Renal tubular necrosis associated with anagrelide administration: a case report
AbstractA 62-year-old female patient with essential thrombocythemia experienced rapid renal dysfunction and was subsequently referred to our hospital. Further investigations did not reveal any significant abnormalities except for a slight increase in urinary β2-microglobulin levels. A renal biopsy was performed to investigate the cause of her renal dysfunction, revealing acute tubular necrosis, interstitial edema, and arteriosclerosis. No significant glomerular lesions were observed. Immunofluorescence staining and electron microscopy showed no abnorma lities. She had been using anagrelide for 4 years, and her dosage was...
Source: CEN Case Reports - April 24, 2024 Category: Urology & Nephrology Source Type: research
Safety and tolerability of β-blockers: importance of cardioselectivity
Curr Med Res Opin. 2024;40(sup1):55-62. doi: 10.1080/03007995.2024.2317433. Epub 2024 Apr 10.ABSTRACTCardioselective β-blockade is generally well tolerated in practice and contraindications to this therapy are uncommon. β-blockers are a diverse therapeutic class, and their individual tolerability profiles are influenced strongly by their pharmacodynamic effects across different adrenergic receptors. Bisoprolol, probably the β-blocker with the highest selectivity for blockade of β1- vs. β2-adrenoceptors, does not block β2-adrenoceptors to an appreciable extent at doses in therapeutic use. Side-effects often attributed...
Source: Current Medical Research and Opinion - April 10, 2024 Category: Research Authors: Hans-Peter Marti Abel Alberto Pav ía López Pedro Schwartzmann Source Type: research
Effect of Concomitant Drugs on Sodium Zirconium Cyclosilicate Hydrate in Artificial Intestinal Juice
Chem Pharm Bull (Tokyo). 2024;72(3):286-293. doi: 10.1248/cpb.c23-00687.ABSTRACTTo explore drug interactions involving sodium zirconium cyclosilicate hydrate (SZC) and concomitant drugs like calcium antagonists (amlodipine and nifedipine) and β-blockers (carvedilol and bisoprolol), we investigate how these concomitant drugs influenced the administration of SZC in an artificial intestinal juice. Initially, we assessed the potassium ion adsorption capacity, ranking it as follows: calcium polystyrene sulfonate (CPS, 54.9 mg/g) < sodium polystyrene sulfonate (SPS, 62.1 mg/g) < SZC (90.8 mg/g). However, the adsorption eq...
Source: Chemical and Pharmaceutical Bulletin - March 6, 2024 Category: Drugs & Pharmacology Authors: Yuri Mizuno Fumihiko Ogata Yugo Uematsu Naohito Kawasaki Source Type: research
Effect of Concomitant Drugs on Sodium Zirconium Cyclosilicate Hydrate in Artificial Intestinal Juice
Chem Pharm Bull (Tokyo). 2024;72(3):286-293. doi: 10.1248/cpb.c23-00687.ABSTRACTTo explore drug interactions involving sodium zirconium cyclosilicate hydrate (SZC) and concomitant drugs like calcium antagonists (amlodipine and nifedipine) and β-blockers (carvedilol and bisoprolol), we investigate how these concomitant drugs influenced the administration of SZC in an artificial intestinal juice. Initially, we assessed the potassium ion adsorption capacity, ranking it as follows: calcium polystyrene sulfonate (CPS, 54.9 mg/g) < sodium polystyrene sulfonate (SPS, 62.1 mg/g) < SZC (90.8 mg/g). However, the adsorption eq...
Source: Chemical and Pharmaceutical Bulletin - March 6, 2024 Category: Drugs & Pharmacology Authors: Yuri Mizuno Fumihiko Ogata Yugo Uematsu Naohito Kawasaki Source Type: research
Effect of Concomitant Drugs on Sodium Zirconium Cyclosilicate Hydrate in Artificial Intestinal Juice
Chem Pharm Bull (Tokyo). 2024;72(3):286-293. doi: 10.1248/cpb.c23-00687.ABSTRACTTo explore drug interactions involving sodium zirconium cyclosilicate hydrate (SZC) and concomitant drugs like calcium antagonists (amlodipine and nifedipine) and β-blockers (carvedilol and bisoprolol), we investigate how these concomitant drugs influenced the administration of SZC in an artificial intestinal juice. Initially, we assessed the potassium ion adsorption capacity, ranking it as follows: calcium polystyrene sulfonate (CPS, 54.9 mg/g) < sodium polystyrene sulfonate (SPS, 62.1 mg/g) < SZC (90.8 mg/g). However, the adsorption eq...
Source: Chemical and Pharmaceutical Bulletin - March 6, 2024 Category: Drugs & Pharmacology Authors: Yuri Mizuno Fumihiko Ogata Yugo Uematsu Naohito Kawasaki Source Type: research
Effect of Concomitant Drugs on Sodium Zirconium Cyclosilicate Hydrate in Artificial Intestinal Juice
Chem Pharm Bull (Tokyo). 2024;72(3):286-293. doi: 10.1248/cpb.c23-00687.ABSTRACTTo explore drug interactions involving sodium zirconium cyclosilicate hydrate (SZC) and concomitant drugs like calcium antagonists (amlodipine and nifedipine) and β-blockers (carvedilol and bisoprolol), we investigate how these concomitant drugs influenced the administration of SZC in an artificial intestinal juice. Initially, we assessed the potassium ion adsorption capacity, ranking it as follows: calcium polystyrene sulfonate (CPS, 54.9 mg/g) < sodium polystyrene sulfonate (SPS, 62.1 mg/g) < SZC (90.8 mg/g). However, the adsorption eq...
Source: Chemical and Pharmaceutical Bulletin - March 6, 2024 Category: Drugs & Pharmacology Authors: Yuri Mizuno Fumihiko Ogata Yugo Uematsu Naohito Kawasaki Source Type: research
Pancytopenia following adjuvant therapy with interferon gamma (IFN- γ) in a patient with disseminated nocardiosis
We report a case of pancytopenia following treatment with recombinant interferon gamma (IFN- γ) in a patient with disseminated nocardiosis. A 78-year-old woman presented with non-specific symptoms of general weakness, cough, fever, right-hand paresis, unsteady gait, and vision deterioration. Her medical record revealed multiple allergic reactions, notably to salicylates (including aspirin) , histamines, penicillin, ciprofloxacin, erythromycin, bisoprolol, and iodide. She reported having Henoch–Schönlein purpura, asthma, and arterial hypertension. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - March 5, 2024 Category: Infectious Diseases Authors: Thomas Derungs, Denis Poddubnyy, Thomas Schneider Tags: Case Report Source Type: research
Pancytopenia following adjuvant therapy with interferon-gamma in a patient with disseminated nocardiosis
We report a case of pancytopenia following treatment with recombinant interferon-gamma (IFN- γ) in a patient with disseminated nocardiosis. A 78-year-old woman presented with non-specific symptoms of general weakness, cough, fever, right-hand paresis, unsteady gait, and vision deterioration. Her medical record revealed multiple allergic reactions, notably to salicylates (including aspirin) , histamines, penicillin, ciprofloxacin, erythromycin, bisoprolol, and iodide. She reported having Henoch–Schönlein purpura, asthma, and arterial hypertension. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - March 5, 2024 Category: Infectious Diseases Authors: Thomas Derungs, Denis Poddubnyy, Thomas Schneider Tags: Case Report Source Type: research
Exploring the impact of pharmacogenetics on personalized medicine: A systematic review
CONCLUSION: The studies analyzed in this review suggest a strong correlation between genetic variability and individual drug responses, supporting the use of pharmacogenetics for treatment optimization. However, for certain drugs like metformin or quetiapine, the influence of genotype on their response remains unclear. More studies with larger sample sizes, greater ethnic diversity, and consideration of non-genetic factors are needed. The lack of standardization in analysis methods and accessibility to genetic testing are significant challenges in this field. As a conclusion, pharmacogenetics shows immense potential in per...
Source: Farmacia Hospitalaria - February 10, 2024 Category: Drugs & Pharmacology Authors: Laura Amaro- Álvarez Jaime Cordero-Ramos Miguel Ángel Calleja-Hernández Source Type: research
Exploring the impact of pharmacogenetics on personalized medicine: A systematic review
CONCLUSION: The studies analyzed in this review suggest a strong correlation between genetic variability and individual drug responses, supporting the use of pharmacogenetics for treatment optimization. However, for certain drugs like metformin or quetiapine, the influence of genotype on their response remains unclear. More studies with larger sample sizes, greater ethnic diversity, and consideration of non-genetic factors are needed. The lack of standardization in analysis methods and accessibility to genetic testing are significant challenges in this field. As a conclusion, pharmacogenetics shows immense potential in per...
Source: Farmacia Hospitalaria - February 10, 2024 Category: Drugs & Pharmacology Authors: Laura Amaro- Álvarez Jaime Cordero-Ramos Miguel Ángel Calleja-Hernández Source Type: research
Exploring the impact of pharmacogenetics on personalized medicine: A systematic review
CONCLUSION: The studies analyzed in this review suggest a strong correlation between genetic variability and individual drug responses, supporting the use of pharmacogenetics for treatment optimization. However, for certain drugs like metformin or quetiapine, the influence of genotype on their response remains unclear. More studies with larger sample sizes, greater ethnic diversity, and consideration of non-genetic factors are needed. The lack of standardization in analysis methods and accessibility to genetic testing are significant challenges in this field. As a conclusion, pharmacogenetics shows immense potential in per...
Source: Farmacia Hospitalaria - February 10, 2024 Category: Drugs & Pharmacology Authors: Laura Amaro- Álvarez Jaime Cordero-Ramos Miguel Ángel Calleja-Hernández Source Type: research
Exploring the impact of pharmacogenetics on personalized medicine: A systematic review
CONCLUSION: The studies analyzed in this review suggest a strong correlation between genetic variability and individual drug responses, supporting the use of pharmacogenetics for treatment optimization. However, for certain drugs like metformin or quetiapine, the influence of genotype on their response remains unclear. More studies with larger sample sizes, greater ethnic diversity, and consideration of non-genetic factors are needed. The lack of standardization in analysis methods and accessibility to genetic testing are significant challenges in this field. As a conclusion, pharmacogenetics shows immense potential in per...
Source: Farmacia Hospitalaria - February 10, 2024 Category: Drugs & Pharmacology Authors: Laura Amaro- Álvarez Jaime Cordero-Ramos Miguel Ángel Calleja-Hernández Source Type: research
Exploring the impact of pharmacogenetics on personalized medicine: A systematic review
CONCLUSION: The studies analyzed in this review suggest a strong correlation between genetic variability and individual drug responses, supporting the use of pharmacogenetics for treatment optimization. However, for certain drugs like metformin or quetiapine, the influence of genotype on their response remains unclear. More studies with larger sample sizes, greater ethnic diversity, and consideration of non-genetic factors are needed. The lack of standardization in analysis methods and accessibility to genetic testing are significant challenges in this field. As a conclusion, pharmacogenetics shows immense potential in per...
Source: Farmacia Hospitalaria - February 10, 2024 Category: Drugs & Pharmacology Authors: Laura Amaro- Álvarez Jaime Cordero-Ramos Miguel Ángel Calleja-Hernández Source Type: research
Exploring the impact of pharmacogenetics on personalized medicine: A systematic review
CONCLUSION: The studies analyzed in this review suggest a strong correlation between genetic variability and individual drug responses, supporting the use of pharmacogenetics for treatment optimization. However, for certain drugs like metformin or quetiapine, the influence of genotype on their response remains unclear. More studies with larger sample sizes, greater ethnic diversity, and consideration of non-genetic factors are needed. The lack of standardization in analysis methods and accessibility to genetic testing are significant challenges in this field. As a conclusion, pharmacogenetics shows immense potential in per...
Source: Farmacia Hospitalaria - February 10, 2024 Category: Drugs & Pharmacology Authors: Laura Amaro- Álvarez Jaime Cordero-Ramos Miguel Ángel Calleja-Hernández Source Type: research
