Systematic review of the stability of antimicrobial agents in elastomeric devices for outpatient parenteral antimicrobial therapy services based on NHS Yellow Cover Document standards
Review of 6 studies found Yellow Cover Document compliant stability of flucloxacillin and piperacillin over 24hr and cefazolin, ceftazidime& ceftolozane/tazobactam over 12hr periods. Previous review in 2017 failed to find evidence supportive for stability of elastometric pumps. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 18, 2021 Category: Consumer Health News Source Type: news
Effect of antimicrobial therapy on respiratory hospitalization or death in adults with idiopathic pulmonary fibrosis: The CleanUP-IPF randomized clinical trial
In this pragmatic RCT (n=513) the addition of co-trimoxazole or doxycycline to usual care did not reduce rate of first nonelective respiratory hospitalisation or death (20.4 vs 18.4 events per 100 person-years; p=0.83). (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 13, 2021 Category: Consumer Health News Source Type: news
Acquiring sepsis competencies through simulation-based learning bundle during intermediate care unit internship, Medicine
The objective of this study was to analyze whether a simulation-based learning bundle is useful for residents while acquiring competencies in the management of sepsis during their internship in an ImCU.A prospective study, set in a tertiary-care academic medical center was performed enrolling residents who performed their internship in an ImCU from 2014 to 2017. The pillars of the simulation-based learning bundle were sepsis scenario in the simulation center, instructional material, and sepsis lecture, and management of septic patients admitted in the ImCU. Each resident was evaluated in the beginning and at the end of the...
Source: Current Awareness Service for Health (CASH) - April 9, 2021 Category: Consumer Health News Source Type: news
Risk for Acute Kidney Injury High With Protocol for Post-TKA Infection
WEDNESDAY, April 7, 2021 -- Among patients with normal renal function at baseline who are treated with a high-dose antibiotic-loaded bone cement (ALBC) spacer and systemic antibiotic therapy after resection of a periprosthetic joint infection (PJI)... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - April 7, 2021 Category: Pharmaceuticals Source Type: news
Appropriate Use of Short-Course Antibiotics in Common Infections: Best Practice Advice From the American College of Physicians
This best practice advice, which is based on best available evidence (although not a formal systematic review), describes appropriate use of shorter durations of antibiotic therapy for common bacterial infections seen in both inpatient and outpatient health care settings. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 7, 2021 Category: Consumer Health News Source Type: news
Short-Course Antibiotics Noninferior for Pediatric Pneumonia
WEDNESDAY, March 10, 2021 -- Five days of antibiotic therapy is noninferior to standard care for treatment of children with community-acquired pneumonia (CAP), according to a study published online March 8 in JAMA Pediatrics.
Jeffrey M. Pernica,... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - March 10, 2021 Category: Pharmaceuticals Source Type: news
Study unravels antibiotic resistance in MRSA ‘superbug’ infections
FINDINGSResearchers applied a new approach pioneered at UCLA to predict whichmethicillin-resistant Staphylococcus aureus, or MRSA,infections willfail to respond toantibiotic treatment. By focusing on epigenetics — changes to gene expression that can’t be detected by standard DNA sequencing — the study examined how the immune system recognizes dangerous superbugs and works with antibiotics to clear them.BACKGROUNDThe Staphylococcus aureus bacterium can live harmlessly on a person’s skin and in their nose, occasionally causing mild infections that can be treated with standard antibiotics. When itentersthe bloodstre...
Source: UCLA Newsroom: Health Sciences - March 3, 2021 Category: Universities & Medical Training Source Type: news
Biological therapy has proved a suitable alternative to antibiotics
(Tel-Aviv University) Tel Aviv University researchers have developed a biological substitute for the treatment of tuberculosis, which in the future could serve as an alternative for the traditional " chemical " antibiotic therapy. Dr. Freund: " Advances in molecular medicine enable us to develop new tools to rout microbes, which can also solve the problem of drug-resistant germs " . This groundbreaking study has been published in the prestigious scientific journal Nature Communications. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - February 22, 2021 Category: Biology Source Type: news
Procalcitonin to Reduce Long-Term Infection-associated Adverse Events in Sepsis. A Randomized Trial, American journal of respiratory and critical care medicine 203(2): 202-210.
Rationale: Although early antimicrobial discontinuation guided by procalcitonin (PCT) has shown decreased antibiotic consumption in lower respiratory tract infections, the outcomes in long-term sepsis sequelae remain unclear. Objectives: To investigate if PCT guidance may reduce the incidence of long-term infection-associated adverse events in sepsis. Methods: In this multicenter trial, 266 patients with sepsis (by Sepsis-3 definitions) with lower respiratory tract infections, acute pyelonephritis, or primary bloodstream infection were randomized (1:1) to receive either PCT-guided discontinuation of antimicrobials or stand...
Source: Current Awareness Service for Health (CASH) - February 19, 2021 Category: Consumer Health News Source Type: news
Antibiotic stewardship for early-onset sepsis, Seminars in Perinatology 44(8): N.PAG-N.PAG.
Antibiotics are administered to the vast majority of preterm newborns and to a substantial proportion of term infants in the hours after birth due to risk for early-onset sepsis. The approaches taken to determine which newborns should be evaluated for early-onset sepsis, and what type and duration of antibiotics are administered, are important elements of neonatal antibiotic stewardship. The use of multivariate prediction models for sepsis risk assessment among infants born ≥35 weeks ' gestation can safely reduce the use of empiric antibiotic therapy. Approaches incorporating serial physical examination may also contribu...
Source: Current Awareness Service for Health (CASH) - February 11, 2021 Category: Consumer Health News Source Type: news
Incidence of Multidrug Resistant Infections in Emergency Department Patients with Suspected Sepsis, The American journal of the medical sciences 360(6): 650-655
Background: Inappropriate antibiotic therapy in sepsis is associated with poor outcomes, clinicians often provide routine coverage for multidrug resistant (MDR) bacteria. However, these regimens may contribute to problems related to antibiotic overuse. To understand the incidence and related factors of multidrug resistant bacterial infections in ED patients with sepsis, we examined how often patients with sepsis in our emergency department had MDR infections. We also explored risk factors for, and outcomes from, MDR bacterial infections.; Methods: We reviewed records of patients presenting to our emergency department (ED) ...
Source: Current Awareness Service for Health (CASH) - February 11, 2021 Category: Consumer Health News Source Type: news
Managing sepsis in pregnancy, Obstetrics, Gynaecology & Reproductive Medicine 31(1): 13-20
Maternal sepsis is a major contributor to global maternal mortality. The physiological changes associated with pregnancy can obscure some of the recognised signs and symptoms of sepsis. Modified early obstetric warning score charts and sepsis screening tools aid the early identification of the septic patient. Management of maternal sepsis should involve the whole multidisciplinary team and is centred on urgent resuscitation, prompt initiation of antimicrobial therapy and source control. There are logistical challenges in managing maternal sepsis in the peripartum period requiring close collaboration between critical care a...
Source: Current Awareness Service for Health (CASH) - February 11, 2021 Category: Consumer Health News Source Type: news
Antibiotic Use in Sepsis: How and Why Less Can Really Mean More (Survival), American Journal of Respiratory & Critical Care Medicine 203(2): 157-158
The article reports that antibiotic therapy is essential in the management of sepsis with delays in the initiation of appropriate antibiotic therapy being a consistent mortality risk factor. Topics include examines that clinicians have turned to biomarkers that can identify a bacterial infection and have used serial measurements to guide the discontinuation of antibiotic therapy. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - February 11, 2021 Category: Consumer Health News Source Type: news
Hope for a vaccination against Staphylococcus areus infections?
(German Center for Infection Research) Staphylococcus aureus (S. aureus) ranks among the globally most important causes of infections in humans and is considered a dreaded hospital pathogen. Active and passive immunisation against multi-resistant strains is seen as a potentially valuable alternative to antibiotic therapy. However, all vaccine candidates so far have been clinically unsuccessful. With an epitope-based immunisation, scientists at Cologne University Hospital and the German Center for Infection Research (DZIF) have now described a new vaccination strategy against S. aureus in the Nature Partner JournalNPJ VACCI...
Source: EurekAlert! - Infectious and Emerging Diseases - January 20, 2021 Category: Infectious Diseases Source Type: news
Prevalence and treatment of retrograde peri-implantitis: a retrospective cohort study covering a 20-year period
ConclusionsRPI was successfully treated with surgical curettage and bone substitute application and all implants are still in place after a mean follow-up of 8.83 ± 5.34 years.Clinical relevanceBacteria from teeth with failed endodontic treatment or residual lesions might be reactivated by drilling for implant osteotomy, with subsequent colonization of the implant apex and possible failure before prosthetic loading. Therefore, it might be recommended to take a periapical x-ray at implant placement and after 6 –8 weeks in order to intercept RPI before prostheses delivery. (Source: Dental Technology Blog)
Source: Dental Technology Blog - January 16, 2021 Category: Dentistry Source Type: news
