Patient Symptomatology in Anal Dysplasia
This database review of patients undergoing high-resolution anoscopy with biopsy showed that those with anal pain and lesions are at increased risk of high-grade anal dysplasia. See also the Invited Commentary by Fleshman. (Source: JAMA Surgery)
Source: JAMA Surgery - April 15, 2015 Category: Sports Medicine Source Type: research
Considering Standards of Care for Anal Cancer
This Invited Commentary raises questions regarding the routine use of high-resolution anoscopy as a screening tool for anal dysplasia and cancer. (Source: JAMA Surgery)
Source: JAMA Surgery - April 15, 2015 Category: Sports Medicine Source Type: research
Which Lesions Should Be Biopsied During High-Resolution Anoscopy? Prospective Descriptive Study of Simple Morphological Criteria
Conclusions: Several simple morphological criteria are significantly associated with high-grade AIN and are found less often in low-grade AIN. A combination of these morphological criteria provides sufficient positive predictive value to guide biopsy placement during HRA. (Source: Journal of Lower Genital Tract Disease)
Source: Journal of Lower Genital Tract Disease - March 27, 2015 Category: OBGYN Tags: Original Articles: Perianal and Anal Source Type: research
Risk of progression to high-grade anal intraepithelial neoplasia in HIV-infected MSM
Conclusion: The rate of progression to HGAIN varies according to different predictors that should be considered when assessing the particular risk of each patient. Patients with low risk of progression could be screened at longer intervals.
Brief summary: We describe the risk of progression to HGAIN in a cohort of 556 HIV-infected MSM. The incidence rate of HGAIN varies widely according to different predictors. These factors should be considered when assessing the particular risk of each patient. (Source: AIDS)
Source: AIDS - March 19, 2015 Category: Infectious Diseases Tags: Clinical Science Source Type: research
Evaluation of the incidence of haemorrhoidal disease in patients with ankylosing spondylitis
Abstract
Haemorrhoidal disease (HD) is one of the most common diseases encountered by the clinicians of general surgery. Chronic constipation, pushing during defecation and increased abdominal pressure play an important role in development of haemorrhoidal disease. Patients with ankylosing spondylitis (AS) frequently use the Valsalva manoeuvre in their daily lives, which may increase the abdominal pressure, leading to formation of haemorrhoids. The purpose of this study was to evaluate the incidence of haemorrhoidal disease in patients with AS. A total of 221 individuals were included in this study in t...
Source: Clinical Rheumatology - March 1, 2015 Category: Rheumatology Source Type: research
Oncogenic human papillomavirus is not helpful for cytology screening of the precursor lesions of anal cancers in Taiwanese men who are infected with human immunodeficiency virus
Conclusions
Anal cytology yielding atypical squamous cells of undetermined significance or higher grades could detect two-thirds of high-grade anal intraepithelial neoplasias in HIV-infected men and should be promoted for anal cancer prevention. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - February 25, 2015 Category: Cancer & Oncology Source Type: research
Human Papillomavirus 16-Specific T-Cell Responses and Spontaneous Regression of Anal High-Grade Squamous Intraepithelial Lesions
Conclusions. Systemic HPV-16 E6- and E7-specific T-cell responses were common in men who have sex with men. E6-specific CD4+ T-cell responses may be associated with recent HSIL regression.
Clinical Trials Registration. NCT02007421. (Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - January 6, 2015 Category: Infectious Diseases Authors: Tong, W. W. Y., Shepherd, K., Garland, S., Meagher, A., Templeton, D. J., Fairley, C. K., Jin, F., Poynten, I. M., Zaunders, J., Hillman, R. J., Grulich, A. E., Kelleher, A. D., Carr, A., on behalf of the Study of the Prevention of Anal Cancer (SPANC) tea Tags: VIRUSES Source Type: research
MRI defecography in patients with faecal incontinence
ConclusionOther than for anterior rectocele, there is poor correlation between MRI defecography and clinical examination with rigid rectoscopy and can detect a variety of abnormal static and dynamic pelvic disorders. This includes enterocele, which could result in a modification of the surgical approach to intussusception and anterior rectocele.This article is protected by copyright. All rights reserved. (Source: Colorectal Disease)
Source: Colorectal Disease - December 31, 2014 Category: Gastroenterology Authors: C Melchior, V Bridoux, O Touchais, C Savoye‐Collet, A‐M Leroi Tags: Original Article Source Type: research
High-Resolution Anoscopy or Expectant Management for Anal Intraepithelial Neoplasia for the Prevention of Anal Cancer: Is There Really a Difference?
CONCLUSIONS: Patients with squamous-cell dysplasia followed with expectant management or high-resolution anoscopy rarely develop squamous-cell cancer if they are compliant with the protocol. The cost, morbidity, and value of high-resolution anoscopy should be further evaluated in lieu of these findings. (Source: Diseases of the Colon and Rectum)
Source: Diseases of the Colon and Rectum - December 12, 2014 Category: Gastroenterology Tags: Original Contributions: Colorectal/Anal Neoplasia Source Type: research
High-resolution anoscopy in women with cervical neoplasia
Conclusion HRA findings can be systematized, reducing the subjectivity of interpretation. (Source: International Journal of Gynecology and Obstetrics)
Source: International Journal of Gynecology and Obstetrics - November 12, 2014 Category: OBGYN Source Type: research
High-resolution anoscopy in women with cervical neoplasia
To describe high-resolution anoscopy (HRA) findings and compare them with histopathology results. (Source: International Journal of Gynaecology and Obstetrics)
Source: International Journal of Gynaecology and Obstetrics - November 5, 2014 Category: OBGYN Authors: Sandra A. Heráclio, Juliana Schettini, Micheline L. Oliveira, Alex Sandro R. Souza, Paulo Roberto E. Souza, Melania Maria R. Amorim Tags: Clinical article Source Type: research
Does high-risk human papilloma virus genotyping of abnormal anal cytology improve detection of high-grade anal intraepithelial neoplasia?
Conclusions Our results with a small cohort suggest that genotyping for HPV 16/18 may be effective in identifying patients at high risk for anal cancer and in reducing the number of anoscopy referrals. Prospective studies with follow-up are warranted. (Source: Journal of the American Society of Cytopathology)
Source: Journal of the American Society of Cytopathology - October 12, 2014 Category: Cytology Source Type: research
Anal Carcinoma
This article is part of an expert video encyclopedia. (Source: Video Journal and Encyclopedia of GI Endoscopy)
Source: Video Journal and Encyclopedia of GI Endoscopy - October 12, 2014 Category: Gastroenterology Source Type: research
Common Anorectal Conditions: Evaluation and Treatment
Abstract
Anorectal conditions are frequently encountered clinical entities but are often misunderstood and misdiagnosed. Although the most common anorectal disorders are not considered life threatening, they can negatively impact patients’ activities of daily living and quality of life. Comprehensive anorectal examination, including the use of anoscopy, has become a “lost art,” and graduate medical education programs should utilize more formal training in this area. This review discusses the comprehensive anorectal exam and the diagnosis and management of three common anorectal disorders: hemorrho...
Source: Current Gastroenterology Reports - September 5, 2014 Category: Gastroenterology Source Type: research
HPV and Anal Cancer in HIV-Infected Individuals: A Review
Abstract
HIV infection is one of the strongest risk factors for anal squamous cell cancer (ASCC). Most ASCC are caused by HPV, and most HPV-associated ASCC are caused by HPV-16. Anal HPV infections are very common in men who have sex with men (MSM), and nearly universal among HIV-infected MSM. High-grade anal intraepithelial neoplasia (HGAIN), the precursor for ASCC, is present in about 30 % of HIV+ MSM, but neither the progression rate to ASCC nor the regression rate are known. The incidence rate of ASCC among HIV-infected people has risen in the first decade after cART became available, but appears t...
Source: Current HIV/AIDS Reports - September 1, 2014 Category: Infectious Diseases Source Type: research
