Evaluation of droplet digital PCR rapid detection method and precise diagnosis and treatment for suspected sepsis (PROGRESS): a study protocol for a multi-center pragmatic randomized controlled trial.
In this study, a total of 2292 patients with suspected sepsis will be randomly assigned to two arms: the ddPCR group and the control group with a ratio of 3:1. The primary outcome is the diagnostic efficacy, that is, the sensitivity and specificity of the ddPCR assay compared with the synchronous blood culture. Secondary outcomes include the mortality rates and the mean Sequential Organ Failure Assessment (SOFA) score at follow-up time points, the length of stay in the hospital, the time to directed antimicrobial therapy, duration of broad-spectrum antibiotic use, and the EQ-5D-5L score on day 90. Discussion: It is the fir...
Source: Current Awareness Service for Health (CASH) - July 28, 2022 Category: Consumer Health News Source Type: news
Evaluation of droplet digital PCR rapid detection method and precise diagnosis and treatment for suspected sepsis (PROGRESS): a study protocol for a multi-center pragmatic randomized controlled trial
In this study, a total of 2292 patients with suspected sepsis will be randomly assigned to two arms: the ddPCR group and the control group with a ratio of 3:1. The primary outcome is the diagnostic efficacy, that is, the sensitivity and specificity of the ddPCR assay compared with the synchronous blood culture. Secondary outcomes include the mortality rates and the mean Sequential Organ Failure Assessment (SOFA) score at follow-up time points, the length of stay in the hospital, the time to directed antimicrobial therapy, duration of broad-spectrum antibiotic use, and the EQ-5D-5L score on day 90. Discussion: It is the fir...
Source: Current Awareness Service for Health (CASH) - July 28, 2022 Category: Consumer Health News Source Type: news
Short-Course or Extended Antibiotics in Febrile Neutropenia? Short-Course or Extended Antibiotics in Febrile Neutropenia?
Short-course carbapenem antibiotic therapy is effective for chemotherapy-induced unexplained febrile neutropenia, although only for patients whose fever resolves after 3 days, say Dutch researchers.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - July 26, 2022 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news
German Researchers Create Non-invasive Lab-on-a-Chip Biosensor That Detects Antibiotic Levels from Breath Samples
Should the device prove effective, it could replace invasive point-of-care blood draws for clinical laboratory testing during patient drug therapy monitoring What if it were possible to perform therapeutic drug monitoring (TDM) without invasive blood draws using breath alone? Patients fighting infections in hospitals certainly would benefit. Traditional TDM can be a painful process for […]
The post German Researchers Create Non-invasive Lab-on-a-Chip Biosensor That Detects Antibiotic Levels from Breath Samples appeared first on Dark Daily. (Source: Dark Daily)
Source: Dark Daily - June 22, 2022 Category: Laboratory Medicine Authors: Jillia Schlingman Tags: International Laboratory News Laboratory Instruments & Laboratory Equipment Laboratory Pathology Laboratory Testing Advanced Materials anatomic pathology antibiotic levels antibiotic resistance antibiotic therapy biosensor Can Dincer P Source Type: news
Novel Antibiotic Shows Promise for C diff Infection Novel Antibiotic Shows Promise for C diff Infection
A novel antibiotic therapy for Clostridioides difficile infection, currently dubbed CRS3123, has demonstrated narrower selectivity and reduced bacterial derangement in the gut compared with other antibiotics.Medscape Medical News (Source: Medscape Infectious Diseases Headlines)
Source: Medscape Infectious Diseases Headlines - May 6, 2022 Category: Infectious Diseases Tags: Infectious Diseases News Source Type: news
Rapid Test May Help Avoid Aminoglycoside-Induced Hearing Loss in Newborns Rapid Test May Help Avoid Aminoglycoside-Induced Hearing Loss in Newborns
Researchers have developed a rapid genetic point-of-care test to help guide antibiotic therapy and avoid aminoglycoside-induced ototoxicity in babies in the neonatal intensive care unit.Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - March 22, 2022 Category: Pathology Tags: Pediatrics News Source Type: news
Treatment Strategy Studied for Drug Use-Linked Infective Endocarditis
MONDAY, March 14, 2022 -- A modeling study suggests that incorporating outpatient parenteral antimicrobial therapy (OPAT) or partial oral antibiotic approaches along with addiction care services in the treatment of patients with injection drug... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - March 14, 2022 Category: Pharmaceuticals Source Type: news
Adverse effects of delayed antimicrobial treatment and surgical source control in adults with sepsis: results of a planned secondary analysis of a cluster-randomized controlled trial.
Conclusions: Our findings suggest that management of sepsis is time critical both for antimicrobial therapy and source control. Also patients, who are not yet in septic shock, profit fro m early anti-infective treatment since it can prevent further deterioration. Trial registration ClinicalTrials.gov ( NCT01187134 ). Registered 23 August 2010, NCT01187134. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 10, 2022 Category: Consumer Health News Source Type: news
Take-home antibiotic therapies may improve health outcomes, lower costs, for patients with drug use-associated infective endocarditis
Often fatal, endocarditis remains a dangerous but largely unknown health threat for people who inject drugs. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - February 28, 2022 Category: American Health Source Type: news
Take-home antibiotic therapies may improve health outcomes, lower costs, for patients with drug use-associated infective endocarditis
Often fatal, endocarditis remains a dangerous but largely unknown health threat for people who inject drugs (Source: NIDA News)
Source: NIDA News - February 28, 2022 Category: Addiction Tags: News Release, Evidence-Based Practices, Harm Reduction, Treatment Source Type: news
Analysis of Missed Sepsis Patients in a Pediatric Emergency Department With a Vital Sign-Based Electronic Sepsis Alert
Conclusions: In an ED with an electronic sepsis alert, missed patients often had positive sepsis alerts but were not treated for sepsis. Missed patients were more likely than sepsis pathway patients to require escalation of care after admission and less likely to receive timely antibiotics. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - February 10, 2022 Category: Consumer Health News Source Type: news
Risk for Early-Onset Sepsis Low for Infants With Low-Risk Delivery
WEDNESDAY, Jan. 26, 2022 -- Infants born at all gestational ages with low-risk delivery characteristics have a low risk for early-onset sepsis (EOS) and may not require initiation of empiric antibiotic therapy immediately following birth, according... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 26, 2022 Category: Pharmaceuticals Source Type: news
Gastrointestinal PCR Panel Enables Faster, Better Antibiotic Therapy in Kids With Infectious Diarrhea Gastrointestinal PCR Panel Enables Faster, Better Antibiotic Therapy in Kids With Infectious Diarrhea
Using a multiplex gastrointestinal PCR (GI-PCR) panel in children with infectious diarrhea can speed up appropriate prescription of antibiotics, a new study suggests.Reuters Health Information (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - January 19, 2022 Category: Gastroenterology Tags: Pediatrics News Source Type: news
Sepsis Definitions: I Know It When I See It*
Over the past 3 –4 decades, efforts have been made to define sepsis, severe sepsis, and septic shock more objectively. For purposes of this editorial, “sepsis” will include the full spectrum of sepsis, severe sepsis, and septic shock. Why is sepsis so difficult to define? There are many signs, symptoms, and l aboratory abnormalities that commonly occur in patients with sepsis, but there is not a single “gold standard” definition or criterion that clinicians can all agree on and that facilitates the prompt recognition of the syndrome. The manifestations of sepsis are highly variable, and an infecting organism is n...
Source: Current Awareness Service for Health (CASH) - January 11, 2022 Category: Consumer Health News Source Type: news
