Mathematical modeling of antihypertensive therapy
This study is a continuation of research on the modular agent-based model of the cardiovascular and renal systems (presented in the previously published article). In the current work, we included in the model equations simulating the response to antihypertensive therapies with different mechanisms of action. For this, we used the pharmacodynamic effects of the angiotensin II receptor blocker losartan, the calcium channel blocker amlodipine, the angiotensin-converting enzyme inhibitor enalapril, the direct renin inhibitor aliskiren, the thiazide diuretic hydrochlorothiazide, and the β-blocker bisoprolol. We fitted therapy ...
Source: Frontiers in Physiology - December 14, 2022 Category: Physiology Source Type: research
Yokukansankachimpihange therapy fortified with bisoprolol and lifestyle changes in a patient intolerant to antihypertensive agents
ConclusionFortified therapy is an efficacious, advanced integrated medicine approach that can be used to treat patients with hypertension. (Source: Traditional and Kampo Medicine)
Source: Traditional and Kampo Medicine - December 3, 2022 Category: Complementary Medicine Authors: Dai Katayose Tags: CASE REPORT Source Type: research
EE207 Real-World Analysis of Adherence, Outcomes and Healthcare Costs of Patients Under Quadruple Combination of Antihypertensives in Italy
this real-world analysis aimed to evaluate adherence, outcomes and direct healthcare costs in hypertensive patients treated with 4 antihypertensive drugs belonging to ACE-inhibitor/calcium-antagonist/diuretic/beta-blocker(ACE-I/CCB/DIU/BB) classes or with perindopril/amlodipine/indapamide/bisoprolol(PER/AML/IND/BIS), in Italy. (Source: Value in Health)
Source: Value in Health - December 1, 2022 Category: International Medicine & Public Health Authors: L Degli Esposti, S Brouwers, G Desideri, V Perrone, K Narkiewicz, G Mancia Source Type: research
NLRP3 Inflammasome Activation Through Heart-Brain Interaction Initiates Cardiac Inflammation and Hypertrophy During Pressure Overload
CONCLUSIONS: Cardiac inflammation and hypertrophy are regulated by heart-brain interaction. Controlling neural signals might be important for the treatment of hypertensive heart disease.PMID:36440584 | DOI:10.1161/CIRCULATIONAHA.122.060860 (Source: Circulation)
Source: Circulation - November 28, 2022 Category: Cardiology Authors: Yasutomi Higashikuni Wenhao Liu Genri Numata Kimie Tanaka Daiju Fukuda Yu Tanaka Yoichiro Hirata Teruhiko Imamura Eiki Takimoto Issei Komuro Masataka Sata Source Type: research
NLRP3 Inflammasome Activation Through Heart-Brain Interaction Initiates Cardiac Inflammation and Hypertrophy During Pressure Overload
CONCLUSIONS: Cardiac inflammation and hypertrophy are regulated by heart-brain interaction. Controlling neural signals might be important for the treatment of hypertensive heart disease.PMID:36440584 | DOI:10.1161/CIRCULATIONAHA.122.060860 (Source: Circulation)
Source: Circulation - November 28, 2022 Category: Cardiology Authors: Yasutomi Higashikuni Wenhao Liu Genri Numata Kimie Tanaka Daiju Fukuda Yu Tanaka Yoichiro Hirata Teruhiko Imamura Eiki Takimoto Issei Komuro Masataka Sata Source Type: research
ECG worth a 'few hundred words
Clinical introduction A 76-year-old Chinese woman presents to the emergency department with recurrent palpitations for 3 months. She has a medical history of diabetes mellitus, hypertension, hyperlipidaemia and minor coronary artery disease. Her palpitations were described as regular, rapid, with gradual onset, lasting up to 30 min on a weekly to fortnightly basis. On admission, there were presyncopal symptoms prompting her presentation. She was previously started on bisoprolol 2.5 mg once a day from another institute though no prior diagnosis or ECG was made or available. An ECG performed by the attending paramedics fortu...
Source: Emergency Medicine Journal - November 22, 2022 Category: Emergency Medicine Authors: Ng, S., Leong, K. M. W., Chia, P.-L. Tags: EMJ Image Challenge Source Type: research
Atraumatic splenic rupture in a patient treated with rivaroxaban: A case report and a narrative review
When a patient on rivaroxaban presents with abdominal tenderness and hemodynamic instability, the clinician should consider ASR in the differential diagnosis. Delayed management can be fatal in such cases. Rivaroxaban should be discontinued, and emergency splenectomy should be performed. ASR has also been reported in dabigatran and apixaban. AbstractAtraumatic splenic rupture (ASR) is a rare condition mostly associated with neoplastic, infectious, and inflammatory diseases. ASR associated with drug treatment is even rarer. In this case report, we highlight an unusual complication of the direct oral anticoagulant rivaroxaba...
Source: Clinical Case Reports - November 4, 2022 Category: General Medicine Authors: Marie ‐Laure Labaki,
Marc De Kock Tags: CASE REPORT Source Type: research
Suboptimal Dosing of β-Blockers in Chronic Heart Failure: A Missed Opportunity?
Background
The evidence base for the benefits of β-blockers in heart failure with reduced ejection fraction (HFrEF) suggests that higher doses are associated with better outcomes.
Objectives
The aim of this study was to report the proportion of patients receiving optimized doses of β-blockers, outcomes, and factors associated with suboptimal dosing.
Methods
This was a prospective cohort study of 390 patients with HFrEF undergoing clinical and echocardiography assessment at baseline and at 1 year.
Results
Two hundred thirty-seven patients (61%) were receiving optimized doses (≥5-mg/d bisoprolol ...
Source: Journal of Cardiovascular Nursing - October 17, 2022 Category: Nursing Tags: ARTICLES: Brief Reports Source Type: research
Ventricular fibrillation immediately after the treatment of Graves ’ disease coexisting with atypical angina and long QT syndrome: a case report
ConclusionsWhen beta-blockers are administered to patients with Graves ’ disease who have severe chest symptoms, fatal arrhythmias are possible. ICD implantation should be considered for the secondary prevention of fatal arrhythmias. (Source: Thyroid Research)
Source: Thyroid Research - October 3, 2022 Category: Endocrinology Source Type: research
Significant Prolongation of the International Normalized Ratio Associated with COVID-19 Treatment: Possible Drug Interaction with Remdesivir
Yakugaku Zasshi. 2022;142(10):1125-1127. doi: 10.1248/yakushi.22-00099.ABSTRACTA 55-year-old man with hypertrophic cardiomyopathy and a pacemaker was admitted with coronavirus disease 2019 (COVID-19). Before admission, the patient's medications included amiodarone, diltiazem, bisoprolol, atorvastatin, etizolam, and warfarin (WF). After admission, dexamethasone (DXM) and remdesivir (RDV) were initiated for treating COVID-19. The international normalized ratio (INR) on admission was 1.8, which increased to 3.4 on day 5 and to 6.9 on day 10 after admission. Although there have been reports that RDV may occasionally prolong pr...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - October 2, 2022 Category: Drugs & Pharmacology Authors: Hidetoshi Ishii Norio Yokota Yuki Bando Katsuya Otori Source Type: research
Significant Prolongation of the International Normalized Ratio Associated with COVID-19 Treatment: Possible Drug Interaction with Remdesivir
Yakugaku Zasshi. 2022;142(10):1125-1127. doi: 10.1248/yakushi.22-00099.ABSTRACTA 55-year-old man with hypertrophic cardiomyopathy and a pacemaker was admitted with coronavirus disease 2019 (COVID-19). Before admission, the patient's medications included amiodarone, diltiazem, bisoprolol, atorvastatin, etizolam, and warfarin (WF). After admission, dexamethasone (DXM) and remdesivir (RDV) were initiated for treating COVID-19. The international normalized ratio (INR) on admission was 1.8, which increased to 3.4 on day 5 and to 6.9 on day 10 after admission. Although there have been reports that RDV may occasionally prolong pr...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - October 2, 2022 Category: Drugs & Pharmacology Authors: Hidetoshi Ishii Norio Yokota Yuki Bando Katsuya Otori Source Type: research
Significant Prolongation of the International Normalized Ratio Associated with COVID-19 Treatment: Possible Drug Interaction with Remdesivir
Yakugaku Zasshi. 2022;142(10):1125-1127. doi: 10.1248/yakushi.22-00099.ABSTRACTA 55-year-old man with hypertrophic cardiomyopathy and a pacemaker was admitted with coronavirus disease 2019 (COVID-19). Before admission, the patient's medications included amiodarone, diltiazem, bisoprolol, atorvastatin, etizolam, and warfarin (WF). After admission, dexamethasone (DXM) and remdesivir (RDV) were initiated for treating COVID-19. The international normalized ratio (INR) on admission was 1.8, which increased to 3.4 on day 5 and to 6.9 on day 10 after admission. Although there have been reports that RDV may occasionally prolong pr...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - October 2, 2022 Category: Drugs & Pharmacology Authors: Hidetoshi Ishii Norio Yokota Yuki Bando Katsuya Otori Source Type: research
Significant Prolongation of the International Normalized Ratio Associated with COVID-19 Treatment: Possible Drug Interaction with Remdesivir
Yakugaku Zasshi. 2022;142(10):1125-1127. doi: 10.1248/yakushi.22-00099.ABSTRACTA 55-year-old man with hypertrophic cardiomyopathy and a pacemaker was admitted with coronavirus disease 2019 (COVID-19). Before admission, the patient's medications included amiodarone, diltiazem, bisoprolol, atorvastatin, etizolam, and warfarin (WF). After admission, dexamethasone (DXM) and remdesivir (RDV) were initiated for treating COVID-19. The international normalized ratio (INR) on admission was 1.8, which increased to 3.4 on day 5 and to 6.9 on day 10 after admission. Although there have been reports that RDV may occasionally prolong pr...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - October 2, 2022 Category: Drugs & Pharmacology Authors: Hidetoshi Ishii Norio Yokota Yuki Bando Katsuya Otori Source Type: research
Significant Prolongation of the International Normalized Ratio Associated with COVID-19 Treatment: Possible Drug Interaction with Remdesivir
Yakugaku Zasshi. 2022;142(10):1125-1127. doi: 10.1248/yakushi.22-00099.ABSTRACTA 55-year-old man with hypertrophic cardiomyopathy and a pacemaker was admitted with coronavirus disease 2019 (COVID-19). Before admission, the patient's medications included amiodarone, diltiazem, bisoprolol, atorvastatin, etizolam, and warfarin (WF). After admission, dexamethasone (DXM) and remdesivir (RDV) were initiated for treating COVID-19. The international normalized ratio (INR) on admission was 1.8, which increased to 3.4 on day 5 and to 6.9 on day 10 after admission. Although there have been reports that RDV may occasionally prolong pr...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - October 2, 2022 Category: Drugs & Pharmacology Authors: Hidetoshi Ishii Norio Yokota Yuki Bando Katsuya Otori Source Type: research
