In vitro and in vivo evaluation of Olmesartan Medoxomil microcrystals and nanocrystals: Preparation, characterization, and pharmacokinetic comparison in Beagle Dogs.

Conclusion：Particles size reduction to nano-scale by means of nanocrystals technology significantly increased in vitro dissolution rate and in vivo oral bioavailability of OLM.
PMID: 31244438 [PubMed - as supplied by publisher]

Source: Current Drug Delivery - June 26, 2019 Category: Drugs & Pharmacology Authors: Chai R, Gao H, Ma Z, Guo M, Fu Q, Liu H, He Z Tags: Curr Drug Deliv Source Type: research