Prevalence ofAntibiotic-Resistant Pathogens in Culture-Proven Sepsis and Outcomes Associated With Inadequate and Broad-Spectrum Empiric Antibiotic Use
Conclusions and Relevance: In this study, most patients with community-onset sepsis did not have resistant pathogens, yet broad-spectrum antibiotics were frequently administered. Both inadequate and unnecessarily broad empiric antibiotics were associated with higher mortality. These findings underscore the need for better tests to rapidly identify patients with resistant pathogens and for more judicious use of broad-spectrum antibiotics for empiric sepsis treatment. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 6, 2020 Category: Consumer Health News Source Type: news
Analysis to determine cost-effectiveness of procalcitonin-guided antibiotic use in adult patients with suspected bacterial infection and sepsis
Conclusion(s): Real-world implementation of PCT-guided antibiotic use may have improved patients ' quality of life while decreasing hospital costs in MICU patients with undifferentiated sepsis. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 6, 2020 Category: Consumer Health News Source Type: news
Bacterial and fungal etiology of sepsis in children in the United States: Reconsidering empiric therapy
Conclusion(s): In this nationally representative administrative database, the most common identified pathogen was S. aureus in previously healthy and chronically ill children. In addition, a high proportion of children with sepsis and select chronic diseases had infections with methicillin-resistant S. aureus, fungal infections, Pseudomonas infections, and C. difficile. Clinicians caring for pediatric patients should consider coverage of these organisms when administering empiric antimicrobials for sepsis. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 6, 2020 Category: Consumer Health News Source Type: news
Reduced antibiotic exposure by serial physical examinations in term neonates at risk of early-onset sepsis
Background: Suspected early-onset sepsis (EOS) results in antibiotic treatment of a substantial number of neonates who are uninfected. We evaluated if an approach using serial physical examinations (SPEs) can reduce antibiotic exposure for suspected EOS in term neonates during the first 3 days of life, without affecting safety. Method(s): Within a quality-improvement framework, SPEs for 24-48 hours for neonates with suspected EOS was implemented in the neonatal intensive care unit, Stavanger, Norway. The proportion of neonates>=37 weeks gestation exposed to antibiotics, antibiotic therapy-days and the safety outcome time f...
Source: Current Awareness Service for Health (CASH) - May 6, 2020 Category: Consumer Health News Source Type: news
Long-lasting, low toxicity antimicrobial peptide fights 'superbug' lung infections
(University of Pittsburgh) Through serendipity, researchers considerably reduced the toxicity of a potential antibiotic against the most feared drug-resistant bacteria, while also improving its stability in fighting infections. The new antibiotic -- administered via the windpipe to target lung infections -- proved more effective than its experimental predecessor and traditional last-resort antibiotic therapies in fighting drug-resistant bacteria in laboratory cell cultures and mice. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - May 1, 2020 Category: Infectious Diseases Source Type: news
Antibiotic Prophylaxis in Open Fractures Antibiotic Prophylaxis in Open Fractures
Prophylactic antibiotic therapy plays a key role in the management of open fractures by reducing the risk of infection. Which regimens are most effective?Journal of the American Academy of Orthopaedic Surgeons (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 28, 2020 Category: Consumer Health News Tags: Orthopaedics Journal Article Source Type: news
The History of Biomarkers: How Far Have We Come?
Sepsis is one of the oldest and most elusive syndromes in medicine that is still incompletely understood. Biomarkers may help to transform sepsis from a physiologic syndrome to a group of distinct biochemical disorders. This will help to differentiate between systemic inflammation of infectious and noninfectious origin and aid therapeutic decision making, hence improve the prognosis for patients, guide antimicrobial therapy, and foster the development of novel adjunctive sepsis therapies. To reach this goal requires increased systematic investigation that includes twenty-first century scientific approaches and technologies...
Source: Current Awareness Service for Health (CASH) - March 13, 2020 Category: Consumer Health News Source Type: news
Increased Mortality Seen With Empirical Anti-MRSA Treatment for Pneumonia Increased Mortality Seen With Empirical Anti-MRSA Treatment for Pneumonia
Empirical anti-MRSA treatment is associated with an increased risk of 30-day mortality in patients hospitalized for pneumonia, compared with standard antibiotic therapy, according to a retrospective study.Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - February 22, 2020 Category: Pathology Tags: Pulmonary Medicine News Source Type: news
QOL Similar After Surgery, Antibiotics for Uncomplicated Appendicitis
FRIDAY, Feb. 21, 2020 -- For patients being treated for uncomplicated acute appendicitis, quality of life (QOL) is similar at seven years after appendectomy or antibiotic therapy, according to a study published online Feb. 19 in JAMA Surgery.
Suvi... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - February 21, 2020 Category: Pharmaceuticals Source Type: news
Empirical Anti-MRSA vs Standard Antibiotic Therapy and Risk of 30-Day Mortality in Patients Hospitalized for Pneumonia
US-based cohort study of 88,605 hospitalisations for pneumonia did not find a mortality benefit for treatment with empirical anti –methicillin-resistant S aureus (MRSA) therapy vs standard antibiotics for any group of patients examined, even those with risk factors for MRSA. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - February 20, 2020 Category: Consumer Health News Source Type: news
Effect of Vancomycin or Daptomycin With vs Without an Antistaphylococcal β-Lactam on Mortality, Bacteremia, Relapse, or Treatment Failure in Patients With MRSA Bacteremia: A Randomized Clinical Trial
RCT (n=352) found no significant difference in the primary composite end point of mortality, persistent bacteremia, relapse, or treatment failure for addition of an antistaphylococcal β-lactam to standard antibiotic therapy (vancomycin or daptomycin) vs standard therapy alone. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - February 13, 2020 Category: Consumer Health News Source Type: news
Partnership Seeks to Address Gaps in Diagnosing Sepsis
Sepsis continues to be a serious threat to patients globally. Recent studies estimate that more than 30 million people are impacted worldwide every year and may be implicated in 6 million deaths,1 David Dolinger, VP Product Realisation at QuantuMDx Group Limited, told MD+DI.
Infection and drug resistance contribute significantly to sepsis risks. In neonatal care alone, it is estimated that one million newborn deaths each year are associated with maternal infection, such as maternal sepsis,2Â pointed out Dolinger. And three out of every ten deaths because of neonatal sepsis are thought to be caused by resistant p...
Source: MDDI - February 1, 2020 Category: Medical Devices Authors: Daphne Allen Tags: IVD Source Type: news
Risk and Prognostic Factors in Very Old Patients with Sepsis Secondary to Community-Acquired Pneumonia.
Little is known about risk and prognostic factors in very old patients developing sepsis secondary to community-acquired pneumonia (CAP). In very old patients hospitalized with CAP, in-hospital and 1-year mortality rates were increased if they developed sepsis. Antibiotic therapy before hospital admission was associated with a lower risk of sepsis. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 3, 2020 Category: Consumer Health News Source Type: news
Journal Highlights From the January and February Issues of JAMDA
Antibiograms, created by a facility ’s contracted microbiology laboratory, can help hospitals and nursing homes identify trends in antibiotic resistance and create protocols for empiric antimicrobial therapy. In a recent study conducted in Providence, RI, Maria-Stephanie A. Hughes, PharmD, a fellow at the Providence Veterans Affairs Medical Center, and colleagues found a lack of agreement between antibiograms of Veterans Affairs (VA) nursing homes and their affiliated acute-care facilities. (Source: Caring for the Ages)
Source: Caring for the Ages - December 25, 2019 Category: Health Management Tags: Journal Highlights Source Type: news
Pleural Effusion: An Atypical Presentation of Kawasaki Disease Pleural Effusion: An Atypical Presentation of Kawasaki Disease
This case of a 7-year-old patient highlights the need to consider the diagnosis of Kawasaki disease in the presence of pneumonia and pleural effusion that is nonresponsive to antibiotic therapy.Journal of Medical Case Reports (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - December 24, 2019 Category: Intensive Care Tags: Family Medicine/Primary Care Journal Article Source Type: news
