Sepsis in 2018: a review
This article provides a summary of the most recent clinical evidence and professional guidelines for the diagnosis and treatment of the sepsis in the critical care setting. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - September 4, 2019 Category: Consumer Health News Source Type: news
Challenges and opportunities for antibiotic stewardship among preterm infants
Antibiotic stewardship programmes aim to optimise antimicrobial use to prevent the emergence of resistance species and protect patients from the side effects of unnecessary medication. The high incidence of systemic infection and associated mortality from these infections leads neonatal providers to frequently initiate antibiotic therapy and make empiric antibiotic courses one of the main contributors of antibiotic use in the neonatal units. Yet, premature infants are also at risk for acute life-threatening complications associated with antibiotic use such as necrotising enterocolitis and for long-term morbidities...
Source: Current Awareness Service for Health (CASH) - September 4, 2019 Category: Consumer Health News Source Type: news
Oral versus intravenous antibiotics for bone and joint infections: the OVIVA non-inferiority RCT
RCT (n=1054) found oral antibiotic therapy non-inferior to IV therapy when used during first 6 weeks in treatment for bone/joint infection, as assessed by definitive treatment failure within 1 year of randomisation (14.62% IV vs 13.16% oral), challenging current standard of care (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - August 27, 2019 Category: Consumer Health News Source Type: news
Antibiotic therapy for chronic infection with Burkholderia cepacia complex in people with cystic fibrosis
Review located one suitable RCT (n=100) which found that inhaled aztreonam lysine did not improve FEV1 and time to next exacerbation vs placebo. Authors therefore conclude that there is insufficient evidence to determine an effective antibiotic strategy for this infection. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - August 8, 2019 Category: Consumer Health News Source Type: news
Practical Tips for Diagnosing and Treating Bacterial Pneumonia in the Nursing Home
A clinical diagnosis of bacterial pneumonia in nursing home residents most often can be treated with a single oral course of antibiotic therapy targeted toward community-acquired pneumonia pathogens, Ghinwa Dumyati, MD, said at the AMDA — The Society for Post-Acute and Long-Term Care Medicine’s annual conference. (Source: Caring for the Ages)
Source: Caring for the Ages - July 30, 2019 Category: Health Management Authors: Christine Kilgore Source Type: news
Enteral lactoferrin for the treatment of sepsis and necrotizing enterocolitis in neonates
Neonatal sepsis and necrotizing enterocolitis (NEC) cause significant neonatal mortality and morbidity despite appropriate antibiotic therapy. Enhancing host defense and modulating inflammation by using lactoferrin as an adjunct to antibiotics in the treatment of sepsis, NEC, or both, may improve clinical outcomes. The primary objective was to assess safety and efficacy of oral lactoferrin as an adjunct to antibiotics in the treatment of neonates with suspected or confirmed sepsis, NEC, or both. Implications for practice: currently there is no evidence to support or refute the use of enteral lactoferrin, as an adjunct to a...
Source: Current Awareness Service for Health (CASH) - July 24, 2019 Category: Consumer Health News Source Type: news
Can Early Changes in Vital signs Predict Duration of Antibiotic Therapy in Suspected Neonatal Sepsis?
Suspected sepsis remains a leading causes of Neonatal Intensive Care Unit admission, with infants often receiving 48-72 hours of empirical antibiotic therapy. Early in treatment it is difficult to predict infants who will require prolonged antibiotic therapy. Our aim was to assess if vital sign measurements in the initial period of treatment can predict those neonates requiring prolonged antibiotic therapy in term and late-preterm infants. Respiratory rate shows a weak positive correlation with antibiotic duration. Infants requiring prolonged therapy were more likely to have abnormal vital signs 12 hours after initiating a...
Source: Current Awareness Service for Health (CASH) - July 24, 2019 Category: Consumer Health News Source Type: news
Antibiotics before liver transplants lead to better results
A UCLA-led research team has found that giving mice antibiotics for 10 days prior to a liver transplant leads to better liver function after the surgery.After concluding the experiment mice, the scientists discovered data from liver transplants performed between October 2013 and August 2015 at the Ronald Reagan UCLA Medical Center, revealing that the same phenomenon appears to hold true in humans. The statistics from human patients even demonstrated that the people who were in worse health prior to their surgeries but received pre-surgery antibiotics fared better after their transplants than the patients who were health...
Source: UCLA Newsroom: Health Sciences - July 23, 2019 Category: Universities & Medical Training Source Type: news
Bacterial Pathogens Associated With Diabetic Foot Ulcers Bacterial Pathogens Associated With Diabetic Foot Ulcers
A better understanding of the bacterial pathogens associated with diabetic foot ulcers will help guide the choice of antibiotic therapies.Wounds (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 16, 2019 Category: Consumer Health News Tags: Journal Article Source Type: news
Excess Antibiotic Treatment Duration and Adverse Events in Patients Hospitalized With Pneumonia: A Multihospital Cohort Study
Retrospective analysis of data from 43 US hospitals suggest 67.8% of patients received excess antibiotic therapy which was not associated with lower rates of any adverse outcomes, including death, readmission, emergency department visit, or Clostridium difficile infection. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - July 12, 2019 Category: Consumer Health News Source Type: news
Hospitalized Pneumonia Patients Often Get Excess Antibiotics
THURSDAY, July 11, 2019 -- Patients hospitalized with pneumonia often receive excess antibiotic therapy, according to a study published online July 9 in the Annals of Internal Medicine.
Valerie M. Vaughn, M.D., from the University of Michigan in Ann... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - July 11, 2019 Category: Pharmaceuticals Source Type: news
Antibiotics for Pneumonia: Short Course is More Effective Antibiotics for Pneumonia: Short Course is More Effective
Most patients hospitalized with community-acquired pneumonia received longer duration antibiotic therapy than needed, increasing the risk of post-discharge adverse events, a large study found.Medscape Medical News (Source: Medscape Internal Medicine Headlines)
Source: Medscape Internal Medicine Headlines - July 9, 2019 Category: Internal Medicine Tags: Pulmonary Medicine News Source Type: news
Headtohead oral prophylactic antibiotic therapy for chronic obstructive pulmonary disease
Review (2 RCTs; n= 391) found very limited evidence to support a difference in efficacy or safety between different classes or regimens of prophylactic antibiotic, given for 12 to 13 weeks for COPD. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 27, 2019 Category: Consumer Health News Source Type: news
An overview of positive cultures and clinical outcomes in septic patients: a sub-analysis of the Prehospital Antibiotics Against Sepsis (PHANTASi) trial
Sepsis remains one of the most important causes of morbidity and mortality worldwide. In approximately 30-50% of cases of suspected sepsis, no pathogen is isolated, disabling the clinician to treat the patient with targeted antimicrobial therapy. Studies investigating the differences in the patient outcomes between culture-positive and culture-negative sepsis patients have only been conducted in subgroups of sepsis patients and results are ambiguous. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 19, 2019 Category: Consumer Health News Source Type: news
European Society of Emergency Medicine position paper on the 1-hour sepsis bundle of the Surviving Sepsis Campaign: expression of concern.
In 2018 the Surviving Sepsis Campaign issued new guidance with a revised version of their sepsis bundle. Instead of the 2016 3-hour sepsis bundle, the Surviving Sepsis Campaign now recommends that blood cultures, lactate measurement, broad-spectrum antibiotic therapy and 30 ml/kg crystalloid fluid administration should be initiated within 1 hour after triage. The European Society of Emergency Medicine wishes to express its concerns regarding the low level of evidence that underlies this guidance, and the potential implications from an emergency physician point of view. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 19, 2019 Category: Consumer Health News Source Type: news
