New drug development: the case of antibiotics
This article in Clinical Infectious Diseases explains the problem and also why drug companies are not doing enough to develop new classes of antibotics.Antimicrobial resistance is a profound global health threat of the 21st century. The United Kingdom ’s AMR Review estimates that by 2050 as many as 10 million persons a year will die of drug-resistant infections if solutions are not found [1]. The World Bank projects that, without containment of antimicrobial resistance, annual global gross domestic product will decrease by 1%, that is,>$1 trillion annually from 2030, and the hardest hit will be persons in low-income c...
Source: Stayin' Alive - February 19, 2021 Category: American Health Source Type: blogs
What is antimicrobial resistance (AMR) and why you should know about it
Today marks the beginning of World Antimicrobial Awareness Week, driven by the World Health Organisation to improve global knowledge of antibiotic drugs. Running from the 18th to the 24th of November, the awareness initiative is focused on uniting to preserve effective antimicrobials and reduce or prevent the spread of Antimicrobial Resistance (AMR), which is becoming an increasing concern across the world.
Before we jump deeper into the AMR and the global impact it will have if not addressed, let’s briefly cover the history of antimicrobials in medicine.
1910, the first breakthrough in antimicrobial treatment
T...
Source: GIDEON blog - November 18, 2020 Category: Databases & Libraries Authors: Kristina Symes Tags: Events News Source Type: blogs
AMR – what it is and why you should know about it
Today marks the beginning of World Antimicrobial Awareness Week, driven by the World Health Organisation to improve global knowledge of antibiotic drugs. Running from the 18th to the 24th of November, the awareness initiative is focused on uniting to preserve effective antimicrobials and reduce or prevent the spread of Antimicrobial Resistance (AMR), which is becoming an increasing concern across the world.
Before we jump deeper into the AMR and the global impact it will have if not addressed, let’s briefly cover the history of antimicrobials in medicine.
1910, the first breakthrough in antimicrobial treatment
T...
Source: GIDEON blog - November 18, 2020 Category: Databases & Libraries Authors: Kristina Symes Tags: Events News Source Type: blogs
New insights on antibiotics use on crops amongst smallholder farmers
Philip Taylor and Robert Reeder, research scientists at CABI, did not start out looking for trends in antibiotic use in crops. In fact, both Drs. Taylor and Reeder’s primary interest at the start of their study was to simply understand the general use of agrochemicals and other agents by smallholder farmers in lower and middle income countries (LMIC). What they found, however, as explained in their recently published article in CABI Agriculture and Bioscience, demonstrates how real-world data, drawn from community support networks, can unearth previously unknown uses of antibiotics which help protect the livelihoods of...
Source: BioMed Central Blog - August 10, 2020 Category: General Medicine Authors: Dylan Parker Tags: Biology Developing World Uncategorized agriculture AMR antimicrobial resistance Source Type: blogs
Fight Aging! Newsletter, January 20th 2020
This study provides strong evidence that following a healthy lifestyle can substantially extend the years a person lives disease-free."
Commentary on Recent Evidence for Cognitive Decline to Precede Amyloid Aggregation in Alzheimer's Disease
https://www.fightaging.org/archives/2020/01/commentary-on-recent-evidence-for-cognitive-decline-to-precede-amyloid-aggregation-in-alzheimers-disease/
I can't say that I think the data presented in the research noted here merits quite the degree of the attention that it has been given in the popular science press. It is interesting, but not compelling if its role is ...
Source: Fight Aging! - January 19, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Transplantation of Engineered Macrophages Rescues Mice from Sepsis
In this study, researchers collected monocytes from the bone marrow of healthy mice and cultured them in conditions that transformed them into macrophages. The lab also developed vitamin-based nanoparticles that were especially good at delivering messenger RNA, molecules that translate genetic information into functional proteins.
The scientists, who specialize in messenger RNA for therapeutic purposes, constructed a messenger RNA encoding an antimicrobial peptide and a signal protein. The signal protein enabled the specific accumulation of the antimicrobial peptide in internal macrophage structures called lysosomes...
Source: Fight Aging! - January 13, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Smartphone Camera Test for Urinary Tract Infections
Researchers at the University of Bath have developed a simple point-of-care test for urinary tract infections that uses a smartphone camera. The system can rapidly detect the presence of E. coli in urine samples and could guide doctors in their decision to prescribe antibiotics, ensuring appropriate patient care and avoiding the overuse of antimicrobial medication.
It can sometimes be difficult for clinicians to know whether to prescribe antibiotics. Unnecessary use of antibiotics is resulting in antimicrobial resistance, which will pose significant challenges to healthcare in the coming years. However, if a patient ha...
Source: Medgadget - January 9, 2020 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Medicine Urology Source Type: blogs
There ’s a new cure for the deadliest strain of tuberculosis. So what’s that mean for the REACH Initiative’s HIV research in South Africa?
“This strain of tuberculosis (TB) is XDR-TB – extremely drug resistant tuberculosis– and is, as the name implies, highly resistant to the standard treatments,” says professor and TB/HIV expert Jason Farley, PhD, MPH, ANP-BC, AACRN, FAAN. HIV weakens the immune system, increasing the risk of TB in people with HIV. Dr. Farley’s Center, The REACH
The post There’s a new cure for the deadliest strain of tuberculosis. So what’s that mean for the REACH Initiative’s HIV research in South Africa? appeared first on Johns Hopkins Nursing Magazine. (Source: Nursing Blogs at Johns Hopkins University)
Source: Nursing Blogs at Johns Hopkins University - August 16, 2019 Category: Nursing Authors: Online Editor Tags: On the Pulse antimicrobial resistance hiv REACH initiative TB tuberculosis Source Type: blogs
Phage therapy gains momentum
Shortly after Félix d’Herelle discovered viruses that infect bacteria in 1917 (also found in 1915 by Twort), he recognized their therapeutic potential for treating infections. The discovery of penicillin in 1928 began the golden age of antibiotics, which pushed aside progress in treating infections with bacteriophages. With the advent of widespread antimicrobial resistance, development of […] (Source: virology blog)
Source: virology blog - June 28, 2019 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information antibiotic resistance bacteriophage perfect predator phage therapy viral virus viruses Source Type: blogs
Gut Pathogens celebrates its 10th anniversary
Gut Pathogens was founded in 2009 as a journal focusing on enteric infections and aimed at an audience in the Global South and middle income countries. The focus of the first articles remained directed at virulence, epidemiology and genomics of classical pathogens. However, soon after the developments in the field of probiotics turned the journal into a preferred venue for research on this topic.
Furthermore, parallel developments in genomics of bacteria resulted in an increase of short articles documenting bacterial genomics, and this led us to create a new short article type called Genome Announcements. Soon after, the s...
Source: BioMed Central Blog - June 26, 2019 Category: General Medicine Authors: Niyaz Ahmed Tags: Biology Developing World Health Medicine bacterial genomics enteric infections gastroenterology gut gut pathogens gut-brain axis microbiome Source Type: blogs
Averting the AMR crisis: what are the avenues for policy action for countries in Europe?
European Observatory on Health Systems and Policies -This policy briefing summarises some of the key policy avenues for tackling antimicrobial resistance (AMR). Following the widely accepted ‘One Health’ approach to combating AMR, the brief aims to support the implementation of national action plans on AMR, drawing on numerous examples of effective policies implemented by European Union member states and involving the human, animal and environmental health sectors.BriefingMore detail (Source: Health Management Specialist Library)
Source: Health Management Specialist Library - April 8, 2019 Category: UK Health Authors: The King ' s Fund Information & Knowledge Service Tags: Local authorities, public health and health inequalities Source Type: blogs
Reservoirs of antimicrobial resistance
Parliamentary Office of Science and Technology (POST) - The widespread use of antimicrobials, particularly antibiotics, has accelerated the spread of antimicrobial resistance (AMR) in microbes. A recent report by the Health and Social Care Committee called for AMR to be a ‘top five policy priority’. This POSTnote evaluates the main reservoirs of AMR microbes arising from the use of antimicrobials in both humans and animals.POSTnoteMore detail (Source: Health Management Specialist Library)
Source: Health Management Specialist Library - February 19, 2019 Category: UK Health Authors: The King ' s Fund Information & Knowledge Service Tags: Local authorities, public health and health inequalities Source Type: blogs
Contained and controlled: the UK ’s 20-year vision for antimicrobial resistance
Department of Health and Social Care -This document contains a plan on how the UK will contribute to containing and controlling antimicrobial resistance by 2040. The vision and plan were developed across the government, its agencies and administrations in Scotland, Wales and Northern Ireland, with support from a range of stakeholders. It is supported by the UK five-year action plan for antimicrobial resistance 2019 to 2024.ReportFive year planDepartment of Health and Social Care - publications (Source: Health Management Specialist Library)
Source: Health Management Specialist Library - January 24, 2019 Category: UK Health Authors: The King ' s Fund Information & Knowledge Service Tags: Local authorities, public health and health inequalities Source Type: blogs
