Balsacone C, a New Antibiotic Targeting Bacterial Cell Membranes, Inhibits Clinical Isolates of Methicillin-Resistant Staphylococcus aureus (MRSA) Without Inducing Resistance
New options are urgently needed for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections. Balsacone C is a new dihydrochalcone extracted from Populus balsamifera that has been reported previously as being active against Staphylococcus aureus. Here, we evaluate the antibacterial activity of balsacone C against MRSA. Thirty-four (34) MRSA isolates were obtained from hospitalized patients; these isolates were then characterized for their resistance. Most of these MRSA (>85%) were resistant to penicillin, amoxicillin/clavulanic acid, ciprofloxacin, moxifloxacin, levofloxacin, clindamycin, erythromy...
Source: Frontiers in Microbiology - October 15, 2019 Category: Microbiology Source Type: research

Gatifloxacin is superior to levofloxacin and moxifloxacin in shorter treatment regimens for multidrug-resistant TB
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - October 11, 2019 Category: Respiratory Medicine Authors: Van Deun, A. Decroo, T. Kuaban, C. Noeske, J. Piubello, A. Aung, K. J. M. Rieder, H. L. Tags: ORIGINAL ARTICLES Source Type: research

Ototoxic Adverse Drug Reactions: A Disproportionality Analysis Using the Italian Spontaneous Reporting Database
Conclusions: This study is largely consistent with results from literature. Nevertheless, propafenone, antituberculars, hormone antagonists, teriparatide, tramadol, and pomalidomide are unknown for being ototoxic. Hypoacusis after the use of vinorelbine, methotrexate, and pemetrexed is unexpected, such as tinnitus related with etoposide, nebivolol, betamethasone, abatacept, sofosbuvir/ledipasvir, and tapentadol, but these considerations require further investigation to better define the risk due to the paucity of data. Moreover, physicians should be aware of the clinical significance of ototoxicity and be conscious about t...
Source: Frontiers in Pharmacology - October 8, 2019 Category: Drugs & Pharmacology Source Type: research

Cenegermin in Pediatric Neurotrophic Keratopathy
Conclusions: Cenegermin was effective in restoring corneal integrity in this pediatric patient with NK. (Source: Cornea)
Source: Cornea - October 4, 2019 Category: Opthalmology Tags: Case Report Source Type: research

Pretomanid: First Approval
This article summarizes the milestones in the development of pretomanid leading to this first regulatory approval. (Source: Drugs)
Source: Drugs - October 3, 2019 Category: Drugs & Pharmacology Source Type: research

Impact of antibiotic prophylaxis on the incidence, nature, magnitude, and duration of bacteremia associated with dental procedures: A systematic review.
Authors: Lafaurie GI, Noriega LA, Torres CC, Castillo Y, Moscoso SB, Mosquera S, Díaz-Báez D, Chambrone L Abstract BACKGROUND: Antibiotic prophylaxis (AP) is used routinely in high-risk groups of patients to reduce bacteremia and the risk of developing infective endocarditis (IE). In this systematic review, the authors evaluated the efficacy of AP on the incidence, nature, magnitude, and duration of post-dental procedure bacteremia. METHODS: The authors conducted a systematic search of the literature using MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials up to and including ...
Source: Journal of the American Dental Association - September 30, 2019 Category: Dentistry Tags: J Am Dent Assoc Source Type: research

Effect of Oral Lefamulin vs Oral Moxifloxacin on Community-Acquired Bacterial Pneumonia
This noninferiority randomized trial compares the effects of oral lefamulin vs oral moxifloxacin on clinical response at 96 hours among adult patients with community-acquired bacterial pneumonia. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - September 27, 2019 Category: General Medicine Source Type: research

Machine Learning Predicts Accurately Mycobacterium tuberculosis Drug Resistance From Whole Genome Sequencing Data
Conclusion: Our work demonstrates the utility of machine learning as a flexible approach to drug resistance prediction that is able to accommodate a much larger number of predictors and to summarize their predictive ability, thus assisting clinical decision making and single nucleotide polymorphism detection in an era of increasing WGS data generation. (Source: Frontiers in Genetics)
Source: Frontiers in Genetics - September 26, 2019 Category: Genetics & Stem Cells Source Type: research

Effect of Quinolones Versus Cefixime on International Normalized Ratio Levels After Valve Replacement Surgery with Warfarin Therapy.
Conclusion: Results showed that, after adding levofloxacin and moxifloxacin in patients on warfarin, therapy contributed to remarkable increase in INR. However, addition of cefixime prevented frequent coagulopathies; therefore, close monitoring of INR and switching to a safe antibiotic such as cefixime is recommended. PMID: 31561580 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - September 26, 2019 Category: Universities & Medical Training Authors: Liaqat A, Khan AU, Asad M, Khalil AH Tags: Medicina (Kaunas) Source Type: research

Effects of Celecoxib on the QTc Interval: A Thorough QT/QTc Study.
Abstract PURPOSE: Celecoxib is a selective cyclooxygenase-2 inhibitor widely used in patients with osteoarthritis and rheumatoid arthritis. Recently, nonclinical data on the inhibition of human ether-à-go-go-related gene potassium channels by celecoxib were reported, but there is no compelling evidence for this finding in humans. The aim of this study was to assess the potential effects of celecoxib on cardiac repolarization by conducting a thorough QT study, which was designed in compliance with the related guidelines. METHODS: This randomized, open-label, positive- and negative-controlled, crossover ...
Source: Clinical Therapeutics - September 26, 2019 Category: Drugs & Pharmacology Authors: Kim S, Lee H, Ko JW, Kim JR Tags: Clin Ther Source Type: research

R on T Phenomenon and Long QTc Syndrome due to Moxifloxacin in a Healthy Female.
Authors: Anyfantakis D, Makrakis G Abstract Long QT syndrome is characterized by prolongation of the corrected QT interval and is associated with fatal arrhythmias. R on T phenomenon is the coincidence of a premature ventricular complex with a T wave and may result to syncope and sudden cardiac death. Here we present a case of a 59-year-old woman with no previous history of medication, receiving moxifloxacin for community-acquired pneumonia. She was admitted complaining for thoracic pain and shortness of breath. Electrocardiogram showed both R on T phenomenon and QT prolongation. After discontinuation of the antibi...
Source: Puerto Rico Health Sciences Journal - September 20, 2019 Category: International Medicine & Public Health Tags: P R Health Sci J Source Type: research

Antibiotic susceptibility profile and synergistic effect of non-steroidal anti-inflammatory drugs on antibacterial activity of resistant antibiotics (Oxytetracycline and Gentamicin) against methicillin resistant Staphylococcus aureus (MRSA)
Publication date: Available online 19 September 2019Source: Microbial PathogenesisAuthor(s): Muhammad Altaf, Muhammad Ijaz, Awais Ghaffar, Abdul Rehman, Muhammad AvaisAbstractNon-steroidal anti-inflammatory drugs (NSAIDs) may exhibit antibacterial activity and have synergistic effects with antibiotics. One way to re-sensitize MRSA to resistant antibiotics is by combining with approved non-antibiotics. The study was intended to explore susceptibility of MRSA to various antibiotics and non-antibiotics (NSAIDs) by micro dilution broth method. MRSA isolates were confirmed by PCR (mecA gene) and in-vitro antibiotic susceptibili...
Source: Microbial Pathogenesis - September 20, 2019 Category: Infectious Diseases Source Type: research

Bedaquiline containing triple combination powder for inhalation to treat drug-resistant tuberculosis
Publication date: 30 October 2019Source: International Journal of Pharmaceutics, Volume 570Author(s): Bhamini Rangnekar, Mohammad A.M. Momin, Basanth Babu Eedara, Shubhra Sinha, Shyamal C. DasAbstractDrug-resistant tuberculosis (DR-TB) is an emerging health problem, challenging the effective control of global TB. Current treatment of DR-TB includes administration of multiple anti-TB drugs via oral and parenteral routes for a duration of 20–28 months. High systemic exposure, side effects and lengthy treatment time are problems affecting current treatment. The success rate of current lengthy treatment regimens is gen...
Source: International Journal of Pharmaceutics - September 19, 2019 Category: Drugs & Pharmacology Source Type: research

Antimicrobial Susceptibility, Biotypes and Phylotypes of Clinical Cutibacterium (Formerly Propionibacterium ) acnes Strains Isolated from Acne Patients: An Observational Study
ConclusionErythromycin and clindamycin resistances are the most common in clinicalC. acnes strains; BIII is the predominant biotype and IA1 is the major phylotype ofC. acnes, which are mainly related to disease severity. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - September 19, 2019 Category: Dermatology Source Type: research

An evaluation of reports of ciprofloxacin, levofloxacin, and moxifloxacin-association neuropsychiatric toxicities, long-term disability, and aortic aneurysms/dissections disseminated by the Food and Drug Administration and the European Medicines Agency.
Authors: Bennett AC, Bennett CL, Witherspoon BJ, Knopf KB Abstract Introduction: Ciprofloxacin, levofloxacin, and moxifloxacin belong to the fluoroquinolone class of antibiotics and are amongst the most commonly prescribed antibiotics. In 2018 and 2019, Food and Drug Administration (FDA) and the European Medicine Agency (EMA) requested that manufacturers harmonize FQ safety information related to neuropsychiatric, aortic dissection, and long-term disability. The authors hypothesize that FDA and EMA epidemiologists support a strong association between these drugs and the three toxicities. Areas covered: Studies of F...
Source: Expert Opinion on Drug Safety - September 11, 2019 Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research

Reduced moxifloxacin exposure in patients with tuberculosis and diabetes
Prevalence of diabetes mellitus (DM) in patients with tuberculosis (TB) is increasing and may negatively impact TB outcomes in patients with active disease [1]. Gastrointestinal problems, including gastroparesis, may result in delayed drug absorption or malabsorption in patients with DM, which may cause suboptimal drug exposure and poor outcome [2]. Studies on the pharmacokinetics of the first-line anti-TB drugs in patients with DM yielded conflicting results on low drug exposure [3–7]. Moxifloxacin is a potent bactericidal drug against Mycobacterium tuberculosis and is key for the treatment of multidrug-resistant tu...
Source: European Respiratory Journal - September 5, 2019 Category: Respiratory Medicine Authors: Dekkers, B. G. J., Bolhuis, M. S., ter Beek, L., de Lange, W. C. M., van der Werf, T. S., Alffenaar, J.-W. C., Akkerman, O. W. Tags: Original Articles: Research letters Source Type: research

A pilot study on the comparative minimum inhibitory and mutant prevention concentration values for moxifloxacin and pradofloxacin against canine and human isolates of Staphylococcus pseudintermedius and S.  schleiferi.
CONCLUSIONS AND CLINICAL IMPORTANCE: The narrow MSW of these drugs may reduce the risk of selecting for antibiotic-resistant subpopulations. Pharmacokinetic, pharmacodynamic and safety studies are needed. PMID: 31486554 [PubMed - as supplied by publisher] (Source: Veterinary Dermatology)
Source: Veterinary Dermatology - September 5, 2019 Category: Veterinary Research Authors: Plowgian C, Blondeau JM, Levinson M, Rosenkrantz W Tags: Vet Dermatol Source Type: research

Quality assurance for genotyping and resistance testing of Clostridium (Clostridioides) difficile isolates - experiences from the first inter-laboratory ring trial in four German speaking countries.
y group Abstract Clostridium (Clostridioides) difficile is a major cause of nosocomial diarrhoea. A first inter-laboratory ring trial was performed in four European countries to evaluate the genotyping and antibiotic susceptibility testing (AST) accuracy. Six C. difficile isolates representing the epidemiologic important ribotypes (RT), RT001, RT002, RT010, RT014, RT027, and RT078 were blinded and send to 21 participating laboratories. Participants tested the samples with their genotyping and AST methods in use for concordance with reference. A total of 21 genotyping- and 14 antimicrobial susceptibility data sets ...
Source: Anaerobe - September 5, 2019 Category: Microbiology Authors: Berger FK, Mellmann A, von Müller L, Bischoff M, Gärtner BC, German speaking C. difficile laboratory study group Tags: Anaerobe Source Type: research

Prevalence, characteristics and antimicrobial susceptibility patterns of Clostridioides difficile isolated from hospitals in Iran
ConclusionThis is the first report of the isolation of C. difficile from different governmental hospitals of Iran and indicates that CDI might be an important nosocomial infection in different hospital wards. Moreover, this study provides a comprehensive picture of the MDR phenotype characteristics of C. difficile isolates in Iran. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - September 2, 2019 Category: Infectious Diseases Source Type: research

Case Report: Corneal Ulceration from Bilateral Ectropion Due to Congenital Ichthyosis
CONCLUSIONS Chronic corneal exposure from autosomal recessive congenital ichthyosis may lead to severe dry eye, ulcerative keratitis, or perforation. Patients should be monitored carefully for corneal disease, educated on methods and devices to protect the corneal surface, and referred for surgical repair if indicated. Although rare, this condition presents unique findings that may be visually devastating. Awareness of the condition, as well as the various clinical presentations and appropriate management necessary, will prove beneficial to the patient. (Source: Optometry and Vision Science)
Source: Optometry and Vision Science - September 1, 2019 Category: Opthalmology Tags: REPORTS Source Type: research

A case of pulmonary actinomycosis presented with endobronchial involvement
Publication date: Available online 29 August 2019Source: Respiratory Medicine Case ReportsAuthor(s): Petros Oikonomidis, Fotios Fousekis, Panagiotis Kotsaftis, Ioannis Pilios, Dionysios Dimas, Georgios GiannoulisAbstractPulmonary actinomycosis is a rare infectious disease, which is characterized by a wide range of symptoms and no specific imaging findings and may be confused with neoplasia, tuberculosis or pneumonia. Endobronchial involvement of actinomycosis may be caused by aspiration of foreign bodies or broncholithiasis and may bronchoscopically masquerade as malignancy. A case of 68-year-old man is reported, who prese...
Source: Respiratory Medicine Case Reports - August 30, 2019 Category: Respiratory Medicine Source Type: research

Revefenacin, a Long ‐Acting Muscarinic Antagonist, Does Not Prolong QT Interval in Healthy Subjects: Results of a Placebo‐ and Positive‐Controlled Thorough QT Study
AbstractRevefenacin is a novel once ‐daily, lung‐selective, long‐acting muscarinic antagonist developed as a nebulized inhalation solution for the maintenance treatment of chronic obstructive pulmonary disease. In a randomized, 4‐way crossover study, healthy subjects received a single inhaled dose of revefenacin 175 µg (ther apeutic dose), revefenacin 700 µg (supratherapeutic dose), and placebo via standard jet nebulizer, and a single oral dose of moxifloxacin 400 mg (open‐label) in separate treatment periods. Electrocardiograms were recorded, and pharmacokinetic samples were collected ...
Source: Clinical Pharmacology in Drug Development - August 29, 2019 Category: Drugs & Pharmacology Authors: Marie T. Borin, Chris N. Barnes, Borje Darpo, Srikanth Pendyala, Hongqi Xue, David L. Bourdet Tags: Original Manuscript Source Type: research

Spongy wound dressing of pectin/carboxymethyl tamarind seed polysaccharide loaded with moxifloxacin beads for effective wound heal.
Abstract An attempt was made to formulate moxifloxacin loaded alginate beads incorporated into spongy wound dressing to heal chronic wounds as well as to reduce frequency of painful dressing change. Moxifloxacin loaded beads (sodium alginate:pectin, 1:1) were prepared by ionic gelation method, with entrapment efficiency 94.52%, crushing strength 25.30 N and drug release 90.52%. Beads were further incorporated into wound dressing, made of pectin and carboxymethyl tamarind seed polysaccharide (CMTSP). Spongy wound dressing was obtained by freeze drying technology, which showed good folding endurance, high wound fl...
Source: International Journal of Biological Macromolecules - August 27, 2019 Category: Biochemistry Authors: Pandit AP, Koyate KR, Kedar AS, Mute VM Tags: Int J Biol Macromol Source Type: research

Lefamulin (Xenleta) for Community-Acquired Bacterial Pneumonia
Date: September 23, 2019 Issue #:  1581Summary:  Lefamulin (Xenleta– Nabriva), a semisynthetic pleuromutilin antibiotic, has been approved by the FDA for IV and oral treatment of community-acquired bacterial pneumonia (CABP) in adults. It is the first systemic pleuromutilin antibiotic to be approved in the US; retapamulin(Altabax), a 1% topical ointment for treatment of impetigo, was approved in 2007. (Source: The Medical Letter)
Source: The Medical Letter - August 20, 2019 Category: Drugs & Pharmacology Authors: admin Tags: Amoxicillin Ampicillin/sulbactam Avelox Azithromycin Cefotaxime Cefpodoxime ceftaroline Ceftriaxone Chlamydophila pneumoniae Doxycycline Fluoroquinolones Haemophilus influenzae lefamulin Levaquin Levofloxacin Linezolid meth Source Type: research

Antimicrobial susceptibility pattern of oral isolates of Aggregatibacter actinomycetemcomitans
Conclusion: The isolates of A. actinomycetemcomitans displayed a high level of resistance to azithromycin and clindamycin. Development of resistance against tetracycline also appears to be significant. Variable resistance among the different members of the cephalosporin group is a factor to be investigated further since susceptibility profile against these antibiotics and interpretative criteria for oral bacteria are not available. (Source: Journal of Oral and Maxillofacial Pathology)
Source: Journal of Oral and Maxillofacial Pathology - August 20, 2019 Category: ENT & OMF Authors: Kishore G Bhat Preeti Khot Suvarna Patil Geetha Pattar Sanjeevini Majukar Source Type: research

Synthesis of a Moxifloxacin Fragment
Synfacts 2019; 15: 1085- DOI: 10.1055/s-0039-1690487 © Georg Thieme Verlag Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Synfacts)
Source: Synfacts - August 20, 2019 Category: Chemistry Tags: Flow Chemistry Source Type: research

[Frequently Isolated Slow Growing Nontuberculous Mycobacteria from Pulmonary Samples and Evaluation of Drug Susceptibility Testing Results in a Referral Hospital in Turkey].
In this study, Mycobacterium avium (n= 77, 17.7%), Mycobacterium intracellulare (n= 70, 16.1%), Mycobacterium szulgai (n= 19, 4.4%), Mycobacterium kansasii (n= 10, 2.3%) ve Mycobacterium smiae (n= 9, 2.1%) were isolated as slowly growing mycobacteria from the pulmonary patients. Susceptibility testing was performed in cation-adjusted Mueller-Hinton broth (CAMH), supplemented with "oleic acid, albumin dextrose catalase" according to CLSI/ M24-A2 guideline recommendations. For the antibiotic susceptibility test, ready-to-use plaque drugs for slow-growing mycobacteria (SLOMYCO-Sensititre, TREK Diagnostic Systems Ltd...
Source: Mikrobiyoloji Bulteni - August 17, 2019 Category: Microbiology Tags: Mikrobiyol Bul Source Type: research

[Detection and Molecular Analysis of Moxifloxacin MIC Values of Mycobacterium tuberculosis Strains Isolated from Clinical Specimens].
Authors: Bozok T, Kayar B, Yakıcı G, Eker E, Marzi M, Karslı F, Köksal F Abstract Tuberculosis (TB) is a chronic, granulomatous and necrotizing disease caused by microorganisms belonging to the Mycobacterium tuberculosis complex group. In 2017, 6.4 million new TB cases have been reported according to the World Health Organization 2018 Global Tuberculosis Report. TB remains among the major health problems of our time due to the increasing drug resistance problem and the difficulties in definitive diagnosis in recent years. It is stated by clinicians that intensive use of quinolone group drugs with oral form ...
Source: Mikrobiyoloji Bulteni - August 17, 2019 Category: Microbiology Tags: Mikrobiyol Bul Source Type: research

Phenotypic screening for quinolone resistance in Escherichia coli
AbstractRecent studies show that rectal colonization with low-level ciprofloxacin-resistantEscherichia coli (ciprofloxacin minimal inhibitory concentration (MIC) above the epidemiological cutoff point, but below the clinical breakpoint for resistance), i.e., in the range>  0.06–0.5 mg/L is an independent risk factor for febrile urinary tract infection after transrectal ultrasound-guided biopsy (TRUS-B) of the prostate, adding to the other risk posed by established ciprofloxacin resistance inE. coli (MIC  >  0.5 mg/L) as currently defined. We aimed to identify the quinolone that by...
Source: European Journal of Clinical Microbiology and Infectious Diseases - August 16, 2019 Category: Microbiology Source Type: research

A Randomized, Double-Blind, Placebo- and Positive-Controlled Crossover Study of the Effects of Omadacycline on QT/QTc Intervals in Healthy Subjects.
Abstract Omadacycline, an aminomethylcycline, is a once-daily intravenous (i.v.) and oral antibiotic that is approved in the United States for treatment of adults with acute bacterial skin and skin structure infections and community-acquired bacterial pneumonia. In this thorough QT study, the effects of a therapeutic (100 mg i.v.) and a supratherapeutic (300 mg i.v.) dose of omadacycline on the electrocardiogram were studied, with placebo and moxifloxacin as negative and positive controls. Omadacycline at these doses had no effect on the QTc interval. The largest mean placebo-corrected change-from-baseline QTcS (p...
Source: Antimicrobial Agents and Chemotherapy - August 12, 2019 Category: Microbiology Authors: Darpo B, Xue H, Tanaka SK, Tzanis E Tags: Antimicrob Agents Chemother Source Type: research

Antibiotic resistance and azithromycin resistance mechanism of Legionella pneumophila serogroup 1 in China.
Abstract Legionnaires' disease, caused by Legionella pneumophila (Lp), was primarily treated with antibiotics. However, few reports have been published on antibiotic-resistant Legionella in China. Our aim was to determine the azithromycin resistance mechanism of Lp serogroup 1 in China. The sensitivities of 149 Lp1 strains, isolated from clinical cases or environmental water in China from 2005 to 2012, to five antibiotics including erythromycin, azithromycin, levofloxacin, moxifloxacin and rifampicin were evaluated. The mechanisms of the resistance of Lp1 to azithromycin were studied. The expression levels of effl...
Source: Antimicrobial Agents and Chemotherapy - August 12, 2019 Category: Microbiology Authors: Jia X, Ren H, Nie X, Li Y, Li J, Qin T Tags: Antimicrob Agents Chemother Source Type: research

Application of Physiologically ‐Based and Population Pharmacokinetic Modeling for Dose Finding and Confirmation During the Pediatric Development of Moxifloxacin
Moxifloxacin is a widely used fluoroquinolone for the treatment of complicated intra ‐abdominal infections. We applied physiologically‐based pharmacokinetic (PBPK) and population pharmacokinetic (popPK) modeling to support dose selection in pediatric patients. We scaled an existing adult PBPK model to children based on prior physiological knowledge. The resulting model proposed an age‐dependent dosing regimen that was tested in a phase I study. Refined doses were then tested in a phase III study. A popPK analysis of all clinical pediatric data confirmed the PBPK predictions, including the proposed dosing schedule in ...
Source: CPT: Pharmacometrics and Systems Pharmacology - August 7, 2019 Category: Drugs & Pharmacology Authors: Stefan Willmann, Matthias Frei, Gabriele Sutter, Katrin Coboeken, Thomas Wendl, Thomas Eissing, J örg Lippert, Heino Stass Tags: Article Source Type: research

Effect of Cefiderocol, a Siderophore Cephalosporin, on QT/QTc Interval in Healthy Adult Subjects.
Abstract PURPOSE: Cefiderocol is a novel siderophore cephalosporin with potent activity against gram-negative bacteria, including multidrug-resistant strains. This Phase I study was conducted to assess the tolerability of single-ascending doses of cefiderocol (part 1) and the effect of cefiderocol on cardiac repolarization, assessed using the electrocardiographic corrected QT interval (QTcF) and other ECG parameters (part 2), in healthy adult subjects. METHODS: Part 1 was a randomized, double-blind, placebo-controlled, single-ascending dose study in healthy adult male and female subjects. Part 2 was a 4-perio...
Source: Clinical Therapeutics - August 1, 2019 Category: Drugs & Pharmacology Authors: Sanabria C, Migoya E, Mason JW, Stanworth SH, Katsube T, Machida M, Narukawa Y, Den Nagata T Tags: Clin Ther Source Type: research

Non-tuberculous mycobacteria profiles and their anti-mycobacterial resistance at a major medical center in Lebanon
Conclusion: The revelaed different NTM species, with predominance ofM.simiaeand various AMR profiles provide a current epidemiologic database and help guiding the selection of appropriate empirical therapy once the clinical relevance is established. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - July 31, 2019 Category: Infectious Diseases Source Type: research

Evaluation of Whole-Genome Sequence Method to Diagnose Resistance of 13 Anti-tuberculosis Drugs and Characterize Resistance Genes in Clinical Multi-Drug Resistance Mycobacterium tuberculosis Isolates From China
Conclusions. WGS is a promising approach to predict resistance to INH, RIF, PZA, LFX, SM, second-line injectable drugs (SLIDs), and PTO with satisfactory accuracy, sensitivity, and specificity of over 85.0%. The specificity of WGS in diagnosing resistance to EMB and high-level resistance to MFX (2.0 mg/L) needs to be improved. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - July 31, 2019 Category: Microbiology Source Type: research

Design, synthesis and antibacterial activity evaluation of moxifloxacin-amide-1,2,3-triazole-isatin hybrids.
Abstract In this work, a series of novel moxifloxacin-amide-1,2,3-triazole-isatin hybrids 7a-l were designed and synthesized. The in vitro antibacterial activity against a panel of clinically important Gram-positive and Gram-negative bacteria including drug-resistant pathogens was also evaluated. All hybrids showed considerable activity against the tested pathogens with MIC values of ≤0.03 to 128 μg/mL, and some of them such as hybrids 7e, 7g and 7j were comparable to or better than the parent moxifloxacin (MIC: ≤0.03-8 μg/mL). Moreover, hybrids 7e, 7g and 7j also demonstrated low cytotoxicity towa...
Source: Bioorganic Chemistry - July 28, 2019 Category: Chemistry Authors: Gao F, Ye L, Kong F, Huang G, Xiao J Tags: Bioorg Chem Source Type: research

A novel, broad-spectrum antimicrobial combination for the treatment of Pseudomonas aeruginosa corneal infections.
Abstract Bacterial keratitis causes significant blindness, yet antimicrobial resistance has rendered current treatments ineffective. Polymyxin B/trimethoprim (PT) and rifampicin has potent in vitro activity against Staphylococcus aureus and Pseudomonas aeruginosa, two important causes of keratitis. Here we further characterize this combination against P. aeruginosa in a murine keratitis model. PT + rifampicin performed comparably or better than moxifloxacin, the gold standard, suggesting the combination may be a promising therapy for bacterial keratitis. PMID: 31332071 [PubMed - as supplied by publisher] (Sou...
Source: Antimicrobial Agents and Chemotherapy - July 22, 2019 Category: Microbiology Authors: Chojnacki M, Philbrick A, Scherzi T, Pecora N, Dunman PM, Wozniak RAF Tags: Antimicrob Agents Chemother Source Type: research

Synthesis and biological evaluation of moxifloxacin-acetyl-1,2,3-1H-triazole-methylene-isatin hybrids as potential anti-tubercular agents against both drug-susceptible and drug-resistant Mycobacterium tuberculosis strains.
Abstract Herein, synthesis and biological evaluation of fourteen moxifloxacin-acetyl-1,2,3-1H-triazole-methylene-isatin hybrids as potential anti-tubercular agents against both drug-susceptible (MTB H37Rv), rifampicin-resistant and multidrug-resistant Mycobacterium tuberculosis strains were reported, and cytotoxicity towards VERO cells as well as inhibitory activity against MTB DNA gyrase were also discussed in this paper. The structure-activity relationship and structure-cytotoxicity relationship demonstrated that substituents on the C-3 and C-5/C-7 positions of isatin framework were closely related with the anti...
Source: European Journal of Medicinal Chemistry - July 22, 2019 Category: Chemistry Authors: Gao F, Chen Z, Ma L, Fan Y, Chen L, Lu G Tags: Eur J Med Chem Source Type: research

Nocardia intracranial mycotic aneurysm associated with proteasome inhibitor
We report a case of Nocardia farcinica ruptured intracranial mycotic aneurysm associated with bortezomib and corticosteroid treatment in a multiple myeloma patient. The patient was treated with trimethoprim-sulfamethoxazole and moxifloxacin together with surgical repairment of intracranial mycotic aneurysm. (Source: IDCases)
Source: IDCases - July 19, 2019 Category: Infectious Diseases Source Type: research

Electrophysiological characterization of drug response in hSC-derived cardiomyocytes using voltage-sensitive optical platforms
In conclusion, VSOs represent a powerful and appropriate method to assess the electrophysiological effects of drugs on iPSC-CMs for the evaluation of proarrhythmic risk. Protocol considerations and recommendations are provided toward standardizing conditions to reduce variability of baseline AP waveform characteristics and drug responses. (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - July 17, 2019 Category: Drugs & Pharmacology Source Type: research

Moxifloxacin-associated Neutropenia in a Patient Planned for Renal Transplantation
Arunkumar Subbiah, Soumita Bagchi, Raj K Yadav, Sandeep Mahajan, Dipankar Bhowmik, Sanjay K AgarwalIndian Journal of Nephrology 2019 29(4):303-305 (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - July 16, 2019 Category: Urology & Nephrology Authors: Arunkumar Subbiah Soumita Bagchi Raj K Yadav Sandeep Mahajan Dipankar Bhowmik Sanjay K Agarwal Source Type: research

Application of physiologically ‐based and population PK modeling for dose finding and confirmation during the pediatric development of moxifloxacin
This article is protected by copyright. All rights reserved. (Source: CPT: Pharmacometrics and Systems Pharmacology)
Source: CPT: Pharmacometrics and Systems Pharmacology - July 16, 2019 Category: Drugs & Pharmacology Authors: Stefan Willmann, Matthias Frei, Gabriele Sutter, Katrin Coboeken, Thomas Wendl, Thomas Eissing, J örg Lippert, Heino Stass Tags: Article Source Type: research

Impact of antibiotic gut exposure on the temporal changes in microbiome diversity.
group Abstract Although the global deleterious impact of antibiotics on the intestinal microbiota is well known, the temporal changes in microbial diversity during and after an antibiotic treatment are still poorly characterized. We used plasma and fecal samples frequently collected during and up to one month after treatment in 22 healthy volunteers assigned to a 5-day treatment by moxifloxacin (N=14) or no intervention (N=8). Moxifloxacin concentrations were measured both in plasma and feces, and bacterial diversity was determined in feces by 16S rRNA gene profiling and quantified using Shannon index and number o...
Source: Antimicrobial Agents and Chemotherapy - July 15, 2019 Category: Microbiology Authors: Burdet C, Nguyen TT, Duval X, Ferreira S, Andremont A, Guedj J, Mentré F, DAV132-CL-1002 study group Tags: Antimicrob Agents Chemother Source Type: research

Repeated determination of moxifloxacin concentrations in interstitial space fluid of muscle and subcutis in septic patients
ConclusionsSurprisingly, the first dose already achieved exposure comparable to steady-state conditions. The approved daily dose of 400  mg was adequate in our patient population. Thus, it seems that in septic patients a loading dose on the first day of treatment with moxifloxacin is not required. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - July 12, 2019 Category: Microbiology Source Type: research

Moxifloxacin-loaded acrylic intraocular lenses: in vitro and in vivo performance
Acrylic IOLs loaded with moxifloxacin release the drug in a controlled way, leading to therapeutic levels in the aqueous humour during at least 1 week, without any hazardous biological issues. (Source: Journal of Cataract and Refractive Surgery)
Source: Journal of Cataract and Refractive Surgery - July 12, 2019 Category: Opthalmology Authors: Helena P. Filipe, Dimitriya Bozukova, Andreia Pimenta, Ana Paula Vieira, Andreia Sofia Oliveira, Raquel Galante, Ana Topete, M ár Masson, Patrícia Alves, Patrícia Coimbra, M.Helena Gil, A.Jorge Guiomar, José Mata, Rogério Colaço, Benilde Saramago, L Source Type: research

Moxifloxacin-rifampicin combination for the treatment of non-staphylococcal Gram-positive orthopedic implant-related infections.
CONCLUSION: The moxifloxacin-rifampicin combination is a valuable alternative for the treatment of non-staphylococcal Gram-positive implant-related infections because of the good activity of moxifloxacin against these bacteria and the potential activity on the biofilm. PMID: 31277834 [PubMed - as supplied by publisher] (Source: Medecine et Maladies Infectieuses)
Source: Medecine et Maladies Infectieuses - July 7, 2019 Category: Infectious Diseases Tags: Med Mal Infect Source Type: research

Prevalence of genital Mycoplasma and response to eradication treatment in patients undergoing assisted reproductive techniques.
CONCLUSIONS: We consider that genital mycoplasma routine screening could be useful in order to increase the quality of semen which could simplify the in vitro fertilisation procedures and raise the success rate of embryo implantation and pregnancy, especially when fast, sensitive and specific technics as real time PCR are used. PMID: 31271277 [PubMed - as supplied by publisher] (Source: Revista Espanola de Quimioterapia)
Source: Revista Espanola de Quimioterapia - July 4, 2019 Category: Drugs & Pharmacology Authors: Veiga E, Treviño M, Romay AB, Navarro D, Trastoy R, Macía M Tags: Rev Esp Quimioter Source Type: research