Population Pharmacokinetics of Levofloxacin and Moxifloxacin, and the Probability of Target Attainment in Ethiopian Patients with Multidrug-Resistant Tuberculosis
(Source: Infection and Drug Resistance)
Source: Infection and Drug Resistance - November 28, 2022 Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research

Molecules, Vol. 27, Pages 8283: Development and Validation of a Method for Determination of 43 Antimicrobial Drugs in Western-Style Pork Products by UPLC-MS/MS with the Aid of Experimental Design
This study applied a modified QuEChERS method combined with ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MSMS) to develop a rapid and sensitive method for determining antimicrobial drugs in bacon and ham was successfully evaluated methodologically by EU 2002/657/EC. This study used a three-level, three-factor Box–Behnken design (BBD) to optimize the QuEChERS method by response surface methodology. The excellent linearity of the calibration curve was shown in the corresponding concentration range with a coefficient of determination greater than 0.99. The values of decision limit (CC&a...
Source: Molecules - November 28, 2022 Category: Chemistry Authors: Xiaoxuan Yu Xingqiang Wu Yujie Xie Kaixuan Tong Minglin Wang Jianhui Li Chunlin Fan Hui Chen Tags: Article Source Type: research

IJERPH, Vol. 19, Pages 15796: Are Prophylactic Systemic Antibiotics Required in Patients with Cataract Surgery at Local Anesthesia?
This study showed neither harm nor risk in reduced use and, consequently, no use of prophylactic systemic antibiotics in cataract surgery as far as local precautionary measures were secured. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - November 27, 2022 Category: Environmental Health Authors: Toshihiko Matsuo Masahiro Iguchi Noriyasu Morisato Tatsuya Murasako Hideharu Hagiya Tags: Article Source Type: research

IJERPH, Vol. 19, Pages 15609: Antibiotic Resistance in Patients with Peri-Implantitis: A Systematic Scoping Review
les The implementation of adjunctive antibiotics has been recommended for the therapy of peri-implantitis (PI). In this review, antibiotic resistance patterns in PI patients were assessed. A systematic scoping review of observational studies and trials was established in conjunction with the PRISMA extension for scoping reviews. The SCOPUS, PubMed/MEDLINE, EMBASE, SCIELO, Web of Science, and LILACS databases were reviewed along with the gray literature. The primary electronic examination produced 139 investigations. Finally, four observational studies met the selection criteria. These studies evaluated 214 implants in ...
Source: International Journal of Environmental Research and Public Health - November 24, 2022 Category: Environmental Health Authors: Carlos M. Ardila Annie Marcela Vivares-Builes Tags: Review Source Type: research

Effect of Futibatinib on Cardiac Repolarization: Results of a Randomized, Controlled, Double ‐Blind, QT/QTc, Phase 1 Study in Healthy Subjects
AbstractFutibatinib, a fibroblast growth factor receptor (FGFR) 1 –4 inhibitor, is being investigated forFGFR-aberrant tumors. A 4-period, crossover, phase 1 thorough QT/QTc study compared effects on Fridericia heart rate –corrected QT (QTcF) interval of single doses of futibatinib 20 and 80 mg (therapeutic and supratherapeutic doses, respectively), placebo, and moxifloxacin (positive control) in healthy subjects. The study objective was to assess the time-matched difference in change from baseline in QTcF (ddQTcF ) between futibatinib and placebo. In addition, changes from baseline in QTcF and other electrocardiogram...
Source: Clinical Pharmacology in Drug Development - November 21, 2022 Category: Drugs & Pharmacology Authors: Ikuo Yamamiya, Robert Lester, Daryl Sonnichsen, Mark Mina, Yaohua He, Karim A. Benhadji Tags: Original Article Source Type: research

Molecules, Vol. 27, Pages 8026: The New Strategy for Studying Drug-Delivery Systems with Prolonged Release: Seven-Day In Vitro Antibacterial Action
. Kudryashova The new method of antibacterial-drug-activity investigation in vitro is proposed as a powerful strategy for understanding how carriers affect drug action during long periods (7 days). In this paper, we observed fluoroquinolone moxifloxacin (MF) antibacterial-efficiency in non-covalent complexes, with the sulfobutyl ether derivative of β-cyclodextrin (SCD) and its polymer (SCDpol). We conducted in vitro studies on two Escherichia coli strains that differed in surface morphology. It was found that MF loses its antibacterial action after 3–4 days in liquid media, whereas the inclus...
Source: Molecules - November 18, 2022 Category: Chemistry Authors: Anna A. Skuredina Tatiana Yu. Kopnova Anastasia S. Tychinina Sergey A. Golyshev Irina M. Le-Deygen Natalya G. Belogurova Elena V. Kudryashova Tags: Article Source Type: research

Impact of topical moxifloxacin prophylaxis and povidone iodine on conjunctival bacterial flora in patients receiving intravitreal injections in a tertiary healthcare center in India
CONCLUSION: We could not establish any additional benefits of topical moxifloxacin prophylaxis with regard to a reduction in conjunctival flora when compared with PVI 5%. PVI can be used as an efficient monotherapy in patients undergoing repeated IVI.PMID:36387728 | PMC:PMC9648245 | DOI:10.4103/jfmpc.jfmpc_928_21 (Source: Primary Care)
Source: Primary Care - November 17, 2022 Category: Primary Care Authors: Gayathri Priya Yamini Sahu Rita Aggarwal Source Type: research

Impact of topical moxifloxacin prophylaxis and povidone iodine on conjunctival bacterial flora in patients receiving intravitreal injections in a tertiary healthcare center in India
CONCLUSION: We could not establish any additional benefits of topical moxifloxacin prophylaxis with regard to a reduction in conjunctival flora when compared with PVI 5%. PVI can be used as an efficient monotherapy in patients undergoing repeated IVI.PMID:36387728 | PMC:PMC9648245 | DOI:10.4103/jfmpc.jfmpc_928_21 (Source: Primary Care)
Source: Primary Care - November 17, 2022 Category: Primary Care Authors: Gayathri Priya Yamini Sahu Rita Aggarwal Source Type: research

Molecules, Vol. 27, Pages 7934: Simultaneous Determination of Moxifloxacin Hydrochloride and Dexamethasone Sodium Phosphate in Rabbit Ocular Tissues and Plasma by LC-MS/MS: Application for Pharmacokinetics Studies
un Qiao Treatment of ocular infection involves pharmacotherapy with steroids and antibiotic drops, such as moxifloxacin hydrochloride (MFH) and dexamethasone sodium phosphate (DSP). To characterize the pharmacokinetics of these two compounds, we performed and validated a liquid chromatography-mass spectrometry (LC-MS/MS) method to quantify them in rabbit ocular tissues and plasma. We used protein precipitation to extract the compounds. The analyte and internal standard (IS) were separated using a Shim-pack Scepter C18 column. The mobile phase was composed of 0.1% formic acid water (A) and methanol (B). MFH and DSP were...
Source: Molecules - November 16, 2022 Category: Chemistry Authors: Xinxin Zhao Yanjuan Yuan Qing Shao Hongqun Qiao Tags: Article Source Type: research

Colon-Targeted Layer-by-Layer Self-assembled Film: Pharmacokinetic Analysis of BCS Class I and Class III Model Drugs
AAPS PharmSciTech. 2022 Nov 15;23(8):299. doi: 10.1208/s12249-022-02450-2.ABSTRACTThe aim of the study was to investigate the pharmacokinetic parameters of 5-fluorouracil (5FU) and moxifloxacin HCl (MF) after oral administration using layer-by-layer assembled film in enteric-coated capsule. The layer-by-layer (LbL) film was prepared by sequential layering of chitosan and sodium alginate polyelectrolytes containing either 5FU or MF. The films were in vitro evaluated for physical characteristics, drug loading and release behaviour. In vivo pharmacokinetic evaluation was performed in the rat model for three different drug con...
Source: AAPS PharmSciTech - November 15, 2022 Category: Drugs & Pharmacology Authors: Leela Sai Lokesh Janardhanam Ashwini Suresh Deokar Srivarsha Reddy Bollareddy Venkata Vamsi Krishna Venuganti Source Type: research

Antibiotic Prescribing Practices Differ between Patients with Penicillin Intolerance and Penicillin Allergy Labels
Conclusions: This study supports that prescribing practices differ between patients with penicillin allergy labels and intolerance labels. Penicillin challenges may be undertaken safely in the inpatient setting. Further studies are required to investigate how best to interrogate penicillin allergy labels in this cohort.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - November 11, 2022 Category: Allergy & Immunology Source Type: research

Siderophore-linked Ruthenium Catalysts for Targeted Allyl Ester Prodrug Activation within Bacterial Cells
Chemistry. 2022 Nov 10. doi: 10.1002/chem.202202536. Online ahead of print.ABSTRACTDue to rising resistance, new antibacterial strategies are needed, including methods for targeted antibiotic release. As targeting vectors, chelating molecules released by bacteria to acquire iron called siderophores have been investigated for conjugation to antibacterials, leading to the clinically-approved drug cefiderocol. The use of small-molecule catalysts for prodrug activation within cells has shown promise in recent years, and here we investigate siderophore-linked ruthenium catalysts for the activation of antibacterial prodrugs with...
Source: Chemistry - November 10, 2022 Category: Chemistry Authors: James Southwell Reyme Herman Daniel Raines Justin Clarke Isabelle Boeswald Thorsten Dreher Sophie Gutenthaler Nicole Schubert Jana Seefeldt Nils Metzler-Nolte Gavin Thomas Keith Wilson Anne-Kathrin Duhme-Klair Source Type: research

Siderophore-linked Ruthenium Catalysts for Targeted Allyl Ester Prodrug Activation within Bacterial Cells
Chemistry. 2022 Nov 10. doi: 10.1002/chem.202202536. Online ahead of print.ABSTRACTDue to rising resistance, new antibacterial strategies are needed, including methods for targeted antibiotic release. As targeting vectors, chelating molecules released by bacteria to acquire iron called siderophores have been investigated for conjugation to antibacterials, leading to the clinically-approved drug cefiderocol. The use of small-molecule catalysts for prodrug activation within cells has shown promise in recent years, and here we investigate siderophore-linked ruthenium catalysts for the activation of antibacterial prodrugs with...
Source: Chemistry - November 10, 2022 Category: Chemistry Authors: James Southwell Reyme Herman Daniel Raines Justin Clarke Isabelle Boeswald Thorsten Dreher Sophie Gutenthaler Nicole Schubert Jana Seefeldt Nils Metzler-Nolte Gavin Thomas Keith Wilson Anne-Kathrin Duhme-Klair Source Type: research

An ocular insert with zero-order extended delivery: release kinetics and mathematical models
Eur J Pharm Biopharm. 2022 Nov 5:S0939-6411(22)00251-X. doi: 10.1016/j.ejpb.2022.10.023. Online ahead of print.ABSTRACTOcular inserts (InEye®), were prepared based on two distinct formulations of PCL-PEG-PCL block copolymers - one with 33 % and the other with 24 % of PEG 600. Ring-open-polymerisation was used to link ε-caprolactone monomers to PEG hydroxyl end-groups. Molecular weight, PCL/PEG ratio, mass loss and swelling of different polymeric samples where determined. Based on the previously prepared block copolymers, ophthalmic inserts were assembled. These were prepared with an ellipsoidal shape by dripping melted p...
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 9, 2022 Category: Drugs & Pharmacology Authors: M Mariz J Murta M H Gil P Ferreira Source Type: research

An ocular insert with zero-order extended delivery: release kinetics and mathematical models
Eur J Pharm Biopharm. 2022 Nov 5:S0939-6411(22)00251-X. doi: 10.1016/j.ejpb.2022.10.023. Online ahead of print.ABSTRACTOcular inserts (InEye®), were prepared based on two distinct formulations of PCL-PEG-PCL block copolymers - one with 33 % and the other with 24 % of PEG 600. Ring-open-polymerisation was used to link ε-caprolactone monomers to PEG hydroxyl end-groups. Molecular weight, PCL/PEG ratio, mass loss and swelling of different polymeric samples where determined. Based on the previously prepared block copolymers, ophthalmic inserts were assembled. These were prepared with an ellipsoidal shape by dripping melted p...
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 9, 2022 Category: Drugs & Pharmacology Authors: M Mariz J Murta M H Gil P Ferreira Source Type: research