A novel nano-formulation of olmesartan medoxomil with improved delivery and efficacy in the treatment of indomethacin-induced duodenitis in rats
This study was designed to investigate the effects of a recently developed biotechnological product, a nano-formulation of olmesartan medoxomil (OM) - olmesartan medoxomil zeinmersomes (OMZ) - for the treatment of indomethacin-induced duodenitis in rats. Adult male Wistar rats were given indomethacin (10 mg/kg/day) for four weeks. They were divided into a positive control group (PC, untreated) and two groups treated orally with 3 mg/kg per day of OM or OMZ for the last two weeks of the 4-week indomethacin-treatment. At end of the four weeks, blood and duodenum were collected. Duodenal homogenate was used for measurement of...
Source: Brazilian Journal of Medical and Biological Research - May 31, 2023 Category: Research Authors: H A Murad T M Alqurashi Source Type: research
A novel nano-formulation of olmesartan medoxomil with improved delivery and efficacy in the treatment of indomethacin-induced duodenitis in rats
This study was designed to investigate the effects of a recently developed biotechnological product, a nano-formulation of olmesartan medoxomil (OM) - olmesartan medoxomil zeinmersomes (OMZ) - for the treatment of indomethacin-induced duodenitis in rats. Adult male Wistar rats were given indomethacin (10 mg/kg/day) for four weeks. They were divided into a positive control group (PC, untreated) and two groups treated orally with 3 mg/kg per day of OM or OMZ for the last two weeks of the 4-week indomethacin-treatment. At end of the four weeks, blood and duodenum were collected. Duodenal homogenate was used for measurement of...
Source: Braz J Med Biol Res - May 31, 2023 Category: Research Authors: H A Murad T M Alqurashi Source Type: research
A novel nano-formulation of olmesartan medoxomil with improved delivery and efficacy in the treatment of indomethacin-induced duodenitis in rats
This study was designed to investigate the effects of a recently developed biotechnological product, a nano-formulation of olmesartan medoxomil (OM) - olmesartan medoxomil zeinmersomes (OMZ) - for the treatment of indomethacin-induced duodenitis in rats. Adult male Wistar rats were given indomethacin (10 mg/kg/day) for four weeks. They were divided into a positive control group (PC, untreated) and two groups treated orally with 3 mg/kg per day of OM or OMZ for the last two weeks of the 4-week indomethacin-treatment. At end of the four weeks, blood and duodenum were collected. Duodenal homogenate was used for measurement of...
Source: Brazilian Journal of Medical and Biological Research - May 31, 2023 Category: Research Authors: H A Murad T M Alqurashi Source Type: research
Amlodipine/olmesartan-medoxomil/rosuvastatin
(Source: Reactions Weekly)
Source: Reactions Weekly - February 1, 2023 Category: Drugs & Pharmacology Source Type: research
Olmesartan Ameliorates Organ Injury and Mortality in Rats With Peritonitis-Induced Sepsis
Sepsis and related complications lead to high morbidity and mortality in humans and animals. Olmesartan medoxomil (OLM), a nonpeptide angiotensin II type 1 receptor blocker, has antiinflammatory and antioxidative effects in various experimental animal models. The present study aimed to investigate whether OLM protects against sepsis in a clinically relevant model of polymicrobial sepsis induced by cecal ligation and puncture (CLP). (Source: Journal of Surgical Research)
Source: Journal of Surgical Research - July 19, 2022 Category: Surgery Authors: Hsin-Jung Tsai, Chih-Feng Chian, Chih-Chin Shih, Shiu-Jen Chen, Wen-Jinn Liaw, Hsieh-Chou Huang, Cheng-Ming Tsao, Chin-Chen Wu Tags: Acute Care Surgery Source Type: research
Olmesartan medoxomil self-microemulsifying drug delivery system reverses apoptosis and improves cell adhesion in trinitrobenzene sulfonic acid-induced colitis in rats
In conclusion, OMS could be a potential additive treatment for Crohn's disease colitis.PMID:35766160 | PMC:PMC9246205 | DOI:10.1080/10717544.2022.2086939 (Source: Drug Delivery)
Source: Drug Delivery - June 29, 2022 Category: Drugs & Pharmacology Authors: Hussam Murad Osama Ahmed Thamer Alqurashi Mostafa Hussien Source Type: research
Olmesartan medoxomil self-microemulsifying drug delivery system reverses apoptosis and improves cell adhesion in trinitrobenzene sulfonic acid-induced colitis in rats
In conclusion, OMS could be a potential additive treatment for Crohn's disease colitis.PMID:35766160 | DOI:10.1080/10717544.2022.2086939 (Source: Drug Delivery)
Source: Drug Delivery - June 29, 2022 Category: Drugs & Pharmacology Authors: Hussam Murad Osama Ahmed Thamer Alqurashi Mostafa Hussien Source Type: research
Role of olmesartan in ameliorating diabetic nephropathy in rats by targeting the AGE/PKC, TLR4/P38-MAPK and SIRT-1 autophagic signaling pathways
This study shows that OM has a reno-protective effect against DN in rats by inhibiting the AGE/PKC, TLR4/P38-MAPK, and SIRT-1 autophagic signaling pathways.PMID:35752350 | DOI:10.1016/j.ejphar.2022.175117 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - June 25, 2022 Category: Drugs & Pharmacology Authors: Nesma M E Abo El-Nasr Dalia O Saleh Ingy M Hashad Source Type: research
Role of olmesartan in ameliorating diabetic nephropathy in rats by targeting the AGE/PKC, TLR4/P38-MAPK and SIRT-1 autophagic signaling pathways
This study shows that OM has a reno-protective effect against DN in rats by inhibiting the AGE/PKC, TLR4/P38-MAPK, and SIRT-1 autophagic signaling pathways.PMID:35752350 | DOI:10.1016/j.ejphar.2022.175117 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - June 25, 2022 Category: Drugs & Pharmacology Authors: Nesma M E Abo El-Nasr Dalia O Saleh Ingy M Hashad Source Type: research
Chemometric Assisted Spectrophotometric Method for the Simultaneous Determination of Olmesartan Medoxomil and Hydrochlorothiazide in Bulk and Tablet Dosage Form
Binny Mehta*, H. Joshi, U. Shah and P. Patel (Source: Indian Journal of Pharmaceutical Sciences)
Source: Indian Journal of Pharmaceutical Sciences - June 18, 2022 Category: Drugs & Pharmacology Source Type: research
Effects of α lipoic acid combined with olmesartan medoxomil on blood glucose and oxidation indicators in patients with diabetic nephropathy: A protocol for a parallel, randomized, double-blind, controlled clinical trial
This study will evaluate the effects of α lipoic acid combined with olmesartan medoxomil on blood glucose and oxidation indicators in patients with DN. The results of this study will provide a reference for the clinical use of α lipoic acid combined with olmesartan medoxomil in the treatment of DN.
Trial registration:
OSF Registration number: DOI 10.17605/OSF.IO/VJWXS (Source: Medicine)
Source: Medicine - April 29, 2022 Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research
“Ghost peaks” of olmesartan medoxomil: Two solution degradation products of olmesartan medoxomil via oxidation mediated by metal ions
AbstractTwo unknown solution degradants were found during the dissolution testing in 0.1-M HCl for olmesartan medoxomil (OLM) tablets. The structure of the degradants was identified and characterized by liquid chromatography –ultraviolet (LC–UV), liquid chromatography with tandem mass spectrometry (LC–MS/MS), and nuclear magnetic resonance (NMR) and demonstrated to be cyclization of tetrazole and benzene in the olmesartan (OL) and OLM structures. A series of studies including stress studies, simulation studies, an d mechanism-based studies were performed to reveal the potential mechanisms that lead to the formation o...
Source: Journal of Mass Spectrometry - March 29, 2022 Category: Chemistry Authors: Minxia Huang,
Beiyang Yao,
Manhua Jiang,
Fuzhou Sun,
Jinsong You,
Fangfang Huang,
Yanping Zhao,
Shuming Wu,
Xinqian He,
Xuezhi Song Tags: RESEARCH ARTICLE Source Type: research
Pharmacokinetics and Bioequivalence Evaluation of 2 Olmesartan Medoxomil and Amlodipine Besylate Fixed ‐Dose Combination Tablets in Healthy Chinese Volunteers Under Fasting and Fed Conditions
AbstractCombined antihypertensive drugs have become the basic method of treating hypertension. Olmesartan and amlodipine, as representative drugs of angiotensin receptor blockers and calcium channel blockers, were developed as a compound formulation for antihypertensive treatment. The purpose of this study was to evaluate the bioequivalence of olmesartan medoxomil/amlodipine besylate tablet (20 mg/5 mg) under fasting and fed conditions in healthy Chinese volunteers. A phase 1 randomized, open-label, 2-period, single-dose crossover study (n = 56) was designed, with subjects under fasting (n = 28) or fed (n = 28) co...
Source: Clinical Pharmacology in Drug Development - March 16, 2022 Category: Drugs & Pharmacology Authors: Xinjing Li,
Enpan Mo,
Lin Chen Tags: Original Article Source Type: research
“Ghost peaks” of Olmesartan Medoxomil: Two Solution Degradation Products of Olmesartan Medoxomil via Oxidation Mediated by Metal Ions
AbstractTwo unknown degradations were found in the analytical solution of Olmesartan Medoxomil in 0.1 N HCl dissolution medium. The degradations could be observed when analytical solution in contact with materials such as aluminum foil, medicinal spoon and HPLC injection needle and all above contained metal elements. The unknown degradations would be found and increased with time also when the solution was stored in glass HPLC vials. By Agilent LC-DAD-Q-TOF MS, they were identified as oxidative degradation products, the molecular formula of ghost peak I was C24H24N6O3, and the ghost peak II was C29H28N6O6. Through ICP-MS c...
Source: Journal of Mass Spectrometry - March 14, 2022 Category: Chemistry Authors: Minxia Huang,
Beiyang Yao,
Manhua Jiang,
Fuzhou Sun,
Jinsong You,
Fangfang Huang,
Gugu Hao,
Shuming Wu,
Zhongqing Wang,
Xinqian He,
Xue Zhi Song Tags: RESEARCH ARTICLE Source Type: research
