Transforming Growth Factor- β1 Regulates Peroxisomal Genes/Proteins via Smad Signaling in Idiopathic Pulmonary Fibrosis Fibroblasts and Transgenic Mouse Models

Idiopathic pulmonary fibrosis (IPF) is a chronic human disease with persistent destruction of lung parenchyma. A pivotal role in the initiation and pathogenesis of IPF is played by transforming growth factor (TGF)- β1 signaling. As shown herein, TGF-β1 signaling down-regulates not only peroxisome biogenesis but also the metabolism of these organelles in human IPF fibroblasts. In accordance with the in vitro cell culture observations in human fibroblasts and human lung tissue, peroxisomal biogenesis and meta bolic proteins were significantly down-regulated in the lung of 1-month–old transgenic mice expressing a constitutively active TGF-β type I receptor (ALK5).

Source: American Journal of Pathology - December 12, 2022 Category: Pathology Authors: Gani Oruqaj, Srikanth Karnati, Lakshmi Kanth Kotarkonda, Eistine Boateng, Marek Bartkuhn, Wenming Zhang, Clemens Ruppert, Andreas G ünther, Laurent Bartholin, Wei Shi, Eveline Baumgart-Vogt Tags: Regular article Source Type: research