Microsoft Teams and Boostlingo Integration Improves Healthcare Interpretation Efficiency
Talking with a CIO this week, he described how telehealth is now just part of the infrastructure for how they see patients.  Certainly telehealth balooned during COVID and has come back to more reasonable levels now, but in many cases telehealth appointments have still settled at 100 times what they were before COVID.  Patients and clinicians are now more comfortable with telehealth as an option that provides great convenience for the patients. One of the most common telehealth platforms being used right now is Microsoft Teams.  My guess is that it was widely adopted because it was included in the Microsoft package that...
Source: EMR and HIPAA - March 28, 2024 Category: Information Technology Authors: John Lynn Tags: Ambulatory Clinical Communication and Patient Experience Health IT Company Healthcare IT Hospital - Health System IT Infrastructure and Dev Ops LTPAC Telemedicine and Remote Monitoring Boostlingo Healthcare Interpreters Healthcare Sc Source Type: blogs

Further Progress Towards Regeneration of Sensory Hair Cells to Treat Deafness
In recent years, researchers have attempted to provoke the regeneration of lost sensory hair cells in the inner ear, a potential treatment for forms of deafness. Various genes related to the creation of these cells during development have been identified, and gene therapy interventions attempted in animal models. Progress has been made, but it is incremental, and the results not yet satisfactory. Noted here is a recent example of this sort of work, in which a cocktail of genes is employed rather than focusing on single gene interventions. The transcription factors (genes) Gfi1, Atoh1, Pou4f3, and Six1 (known colle...
Source: Fight Aging! - March 14, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Exploring gene therapy for chronic pain [PODCAST]
Subscribe to The Podcast by KevinMD. Watch on YouTube. Catch up on old episodes! Join L. Joseph Parker, a research physician, as we explore recent breakthroughs in gene editing, including its use in curing deafness and treating sickle cell anemia. Joseph discusses the ethical implications, accessibility challenges, and the potential of gene therapy in revolutionizing Read more… Exploring gene therapy for chronic pain [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - March 1, 2024 Category: General Medicine Authors: Tags: Podcast Pain Management Source Type: blogs

Amie Fornah Sankoh Achieves a Scientific Dream
Credit: LinkedIn. “I wanted to give up so many times. Although I tried to remain positive, I never thought I’d be able to finish my Ph.D. But I made it, and I’m extremely proud of myself,” says Amie Fornah Sankoh, Ph.D., a research scientist with Dow Chemical Company who received NIGMS support as a graduate student. Human and Plant Communication Dr. Sankoh has loved science and mathematics since she was just a child growing up in Sierra Leone. When she was 3 years old, Dr. Sankoh became deaf from a childhood disease. Math, unlike other subjects, is very visual, which played a part in her interest in it. “...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - February 28, 2024 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Chemistry, Biochemistry and Pharmacology Profiles Training Source Type: blogs

Sunday Sermonette: Right to life?
The RSV labels Psalm 58 " A prayer for vengeance. " Since that is an addition by modern translators, I don ' t include it here, but at least they ' re frank about it. There ' s no indication of what, specifically, has provoked this fantasy of gory torture and murder, but the writer (not actually David) was really pissed about something. Note that according to the Bible, the literal, inerrant word of God, God wants the unborn babies of the unrighteous to be aborted (verse 8). I ' m not sure what the " pots " are in verse 9, and I can ' t find an explanation. Note in verse 1 that there are multiple Gods. Evidently the o...
Source: Stayin' Alive - February 4, 2024 Category: American Health Source Type: blogs

Fight Aging! Newsletter, January 22nd 2024
In this study, we found that DMC reduced the SASP level in senescent cells. Furthermore, senescent cells enter irreversible cell cycle arrest, which involves the activation of p53/p21 and Rb/p16. In this study we found that the expression levels of p21 and p16 were decreased after DMC treatment. The downregulation of p21 may be attributed to the decrease of p53. In this study, we found that the mRNA level of p53 was reduced after DMC treatment. Ferroptosis is an iron-dependent cell death process, which is accompanied by iron accumulation. Our previous study reported an important role of FECH, an enzyme inserts ferro...
Source: Fight Aging! - January 21, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Evidence for the Unfolded Protein Response to be Involved in Age-Related Deafness
Researchers have found that deafness-associated gene TMTC4 causes pathology via an excessive increase in the unfolded protein response in sensory hair cells of the inner ear, and loud noise does much the same. This suggests that inhibition of the unfolded protein response in these cells might be a way to slow loss of hearing capacity, or protect against the effects of loud noise and drugs that can harm hair cells. Still, this isn't a path to restoration of hearing capacity. That would require some way to replace lost hair cells and their connections to the brain. Mutations to the TMTC4 gene trigger a molecular dom...
Source: Fight Aging! - January 15, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, January 15th 2024
In conclusion, FMD cycles have high potential to be effective in increasing the toxicity of a range of therapies against ALL and other blood cancers and should be tested in randomized clinical trials, especially in combination with immunotherapy and low toxicity cancer therapies. In summary, we present a new strategy for improving leukemia treatment by combining FMD with chemotherapy to promote the killing of ALL cells in part by an immune-dependent mechanism. Fasting/FMD has been shown to reduce chemotherapy-associated toxicity in pre-clinical and clinical studies and thus represents a safe and potentially effectiv...
Source: Fight Aging! - January 14, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Another Large Study of Hearing Aid Use Shows Deafness Increases Dementia Risk
You might compare the research noted here with another similar study published a year ago. In both cases, data on hearing aid use in large patient populations is used to demonstrate that hearing loss contributes to the onset and progression of dementia. This data doesn't favor any specific theory regarding the mechanism, such as atrophy of brain structures resulting from disuse versus some form of maladaptive compensatory activity in the brain. Greater understanding of the mechanisms involved will require further research. Hearing loss has been suggested as a risk factor for dementia, but there is still a need for...
Source: Fight Aging! - January 10, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Wednesday Bible Study: Misery
In psalms 38 and 39, the singer -- purportedly David --  is suffering from some very unpleasant disease.  Of course, back then they believed that diseases were punishments by God, and so the psalmist believes. Although the attribution of these psalms to David is fictitious, it would not be surprising if he had some sort of sexually transmitted disease, assuming he actually existed and 1/10th of the stories about him are true. Anyway . . . The reference in the introduction to psalm 39, "To the choirmaster: to Jeduthun " is to 1 Chronicles 16, in which David establishes the tradition of musical performance bef...
Source: Stayin' Alive - January 3, 2024 Category: American Health Source Type: blogs

Fight Aging! Newsletter, December 25th 2023
This study generates a comprehensive single-cell transcriptomic atlas of human atherosclerosis including 118,578 high-quality cells from atherosclerotic coronary and carotid arteries. By performing systematic benchmarking of integration methods, we mitigated data overcorrection while separating major cell lineages. Notably, we define cell subtypes that have not been previously identified from individual human atherosclerosis scRNA-seq studies. Besides characterizing granular cell-type diversity and communication, we leverage this atlas to provide insights into smooth muscle cell (SMC) modulation. We integrate genome...
Source: Fight Aging! - December 24, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Inflammaging in the Inner Ear, a Path to Hearing Loss
Inflammaging is a blanket term for the inappropriate inflammatory reaction of the immune system to the accumulation of molecular damage and other changes that take place with age. Constant, low-grade, unresolved inflammatory activation of the immune system is a feature of aging. It alters cell behavior for the worse and is disruptive to tissue structure and function. A number of different mechanisms contribute to forming and maintaining the state of inflammaging, such as pro-inflammatory signaling produced by ever-larger numbers of senescent cells, and innate immune recognition of mislocalized mitochondrial DNA that result...
Source: Fight Aging! - December 20, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Seeking Success in Science Through NIH-Funded Training
Credit: Courtesy of Hasset Nurelegne. “What’s great about a career in research is that there are so many paths you can take. I get so excited for the future when I think about all the open doors ahead of me,” says Hasset Nurelegne, a senior at Emory University in Atlanta, Georgia. Hasset is majoring in neuroscience and behavioral biology (NBB) as well as English. Since her first year on campus, Hasset has been an active participant in an NIGMS-funded program at Emory that aims to develop a diverse pool of scientists, the Initiative for Maximizing Student Development (IMSD) (which is now just for graduate student...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - December 20, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Profiles Training Source Type: blogs

GTCR to Acquire Cloudbreak Health
Leading Video-Focused Language Interpretation Service Provider to Become Independent Company GTCR, a leading private equity firm, announced today that it has signed a definitive agreement to acquire Cloudbreak Health, LLC, a leading provider of tech-enabled, healthcare-focused language interpretation services, in a corporate carve-out transaction from UpHealth, Inc. Under the terms of the agreement, the purchase price is $180 million, and the transaction is expected to close in the first quarter of 2024 following the receipt of customary regulatory and stockholder approvals and closing conditions. Headquartered in Columb...
Source: EMR and HIPAA - December 15, 2023 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT Andy Panos CloudBreak Cloudbreak Health Geoffrey Tresley GTCR Health IT Acquisitions Healthcare M&A Kirkland & Ellis LLP Mark Anderson Martti Monroe and Barings My Accessible Real-Time Trusted Inte Source Type: blogs

Wednesday Bible Study: Petitioning the Lord with Prayer
To me, one of the strangest conceits of religion -- and it seems to be pretty much universal among theists -- is that it ' s worth your while to beg The Almighty to conform to your wishes. He is supposedly all knowing, all powerful, and infinitely wise, but evidently he needs your advice in order to do what ' s right. Obviously, he doesn ' t always take it, but that doesn ' t stop people from continuing to give it, as in Psalm 28.  Psalm 29 is a panegyric to God ' s power and greatness, quite reminiscent of parts of the Book of Job. However, if you read this literally it seems to refer to a natural disaster of so...
Source: Stayin' Alive - December 13, 2023 Category: American Health Source Type: blogs