Fight Aging! Newsletter, December 4th 2023
This study produced a great deal of data that continues to be mined for insights into human aging and effects of calorie restriction in a long-lived species such as our own, to contrast with the sizable effects on health and longevity in short-lived species such as mice.
In particular, and the topic for today, cellular senescence and its role in degenerative aging has garnered far greater interest in the research community in the years since the CALERIE study took place. Thus in today's open access paper, scientists examine CALERIE study data to find evidence for calorie restriction to reduce the burden of cellular ...
Source: Fight Aging! - December 3, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Frailty Correlates with Hearing Loss in Later Life
Many seemingly unrelated aspects of aging correlate with one another in incidence and progression. All of the myriad manifestations of degeneration aging arise from the same small set of underlying processes of cell and tissue damage, so such correlations are perhaps unsurprising. There are cases in which a direct causal connection is found, as in the case of hearing loss contributing to dementia, but in the case of hearing loss and frailty we might expect correlation to arise from shared underlying mechanisms, such as the chronic inflammation that is characteristic of later life.
In a nationally representative sa...
Source: Fight Aging! - November 30, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Will We All Have To Become Biologically Enhanced Superhumans?
Okay, hands up who can tell who’s the most famous biologically enhanced superhuman in the world? True, it’s a quite close call between Captain America and The Incredible Hulk (sorry Spidey, you’re not even close). But are human-invented superhumans just a thing of a Stan Lee comic, or is it an actual scientific idea from a real laboratory?
As a matter of fact, enhancing human capabilities has been on the minds of people for ages, but it has come a long way from ancient training methods to exoskeletons. Enhancing our abilities, be it permanently or temporarily is a tempting but risky matter. Will it be possibl...
Source: The Medical Futurist - November 21, 2023 Category: Information Technology Authors: berci.mesko Tags: Forecast Artificial Intelligence in Medicine Augmented Reality Bioethics Biotechnology Cyborgization Digital Health Research E-Patients Genomics Health Sensors & Trackers Healthcare Policy Medical Education Robotics Science Ficti Source Type: blogs
Curiosity-Driven Science: Q & A With Saad Bhamla
What do worm blobs and insect pee have to do with human health? We talked to Saad Bhamla, Ph.D., assistant professor of chemical and biomolecular engineering at Georgia Institute of Technology (Georgia Tech) in Atlanta, to find out.
Q: What did your path to becoming a scientist look like?
Credit: Rob Felt, Georgia Tech.
A: I grew up in Dubai and did my undergraduate work in India, which is where I was first introduced to science. The science faculty members seemed to be having so much fun and would say things like “for the love of science,” but I couldn’t figure out what joy they were getting until I got a ta...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - November 15, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Tools and Techniques Cool Tools/Techniques Profiles Research Organisms Source Type: blogs
More Evidence for Impaired Hearing to Contribute to Cognitive Decline
In conclusion, cochlear implant use seems to boost cognitive trajectories in the first years after implantation. However, long-term prevention of dementia seems to need far more than restoration of hearing loss. (Source: Fight Aging!)
Source: Fight Aging! - October 16, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, October 9th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - October 8, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Bidirectional Relationship Between Hearing Loss and Cognitive Decline?
In today's open access review paper, researchers lay out summarize hypotheses and evidence for there to be a bidirectional relationship between age-related hearing loss and loss of cognitive function. Their summary is informative, but in their view the present literature is too sparse to be conclusive, and further studies are needed to provide a greater breadth of human data.
There is good reason to think that hearing loss contributes directly to a more rapid pace of cognitive decline. The brain is very much a "use it or lose it" organ, and lacking use in later life, it declines more rapidly. Evidence from study pop...
Source: Fight Aging! - October 5, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
What is Known of the Mechanisms of Age-Related Hearing Loss
Hearing loss is prevalent in older individuals, either involving the destruction of sensory hair cells in the inner ear, or the axonal connections between those hair cells and the brain, or both. Hair cells do not normally regenerate to any great degree in adults, which has led to efforts to grow patient matched replacement cells, or reprogram native cells to convince them to produce new hair cells. Despite promising advances, it is not as yet a solved problem.
Age-related hearing loss, or presbycusis, is a common cause of hearing loss in elderly people worldwide. It typically presents as progressive, irreversible...
Source: Fight Aging! - October 4, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Reasons, Rewards, and Tips for a More Accessible and Inclusive Web
The following is a guest article by Ben Cash, Founding Partner and CEO at Reason One
The end of September marks International Week of the Deaf, followed soon after by Blind Americans Equality Day. Both are reminders of the need to make online resources accessible to all. Supporting this is the Americans with Disabilities Act (ADA), intended to protect the civil rights of persons with disabilities when it comes to areas like employment, government services, public accommodations, transportation, and telecommunications.
For any organization – and particularly healthcare entities and systems – accessibility should...
Source: EMR and HIPAA - September 19, 2023 Category: Information Technology Authors: Guest Author Tags: C-Suite Leadership Communication and Patient Experience Health IT Company Healthcare IT Hospital - Health System Accessibility Ada Automated Tools Ben Cash DE&I Digital Accessibility ESG Healthcare Accessibility Reason One Scre Source Type: blogs
Ensuring Fairness in Medical Education Assessment
This study takes a first step in centering the margins as we as medical educators grow our understanding of the dynamics of promoting fairness in assessment. Future studies should explore feedback with intentional inclusion and involvement of diverse students, teachers, and researchers at every stage of the research process from conceptualization through dissemination and application of the new learning. We thank our participants for their time and candor discussing this sensitive topic and the Group on Educational Affairs for funding our work. Thank you for your time and attention and the focus that you’ll put on th...
Source: Academic Medicine Blog - September 18, 2023 Category: Universities & Medical Training Authors: amrounds Tags: AM Podcast AM Podcast Transcript Academic Medicine podcast assessment equity Macy Foundation medical education Source Type: blogs
Fight Aging! Newsletter, August 28th 2023
In conclusion, we identified 20 genes with significant evolutionary signals unique to long-lived species, which provided new insight into the lifespan extension of mammals and might bring new strategies to extend human lifespan.
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Trials of Xenotransplantation of Pig Organs into Humans Continue
https://www.fightaging.org/archives/2023/08/trials-of-xenotransplantation-of-pig-organs-into-humans-continue/
Researchers have genetically engineered pigs to overcome the known barriers to transplantation of pig organs into humans, and have reached the stage of conducting transplants i...
Source: Fight Aging! - August 27, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Towards the Regrowth of Lost Sensory Hair Cells in the Inner Ear
Age-related deafness arises from some combination of (a) the loss of sensory hair cells in the inner ear, and (b) the loss of connections between those cells and the brain. There is some disagreement in the literature as to which of these mechanisms is the most relevant, but most recent efforts in the field are focused on trying to coerce the body into producing new hair cells. If that production of new hair cells in the inner ear follows the normal developmental processes, then it might solve both of the above mentioned issues, providing both cells and connections to the brain.
Today's research materials illustrate...
Source: Fight Aging! - August 23, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Up Your Game With NIH Kahoot! Quizzes
NIH is now a premium partner with Kahoot! Credit: NIGMS.
We’re excited to announce our new partnership with Kahoot! Although we aren’t new Kahoot! gamers, we’ve recently partnered with them to provide you quizzes from across the National Institutes of Health (NIH) in a single place. “Reaching young people to teach them about biomedical science and inspire them to pursue careers in science is critically important to ensuring a diverse and vibrant biomedical research enterprise,” says NIGMS Director Jon Lorsch, Ph.D. “Our partnership with Kahoot! expands NIH’s STEM offerings, providing educators with free, in...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - August 23, 2023 Category: Research Authors: Chrissa Chverchko Tags: STEM Education Source Type: blogs
Fight Aging! Newsletter, August 14th 2023
This study demonstrates just how vital the thymus is to maintaining adult health."
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Does Amyloid-β Aggregation Cause Broad Disruption of Proteostasis?
https://www.fightaging.org/archives/2023/08/does-amyloid-%ce%b2-aggregation-cause-broad-disruption-of-proteostasis/
Researchers here speculate on the ability of insoluble amyloid-β aggregates to be broadly disruptive of the solubility of many other proteins, and thus disruptive to cell and tissue function. Is this important in aging? The evidence here shows the existence of the mechanism in a lower species, but that doesn't ...
Source: Fight Aging! - August 13, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Stimulating the Olfactory System as a Way to Improve Late Life Cognitive Function
The research noted here adds to evidence for the lack of use of the senses to contribute to age-related declines in cognitive function: a sort of "use it or lose it" proposition for the brain that becomes especially pronounced in later life. This effect is better studied in the context of age-related deafness, given the sizable amount of data on hearing aid use. Here, however, researchers focus on the sense of smell, and find that cognitive function can be improved by stimulation via scents.
When a fragrance wafted through the bedrooms of older adults for two hours every night for six months, memories skyrocketed....
Source: Fight Aging! - August 7, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
