TIF1{gamma}-deficiency Promotes Mitotic Checkpoints Defects
The transcription accessory factor TIF1γ/TRIM33/RFG7/PTC7/Ectodermin functions as a tumor suppressor that promotes development and cellular differentiation. However, its precise function in cancer has been elusive. In the present study, we report that TIF1γ inactivation causes cells to accumulate chromosomal defects, a hallmark of cancer, due to attenuations in the spindle assembly checkpoint and the post-mitotic checkpoint. TIF1γ deficiency also caused a loss of contact growth inhibition and increased anchorage-independent growth in vitro and in vivo. Clinically, reduced TIF1γ expression in human tumors correlated wit...
Source: Cancer Research - October 14, 2015 Category: Cancer & Oncology Authors: Pommier, R. M., Gout, J., Vincent, D. F., Alcaraz, L. B., Chuvin, N., Arfi, V., Martel, S., Kaniewski, B., Devailly, G., Fourel, G., Bernard, P., Moyret-Lalle, C., Ansieau, S., Puisieux, A., Valcourt, U., Sentis, S., Bartholin, L. Tags: Molecular and Cellular Pathobiology Source Type: research
Lipoblastoma-like Tumor of the Vulva: Further Characterization in 8 New Cases
Lipoblastoma-like tumor of the vulva (LLTV) is an exceptionally rare adipocytic mesenchymal tumor with only 4 cases reported previously. The aim of this study is to help characterize this tumor type. Eight cases of LLTV were identified in the consult files of one of the authors (C.D.M.F.). Clinical data and follow-up information were obtained from the referring pathologists. Detailed clinical information is available in all 8 cases. Patient age ranged from 17 to 46 years (median 27 y). Lesions presented as a vulvar mass with a variable growth rate, sometimes being painful. The most common preoperative clinical diagnosis wa...
Source: The American Journal of Surgical Pathology - August 18, 2015 Category: Pathology Tags: Original Articles Source Type: research
Clinical Manifestations and Therapeutic Management of Vulvar Cellulitis and Abscess: Methicillin-resistant Staphylococcus aureus, Necrotizing Fasciitis, Bartholin Abscess, Crohn Disease of the Vulva, Hidradenitis Suppurativa
Infections of the vulva can present a complex differential to the gynecologist, ranging from superficial skin infections to life-threatening necrotizing fasciitis. Recognition and timely treatment remain universal to skin and soft-tissue infections as the subcutaneous anatomy of the vulva can facilitate rapid spread to other tissues with significant morbidity and mortality. Ineffective antibiotics or deferring necessary surgical debridement have proven to be costly to the patient, and the gynecologist must maintain an appropriately high index of suspicion. Employing a multidisciplinary team approach to care for vulvar cell...
Source: Clinical Obstetrics and Gynecology - August 4, 2015 Category: OBGYN Tags: Vulvovaginal Diseases Source Type: research
Abstract CT310: First-in-man (FIM) pharmacodynamic (PD) and pharmacokinetic (PK) phase I trial of PQR309 in advanced solid tumors
Background: PQR309 is a novel, oral, balanced pan-PI3K, mTORC1 and mTORC2 inhibitor. Preclinical experiments show promising anti-cancer activity. The primary objectives of this FIM trial of PQR309 were definition of maximal tolerated dose (MTD), and safety.Methods: The trial was designed as an accelerated 3+3 study. Patients with advanced solid tumors with no standard management options were eligible. Dose-limiting toxicity (DLT) was defined as either grade 4 neutropenia >7 days, febrile neutropenia, grade 4 thrombocytopenia, non-hematological toxicity of either grade 4, uncontrolled grade 3 >7 days or dose-limiting grade ...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Wicki, A., Sessa, C., Childs, A., Stathis, A., Hess, D., Joerger, M., von Moos, R., Rodon, J., Hierro, C., Cmiljanovic, N., Bize, V., Berardi, S., Xyrafas, A., Kristeleit, R. Tags: Clinical Trials Source Type: research
Management of Bartholin's cyst and abscess using the Word catheter: implementation, recurrence rates and costs
Conclusions The present study indicates that the Word catheter is an easy to handle, low cost outpatient procedure with acceptable short-term recurrence rates. Treatment costs are seven times lower than for marsupialization. (Source: European Journal of Obstetrics and Gynecology and Reproductive Biology)
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - June 4, 2015 Category: OBGYN Source Type: research
