Emerging evidence of context-dependent synapse elimination by phagocytes in the CNS
J Leukoc Biol. 2024 May 3:qiae098. doi: 10.1093/jleuko/qiae098. Online ahead of print.ABSTRACTPrecise synapse elimination is essential for the establishment of a fully developed neural circuit during brain development and higher function in adult brain. Beyond immune and nutrition support, recent groundbreaking studies have revealed that phagocytic microglia and astrocytes can actively and selectively eliminate synapses in normal and diseased brains, thereby mediating synapse loss and maintaining circuit homeostasis. Multiple lines of evidence indicate that the mechanisms of synapse elimination by phagocytic glia are not u...
Source: Journal of Leukocyte Biology - May 3, 2024 Category: Hematology Authors: Fang-Shuai Shen Cui Liu Hui-Zhe Sun Xin-Yi Chen Yan Xue Lei Chen Source Type: research
β-blockers as the First Line of Treatment for Hypertension Management
J Assoc Physicians India. 2023 Sep;71(9):95-100. doi: 10.59556/japi.71.0341.ABSTRACTβ-adrenergic blocker group of medicines has been traditionally used to control high blood pressure since propranolol was discovered by Sir James Black almost 50 years ago. They were the drug of choice in hypertension (HTN) associated with ischemic heart disease, tachyarrhythmias including atrial fibrillation (AF), and anxiety. Congestive cardiac failure was a relative contraindication, but with major advances in science, it became an absolute indication. However, with the advent of newer antihypertensives, especially calcium channel blocke...
Source: Journal of the Association of Physicians of India - May 3, 2024 Category: General Medicine Authors: Saumitra Ray Saboo Banshi Joshi Shashank Tiwaskar Mangesh Bansal Sandeep Kamal Kumar Nath Baishali Source Type: research
Increased Pill Burden and Adverse Effects of Psychotropics Correlated with Poor Quality of Life and Medication Nonadherence: A Cross-sectional Drug Utilization Study at a Tertiary Care Hospital in Delhi during COVID-19 Pandemic
CONCLUSION: In the tertiary care hospital described, rational drug prescribing was followed. Increase in the number of drugs per prescription was found to be associated with poor QOL and the development of ADRs led to medication nonadherence in the patients. Further studies with larger sample sizes are needed to confirm these results. How to cite this article: Kumar A, Halder S, Srivastava S, et al. Increased Pill Burden and Adverse Effects of Psychotropics Correlated with Poor Quality of Life and Medication Nonadherence: A Cross-sectional Drug Utilization Study at a Tertiary Care Hospital in Delhi during COVID-19 Pandemic...
Source: Journal of the Association of Physicians of India - May 3, 2024 Category: General Medicine Authors: Ashish Kumar Sumita Halder Shruti Srivastava Rachna Gupta Source Type: research
Pilot Study on Therapeutic Horticulture for Chronic Low Back Pain: A Mixed Methods Study
CONCLUSION: Patients presenting to an outpatient spine clinic may be receptive to trying TH in conjunction with or in place of conventional medicine to promote health and well-being. The pilot experimental group data suggested that acute TH is enjoyable and may confer the benefits of reducing anxiety and improving spine motion. Future larger studies could use different dose response approaches, explore different TH activity types and involve participants from different geographic locations while controlling for LBP history and psychological status.PMID:38702158 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - May 3, 2024 Category: Complementary Medicine Authors: Sharareh Sharififar Michael Sein Elizabeth Diehl Siang-Yu Tham Ryan M Nixon Carter Sheppard Jamie Bolling Mohammad Majid Cynthia Apfelbaum Heather K Vincent Source Type: research
Effects of WeChat-Based Mindfulness-Based Stress Reduction on Psychological Resilience and Quality of Life Among Patients Undergoing Loose Body Removal Surgery
CONCLUSIONS: WeChat-based MBSR emerges as a promising intervention, significantly alleviating depression and anxiety while enhancing the quality of life and psychological resilience in patients undergoing loose body removal surgery, suggesting its potential for widespread clinical application.PMID:38702156 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - May 3, 2024 Category: Complementary Medicine Authors: Yuncheng Qiu Huan Xu Source Type: research
The Application Effect of Evidence-Based Targeted Nursing in Severe Preeclamptic Women and Its Impact on Maternal Psychological Status, Quality of Life, and Maternal-Infant Outcomes
CONCLUSION: Evidence-based targeted nursing intervention in severe preeclamptic women demonstrates significant benefits in improving maternal psychological well-being, quality of life, and maternal-infant outcomes. The intervention effectively reduces depression and anxiety levels, enhances overall quality of life, and reduces the incidence of adverse pregnancy and neonatal outcomes. The use of personalized care plans and enhanced patient education may contribute to these positive outcomes. Furthermore, evidence-based targeted nursing intervention promotes higher levels of nursing satisfaction and fosters better doctor-pat...
Source: Alternative Therapies in Health and Medicine - May 3, 2024 Category: Complementary Medicine Authors: Wei Yan Ying Zhou Source Type: research
Electric and magnetic field pollution in near substations and investigation of anxiety and depressive effects on adult individuals living in this area
In conclusion, there is no statistically convincing evidence of a relationship between EMF exposure and anxiety-depression (p > 0.05). This result shows that there may be more meaningful results in places with higher EMF levels. We interpreted the fact that exposure to electromagnetic fields does not cause anxiety and depression in individuals, as the measured values are below the limit values.PMID:38699873 | DOI:10.1080/15368378.2024.2348574 (Source: Electromagnetic Biology and Medicine)
Source: Electromagnetic Biology and Medicine - May 3, 2024 Category: Physics Authors: Cemil Sert Nurdag ül Başak İbrahim Koruk Source Type: research
Qualitative Study of Food Insecurity in Hospitalized Pediatric Patients during the COVID-19 Pandemic
CONCLUSIONS: The COVID-19 pandemic impacted unemployment and poverty and consequently exacerbated FI. Our findings point to the need to focus on proximal societal solutions, such as federal policies aimed at food assistance and childcare. Understanding the challenges related to FI that caregivers and patients experience can improve screening, support, and treatment of patients presenting for care and inform the design of necessary interventions for individuals and communities beyond COVID-19.PMID:38701847 | PMC:PMC11073801 | DOI:10.14423/SMJ.0000000000001684 (Source: Southern Medical Journal)
Source: Southern Medical Journal - May 3, 2024 Category: General Medicine Authors: Natalie King Adolfo Molina Samantha Hanna Lori Brand Bateman Source Type: research
The impact of negative affects on the high prevalence of anxiety, depression and stress in healthcare professionals
CONCLUSIONS: The high prevalence of anxiety, depression and stress in healthcare professionals is associated with the presence of negative affects. Mental disorders should be measured, and practices adopted to ensure well-being and job performance.PMID:38701170 | DOI:10.3233/WOR-230257 (Source: Work)
Source: Work - May 3, 2024 Category: Occupational Health Authors: Ana Merzel Kernkraut Luciana Diniz Nagem Janot de Matos Source Type: research
Did a workplace sugar-sweetened beverage sales ban reduce anxiety-related SSB consumption during the COVID-19 pandemic?
CONCLUSIONS: SSB sales bans likely reduce SSB consumption through multiple pathways; buffering stress-related consumption may be one mechanism.PMID:38698591 | DOI:10.1017/S1368980024000995 (Source: Public Health Nutrition)
Source: Public Health Nutrition - May 3, 2024 Category: International Medicine & Public Health Authors: Laurie M Jacobs Laura A Schmidt Dean Schillinger Jamey M Schmidt Katie E Alegria Bethany Parrett Amanda Pickett Elissa S Epel Source Type: research
Assessment of Knowledge and Concern of People Living with HIV Regarding Human Mpox and Vaccination
CONCLUSION: The future study should focus on continuous education, promoting awareness through programs and establishing measures to successfully overcome identified variables that contribute to mpox pandemic understanding and attitudes. Applying the lessons learned from the COVID-19 pandemic will help the management of mpox virus.PMID:38698752 | DOI:10.2174/011570162X293673240427062123 (Source: Current HIV Research)
Source: Current HIV Research - May 3, 2024 Category: Infectious Diseases Authors: Deniz Borcak Yusuf Emre Özdemir Ye şilyurt Zuhal Esra Ensaro ğlu Samiha Akkaya Kadriye Kart Ya şar Source Type: research
Emerging evidence of context-dependent synapse elimination by phagocytes in the CNS
J Leukoc Biol. 2024 May 3:qiae098. doi: 10.1093/jleuko/qiae098. Online ahead of print.ABSTRACTPrecise synapse elimination is essential for the establishment of a fully developed neural circuit during brain development and higher function in adult brain. Beyond immune and nutrition support, recent groundbreaking studies have revealed that phagocytic microglia and astrocytes can actively and selectively eliminate synapses in normal and diseased brains, thereby mediating synapse loss and maintaining circuit homeostasis. Multiple lines of evidence indicate that the mechanisms of synapse elimination by phagocytic glia are not u...
Source: Journal of Leukocyte Biology - May 3, 2024 Category: Hematology Authors: Fang-Shuai Shen Cui Liu Hui-Zhe Sun Xin-Yi Chen Yan Xue Lei Chen Source Type: research
Electric and magnetic field pollution in near substations and investigation of anxiety and depressive effects on adult individuals living in this area
In conclusion, there is no statistically convincing evidence of a relationship between EMF exposure and anxiety-depression (p > 0.05). This result shows that there may be more meaningful results in places with higher EMF levels. We interpreted the fact that exposure to electromagnetic fields does not cause anxiety and depression in individuals, as the measured values are below the limit values.PMID:38699873 | DOI:10.1080/15368378.2024.2348574 (Source: Electromagnetic Biology and Medicine)
Source: Electromagnetic Biology and Medicine - May 3, 2024 Category: Physics Authors: Cemil Sert Nurdag ül Başak İbrahim Koruk Source Type: research
cGAS/STING signaling pathway-mediated microglial activation in the PFC underlies chronic ethanol exposure-induced anxiety-like behaviors in mice
In this study, we initially confirmed that chronic ethanol exposure (CEE) induces anxiety-like behaviors in mice through open field test and elevated plus maze test. The cGAS/STING signaling pathway has been confirmed to exhibits a significant association with inflammatory signaling responses in both peripheral and central systems. Western blot analysis confirmed alterations in the cGAS/STING signaling pathway during CEE, including the upregulation of p-TBK1 and p-IRF3 proteins. Moreover, we observed microglial activation in the prefrontal cortex (PFC) of CEE mice, characterized by significant alterations in branching morp...
Source: International Immunopharmacology - May 3, 2024 Category: Allergy & Immunology Authors: Wei Zhao Shuang Zhao Ran Wei Ziqi Wang Fang Zhang Fangjiao Zong Han-Ting Zhang Source Type: research
Pilot Study on Therapeutic Horticulture for Chronic Low Back Pain: A Mixed Methods Study
CONCLUSION: Patients presenting to an outpatient spine clinic may be receptive to trying TH in conjunction with or in place of conventional medicine to promote health and well-being. The pilot experimental group data suggested that acute TH is enjoyable and may confer the benefits of reducing anxiety and improving spine motion. Future larger studies could use different dose response approaches, explore different TH activity types and involve participants from different geographic locations while controlling for LBP history and psychological status.PMID:38702158 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - May 3, 2024 Category: Complementary Medicine Authors: Sharareh Sharififar Michael Sein Elizabeth Diehl Siang-Yu Tham Ryan M Nixon Carter Sheppard Jamie Bolling Mohammad Majid Cynthia Apfelbaum Heather K Vincent Source Type: research
