Fight Aging! Newsletter, July 24th 2023
In this study, we tested the hypothesis that periodontal disease (PD) as a source of infection alters inflammatory activation and Aβ phagocytosis by the microglial cells.
Experimental PD was induced using ligatures in C57BL/6 mice for 1, 10, 20, and 30 days to assess the progression of PD. Animals without ligatures were used as controls. Ligature placement caused progressive periodontal disease and bone resorption that was already significant on day 1 post-ligation and continued to increase until day 30. The severity of periodontal disease increased the frequency of activated microglia in the brains on day 30 by 36...
Source: Fight Aging! - July 23, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Sensory Hair Cells of the Inner Ear Can Repair Themselves to Some Degree
Hearing loss involves either damage or loss of sensory hair cells in the inner ear, or loss of their connections to the brain. It remains somewhat unclear as to whether cell damage, cell death, or connection loss is the primary mechanism of interest in mammals. Researchers here investigate the way in which hair cells repair themselves. Where a mechanism like this exists and is understood, there is the potential to increase its efficiency as a basis for therapy. This may prove to be a useful treatment for some forms of deafness, but only those in which the cells and their connections remain, where hearing loss results from ...
Source: Fight Aging! - July 17, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Matthew ’s health care tidbits: Hedge Funds that Do Health Care on the Side
Each time I send out the THCB Reader, our newsletter that summarizes the best of THCB (Sign up here!) I include a brief tidbits section. Then I had the brainwave to add them to the blog. They’re short and usually not too sweet! –Matthew Holt
Lots of news about bad behavior in health care this week, with real shots about patient & staff safety at home care company Papa, and Grail misinforming 400 people that they had cancer. But the prize for tone deafness this week comes from another very well funded health care provider system being heartless to its poorest patients.
This week it’s Allina, a Minn...
Source: The Health Care Blog - June 5, 2023 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Matthew Holt Allina Ascension UPMC Source Type: blogs
La Sombrita, or, How to Fail at Infrastructure
Paul MatzkoLos Angeles spent $200,000 on La Sombrita ( ‘“in the shade”), a bus stop shade/light structure that provides littleshade or light. It has been almost too easy to criticize its design, the token DEI framing given to the project, how most of the funds went to a global junket for the designers, or the fact that city officials held a tone deaf celebratory press conference for its unveiling. Would this “make waiting for the bus at night [feel]safer” to you?But La Sombrita isn ’t really the problem. Rather, its failures are symptoms of its designers trying to work around deeper, structural problems ...
Source: Cato-at-liberty - May 22, 2023 Category: American Health Authors: Paul Matzko Source Type: blogs
Fight Aging! Newsletter, May 22nd 2023
Conclusions to be Drawn
A High Fat Diet Accelerates Atherosclerosis Less Directly than One Might Suspect
How to Construct Measures of Biological Age
A Long-Term Comparison of Metformin in Diabetics with Non-Diabetic Controls
In Search of Distinctive Features of the Gut Microbiome in Long-Lived Individuals
Greater Fitness in Humans Implies a Younger Epigenome and Transcriptome
Intestinal Barrier Dysfunction as a Feature of Aging in Many Species
NAFLD as an Age-Related Condition
Towards Sensory Hair Cell Regeneration in the Inner Ear
Raised Leve...
Source: Fight Aging! - May 21, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Towards Sensory Hair Cell Regeneration in the Inner Ear
Numerous forms of deafness, including age-related hearing loss, involve either loss of hair cells in the inner ear or loss of their axonal connections to the brain. These cells do not normally regenerate in mammals, and there is some interest in finding a way to bypass the suppression mechanisms that allow growth of hair cells during development but prevent regrowth during adult life. Approaches that show promise in animal studies include stem cell transplants, gene therapies, and small molecules targeting regulatory pathways. Here, researchers report on the ability of a mix of small molecules and siRNAs to produce regener...
Source: Fight Aging! - May 18, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Deep Elaboration & Other Stories of Teaching Anatomy & Physiology | TAPP 136
In Episode 136, host Kevin Patton looks at theeffects of tattoos on sweat glands, we discussaural diversity and how we can accommodate it, and we explore how to use the process ofdeep elaboration in our course to help challenged learners develop stronger and more useful memories.00:00 | Introduction00:47 | Tattoos May Impair Sweating05:37 | Sponsored by AAA06:41 | Aural Diversity. It ' s a Thing.22:36 | Sponsored by HAPI24:03 | Deep Elaboration34:22 | Sponsored by HAPS35:29 | Deeper Elaboration47:53 | Staying Connected ★ If you cannot see or activate the audio player, go to:theAPprofessor.org/podcast-...
Source: The A and P Professor - May 9, 2023 Category: Physiology Authors: Kevin Patton Source Type: blogs
Career Conversations: Q & A With Polymer Chemist Frank Leibfarth
Credit: Courtesy of Dr. Frank Leibfarth.
“I love that you can change the molecular-level structure of a material, then pull it, bend it, or twist it and see firsthand how the molecular changes you introduced influence its stretchiness or bendiness,” says Frank Leibfarth Ph.D., an associate professor of chemistry at the University of North Carolina (UNC) at Chapel Hill. In an interview, Dr. Leibfarth shares with us his scientific journey, his use of chemistry to tackle challenges in human health and sustainability, and his beliefs on what makes a career in science exciting.
Q: What led you to study chemistry?
...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - April 19, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Chemistry, Biochemistry and Pharmacology Tools and Techniques Cool Tools/Techniques Profiles Source Type: blogs
111 Tired Quotes You Can Relate to (But Also Get a Boost of Energy From)
If you’re tired today then maybe this post can help you.
In it I want to share relatable and timeless thoughts on tiredness. To give you some comfort. To remind you that you’re not alone in feeling this way.
But I also want to offer thoughts that can bring you a new spark of energy and motivation. And wisdom that may give you new ideas about how to tackle being tired. To hopefully be less tired in the coming weeks and months.
This is 111 of the best and most powerful tired quotes. I truly hope you’ll find something helpful here.
And if you want more useful motivation then check out this post with quotes on dealing w...
Source: Practical Happiness and Awesomeness Advice That Works | The Positivity Blog - April 11, 2023 Category: Consumer Health News Authors: Henrik Edberg Tags: Inspirational Quotes Personal Development Source Type: blogs
Utilizing Technology to Expand Language Access
The following is a guest article by Nic McMahon, CEO at United Language Group
Communication and connection are crucial in healthcare settings. To better connect with their community and ensure equitable access, healthcare organizations are shifting to a more human-focused, patient-centered care approach. Without a strong focus on language access, some groups of vulnerable patients may fall through the cracks.
As of 2019, almost 68 million people in the United States spoke a language other than English at home. A significant percentage of these people have limited English proficiency (LEP).
Research shows that patients ...
Source: EMR and HIPAA - April 5, 2023 Category: Information Technology Authors: Guest Author Tags: Administration AI/Machine Learning Ambulatory Clinical Communication and Patient Experience Health IT Company Healthcare IT Hospital - Health System LTPAC Accessible Communication Blind Patients Deaf Patients Hard of Hearing Patien Source Type: blogs
Fight Aging! Newsletter, March 27th 2023
This study has potentially significant implications in the field of OA as it provides a novel strategy for OA treatment.
A Vicious Cycle of Heart Failure and Dementia
https://www.fightaging.org/archives/2023/03/a-vicious-cycle-of-heart-failure-and-dementia/
The end of life is not pretty. The body is a failing machine of many complex essential parts, and the failures cascade and feed into one another as it breaks down. There is pain, loss of capacity, loss of the self as the brain runs down. There is a tendency to paper over the ugly reality in public discussion, to not talk about the facts of the matter...
Source: Fight Aging! - March 26, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Mitochondrial Dysfunction in Age-Related Hearing Loss
Loss of sensory hair cells in the inner ear, or loss of the connections between these cells and the brain, drive age-related hearing loss. Researchers here focus on the contribution of mitochondrial dysfunction to this condition, alongside the decline of autophagy in older individuals, leading to poor quality control of mitochondria and consequent loss of function. Many pharmacological approaches exist or are under development to improve autophagy to a degree similar to that resulting from structured exercise programs, but compelling evidence for significantly greater improvements are so far lacking. We can reasonably deba...
Source: Fight Aging! - March 24, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Automating Cellular Image Analysis to Find Potential Medicines
Dr. Anne Carpenter. Credit: Juliana Sohn.
When she started college, Anne Carpenter, Ph.D., never guessed she’d one day create software for analyzing images of cells that would help identify potential medicines and that thousands of researchers would use. She wasn’t planning to become a computational biologist, or even to focus on science at all, but she’s now an institute scientist and the senior director of the Imaging Platform at the Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard in Cambridge.
Starting Out in Science
Before beginning her undergraduate studies at Purdue University...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - March 22, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Cells Tools and Techniques Bioinformatics Cellular Imaging Computational Biology Cool Tools/Techniques Profiles Source Type: blogs
Launching Biomedical Careers for Students Who Are Deaf and Hard of Hearing
Group of RIT U-RISE students, including Bo Allaby (standing second from the right) and Maameyaa Asiamah (kneeling in front) who are interviewed in this post. Credit: Dr. Bonnie Jacob.
Scientists who are deaf and hard of hearing (DHH) are underrepresented at all career stages, especially at the Ph.D. level. To address this, the Undergraduate Research Training Initiative for Student Enhancement (U-RISE) training program for undergraduates who are deaf and hard of hearing at the Rochester Institute of Technology (RIT) in Rochester, New York, has committed to lifting barriers and increasing DHH representation in science.
...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - March 8, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Profiles Training Source Type: blogs
What's new in midwifery - 23rd February 2023
First, some research that has been picked up by the media:A study of school performance in 12 year olds, looking at performance in children who were born following an induced labour. Thestudy is open access andgot coverage in the Guardian. Then, some things about breastfeeding:Claims made on formula milk are not backed up by evidence,a study in the BMJ finds,discussed in the Guardian and by the BBC.TheGuardian ’s coverage of a new series ofopen access articles in the Lancet.Office for Health Improvement and Disparities, statistics on breastfeeding at 6-8 weeks after birth, quarterl...
Source: Browsing - February 23, 2023 Category: Databases & Libraries Tags: breastfeeding midwifery Source Type: blogs
