Exploring the impact of pharmacogenetics on personalized medicine: A systematic review
CONCLUSION: The studies analyzed in this review suggest a strong correlation between genetic variability and individual drug responses, supporting the use of pharmacogenetics for treatment optimization. However, for certain drugs like metformin or quetiapine, the influence of genotype on their response remains unclear. More studies with larger sample sizes, greater ethnic diversity, and consideration of non-genetic factors are needed. The lack of standardization in analysis methods and accessibility to genetic testing are significant challenges in this field. As a conclusion, pharmacogenetics shows immense potential in per...
Source: Farmacia Hospitalaria - February 10, 2024 Category: Drugs & Pharmacology Authors: Laura Amaro- Álvarez Jaime Cordero-Ramos Miguel Ángel Calleja-Hernández Source Type: research
Exploring the impact of pharmacogenetics on personalized medicine: A systematic review
CONCLUSION: The studies analyzed in this review suggest a strong correlation between genetic variability and individual drug responses, supporting the use of pharmacogenetics for treatment optimization. However, for certain drugs like metformin or quetiapine, the influence of genotype on their response remains unclear. More studies with larger sample sizes, greater ethnic diversity, and consideration of non-genetic factors are needed. The lack of standardization in analysis methods and accessibility to genetic testing are significant challenges in this field. As a conclusion, pharmacogenetics shows immense potential in per...
Source: Farmacia Hospitalaria - February 10, 2024 Category: Drugs & Pharmacology Authors: Laura Amaro- Álvarez Jaime Cordero-Ramos Miguel Ángel Calleja-Hernández Source Type: research
Exploring the impact of pharmacogenetics on personalized medicine: A systematic review
CONCLUSION: The studies analyzed in this review suggest a strong correlation between genetic variability and individual drug responses, supporting the use of pharmacogenetics for treatment optimization. However, for certain drugs like metformin or quetiapine, the influence of genotype on their response remains unclear. More studies with larger sample sizes, greater ethnic diversity, and consideration of non-genetic factors are needed. The lack of standardization in analysis methods and accessibility to genetic testing are significant challenges in this field. As a conclusion, pharmacogenetics shows immense potential in per...
Source: Farmacia Hospitalaria - February 10, 2024 Category: Drugs & Pharmacology Authors: Laura Amaro- Álvarez Jaime Cordero-Ramos Miguel Ángel Calleja-Hernández Source Type: research
Exploring the impact of pharmacogenetics on personalized medicine: A systematic review
CONCLUSION: The studies analyzed in this review suggest a strong correlation between genetic variability and individual drug responses, supporting the use of pharmacogenetics for treatment optimization. However, for certain drugs like metformin or quetiapine, the influence of genotype on their response remains unclear. More studies with larger sample sizes, greater ethnic diversity, and consideration of non-genetic factors are needed. The lack of standardization in analysis methods and accessibility to genetic testing are significant challenges in this field. As a conclusion, pharmacogenetics shows immense potential in per...
Source: Farmacia Hospitalaria - February 10, 2024 Category: Drugs & Pharmacology Authors: Laura Amaro- Álvarez Jaime Cordero-Ramos Miguel Ángel Calleja-Hernández Source Type: research
Cu-Co Bimetallic Catalyst-based Electrochemical Sensing Platform for Determination of Bisoprolol in Clinical Samples
CONCLUSION: The presence of Cu metal due to galvanic displacement increased the sensitivity. These findings suggest that the new nanocatalyst has potential applications in sensors and electronics.PMID:38305403 | DOI:10.2174/0113862073270729231106090749 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - February 2, 2024 Category: Chemistry Authors: Mohammad Reza Salemi Shahla Fathi Fereshteh Chekin Banafsheh Norouzi Source Type: research
Management of arrhythmogenic right ventricular cardiomyopathy
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a disease characterised by fibrofatty replacement of the ventricular myocardium due to specific mutations, leading to ventricular arrhythmias and sudden cardiac death. Treating this condition can be challenging due to progressive fibrosis, phenotypic variations and small patient cohorts limiting the feasibility of conducting meaningful clinical trials. Although widely used, the evidence base for anti-arrhythmic drugs is limited. Beta-blockers are theoretically sound, yet their efficacy in reducing arrhythmic risk is not robust. Additionally, the impact of sotalol an...
Source: Heart - January 10, 2024 Category: Cardiology Authors: Al-Aidarous, S., Protonotarios, A., Elliott, P. M., Lambiase, P. D. Tags: Review articles Reviews Source Type: research
Bisoprolol/olanzapine/venlafaxine
(Source: Reactions Weekly)
Source: Reactions Weekly - January 1, 2024 Category: Drugs & Pharmacology Source Type: research
Metastatic nodular melanoma developing on nevus spilus during intake of beta blockers (bisoprolol/nebivolol) and ace inhibitors (perindopril). potential links t О the drug related nitrosogenesis/carcinogenesis, dunning-kruger effect and genetic weapons of the new generation
We report systemically administered drugs for the treatment of high blood pressure from the group of beta blockers (bisoprolol/nebivolol) and ACE inhibitors (perindopril) that have been identified by regulators in the face of FDA as hypothetically contaminated with nitrosamines/NDSRIs with a carcinogenic potency between 4 and 5, respectively. Within this cumulative intake, (which according to the regulators was not at risk of developing cancerous forms), similar to other cases in the world literature, the patient developed a relatively short-term, metastatic nevus spilus-based nodular melanoma. The paper analyses not only ...
Source: Cancer Control - December 14, 2023 Category: Cancer & Oncology Authors: G Tchernev Source Type: research
Assessing the hypolipidemic and gastro-liver protective activity of herbal combination with emphasis on PPI amid selected multiple antihypertensive drug combination in experimental animal models
CONCLUSIONS: CThis investigation reported that antihypertensive drugs did not produce gastrointestinal (GI) toxicity, and the morphological structure of the organ was not changed. So, it could be concluded that the herbal combination used in this experiment has a promising role in controlling lipid profile, liver function, and antiulcer effects. Moreover, multiple drug therapy for hypertension does not cause any harm to the stomach. Further investigations might be carried out on a larger scale to make these statements more valid.PMID:38039033 | DOI:10.26355/eurrev_202311_34471 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - December 1, 2023 Category: Drugs & Pharmacology Authors: R P Monisa A K Azad I Rahma J T Israt A Shopnil A K Ayaz U H Taqweem T Aziz A Metab H A Thamer F A Abdullah Source Type: research
Assessing the hypolipidemic and gastro-liver protective activity of herbal combination with emphasis on PPI amid selected multiple antihypertensive drug combination in experimental animal models
CONCLUSIONS: CThis investigation reported that antihypertensive drugs did not produce gastrointestinal (GI) toxicity, and the morphological structure of the organ was not changed. So, it could be concluded that the herbal combination used in this experiment has a promising role in controlling lipid profile, liver function, and antiulcer effects. Moreover, multiple drug therapy for hypertension does not cause any harm to the stomach. Further investigations might be carried out on a larger scale to make these statements more valid.PMID:38039033 | DOI:10.26355/eurrev_202311_34471 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - December 1, 2023 Category: Drugs & Pharmacology Authors: R P Monisa A K Azad I Rahma J T Israt A Shopnil A K Ayaz U H Taqweem T Aziz A Metab H A Thamer F A Abdullah Source Type: research
Assessing the hypolipidemic and gastro-liver protective activity of herbal combination with emphasis on PPI amid selected multiple antihypertensive drug combination in experimental animal models
CONCLUSIONS: CThis investigation reported that antihypertensive drugs did not produce gastrointestinal (GI) toxicity, and the morphological structure of the organ was not changed. So, it could be concluded that the herbal combination used in this experiment has a promising role in controlling lipid profile, liver function, and antiulcer effects. Moreover, multiple drug therapy for hypertension does not cause any harm to the stomach. Further investigations might be carried out on a larger scale to make these statements more valid.PMID:38039033 | DOI:10.26355/eurrev_202311_34471 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - December 1, 2023 Category: Drugs & Pharmacology Authors: R P Monisa A K Azad I Rahma J T Israt A Shopnil A K Ayaz U H Taqweem T Aziz A Metab H A Thamer F A Abdullah Source Type: research
Assessing the hypolipidemic and gastro-liver protective activity of herbal combination with emphasis on PPI amid selected multiple antihypertensive drug combination in experimental animal models
CONCLUSIONS: CThis investigation reported that antihypertensive drugs did not produce gastrointestinal (GI) toxicity, and the morphological structure of the organ was not changed. So, it could be concluded that the herbal combination used in this experiment has a promising role in controlling lipid profile, liver function, and antiulcer effects. Moreover, multiple drug therapy for hypertension does not cause any harm to the stomach. Further investigations might be carried out on a larger scale to make these statements more valid.PMID:38039033 | DOI:10.26355/eurrev_202311_34471 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - December 1, 2023 Category: Drugs & Pharmacology Authors: R P Monisa A K Azad I Rahma J T Israt A Shopnil A K Ayaz U H Taqweem T Aziz A Metab H A Thamer F A Abdullah Source Type: research
Assessing the hypolipidemic and gastro-liver protective activity of herbal combination with emphasis on PPI amid selected multiple antihypertensive drug combination in experimental animal models
CONCLUSIONS: CThis investigation reported that antihypertensive drugs did not produce gastrointestinal (GI) toxicity, and the morphological structure of the organ was not changed. So, it could be concluded that the herbal combination used in this experiment has a promising role in controlling lipid profile, liver function, and antiulcer effects. Moreover, multiple drug therapy for hypertension does not cause any harm to the stomach. Further investigations might be carried out on a larger scale to make these statements more valid.PMID:38039033 | DOI:10.26355/eurrev_202311_34471 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - December 1, 2023 Category: Drugs & Pharmacology Authors: R P Monisa A K Azad I Rahma J T Israt A Shopnil A K Ayaz U H Taqweem T Aziz A Metab H A Thamer F A Abdullah Source Type: research
Assessing the hypolipidemic and gastro-liver protective activity of herbal combination with emphasis on PPI amid selected multiple antihypertensive drug combination in experimental animal models
CONCLUSIONS: CThis investigation reported that antihypertensive drugs did not produce gastrointestinal (GI) toxicity, and the morphological structure of the organ was not changed. So, it could be concluded that the herbal combination used in this experiment has a promising role in controlling lipid profile, liver function, and antiulcer effects. Moreover, multiple drug therapy for hypertension does not cause any harm to the stomach. Further investigations might be carried out on a larger scale to make these statements more valid.PMID:38039033 | DOI:10.26355/eurrev_202311_34471 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - December 1, 2023 Category: Drugs & Pharmacology Authors: R P Monisa A K Azad I Rahma J T Israt A Shopnil A K Ayaz U H Taqweem T Aziz A Metab H A Thamer F A Abdullah Source Type: research
Assessing the hypolipidemic and gastro-liver protective activity of herbal combination with emphasis on PPI amid selected multiple antihypertensive drug combination in experimental animal models
CONCLUSIONS: CThis investigation reported that antihypertensive drugs did not produce gastrointestinal (GI) toxicity, and the morphological structure of the organ was not changed. So, it could be concluded that the herbal combination used in this experiment has a promising role in controlling lipid profile, liver function, and antiulcer effects. Moreover, multiple drug therapy for hypertension does not cause any harm to the stomach. Further investigations might be carried out on a larger scale to make these statements more valid.PMID:38039033 | DOI:10.26355/eurrev_202311_34471 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - December 1, 2023 Category: Drugs & Pharmacology Authors: R P Monisa A K Azad I Rahma J T Israt A Shopnil A K Ayaz U H Taqweem T Aziz A Metab H A Thamer F A Abdullah Source Type: research
