Association Between Vomiting and QT Hysteresis: Data from a TQT Study with the Endothelin A Receptor Antagonist Clazosentan
In conclusion, clazosentan at therapeutic and supratherapeutic doses has QT liability with hysteresis effects being associated with nausea and vomiting. (Source: The AAPS Journal)
Source: The AAPS Journal - August 3, 2020 Category: Drugs & Pharmacology Source Type: research

[Antimicrobial Susceptibility Profiles of Prevotella Species Determined by Gradient Test Method in Two Centers in Istanbul].
In conclusion, piperacillin/tazobactam, cefoxitin, and tigecycline displayed high in vitro activity against Prevotella spp. and they all remained good candidates for empiric therapy. Imipenem and meropenem were also found to be very active, but the usage of carbapenems should be reserved for serious mixed infections, potentially accompanied by other resistant organisms. Intermediate resistance to ampicillinsulbactam and the resistance against metronidazole emphasized the need of periodic monitoring of their susceptibility patterns. The high rates of non-susceptibility to ampicillin, clindamycin, tetracycline and moxifloxac...
Source: Mikrobiyoloji Bulteni - July 30, 2020 Category: Microbiology Tags: Mikrobiyol Bul Source Type: research

[Using of the Sensititre MycoTB Plate Method for the Detection of Anti-tuberculous Drug Susceptibility of Rifampin Resistant Mycobacterium tuberculosis Complex Isolates].
In this study, it was aimed to evaluate whether the Sensititre MycoTB plaque method is suitable for the routine use in determining drug susceptibility of rifampin resistant MTBC strains. Xpert MTBC/ RIF positive rifampin resistant 100 MTBC isolates were included in the study. Xpert MTBC/RIF (Cepheid, USA) test were performed after the samples were processed by homogenization and decontamination and acid-fast staining. Rifampin resistant clinical samples were cultured in automated MGIT/BACTEC 960 (Becton Dickinson, USA) system and acid fast bacteria (AFB) were investigated. The anti-TB drug susceptibility tests of all cultu...
Source: Mikrobiyoloji Bulteni - July 30, 2020 Category: Microbiology Tags: Mikrobiyol Bul Source Type: research

The Pharmacokinetics of Moxifloxacin in Cerebrospinal Fluid Following Intravenous Administration: A Report of Successfully Treated Infant with: Mycoplasma hominis: Meningitis
A female infant underwent myelomeningocele repair and developed persistent ventricular dilatation. Cerebrospinal fluid (CSF) indices demonstrated meningitis with cultures growing Mycoplasma hominis. The infant was treated with multiple antibiotics including moxifloxacin. Moxifloxacin CSF levels were obtained for pharmacokinetic analysis. This case report adds the importance of understanding the pharmacokinetics of CSF moxifloxacin levels among infants. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - July 30, 2020 Category: Infectious Diseases Tags: Antimicrobial Reports Source Type: research

Doxycycline and Sitafloxacin Combination Therapy for Treating Highly Resistant Mycoplasma genitalium.
We present early data on combination therapy with doxycycline and sitafloxacin to treat highly resistant M. genitalium. We found the regimen was well tolerated and cured 11/12 infections that had failed prior regimens with moxifloxacin and pristinamycin. PMID: 32687029 [PubMed - in process] (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - July 22, 2020 Category: Infectious Diseases Authors: Durukan D, Doyle M, Murray G, Bodiyabadu K, Vodstrcil L, Chow EPF, Jensen JS, Fairley CK, Aguirre I, Bradshaw CS Tags: Emerg Infect Dis Source Type: research

Antimicrobial susceptibility patterns of clinically significant Gram-positive anaerobic bacteria in a Greek tertiary-care hospital, 2017-2019.
In this study we analyzed the distribution and antimicrobial susceptibility profiles of 358 Gram-positive clinically significant anaerobes, isolated from 2017 to 2019, in a Greek tertiary-care hospital. The species identification was performed by Vitek 2 and conventional biochemical methods, and the antimicrobial susceptibility testing by the E-test method. The antimicrobial agents tested were penicillin, ampicillin, amoxicillin-clavulanic acid, piperacillin-tazobactam, cefoxitin, imipenem, meropenem, clindamycin, metronidazole, moxifloxacin, chloramphenicol, tigecycline and vancomycin. Clostridioides difficile isolates we...
Source: Anaerobe - July 21, 2020 Category: Microbiology Authors: Maraki S, Mavromanolaki VE, Stafylaki D, Kasimati A Tags: Anaerobe Source Type: research

Use of Antibiotics in Chronic Obstructive Pulmonary Disease: What is Their Current Role in Older Patients?
AbstractChronic obstructive pulmonary disease (COPD) has considerable morbidity and mortality in the older adult population. The role of antibiotics in the management of acute exacerbations of COPD (AECOPD) is currently evolving. Despite only mild benefits, most patients with AECOPD in ambulatory settings receive antibiotics based on clinical criteria. Utilization of point-of-care C-reactive protein (CRP) has reduced antibiotic prescriptions by 20% without compromising clinical outcomes. A strict protocol allowing antibiotic use only in patients with clinical criteria and CRP  ≥ 20 mg/L has the potent...
Source: Drugs and Aging - July 20, 2020 Category: Geriatrics Source Type: research

High Prevalence of Genetically Related Clostridium Difficile Strains at a Single Hemato-Oncology Ward Over 10 Years
Conclusion: The high proportion of infected patients in 2008–2011 may be explained by the predominance of more transmissible and virulent C. difficile strains. Although this retrospective study was not designed to define outbreaks of C. difficile, the finding that most isolates exhibited high levels of genetic relatedness suggests nosocomial acquisition. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - July 20, 2020 Category: Microbiology Source Type: research

Prescription and indications for the use of fluoroquinolones in a group of outpatients in Colombia
Conclusions: Fluoroquinolones, particularly ciprofloxacin, are being prescribed especially to women with urinary tract infections, but up to a quarter of the patients received them for unapproved indications by regulatory agencies. PMID: 32673464 [PubMed - in process] (Source: Biomedica : Revista del Instituto Nacional de Salud)
Source: Biomedica : Revista del Instituto Nacional de Salud - July 18, 2020 Category: International Medicine & Public Health Tags: Biomedica Source Type: research

Management of antibiotic-resistant Helicobacter pylori infection: current perspective in Iran.
Authors: Alihosseini S, Ghotaslou R, Heravi FS, Ahmadian Z, Leylabadlo HE Abstract Helicobacter pylori is a common gastric bacterial pathogen implicated in the pathogenesis of many digestive tract disorders. H. pylori infection prevalence has been reported alarmingly in Iran. A plethora of studies have been conducted to evaluate the efficiency of first-line and second-line eradication attempts in patients diagnosed with H. pylori infections in Iran. The present study, was evaluated the efficacy of first-line and second-line therapy in H. pylori infections in Iran. We aimed to consider the literature review of the v...
Source: Journal of Chemotherapy - July 15, 2020 Category: Cancer & Oncology Tags: J Chemother Source Type: research

The Role of Delafloxacin in Patients with Community-Acquired Bacterial Pneumonia in the Outpatient Setting: A Budget Impact Model
ConclusionThe results of the budget impact analyses provide conservative estimates of the impact of adding delafloxacin to outpatient formularies in substitution of moxifloxacin. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - July 10, 2020 Category: Drugs & Pharmacology Source Type: research

Clinical Utility of Lefamulin: If Not Now, When?
AbstractPurpose of ReviewThe looming threat of antimicrobial resistance requires robust stewardship and new developments in infectious diseases pharmacotherapy. This review discusses the pertinent spectrum and clinical data of lefamulin (Xenleta ®), with a focus on potential real-world use.Recent FindingsLefamulin is a novel pleuromutilin antibiotic that obtained Food and Drug Administration labeling for community-acquired bacterial pneumonia (CABP) in 2019. Lefamulin is available in both intravenous and oral formulations, and it inhibits bacterial protein synthesis inhibition through interactive binding to unique site...
Source: Current Infectious Disease Reports - July 9, 2020 Category: Infectious Diseases Source Type: research

Case Report: Dynamics of Acquired Fluoroquinolone Resistance under Standardized Short-Course Treatment of Multidrug-Resistant Tuberculosis.
We report a case of acquired fluoroquinolone (FQ) resistance under short-course multidrug-resistant tuberculosis (MDR-TB) treatment. The patient was managed at Kabutare hospital, one of the two specialized MDR-TB clinics in Rwanda. A low dose of moxifloxacin was used in the first three critical months. Acquired resistance was identified at the ninth month of treatment, 3 months after stopping kanamycin in a strain initially susceptible only to FQs, kanamycin, and clofazimine. Fluoroquinolone resistance was detected in the same month by deep sequencing as routinely used second-line probe assay and phenotypic drug susceptibi...
Source: The American Journal of Tropical Medicine and Hygiene - July 4, 2020 Category: Tropical Medicine Authors: Semuto Ngabonziza JC, Van Deun A, Migambi P, Belamo NE, Théogène D, Habimana YM, Ushizimpumu B, Mulders W, Decroo T, Affolabi D, Supply P, de Jong BC, Rigouts L Tags: Am J Trop Med Hyg Source Type: research

Microbiological spectrum of microbial keratitis in patients presenting with nasolacrimal duct obstruction.
CONCLUSION: Corneal infection associated with nasolacrimal duct obstruction is commonly caused by gram-positive-bacteria. Irrigation of nasolacrimal duct should be mandatory test in microbial keratitis. The gram-positive bacteria isolated showed maximum susceptibility to vancomycin and cefazolin. Early treatment by surgery and appropriate medical management is recommended for its control. PMID: 32615806 [PubMed - as supplied by publisher] (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - July 3, 2020 Category: Opthalmology Authors: Sharma S, Sahu SK, Rath S, Mallick A, Sharma S, Das S Tags: Eur J Ophthalmol Source Type: research

Modeling the effect of DAV132, a novel colon-targeted adsorbent, on fecal concentrations of moxifloxacin and gut microbiota diversity in healthy volunteers.
te; F Abstract To prevent antibiotic-induced perturbations on gut microbiota, DAV132, a novel colon-targeted adsorbent, which sequesters antibiotic residues in the lower gastrointestinal tract was developed. We built an integrated pharmacological model of how DAV132 reduces fecal free moxifloxacin (MXF) and preserves gut microbiota. We used plasma and fecal free MXF concentrations, and Shannon diversity index from 16S rRNA gene metagenomics analysis of fecal microbiota, of 143 healthy volunteers assigned randomly to receive MXF only, or with ten DAV132 dose regimens, or to a control group. We modeled reduced fecal...
Source: Clinical Pharmacology and Therapeutics - July 2, 2020 Category: Drugs & Pharmacology Authors: Guk J, Guedj J, Burdet C, Andremont A, de Gunzburg J, Ducher A, Mentré F Tags: Clin Pharmacol Ther Source Type: research

Propionibacterium acnes Endophthalmitis Following Baerveldt Glaucoma Device Implantation
Conclusions: Despite the introduction of antibiotics into the intravitreal, intracameral, and subconjunctival space surrounding the Baerveldt implant, infection persisted until complete explantation of the device. Early explantation should be considered in glaucoma drainage device endophthamitis secondary to P. acnes. (Source: Journal of Glaucoma)
Source: Journal of Glaucoma - July 1, 2020 Category: Opthalmology Tags: Online Articles: Brief Reports Source Type: research

Dapsone/moxifloxacin/rituximab
(Source: Reactions Weekly)
Source: Reactions Weekly - July 1, 2020 Category: Drugs & Pharmacology Source Type: research

A Thorough QT Study of the Combination Glecaprevir  + Pibrentasvir on Cardiac Repolarization in Healthy Subjects.
The objective of this study was to evaluate the potential for cardiac repolarization following GLE + PIB administration in healthy adults. METHODS: This placebo- and active-controlled, randomized, single-dose, 4-period, 4-sequence crossover study enrolled 48 healthy subjects. The doses of GLE 400 mg + PIB 120 mg were selected to provide exposures comparable to those with the doses that are therapeutic in the HCV-infected population, GLE 300 mg + PIB 120 mg. The doses of GLE 600 mg + PIB 240 mg were selected to provide supratherapeutic exposures with...
Source: Clinical Therapeutics - July 1, 2020 Category: Drugs & Pharmacology Authors: Oberoi RK, Zhao W, Rosebraugh M, Mensa F, Wang H, Liu W Tags: Clin Ther Source Type: research

Spontaneous sphenoid meningoencephalocele with sepsis.
ust K Abstract Streptococci bacteremia is an unusual source of sepsis from spontaneous cerebrospinal fluid (CSF) rhinorrhea due to sphenoid meningoencephalocele. A spontaneous cause of CSF rhinorrhea should be on the differential along with trauma and congenital and neoplastic lesions. Moxifloxacin 400 mg daily for 2 weeks has a satisfactory CSF penetration to treat Streptococcus viridans bacteremia due to CSF rhinorrhea. PMID: 32675980 [PubMed] (Source: Baylor University Medical Center Proceedings)
Source: Baylor University Medical Center Proceedings - July 1, 2020 Category: Universities & Medical Training Authors: Shah M, Tadeo Bermúdez Borjas MA, Brust K Tags: Proc (Bayl Univ Med Cent) Source Type: research

The association of a reduced susceptibility to moxifloxacin in causative Clostridium ( Clostridioides ) difficile strain with the clinical outcome of patients
AbstractObjectivesTo investigate the relationship betweenClostridium (Clostridioides) difficile strain characteristics andC. difficile infection (CDI) outcome.MethodsBetween October and December 2017, 16 hospitals collected epidemiological data according to the European Centre for Disease Prevention and Control (ECDC) surveillance protocol for CDI.C. difficile isolates were characterized by ribotyping, toxin genes detection and antibiotic susceptibility testing to metronidazole, vancomycin and moxifloxacin.ResultsThe overall mean CDI incidence density was 4.5 [95% CI 3.6 –5.3] cases per 10,000 patient-days. From the ...
Source: Antimicrobial Resistance and Infection Control - June 30, 2020 Category: Infectious Diseases Source Type: research

Wild-Type MIC Distribution for Re-evaluating the Critical Concentration of Anti-TB Drugs and Pharmacodynamics Among Tuberculosis Patients From South India
In this study, we assessed the MICs of anti-TB drugs, including isoniazid (INH), rifampicin (RMP), moxifloxacin (MXF), ethambutol (ETH), and p-aminosalicylic acid (PAS) on drug-sensitive Mtb isolates from pulmonary TB patients in South India. The MIC assays performed using solid- and liquid-growth media showed changes in the CC of a few of the tested antibiotics compared with the WHO-recommended levels. Our observation suggests that the WHO guidelines could potentially lead to overdiagnosis of drug-resistant cases, which can result in inappropriate therapeutic decisions. To evaluate the correlation between drug-resistance ...
Source: Frontiers in Microbiology - June 30, 2020 Category: Microbiology Source Type: research

The impact of antimicrobial stewardship program implementation at four tertiary private hospitals: results of a five-years pre-post analysis
ConclusionImplementation of AMS program at HMG healthcare facilities resulted in reduced antimicrobials use and cost, and lowered incidence of healthcare associated infections. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - June 29, 2020 Category: Infectious Diseases Source Type: research

Primary pulmonary extranodal natural killer/T-cell lymphoma (ENKTL), nasal type: Two case reports and literature review
Conclusion: The diagnosis of ENKTL should be considered when patients present with fever and expansile consolidation of the lung not responding to antibiotics. The diagnosis depends on histopathology and immunophenotyping. Percutaneous transthoracic needle biopsy is a safe and effective biopsy method. Chemotherapy may improve the prognosis, but this should be confirmed by prospective multicenter studies. (Source: Medicine)
Source: Medicine - June 26, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Efficacy of Moxifloxacin against Mycobacterium abscessus in Zebrafish Model in vivo
Publication date: May 2020Source: Biomedical and Environmental Sciences, Volume 33, Issue 5Author(s): Wen Juan NIE, Zhong Yao XIE, Shan GAO, Tian Lu TENG, Wen Qiang ZHOU, Yuan Yuan SHANG, Wei JING, Wen Hui SHI, Qing Feng WANG, Xue Rui HUANG, Bao Yun CAI, Jun WANG, Jing WANG, Ru GUO, Qi Ping GE, Li Hui NIE, Xi Qin HAN, Ya Dong DU, Nai Hui CHU (Source: Biomedical and Environmental Sciences)
Source: Biomedical and Environmental Sciences - June 25, 2020 Category: Biomedical Science Source Type: research

[Unusual anisocoria].
Abstract A 53-year-old female patient presented with increased light sensitivity 3 weeks after oral intake of moxifloxacin tablets for an upper respiratory tract infection. The symptoms were anisocoria and the pupils did not react to light or accommodation. The examination of the anterior segment of the eye revealed extensive bilateral iris transillumination defects (ITD). We diagnosed a bilateral acute iris transillumination (BAIT) syndrome. The BAIT syndrome is a rare disorder associated with massive depigmentation of the iris and atrophy of the iris musculature. A risk factor for BAIT syndro...
Source: Der Ophthalmologe - June 25, 2020 Category: Opthalmology Authors: Klonner J, Salchow D Tags: Ophthalmologe Source Type: research

A case of torsades de pointes induced by the third-generation EGFR-TKI, osimertinib combined with moxifloxacin
Torsade de pointes (TdP) is a malignant arrhythmia that can be induced by QT internal prolongation due to a variety of factors. Here we report an elderly patient with advanced non-small cell lung cancer (NSCLC... (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - June 24, 2020 Category: Respiratory Medicine Authors: Shuang Bian, Xiaomiao Tang and Wei Lei Tags: Case report Source Type: research

Fluoroquinolones: Blessings Or Curses.
Abstract Fluoroquinolones are one of the world's most valuable and popularly used categories of antimicrobial agents. This paper attempts to review the substantial progress of fluoroquinolones from its discovery to black box warning. Antibiotic drug choice will remain difficult in the presence of increasing resistance, but introduction of the fluoroquinolones has created a new and exciting era in antimicrobial treatment. These are a synthetic heterogeneous group of compounds used in both hospital and community practices to treat numerous severe infections. The era of quinolone antibiotics began with the serendipit...
Source: Current Drug Targets - June 21, 2020 Category: Drugs & Pharmacology Authors: Majalekar PP, Shirote PJ Tags: Curr Drug Targets Source Type: research

Antimicrobial susceptibility and prevalence of resistance genes in Bacteroides fragilis isolated from blood culture bottles in two tertiary care hospitals in Japan.
In this study, 50 isolates of B. fragilis were obtained from positive blood bottles from 2014 to 2019 in Saitama, Japan. Their susceptibility to ampicillin/sulbactam was reduced to 70.0% compared with a previous report, whereas they were still sufficiently susceptible to piperacillin/tazobactam (94.0%). Five cfiA-positive isolates (5/50, 10.0%) were identified that were resistant to doripenem and meropenem, and two of them carried an insertion sequence located upstream of the cfiA-coding region. In particular, imipenem should be considered as a first-line carbapenem for the empirical treatment of B. fragilis infection beca...
Source: Anaerobe - June 20, 2020 Category: Microbiology Authors: Ogane K, Tarumoto N, Kodana M, Onodera A, Imai K, Sakai J, Kawamura T, Takeuchi S, Murakami T, Mitsutake K, Ikebuchi K, Maesaki S, Takuya M Tags: Anaerobe Source Type: research

Meta-analysis on Effectiveness and Safety of Moxifloxacin in Treatment of Multidrug Resistant Tuberculosis in Adults
Conclusions: This meta-analysis revealed that the addition of moxifloxacin to the recommended regimen significantly improved the rate of treatment success in the treatment of MDR-TB, with no additional adverse moxifloxacin events. (Source: Medicine)
Source: Medicine - June 19, 2020 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

Parvimonas micra: A potential causative pathogen to consider when diagnosing odontogenic brain abscesses.
Conclusions: This case highlights the potential risk of untreated dental infections causing brain abscesses. Pm should be considered as a possible pathogen of odontogenic brain abscesses despite its presence usually not being detected by standard bacterial cultures. Therefore, 16S rRNA gene sequencing analysis is strongly recommended for bacterial identification before defining brain abscesses as cryptogenic. PMID: 32547827 [PubMed] (Source: Surgical Neurology International)
Source: Surgical Neurology International - June 19, 2020 Category: Neurosurgery Tags: Surg Neurol Int Source Type: research

A Case of Non-tuberculosis Mycobacterium Tenosynovitis with Rice Bodies in a Patient with Systemic Lupus Erythematosus.
Authors: Fujieda Y, Ninagawa K, Matsui Y, Kono M, Kamishima T, Iwasaki N, Atsumi T Abstract Infectious disease with various presentations in systemic lupus erythematosus (SLE) often resembles lupus flare. A 37-year-old woman presented with a swollen left index finger that had not resolved, despite 7 years of immunosuppressive treatment. MRI showed rice-body formation in the flexor tendon sheath and tenosynovectomy demonstrated chronic synovitis with epithelioid granuloma. A mycobacterial culture confirmed invasive mycobacterial tenosynovitis due to Mycobacterium chelonae. The patient was treated with moxifloxacin a...
Source: Internal Medicine - June 18, 2020 Category: Internal Medicine Tags: Intern Med Source Type: research

Absence of QTc prolongation in a thorough QT study with imeglimin, a first in class oral agent for type 2 diabetes mellitus
ConclusionThis thorough QT study demonstrated that therapeutic and supratherapeutic exposures of imeglimin did not induce a QT/QTc prolongation with a strong confidence as evidenced by the assay sensitivity.Trial registration number/dateNCT02924337/ October 5, 2016 (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - June 18, 2020 Category: Drugs & Pharmacology Source Type: research

Determination of levofloxacin, ciprofloxacin, moxifloxacin and gemifloxacin in urine and plasma by HPLC-FLD-DAD using pentafluorophenyl core-shell column: Application to drug monitoring.
In this study, a liquid chromatography method for the determination of levofloxacin, ciprofloxacin, moxifloxacin, and gemifloxacin in human urine and plasma was developed for the first time. Efficiency of 5 different columns in the separation of these fluoroquinolones was compared. Experimental parameters that affect the separation such as percentage of organic solvent, pH, temperature, gradient shape, and detector wavelength were optimized by employing a step-by-step approach. Using a pentafluorophenyl core-shell column (100 mm x 4.6 mm, 2.7 μm), the separation of four analytes was accomplished in less than 7.5 min. Th...
Source: Biomedical Chromatography : BMC - June 18, 2020 Category: Biomedical Science Authors: Yıldırım S, Karakoç HN, Yaşar A, Köksal İ Tags: Biomed Chromatogr Source Type: research

Efficacy of delafloxacin versus moxifloxacin against atypical bacterial respiratory pathogens in adults with community-acquired bacterial pneumonia (CABP): data from the delafloxacin phase 3 CABP trial
Community-acquired bacterial pneumonia (CABP) is a significant cause of morbidity and mortality worldwide. In the US, influenza and pneumonia are the eighth leading cause of death in people ≥65 years of age (Deaths, 2019). Approximately 1.3 million episodes of CABP occur in adults ≥65 years of age each year in the US (Yu et al., 2012). In the Etiology of Pneumonia in the Community (EPIC) study, approximately 4% of patients had the atypical pathogens M. pneumoniae, C. pneumoniae, an d L. pneumophila identified (Jain et al., 2015). (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - June 10, 2020 Category: Infectious Diseases Authors: McCurdy Sandra, Nenninger Ashley, Sheets Amanda, Keedy Kara, Lawrence Laura, Quintas Megan, Cammarata Sue Source Type: research

In Vitro Activities of Eravacycline and Other Antimicrobial Agents Against Human Mycoplasmas and Ureaplasmas.
Abstract We performed in vitro susceptibility testing for eravacycline in comparison to 4 other antimicrobials against 10 Mycoplasma genitalium, 40 M. hominis, 44 M. pneumoniae, 20 Ureaplasma parvum, and 20 U. urealyticum All eravacycline MICs were ≤ 0.25 μg/ml except for one isolate of M. genitalium for which the MIC was 2 μg/ml. Eravacycline was markedly more potent than tetracycline, azithromycin, moxifloxacin, and clindamycin against all isolates tested, which included 37 macrolide, tetracycline, and/or fluoroquinolone-resistant organisms. PMID: 32513794 [PubMed - as supplied by publisher] (Sourc...
Source: Antimicrobial Agents and Chemotherapy - June 8, 2020 Category: Microbiology Authors: Waites KB, Crabb DM, Xiao L, Duffy LB, Leal SM Tags: Antimicrob Agents Chemother Source Type: research

Lefamulin: The First Systemic Pleuromutilin Antibiotic.
Conclusions: Lefamulin is the first systemic pleuromutilin antibiotic that has proven safe and effective for adults with CABP. PMID: 32493034 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - June 4, 2020 Category: Drugs & Pharmacology Authors: Chahine EB, Sucher AJ Tags: Ann Pharmacother Source Type: research

Quinolone-Induced Anaphylaxis
AbstractPurpose of reviewQuinolones are the second most common antibiotic class that may induce IgE and non-IgE-mediated immediate hypersensitivity reactions. The prevalence of true quinolone allergy still remains unknown, but its incidence has increased in recent years, probably due to the extensive utilization of this antibiotic class and the introduction of moxifloxacin.Recent findingsQuinolones may also induce nonallergic reactions through the MRGPRX2 receptor. The diagnosis of hypersensitivity reactions to quinolones is complex, since clinical history is often doubtful, skin tests can induce false-positive results, an...
Source: Current Treatment Options in Allergy - June 2, 2020 Category: Allergy & Immunology Source Type: research

Antibiotics in the Biliary Tract: A Review of the Pharmacokinetics and Clinical Outcomes of Antibiotics Penetrating the Bile and Gallbladder Wall
AbstractBiliary tract infections (BTIs), including cholangitis and cholecystitis, are common causes of bacteremia. Bacteremic BTIs are associated with a mortality rate of 9 ‐12%. The extent to which antibiotics are excreted in the bile and the ratio of their exposure to the minimum inhibitory concentration (MIC) of the infecting organism are among the important factors for the treatment of BTIs. The aim of this review is to update healthcare professionals on the dist ribution of antibiotics in the common bile duct, gallbladder, and gallbladder wall. Antibiotic efficacy in treating BTIs based on the latest available clini...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - June 2, 2020 Category: Drugs & Pharmacology Authors: Abrar K. Thabit Tags: REVIEW OF THERAPEUTICS Source Type: research

Effect of 3 Single Doses of Trazodone on QTc Interval in Healthy Subjects.
This study evaluated the effect of 3 doses of a trazodone hydrochloride 6% oral drops solution on the QT interval of healthy volunteers. Subjects were randomly assigned to receive a single dose of trazodone 20 mg, 60 mg, and 140 mg, moxifloxacin 400 mg, and trazodone-matched placebo in 5 periods separated by 7-day washouts, according to a double-blind, crossover study design. Subjects were monitored continuously, and triplicate ECGs were extracted from baseline (predose) until 24 hours postdose. Blood samples for trazodone and moxifloxacin analyses were collected at the same time points. The concentrati...
Source: The Journal of Clinical Pharmacology - June 2, 2020 Category: Drugs & Pharmacology Authors: Tellone V, Rosignoli MT, Picollo R, Dragone P, Del Vecchio A, Comandini A, Radicioni M, Leuratti C, Calisti F Tags: J Clin Pharmacol Source Type: research

Antibiotics in the Biliary Tract: A Review of the Pharmacokinetics and Clinical Outcomes of Antibiotics Penetrating the Bile and Gallbladder Wall
AbstractBiliary tract infections (BTIs), including cholangitis and cholecystitis, are common causes of bacteremia. Bacteremic BTIs are associated with a mortality rate of 9 ‐12%. The extent to which antibiotics are excreted in the bile and the ratio of their exposure to the minimum inhibitory concentration (MIC) of the infecting organism are among the important factors for the treatment of BTIs. The aim of this review is to update healthcare professionals on the dist ribution of antibiotics in the common bile duct, gallbladder, and gallbladder wall. Antibiotic efficacy in treating BTIs based on the latest available clini...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - June 2, 2020 Category: Drugs & Pharmacology Authors: Abrar K. Thabit Tags: REVIEW OF THERAPEUTICS Source Type: research

Moxifloxacin
(Source: Reactions Weekly)
Source: Reactions Weekly - June 1, 2020 Category: Drugs & Pharmacology Source Type: research

Anterior Uveitis Due to Intracameral Moxifloxacin: A Case Report.
CONCLUSION AND IMPORTANCE: We present the second published case worldwide about anterior uveitis secondary to intracameral moxifloxacin, which may rarely cause hypertensive uveitis that may be confused with viral uveitis. This provides evidence on the importance of postoperative follow-up by the surgeon for an early referral and treatment of these cases. PMID: 32469689 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - May 31, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

In vivo analysis of the effects of intravenously as well as orally administered moxifloxacin on the pharmacokinetic and electrocardiographic variables along with its torsadogenic action in the chronic atrioventricular block cynomolgus monkeys
Publication date: Available online 28 May 2020Source: Journal of Pharmacological SciencesAuthor(s): Ai Goto, Kengo Sakamoto, Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Koki Chiba, Yoshio Nunoi, Hiroko Izumi-Nakaseko, Yoshinori Takei, Akio Matsumoto, Atsushi Sugiyama (Source: Journal of Pharmacological Sciences)
Source: Journal of Pharmacological Sciences - May 29, 2020 Category: Drugs & Pharmacology Source Type: research

Recommendation of Antimicrobial Dosing Optimization During Continuous Renal Replacement Therapy
Continuous Renal Replacement Therapy (CRRT) is more and more widely used in patients for various indications recent years. It is still intricate for clinicians to decide a suitable empiric antimicrobial dosing for patients receiving CRRT. Inappropriate doses of antimicrobial agents may lead to treatment failure or drug resistance of pathogens. CRRT factors, patient individual conditions and drug pharmacokinetics/pharmacodynamics are the main elements effecting the antimicrobial dosing adjustment. With the development of CRRT techniques, some antimicrobial dosing recommendations in earlier studies were no longer appropriate...
Source: Frontiers in Pharmacology - May 29, 2020 Category: Drugs & Pharmacology Source Type: research

In vivo analysis of the effects of intravenously as well as orally administered moxifloxacin on the pharmacokinetic and electrocardiographic variables along with its torsadogenic action in the chronic atrioventricular block cynomolgus monkeys
Publication date: Available online 28 May 2020Source: Journal of Pharmacological SciencesAuthor(s): Ai Goto, Kengo Sakamoto, Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Koki Chiba, Yoshio Nunoi, Hiroko Izumi-Nakaseko, Yoshinori Takei, Akio Matsumoto, Atsushi Sugiyama (Source: Journal of Pharmacological Sciences)
Source: Journal of Pharmacological Sciences - May 28, 2020 Category: Drugs & Pharmacology Source Type: research

The Endophytic Bacteria Bacillus velezensis Lle-9, Isolated from Lilium leucanthum, Harbors Antifungal Activity and Plant Growth-Promoting Effects.
Abstract Bacillus velezensis is an important plant growth-promoting rhizobacterium with immense potential in agriculture development. In the present study, Bacillus velezensis Lle-9 was isolated from the bulbs of Lilium leucanthum. The isolated strain showed antifungal activities against plant pathogens like Botryosphaeria dothidea, Fusarium oxysporum, Botrytis cinerea and Fusarium fujikuroi. The highest percentage of growth inhibition i.e., 68.56±2.35% was observed against Fusarium oxysporum followed by 63.12 ± 2.83%, 61.67 ± 3.39% and 55.82 ± 2.76% against Botrytis cinerea, Botryospha...
Source: Journal of Microbiology and Biotechnology - May 28, 2020 Category: Biotechnology Authors: Khan MS, Gao J, Chen X, Zhang M, Yang F, Du Y, Moe TS, Munir I, Xue J, Zhang X Tags: J Microbiol Biotechnol Source Type: research

Conjunctival bacterial flora and antimicrobial susceptibility in bacterial pathogens isolated prior to cataract surgery
ConclusionsThe increase in resistance of resident bacteria present in the conjunctival sac to antibiotics indicates that systemic and topical antibiotics are no longer effective, especially against external organisms affecting the eye. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - May 27, 2020 Category: Opthalmology Source Type: research

Efficacy and safety of dropless cataract surgery
Conclusion: The study demonstrates that this procedure is advantageous and safe. (Source: Indian Journal of Ophthalmology)
Source: Indian Journal of Ophthalmology - May 25, 2020 Category: Opthalmology Authors: Narayan Bardoloi Sandip Sarkar Ashu Pilania Himangshu Das Source Type: research

Pyridine and quinoline molecules as crucial protagonists in the never-stopping discovery of new agents against tuberculosis.
ov VV Abstract Tuberculosis (TB) disease remains to be an alarming infection worldwide with nearly 1.6 million deaths per year ranking above HIV/AIDS. Although Mycobacterium tuberculosis (Mtb), which causes TB, was identified more than 130 years ago, nowadays only old vaccine (Bacillus Calmette-Guérin vaccine) and classical toxic drugs that are losing its effectiveness are available in clinic practice. Despite enormous efforts in drug research on TB treatment including vaccines and diagnostics investigations, this old contagious, infectious disease is still a major public health problem. The goal of elimina...
Source: European Journal of Pharmaceutical Sciences - May 22, 2020 Category: Drugs & Pharmacology Authors: Villamizar-Mogotocoro AF, Vargas-Méndez LY, Kouznetsov VV Tags: Eur J Pharm Sci Source Type: research

Mycobacterium septicum associated peritonitis: A case report.
We report the first case of PD-associated peritonitis secondary to Mycobacterium septicum. The patient is a 53-year-old Caucasian man who developed end-stage kidney disease due to systemic sclerosis. He was initially started on intermittent hemodialysis and was then switched to PD 10 months later. He presented with generalized abdominal pain and an increase in the number of nucleated cells and neutrophils in the dialysate effluent sample (854 total nucleated cells/µL and 512 neutrophils/µL). Ten days later, the fluid grew M. septicum, a rapidly growing nontuberculous mycobacterium (NTM). Once the organism was i...
Source: Peritoneal Dialysis International - May 21, 2020 Category: Urology & Nephrology Tags: Perit Dial Int Source Type: research