Adenoid cystic carcinoma of Bartholin's gland, a case report with genomic data and literature review
We reported the case of a 31-year-old woman who was treated by local excision and then hemi-vulvectomy, with positive margins and perineural invasion. Radiation therapy (RT) was then performed delivering 45Gy in 25 fractions in bilateral inguinal lymph nodes and 64.8Gy in 36 fractions on the vulvar area. After 30 months, there was no local relapse (LR) but the patient presented a histologically documented lung recurrence. Genomic profiling of the tumor showed a MYB-NFIB fusion transcript and a somatic mutation of PLCG1. A treatment by Lenvatinib was started. We conducted a literature review of 100 published cases. Patients...
Source: Cancer Radiotherapie - February 9, 2023 Category: Cancer & Oncology Authors: C Evin P-A Just B Borghese E Fabiano S Bennani E Canny L Marisa N Derive P Laurent-Puig J Alexandre C Durdux Source Type: research
Adenoid cystic carcinoma of Bartholin's gland, a case report with genomic data and literature review
We reported the case of a 31-year-old woman who was treated by local excision and then hemi-vulvectomy, with positive margins and perineural invasion. Radiation therapy (RT) was then performed delivering 45Gy in 25 fractions in bilateral inguinal lymph nodes and 64.8Gy in 36 fractions on the vulvar area. After 30 months, there was no local relapse (LR) but the patient presented a histologically documented lung recurrence. Genomic profiling of the tumor showed a MYB-NFIB fusion transcript and a somatic mutation of PLCG1. A treatment by Lenvatinib was started. We conducted a literature review of 100 published cases. Patients...
Source: Cancer Radiotherapie - February 9, 2023 Category: Cancer & Oncology Authors: C Evin P-A Just B Borghese E Fabiano S Bennani E Canny L Marisa N Derive P Laurent-Puig J Alexandre C Durdux Source Type: research
Challenges in management of Bartholin gland leiomyoma: A case report
Bartholin gland neoplasms are rare tumors, commonly misdiagnosed as Bartholin's cysts. Excision is the treatment of choice. Short time follow-up allows prompt management of potential postoperative complications. Continuing long-term follow-up is recommended due to recurrence risk. AbstractLeiomyomas are uncommon vulvar neoplasms often misdiagnosed as other Bartholin gland pathology. This case report describes a case of accelerating growth of a vulvar mass, initially diagnosed as Bartholin cyst. Surgical excision led to a histopathologic diagnosis of vulvar leiomyoma. The postoperative recovery was complicated by secondary ...
Source: Clinical Case Reports - January 28, 2023 Category: General Medicine Authors: Angela Elena Vinturache,
Lamiese Ismail,
Stephen Damato,
Hooman Soleymani Maid Tags: CASE REPORT Source Type: research
Prophylactic oophorectomy and aromatase inhibitors for premenopausal deep angiomyxoma: A case report and literature review
In conclusion, prophylactic oophorectomy and postoperative adjuvant therapy with aromatase inhibitors may be a promising treatment option for deep angiomyxoma to optimize the outcome of surgical treatment. Long-term follow-up is required to monitor for the late and/or local recurrence of deep angiomyxoma and possible adverse effects of adjuvant hormonal therapy.PMID:36561620 | PMC:PMC9748652 | DOI:10.3892/etm.2022.11702 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - December 23, 2022 Category: General Medicine Authors: Nobutomo Tonai Kaei Nasu Mitsutake Yano Miho Sato Kentaro Kai Masakazu Nishida Yasushi Kawano Source Type: research
TGF- β1 Regulates Peroxisomal Genes/Proteins via Smad Signaling in Idiopathic Pulmonary Fibrosis Fibroblasts and Transgenic Mouse Models
Am J Pathol. 2022 Dec 12:S0002-9440(22)00392-3. doi: 10.1016/j.ajpath.2022.11.006. Online ahead of print.NO ABSTRACTPMID:36521562 | DOI:10.1016/j.ajpath.2022.11.006 (Source: Am J Pathol)
Source: Am J Pathol - December 15, 2022 Category: Pathology Authors: Gani Oruqaj Srikanth Karnati Lakshmi Kanth Kotarkonda Eistine Boateng Marek Bartkuhn Wenming Zhang Clemens Ruppert Andreas G ünther Laurent Bartholin Wei Shi Eveline Baumgart-Vogt Source Type: research
TGF- β1 Regulates Peroxisomal Genes/Proteins via Smad Signaling in Idiopathic Pulmonary Fibrosis Fibroblasts and Transgenic Mouse Models
Am J Pathol. 2022 Dec 12:S0002-9440(22)00392-3. doi: 10.1016/j.ajpath.2022.11.006. Online ahead of print.NO ABSTRACTPMID:36521562 | DOI:10.1016/j.ajpath.2022.11.006 (Source: The American Journal of Pathology)
Source: The American Journal of Pathology - December 15, 2022 Category: Pathology Authors: Gani Oruqaj Srikanth Karnati Lakshmi Kanth Kotarkonda Eistine Boateng Marek Bartkuhn Wenming Zhang Clemens Ruppert Andreas G ünther Laurent Bartholin Wei Shi Eveline Baumgart-Vogt Source Type: research
TGF- β1 Regulates Peroxisomal Genes/Proteins via Smad Signaling in Idiopathic Pulmonary Fibrosis Fibroblasts and Transgenic Mouse Models
Am J Pathol. 2022 Dec 12:S0002-9440(22)00392-3. doi: 10.1016/j.ajpath.2022.11.006. Online ahead of print.NO ABSTRACTPMID:36521562 | DOI:10.1016/j.ajpath.2022.11.006 (Source: Am J Pathol)
Source: Am J Pathol - December 15, 2022 Category: Pathology Authors: Gani Oruqaj Srikanth Karnati Lakshmi Kanth Kotarkonda Eistine Boateng Marek Bartkuhn Wenming Zhang Clemens Ruppert Andreas G ünther Laurent Bartholin Wei Shi Eveline Baumgart-Vogt Source Type: research
TGF- β1 Regulates Peroxisomal Genes/Proteins via Smad Signaling in Idiopathic Pulmonary Fibrosis Fibroblasts and Transgenic Mouse Models
Am J Pathol. 2022 Dec 12:S0002-9440(22)00392-3. doi: 10.1016/j.ajpath.2022.11.006. Online ahead of print.NO ABSTRACTPMID:36521562 | DOI:10.1016/j.ajpath.2022.11.006 (Source: The American Journal of Pathology)
Source: The American Journal of Pathology - December 15, 2022 Category: Pathology Authors: Gani Oruqaj Srikanth Karnati Lakshmi Kanth Kotarkonda Eistine Boateng Marek Bartkuhn Wenming Zhang Clemens Ruppert Andreas G ünther Laurent Bartholin Wei Shi Eveline Baumgart-Vogt Source Type: research
Transforming Growth Factor- β1 Regulates Peroxisomal Genes/Proteins via Smad Signaling in Idiopathic Pulmonary Fibrosis Fibroblasts and Transgenic Mouse Models
Idiopathic pulmonary fibrosis (IPF) is a chronic human disease with persistent destruction of lung parenchyma. A pivotal role in the initiation and pathogenesis of IPF is played by transforming growth factor (TGF)- β1 signaling. As shown herein, TGF-β1 signaling down-regulates not only peroxisome biogenesis but also the metabolism of these organelles in human IPF fibroblasts. In accordance with the in vitro cell culture observations in human fibroblasts and human lung tissue, peroxisomal biogenesis and meta bolic proteins were significantly down-regulated in the lung of 1-month–old transgenic mice expressing a constit...
Source: American Journal of Pathology - December 12, 2022 Category: Pathology Authors: Gani Oruqaj, Srikanth Karnati, Lakshmi Kanth Kotarkonda, Eistine Boateng, Marek Bartkuhn, Wenming Zhang, Clemens Ruppert, Andreas G ünther, Laurent Bartholin, Wei Shi, Eveline Baumgart-Vogt Tags: Regular article Source Type: research
TGF- β1 Regulates Peroxisomal Genes/Proteins via Smad Signaling in Idiopathic Pulmonary Fibrosis Fibroblasts and Transgenic Mouse Models
Idiopathic pulmonary fibrosis (IPF) is a chronic human disease with persistent destruction of lung parenchyma. A pivotal role in the initiation and pathogenesis of IPF plays the TGF- β1 signaling. As shown here, TGF-β1 signaling downregulates not only peroxisome biogenesis but also the metabolism of these organelles in human IPF fibroblasts. In accordance with the in vitro cell culture observations in human fibroblasts and human lung tissue, peroxisomal biogenesis and metaboli c proteins were significantly downregulated in the lung of one-month-old transgenic mice expressing a constitutively active TGF-β type I receptor...
Source: American Journal of Pathology - December 12, 2022 Category: Pathology Authors: Gani Oruqaj, Srikanth Karnati, Lakshmi Kanth Kotarkonda, Eistine Boateng, Marek Bartkuhn, Wenming Zhang, Clemens Ruppert, Andreas G ünther, Laurent Bartholin, Wei Shi, Eveline Baumgart-Vogt Tags: Regular Article Source Type: research
Management of Bartholin's cyst and abscess
(Source: The Obstetrician and Gynaecologist)
Source: The Obstetrician and Gynaecologist - November 28, 2022 Category: OBGYN Authors: Ayesha Bati ‐Paracha,
Mona Sharma Tags: Tips and Techniques Source Type: research
A Single Institution Cadaveric Study on Anatomical Variation of the Sublingual Gland Duct
This study is carried out by standardized dissection of anterior floor of mouth in 6 formalin-fixed adult cadavers in Silent Mentor Workshop University Malaya in August 2020. The cadavers had no trace of scars, adhesions, signs of trauma or operation. SMG duct opening was identified lateral to the lingual frenulum through a papilla in the floor of mouth behind the lower incisor tooth. A horizontal incision line was done over floor of mouth just lateral to the opening. SMG duct and SLG was traced and skeletonized. Any presence of major duct arising from the SLG and its communication with SMG duct were investigated. We found...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - November 7, 2022 Category: ENT & OMF Source Type: research
