Olmesartan Ameliorates Organ Injury and Mortality in Rats With Peritonitis-Induced Sepsis

Sepsis and related complications lead to high morbidity and mortality in humans and animals. Olmesartan medoxomil (OLM), a nonpeptide angiotensin II type 1 receptor blocker, has antiinflammatory and antioxidative effects in various experimental animal models. The present study aimed to investigate whether OLM protects against sepsis in a clinically relevant model of polymicrobial sepsis induced by cecal ligation and puncture (CLP).

Source: Journal of Surgical Research - July 19, 2022 Category: Surgery Authors: Hsin-Jung Tsai, Chih-Feng Chian, Chih-Chin Shih, Shiu-Jen Chen, Wen-Jinn Liaw, Hsieh-Chou Huang, Cheng-Ming Tsao, Chin-Chen Wu Tags: Acute Care Surgery Source Type: research