Olmesartan medoxomil
(Source: Reactions Weekly)
Source: Reactions Weekly - June 30, 2020 Category: Drugs & Pharmacology Source Type: research
Drugs for Hypertension
Date: May 18, 2020
Issue #:
1598Summary:
Drugs available for treatment of chronic hypertension
and their dosages, adverse effects, and costs are
listed in the tables. Treatment
of hypertensive urgencies and emergencies is not
discussed here. (Source: The Medical Letter)
Source: The Medical Letter - April 29, 2020 Category: Drugs & Pharmacology Authors: admin Tags: Accupril Accuretic ACE inhibitors Acebutolol Adalat Aldactone aliskiren Altace Amiloride Amlodipine ARBs Atacand Atenolol Avalide Avapro azilsartan benazapril Benicar Beta blockers Betaxolol Bisoprolol Bumetanide Source Type: research
Formulation of lyophilized oily-core poly- Ɛ-caprolactone nanocapsules to improve oral bioavailability of Olmesartan Medoxomil.
Conclusion: It is concluded that formulation of lyophilized ONC for OM can significantly enhance its oral bioavailability and consequently, its therapeutic efficacy and patient compliance.
PMID: 32275456 [PubMed - as supplied by publisher] (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - April 12, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
How to deal with the occurrence of rare drug-induced adverse events: the example of sprue-like enteropathy induced by olmesartan medoxomil and other angiotensin-receptor blockers.
Authors: Burnier M, Kjeldsen SE, Narkiewicz K, Oparil S
PMID: 32049554 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - February 13, 2020 Category: Hematology Tags: Blood Press Source Type: research
Severe intoxication caused by sodium-glucose cotransporter 2 inhibitor overdose: a case report.
CONCLUSIONS: Our case showed that an overdose of an SGLT2 inhibitor caused toxic effects on renal function, but severe hypoglycemia was not observed. Additional cases of intoxication from SGLT2 inhibitors alone would be helpful to clarify the mechanism of intoxication.
PMID: 31918741 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - January 11, 2020 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research
Method Validation for Simultaneous Quantification of Olmesartan and Hydrochlorothiazide in Human Plasma Using LC-MS/MS and Its Application Through Bioequivalence Study in Healthy Volunteers
A new, simple, sensitive, selective, rapid and high throughput liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed and validated for simultaneous quantification of Olmesartan and Hydrochlorothiazide in human plasma. Simple liquid–liquid extraction procedure was applied for plasma sample pretreatment using a mixture of diethyl ether and dichloromethane, as an extraction solution. Analytes were separated on Unisol C18 150*4.6 mm, 5 µm column using methanol and 2 mM ammonium acetate pH 5.5 (80:20, v/v) as a mobile phase and detected by electrospray ionization in the multiple reaction monitor...
Source: Frontiers in Pharmacology - July 22, 2019 Category: Drugs & Pharmacology Source Type: research
In vitro and in vivo evaluation of Olmesartan Medoxomil microcrystals and nanocrystals: Preparation, characterization, and pharmacokinetic comparison in Beagle Dogs.
Conclusion：Particles size reduction to nano-scale by means of nanocrystals technology significantly increased in vitro dissolution rate and in vivo oral bioavailability of OLM.
PMID: 31244438 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - June 26, 2019 Category: Drugs & Pharmacology Authors: Chai R, Gao H, Ma Z, Guo M, Fu Q, Liu H, He Z Tags: Curr Drug Deliv Source Type: research
Design and development of a self-microemulsifying drug delivery system of Olmesartan Medoxomil for enhanced bioavailability.
Authors: Komesli Y, Ozkaya AB, Ergur BU, Kirilmaz L, Karasulu E
Abstract
Olmesartan Medoxomil (OM) is a hydrophobic antihypertensive drug with low bioavailability (26%) and is known to have adverse effects such as celiac disease and enteropathy. The purpose of this study was to develop SMEDDS to increase bioavailability and decrease potential side effects of OM. Hydrophilic lipophilic balance was calculated by testing solubility of OM in different oils, surfactants and cosurfactants to obtain the most suitable combination of SMEDDS. Pseudoternary phase diagram was used to select the better oil/water formul...
Source: Drug Development and Industrial Pharmacy - April 17, 2019 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
Olmesartan medoxomil
(Source: Reactions Weekly)
Source: Reactions Weekly - February 1, 2019 Category: Drugs & Pharmacology Source Type: research
Effect of block sequence of hyperbranched block copolymers on the aggregation behavior, drug solubilization and release property
Publication date: Available online 15 January 2019Source: Journal of Molecular LiquidsAuthor(s): Yutao Xue, Jie Sun, Shan Xiong, Huining Chai, Xia Xin, Guiying Xu, Teng LiuAbstractTwo hyperbranched block copolymers H904 and H90R4 which were the same in chemical composition but different in block sequence were synthesized by anionic polymerization. Commercially X shaped Tetronic block copolymers T904 and T90R4 were selected for comparison. The effect of block sequence on the aggregation behaviors of these four copolymers were studied by surface tension, transmission electron microscopy, steady-state fluorescence and dynamic...
Source: Journal of Molecular Liquids - January 15, 2019 Category: Molecular Biology Source Type: research
Inhibition of Co-Crystallization of Olmesartan Medoxomil and Hydrochlorothiazide for Enhanced Dissolution Rate in Their Fixed Dose Combination.
This study investigated the possibility of this interaction during co-processing. The research was extended to inhibit deleterious interactions. The drugs were co-evaporated from ethanolic solution to maximize the chance of interaction. This was performed in the absence and presence of hydroxypropyl methylcellulose (HPMC) and/or aerosil. The products were characterized using Fourier transform infrared spectroscopy (FTIR), differential thermal analysis, and powder X-ray diffraction (PXRD) in addition to dissolution studies. Co-evaporation of Olm with HCTZ in the absence of excipients produced crystalline material with FTIR ...
Source: AAPS PharmSciTech - December 17, 2018 Category: Drugs & Pharmacology Authors: Abdelquader MM, Essa EA, El Maghraby GM Tags: AAPS PharmSciTech Source Type: research
Nanocolloidal lipidic carriers of olmesartan medoxomil surface-tailored with Concavalin-A for lectin receptor targeting
Nanomedicine, Ahead of Print. (Source: Nanomedicine)
Source: Nanomedicine - November 26, 2018 Category: Nanotechnology Authors: Sarwar Beg Hani Choudhry Mazin A Zamzami Khalid S Alharbi Mahfoozur Rahman Bhupinder Singh Source Type: research
Nanocolloidal lipidic carriers of olmesartan medoxomil surface-tailored with Concavalin-A for lectin receptor targeting
Nanomedicine, Ahead of Print. (Source: Future Medicine: Nanomedicine)
Source: Future Medicine: Nanomedicine - November 26, 2018 Category: Nanotechnology Authors: Sarwar Beg Hani Choudhry Mazin A Zamzami Khalid S Alharbi Mahfoozur Rahman Bhupinder Singh Source Type: research
Characterization of the binding and conformational changes of bovine serum albumin upon interaction with antihypertensive olmesartan medoxomil
Publication date: Available online 1 November 2018Source: Journal of Molecular StructureAuthor(s): Atmanand M. Bagoji, Arunkumar T. Buddanavar, Naveen M. Gokavi, Sharanappa T. NandibewoorAbstractThe interaction of bovine serum albumin (BSA) with the olmesartan medoxomil (OLM) was investigated by different spectroscopic and linear sweep voltammetric techniques under experimentally optimised physiological conditions. The alteration of functional properties of BSA when quenched by OLM was illustrated by the continuous decrease of the fluorescence intensity of BSA upon addition of OLM. The quenching constants (Ksv) obtained we...
Source: Journal of Molecular Structure - November 6, 2018 Category: Molecular Biology Source Type: research
Olmesartan medoxomil
(Source: Reactions Weekly)
Source: Reactions Weekly - November 1, 2018 Category: Drugs & Pharmacology Source Type: research
