Pleural Effusion: An Atypical Presentation of Kawasaki Disease Pleural Effusion: An Atypical Presentation of Kawasaki Disease
This case of a 7-year-old patient highlights the need to consider the diagnosis of Kawasaki disease in the presence of pneumonia and pleural effusion that is nonresponsive to antibiotic therapy.Journal of Medical Case Reports (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - December 24, 2019 Category: Intensive Care Tags: Family Medicine/Primary Care Journal Article Source Type: news
Antimicrobial prescribing: ceftolozane with tazobactam for treating hospital-acquired pneumonia, including ventilator-associated pneumonia
The manufacturer of ceftolozane with tazobactam anticipates that it will be used in line with good antimicrobial stewardship, on the advice of a microbiologist, to treat critically ill ventilated adults with HAP and VAP, who are deteriorating or not responding to initial antibiotic therapy, and who have confirmed or highly suspected Pseudomonas aeruginosa. Specialists involved in producing this evidence summary consider that ceftolozane with tazobactam provides a potentially useful alternative for treating some adults with HAP and VAP who have limited treatment options because they have infections suspected or proven to be...
Source: Current Awareness Service for Health (CASH) - December 19, 2019 Category: Consumer Health News Source Type: news
Ruth Bader Ginsburg Released From Hospital After Health Scare
The 86-year-old was first evaluated on Friday at a hospital in Washington, D.C., after feeling unwell. She was then transferred to The Johns Hopkins Hospital in Baltimore. By Saturday, her fever and chills had lessened after receiving intravenous antibiotic therapy and fluids, the spokeswoman said. (Source: WebMD Health)
Source: WebMD Health - November 25, 2019 Category: Consumer Health News Source Type: news
Every 15 Minutes, Someone In The US Dies Of A Drug-Resistant Superbug
(CNN) — Every 15 minutes, someone in the United States dies of a superbug that has learned to outsmart even our most sophisticated antibiotics, according to a new report from the US Centers for Disease Control and Prevention.
That’s about 35,000 deaths each year from drug-resistant infections, according to the landmark report.
The report places five drug-resistant superbugs on the CDC’s “urgent threat” list — two more germs than were on the CDC’s list in 2013, the last time the agency issued a report on antibiotic resistance.
Genetic research shows germs have become especially adep...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - November 16, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Boston News Featured Health Antibiotics Bacteria CNN Superbugs Source Type: news
Antibiotic-Resistant ‘ Superbugs ’ A Growing Health Crisis, New Report Finds
By Elizabeth Cohen and Nadia Kounang, CNN
(CNN) — Every 15 minutes, someone in the United States dies of a superbug that has learned to outsmart even our most sophisticated antibiotics, according to a new report from the US Centers for Disease Control and Prevention.
That’s about 35,000 deaths each year from drug-resistant infections, according to the landmark report.
The report places five drug-resistant superbugs on the CDC’s “urgent threat” list — two more germs than were on the CDC’s list in 2013, the last time the agency issued a report on antibiotic resistance.
Genetic rese...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - November 14, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News Syndicated CBSN Boston Antibiotics CNN Source Type: news
Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy
Myocarditis can develop into inflammatory cardiomyopathy through chronic stimulation of myosin heavy chain 6–specific T helper (TH)1 and TH17 cells. However, mechanisms governing the cardiotoxicity programming of heart-specific T cells have remained elusive. Using a mouse model of spontaneous autoimmune myocarditis, we show that progression of myocarditis to lethal heart disease depends on cardiac myosin–specific TH17 cells imprinted in the intestine by a commensal Bacteroides species peptide mimic. Both the successful prevention of lethal disease in mice by antibiotic therapy and the significantly elevated Bac...
Source: ScienceNOW - November 13, 2019 Category: Science Authors: Gil-Cruz, C., Perez-Shibayama, C., De Martin, A., Ronchi, F., van der Borght, K., Niederer, R., Onder, L., Lütge, M., Novkovic, M., Nindl, V., Ramos, G., Arnoldini, M., Slack, E. M. C., Boivin-Jahns, V., Jahns, R., Wyss, M., Mooser, C., Lambrecht, Tags: Immunology, Medicine, Diseases reports Source Type: news
Oral Vancomycin Prevents C Diff Infection in High-Risk Inpatients Oral Vancomycin Prevents C Diff Infection in High-Risk Inpatients
Oral vancomycin prophylaxis can prevent healthcare-facility-onset C. difficile infection (HCFO-CDI) in high-risk patients receiving systemic antibiotic therapy, according to results from an open-label randomized study.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 31, 2019 Category: Consumer Health News Tags: Infectious Diseases News Source Type: news
Blood Culture Results Before and After Antimicrobial Administration in Patients With Severe Manifestations of Sepsis: A Diagnostic Study
Administering antimicrobial agents before obtaining blood cultures could potentially decrease time to treatment and improve outcomes, but it is unclear how this strategy affects diagnostic sensitivity. We wanted to determine the sensitivity of blood cultures obtained shortly after initiation of antimicrobial therapy in patients with severe manifestations of sepsis. Among patients with severe manifestations of sepsis, initiation of empirical antimicrobial therapy significantly reduces the sensitivity of blood cultures drawn shortly after treatment initiation. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - October 30, 2019 Category: Consumer Health News Source Type: news
Procalcitonin and MR-proAdrenomedullin combination in the etiological diagnosis and prognosis of sepsis and septic shock
Procalcitonin and Mid-regional pro Adrenomedullin have been proposed for sepsis diagnosis, antibiotic therapy guidance and prognosis. . A retrospective analysis of PCT and MR-proADM on 571 consecutive patients with sepsis diagnosis was performed. PCT and MR-proADM combination represents an advantage for sepsis diagnosis and for 90-days mortality risk stratification. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - October 30, 2019 Category: Consumer Health News Source Type: news
Blood Culture Results Before and After Antimicrobial Administration in Patients With Severe Manifestations of Sepsis: A Diagnostic Study
Administering antimicrobial agents before obtaining blood cultures could potentially decrease time to treatment and improve outcomes, but it is unclear how this strategy affects diagnostic sensitivity. We looked to determine the sensitivity of blood cultures obtained shortly after initiation of antimicrobial therapy in patients with severe manifestations of sepsis. Among patients with severe manifestations of sepsis, initiation of empirical antimicrobial therapy significantly reduces the sensitivity of blood cultures drawn shortly after treatment initiation. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - October 30, 2019 Category: Consumer Health News Source Type: news
Association of Use of the Neonatal Early-Onset Sepsis Calculator With Reduction in Antibiotic Therapy and Safety: A Systematic Review and Meta-analysis
Use of the neonatal EOS calculator is associated with a substantial reduction in the use of empirical antibiotics for suspected EOS. Available evidence regarding safety of the use of the EOS calculator is limited, but shows no indication of inferiority compared with conventional management strategies. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - October 30, 2019 Category: Consumer Health News Source Type: news
Antibiotic treatment for spontaneous bacterial peritonitis in people with decompensated liver cirrhosis: a network metaanalysis
This review (12 trials, n=1278; 13 antibiotics) found short ‐term mortality after spontaneous bacterial peritonitis (SBP) is approx. 25%. However, authors report significant uncertainty about which antibiotic therapy is better in people with SBP. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - October 25, 2019 Category: Consumer Health News Source Type: news
Initiating Empirical Tx for Sepsis Reduces Blood Culture Sensitivity
12 percent difference seen in proportion of positive blood cultures before and after antimicrobial therapy (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - September 17, 2019 Category: Cancer & Oncology Tags: Infections, Internal Medicine, Critical Care, Emergency Medicine, Oncology, Pathology, Pharmacy, Journal, Source Type: news
Initiating Empirical Tx for Sepsis Reduces Blood Culture Sensitivity
TUESDAY, Sept. 17, 2019 -- When empirical antimicrobial therapy is initiated in patients with severe manifestations of sepsis, the sensitivity of blood cultures drawn shortly after treatment initiation is reduced, according to a study published... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - September 17, 2019 Category: Pharmaceuticals Source Type: news
Can Antibiotic Therapy for Cancer Improve Treatment Response to Immune Checkpoint Inhibitors?
A new study looked at median overall survival for patients with prior antibiotic therapy compared with patients with no prior antibiotic therapy. (Source: CancerNetwork)
Source: CancerNetwork - September 16, 2019 Category: Cancer & Oncology Authors: Leah Lawrence Source Type: news
