Androgen Independent Prostate Cancer Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

In Silico Bioinformatics Analysis on the Role of Long Non-Coding RNAs as Drivers and Gatekeepers of Androgen-Independent Prostate Cancer Using LNCaP and PC-3 Cells
This study aimed to profile the aberrantly expressed lncRNAs in androgen-dependent (LNCaP) PCa compared to androgen-independent (PC-3) PCa cells. This was achieved by using a 384-well plate of PCa lncRNA gene panel. Differential expression of ±2 up or downregulation was determined using the CFX Maestro software v2.1. LncSEA and DIANA-miRPath were used to identify the enriched pathways. Telomerase RNA component (TERC) lncRNA was illustrated to participate in various tumourigenic classes by in silico bioinformatics analysis and was thus selected for validation using RT-qPCR. Further bioinformatics analysis revealed the invo...
Source: Current Issues in Molecular Biology - September 27, 2023 Category: Molecular Biology Authors: Mandisa Mbeje Jeyalakshmi Kandhavelu Clement Penny Mmamoletla Kgoebane-Maseko Zodwa Dlamini Rahaba Marima Source Type: research

Prostate cancer therapy outcome prediction: are miRNAs a suitable guide for therapeutic decisions?
ConclusionThe selected miRNA-based panel has the potential to be a guide for therapeutic decision making in the effective treatment of PCa. (Source: Andrology)
Source: Andrology - September 27, 2023 Category: Urology & Nephrology Authors: MariaYu Konoshenko, Pavel Laktionov, Olga Bryzgunova Tags: REVIEW ARTICLE Source Type: research

F77 antigen is a promising target for adoptive T cell therapy of prostate cancer
This study entails the generation and evaluation of a second-generation CAR against a carbohydrate antigen on malignant prostate cancer cells. Using a single chain fragment variable (scFv) from an F77-specific mouse monoclonal antibody, we created second-generation CARs with CD28 and CD137 (4-1BB) costimulatory signals. F77 expressing lentiviral CAR T cells produce cytokines and kill tumor cells in a F77 expression-dependent manner. These F77-specific CAR T cells eradicate prostate tumors in a human xenograft model employing PC3 cells. These findings validate F77 as a promising immunotherapeutic target for prostate cancer ...
Source: Biochemical and Biophysical Research communications - September 17, 2023 Category: Biochemistry Authors: Payal Grover Selene Nunez-Cruz John Leferovich Tyra Wentz Atrish Bagchi Michael C Milone Mark I Greene Source Type: research

F77 antigen is a promising target for adoptive T cell therapy of prostate cancer
This study entails the generation and evaluation of a second-generation CAR against a carbohydrate antigen on malignant prostate cancer cells. Using a single chain fragment variable (scFv) from an F77-specific mouse monoclonal antibody, we created second-generation CARs with CD28 and CD137 (4-1BB) costimulatory signals. F77 expressing lentiviral CAR T cells produce cytokines and kill tumor cells in a F77 expression-dependent manner. These F77-specific CAR T cells eradicate prostate tumors in a human xenograft model employing PC3 cells. These findings validate F77 as a promising immunotherapeutic target for prostate cancer ...
Source: Cell Research - September 17, 2023 Category: Cytology Authors: Payal Grover Selene Nunez-Cruz John Leferovich Tyra Wentz Atrish Bagchi Michael C Milone Mark I Greene Source Type: research

Generating a murine PTEN null cell line to discover the key role of p110 β-PAK1 in Castration-Resistant Prostate Cancer invasion
This study also shows that PAK1 is a potential target for CRPC treatment. Implications: This study uses a newly generated PTEN null prostate cancer cell line to define a critical functional role of p110β-PAK1 in CRPC migration/invasion. This study also shows that the p110β-PAK1 axis can potentially be a therapeutic target in CRPC metastasis.PMID:37606694 | DOI:10.1158/1541-7786.MCR-22-0808 (Source: Cell Research)
Source: Cell Research - August 22, 2023 Category: Cytology Authors: Haizhen Wang Yu Zhou Chen Chu Jialing Xiao Shanshan Zheng Manav Korpal Joshua M Korn Tiffany Penaloza Richard Drake Wenjian Gan Xueliang Gao Source Type: research

GSE225207 Nuclear mTOR cooperates with FoxA1 to promote androgen-independent prostate cancer progression
Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - July 23, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research

Carbohydrate effect of novel arene Ru(II) phenanthroline-glycoconjugates on metastatic biological processes
J Inorg Biochem. 2023 Jul 13;247:112326. doi: 10.1016/j.jinorgbio.2023.112326. Online ahead of print.ABSTRACTNovel water-soluble half-sandwich ruthenium(II) polypyridyl-glycoconjugates [Ru(p-cymene)Cl{N-(1,10-phenanthroline-5-yl)-β-glycopyranosylamine}][Cl] (glycopyranosyl = d-glucopyranosyl (1), D-mannopyranosyl (2), L-rhamnopyranosyl (3) and l-xylopyranosyl (4)) have been synthesized and fully characterized. Their behaviour in water under physiological conditions has been studied by nuclear magnetic resonance spectroscopy, revealing their hydrolytic stability. Interactions of the novel compounds with duplex-deoxiribonuc...
Source: Journal of Inorganic Biochemistry - July 21, 2023 Category: Biochemistry Authors: Elena de la Torre-Rubio Laura Mu ñoz-Moreno Ana M Bajo Maria-Selma Arias-P érez Tom ás Cuenca Lourdes Gude Eva Royo Source Type: research

Veratramine Inhibits the Cell Cycle Progression, Migration, and Invasion via ATM/ATR Pathway in Androgen-Independent Prostate Cancer
In this study, we discovered that veratramine exerted antitumor effects on AIPC cells. We demonstrated that veratramine significantly inhibited the proliferation of cancer cells via G0/G1 phase arrest induced by the ATM/ATR and Akt pathways. These results suggest that veratramine is a promising natural therapeutic agent for AIPC.PMID:37385965 | DOI:10.1142/S0192415X2350060X (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - June 29, 2023 Category: Complementary Medicine Authors: Hee-Yeon Kim Seoung-Woo Lee Seong-Kyoon Choi Janbolat Ashim Wansoo Kim Su-Min Beak Jin-Kyu Park Jee Eun Han Gil-Jae Cho Zae Young Ryoo Jain Jeong Yong-Ho Lee Hyohoon Jeong Wookyung Yu Song Park Source Type: research

GSE235514 ESR1+ luminal epithelial cells contribute to androgen-independent prostate survival in the absence of SRD5A2
Contributors : Christina Sharkey ; Xingbo Long ; Ra'ad Al-Faouri ; Douglas Strand ; Aria F Olumi ; Wang ZongweiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSteroid 5 α reductase 2 (SRD5A2) is crucial for prostatic development, converting testosterone to dihydrotestosterone (DHT). While 5α reductase inhibitors (5ARI) effectively reduce prostate size in benign prostate hyperplasia (BPH), their limited efficacy against BPH-related lower urinary tract symptoms (LU TS) and mechanisms of 5ARI resistance remain unclear. Here, we developed a Srd5a2-/- mouse model and employed single...
Source: GEO: Gene Expression Omnibus - June 26, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

Rbf/E2F1 control growth and endoreplication via steroid-independent Ecdysone Receptor signalling in < i > Drosophila < /i > prostate-like secondary cells
by Aashika Sekar, Aaron Leiblich, S. Mark Wainwright, Cl áudia C. Mendes, Dhruv Sarma, Josephine E. E. U. Hellberg, Carina Gandy, Deborah C. I. Goberdhan, Freddie C. Hamdy, Clive Wilson In prostate cancer, loss of the tumour suppressor gene,Retinoblastoma (Rb), and consequent activation of transcription factor E2F1 typically occurs at a late-stage of tumour progression. It appears to regulate a switch to an androgen-independent form of cancer, castration-resistant prostate cancer (CRPC), which frequently still requires androgen receptor (AR) signalling. We have previously shown that upon mating, binucleate secondary cell...
Source: PLoS Genetics - June 26, 2023 Category: Genetics & Stem Cells Authors: Aashika Sekar Source Type: research

Augmentation of Docetaxel-Induced Cytotoxicity in Human PC-3 Androgen-Independent Prostate Cancer Cells by Combination With Four Natural Apoptosis-Inducing Anticancer Compounds
In conclusion, the combination of DTX with the four test compounds could effectively enhance the anti-prostate cancer activity of DTX. This combination has the added value of reducing the DTX effective concentration. We surmise that calebin A, 3'-hydroxypterostilbene, hispolon, and tetrahydrocurcumin were all excellent drug candidates that produced significant antiproliferative activity when used alone and synergistically enhanced the anticancer effect of DTX. Further in vivo studies using animal models of prostate cancer are needed to confirm our in vitro findings.PMID:37292146 | PMC:PMC10249917 | DOI:10.1177/1934578x2311...
Source: Natural Product Communications - June 9, 2023 Category: Biochemistry Authors: Inass A Ahmed Saly Hafiz Sabrina van Ginkel Satyanarayana R Pondugula Azza S Abdelhaffez Hayam G Sayyed Ebtihal A Abd El-Aziz Mahmoud M Mansour Source Type: research