Assessing the hypolipidemic and gastro-liver protective activity of herbal combination with emphasis on PPI amid selected multiple antihypertensive drug combination in experimental animal models
CONCLUSIONS: CThis investigation reported that antihypertensive drugs did not produce gastrointestinal (GI) toxicity, and the morphological structure of the organ was not changed. So, it could be concluded that the herbal combination used in this experiment has a promising role in controlling lipid profile, liver function, and antiulcer effects. Moreover, multiple drug therapy for hypertension does not cause any harm to the stomach. Further investigations might be carried out on a larger scale to make these statements more valid.PMID:38039033 | DOI:10.26355/eurrev_202311_34471 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - December 1, 2023 Category: Drugs & Pharmacology Authors: R P Monisa A K Azad I Rahma J T Israt A Shopnil A K Ayaz U H Taqweem T Aziz A Metab H A Thamer F A Abdullah Source Type: research
Further exploration of the collision ‐induced dissociation of select beta blockers: Acebutolol, atenolol, bisoprolol, carteolol, and labetalol
AbstractBeta blockers are a class of drugs commonly used to treat heart-related diseases; they are also regulated under the World Anti-Doping Agency. Tandem mass spectrometry is often used in the pharmaceutical industry, clinical analysis laboratory, and antidoping laboratory for detection and characterization of drugs and their metabolites. A deeper chemical understanding of dissociation pathways may eventually lead to an improved ability to predict tandem mass spectra of compounds based strictly on their chemical structure (or vice versa), which is especially important for characterization of unknowns such as emerging de...
Source: Journal of Mass Spectrometry - November 22, 2023 Category: Chemistry Authors: Matthew J. Carlo,
Amanda L. Patrick Tags: RESEARCH ARTICLE Source Type: research
Genetic polymorphisms in ADRB1, ADRB2 and CYP2D6 genes and response to beta-blockers in patients with acute coronary syndrome
Biomed Pharmacother. 2023 Nov 10;169:115869. doi: 10.1016/j.biopha.2023.115869. Online ahead of print.ABSTRACTBetablockers (BBs) are prescribed for ischaemia in patients with acute coronary syndrome (ACS). In Spain, bisoprolol and carvedilol are the most prescribed BBs, but patients often had to discontinue them due to adverse effects. Single nucleotide polymorphisms (SNPs) in ADRB1, ADRB2 and CYP2D6 genes have strong evidence of pharmacogenetic association with BBs in heart failure or hypertension, but the evidence in ACS is limited. Therefore, our study focuses on investigating how these genes influence the response to B...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 12, 2023 Category: Drugs & Pharmacology Authors: Celia Casta ño-Amores Alba Ant únez-Rodríguez Ana Pozo-Agundo Sonia Garc ía-Rodríguez Luis Javier Mart ínez-González Cristina Luc ía Dávila-Fajardo Source Type: research
Genetic polymorphisms in ADRB1, ADRB2 and CYP2D6 genes and response to beta-blockers in patients with acute coronary syndrome
Biomed Pharmacother. 2023 Nov 10;169:115869. doi: 10.1016/j.biopha.2023.115869. Online ahead of print.ABSTRACTBetablockers (BBs) are prescribed for ischaemia in patients with acute coronary syndrome (ACS). In Spain, bisoprolol and carvedilol are the most prescribed BBs, but patients often had to discontinue them due to adverse effects. Single nucleotide polymorphisms (SNPs) in ADRB1, ADRB2 and CYP2D6 genes have strong evidence of pharmacogenetic association with BBs in heart failure or hypertension, but the evidence in ACS is limited. Therefore, our study focuses on investigating how these genes influence the response to B...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 12, 2023 Category: Drugs & Pharmacology Authors: Celia Casta ño-Amores Alba Ant únez-Rodríguez Ana Pozo-Agundo Sonia Garc ía-Rodríguez Luis Javier Mart ínez-González Cristina Luc ía Dávila-Fajardo Source Type: research
Evaluation of Potential Drug-Drug Interactions and Association with Adverse Drug Reactions in Predialysis Chronic Kidney Disease Patients at Indonesian National Referral Hospital
CONCLUSION: A significant number of potential DDI were seen in the prescriptions of stage 3-5 pre-dialysis CKD patients at a referral hospital in Indonesia between 2019 - 2020. Cardiovascular disease was identified as the most common risk factor for ADR suspected caused by DDI.PMID:37915149 (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - November 2, 2023 Category: Internal Medicine Authors: Triasti Khusfiani Vivian Soetikno Ni Made Hustrini Nafrialdi Nafrialdi Source Type: research
