals bisoprolol (BIS), sotalol (SOT), and ranitidine (RAN) are among the most consumed pharmaceuticals worldwide and are frequently detected in different aquatic ecosystems. However, very few ecotoxicity data are available in the literature for them. To help fill these data gaps, toxicity tests with the algae Raphidocelis subcapitata, the macrophyte Lemna minor, the cnidarian Hydra attenuata, the crustacean Daphnia similis, and the fish Danio rerio were performed for assessing the ecotoxicity of these pharmaceuticals. Standard, as well as non-standard endpoint, was evaluated, includin...
Source: Environmental Science and Pollution Research International - December 17, 2019 Category: Environmental Health Authors: Godoy AA, Domingues I, de Carvalho LB, Oliveira ÁC, de Jesus Azevedo CC, Taparo JM, Assano PK, Mori V, de Almeida Vergara Hidalgo V, Nogueira AJA, Kummrow F Tags: Environ Sci Pollut Res Int Source Type: research

Effects of cardio-selective beta-blockade on plasma catecholamines and performance during different forms of exercise.
Authors: Fikenzer S, Fikenzer K, Laufs U, Falz R, Schulze A, Busse M Abstract BACKGROUND: Beta-blockers are still frequently used in cardiovascular diseases but may negatively influence the exercise capacity. The aim of the study was to analyze the effect of beta-blockade on physical performance and plasma level of catecholamine during different forms of exercise. METHODS: Ten prehypertensive athletes (age: 25.1±2.5 years, BMI: 24.4±2.4 kg/m2) performed repeated incremental exercise and steady-state-tests without and with the cardio-selective beta-blocker bisoprolol (5mg/day). The cardiopulmonary,...
Source: Journal of Sports Medicine and Physical Fitness - December 11, 2019 Category: Sports Medicine Tags: J Sports Med Phys Fitness Source Type: research

Utility of hairless rats as a model for predicting transdermal pharmacokinetics in humans.
Conclusions: In vivo skin absorption data from HWY hairless rats help predict human concentration profiles for lipophilic compounds. However, the data underestimate human absorption of hydrophilic compounds. PMID: 31814485 [PubMed - as supplied by publisher] (Source: Xenobiotica)
Source: Xenobiotica - December 8, 2019 Category: Research Authors: Yamamoto S, Sano N, Fukushi C, Arai Y, Karashima M, Hirabayashi H, Amano N Tags: Xenobiotica Source Type: research

Thermal baths as sources of pharmaceutical and illicit drug contamination.
Á, Dobosy P, Kondor AC Abstract Despite the fact that there are tens of thousands of thermal baths in existence, knowledge about the occurrence of pharmaceutically active compounds (PhACs) in untreated thermal wastewater is very limited. Because used thermal water is typically legally discharged into surface waters without any treatment, the effluent poses environmental risks for the receiving water bodies. The aim of this study was to show the occurrence patterns and spatiotemporal characteristics of 111 PhACs in thermal wastewater. Six thermal water outflows of different thermal baths were tested in diffe...
Source: Environmental Science and Pollution Research International - December 1, 2019 Category: Environmental Health Authors: Jakab G, Szalai Z, Michalkó G, Ringer M, Filep T, Szabó L, Maász G, Pirger Z, Ferincz Á, Staszny Á, Dobosy P, Kondor AC Tags: Environ Sci Pollut Res Int Source Type: research

Cost-Effectiveness of Rate- and Rhythm-Control Drugs for Treating Atrial Fibrillation in Korea.
CONCLUSION: Propranolol and pilsicainide appear to be cost-effective in patients with AF in Korea assuming that drug usage or compliance is the same. PMID: 31769246 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - November 28, 2019 Category: Universities & Medical Training Authors: Kim M, Kim W, Kim C, Joung B Tags: Yonsei Med J Source Type: research

The use of beta-blockers is not associated with increased daytime sleepiness in patients with obstructive sleep apnoea
Conclusions: Beta-blockers in general are not associated with excessive daytime sleepiness in OSA. However, lipophilic agents penetrating through the blood-brain barrier (i.e. propranolol or metoprolol) should be investigated separately. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Bikov, A., Meszaros, M., Vestbo, J., Mathioudakis, A., Kunos, L. Tags: Sleep and control of breathing Source Type: research

Late Breaking Abstract - The impact of regular bisoprolol on recovery with salbutamol in asthma; a double-blind randomised controlled trial
This study investigates the response after continued exposure to cs-B1B.Methods: 19 mild asthmatics completed a randomized, double-blind, placebo-controlled crossover study powered for non-inferiority of up-titrated bisoprolol to a maximum of 5mg daily against placebo. Controlled bronchoconstriction with mannitol inhalation (Aridol®) dropped the forced expiratory volume in 1 second (FEV1) by 15%. 400µg salbutamol was then given over 15 minutes. This gave a recovery curve of FEV1 over time, the primary endpoint was area under this curve, (AUC, L/min). Open label extension went up to 10mg bisoprolol daily (n=13). U...
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Bennett, M., Hancox, B., Chang, C., Tuffery, C., Hopping, S. Tags: Airway pharmacology and treatment Source Type: research

Pilot study of bisoprolol 8mg transdermal patch at bedtime before coronary computed tomography angiography.
CONCLUSIONS: The bisoprolol 8mg transdermal patch lowered HR and decreased the amount of time needed for CCTA, thus streamlining the evaluation process. PMID: 31627998 [PubMed - as supplied by publisher] (Source: Journal of Cardiology)
Source: Journal of Cardiology - October 15, 2019 Category: Cardiology Authors: Yamazaki D, Shimura Y, Enjoji Y, Nishinaga M, Kanmatuse K, Endo M Tags: J Cardiol Source Type: research

The selection of β-blocker after successful reperfusion in patients with ST-elevation myocardial infarction.
The selection of β-blocker after successful reperfusion in patients with ST-elevation myocardial infarction. Perfusion. 2019 Oct 14;:267659119878396 Authors: Jang HJ, Suh J, Kwon SW, Park SD, Oh PC, Moon J, Lee K, Kang WC, Jung IH, An H, Kim TH Abstract BACKGROUND: The selection of β-blocker for survivors after primary intervention due to acute ST-elevation myocardial infarction seems crucial to improve the outcomes. However, rare comparison data existed for these patients. We aimed to compare the effectiveness of selective β-blockers to that of carvedilol in patients treated with prima...
Source: Perfusion - October 13, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Jang HJ, Suh J, Kwon SW, Park SD, Oh PC, Moon J, Lee K, Kang WC, Jung IH, An H, Kim TH Tags: Perfusion Source Type: research

Ototoxic Adverse Drug Reactions: A Disproportionality Analysis Using the Italian Spontaneous Reporting Database
Conclusions: This study is largely consistent with results from literature. Nevertheless, propafenone, antituberculars, hormone antagonists, teriparatide, tramadol, and pomalidomide are unknown for being ototoxic. Hypoacusis after the use of vinorelbine, methotrexate, and pemetrexed is unexpected, such as tinnitus related with etoposide, nebivolol, betamethasone, abatacept, sofosbuvir/ledipasvir, and tapentadol, but these considerations require further investigation to better define the risk due to the paucity of data. Moreover, physicians should be aware of the clinical significance of ototoxicity and be conscious about t...
Source: Frontiers in Pharmacology - October 7, 2019 Category: Drugs & Pharmacology Source Type: research